Conserved Protein Domain Family
Moulting_cycle

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pfam04870: Moulting_cycle 
Moulting cycle
This family of proteins plays a role in the moulting cycle of nematodes, which involves the synthesis of a new collagen-rich cuticle underneath the existing cuticle and the subsequent removal of the old cuticle.
Statistics
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PSSM-Id: 428165
Aligned: 21 rows
Threshold Bit Score: 350.122
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFP02723      165 PFTLITKQITKSIRALKNK--KEERGWRQIMVDVKKTGEVIEKRRKVKEMIGKSVRSRSAKPKKlylsprkplanndyea 242 
2_pfamImport    1 PFTKITKQITKTIRALKNK--KDERGWRQIMVDVKRTGDLVEKRNKVKEMIGKSVRGRTRSnarkp-------------- 64  
O76555        187 gmTKLAKSLTNTVRAMKNKt-ERAEPWVEAVGRIKKLGEEAKREKKNREVMKKRLKQMIDNTPAefvdpr---------- 255  Caenorhabditi...
CRZ25494      187 PFGILGKHLSKMTRIIKNK--EPNSSWKKTMYEIESLKRREQEKNDFAEKLKKRFPFSFKNTEPkltpe----------- 253 
CAP22655     1036 PFSNIAKHLTNLVREKKNKenEPKKKWQTVINEIKEELDRIKKKKKDREEFKNIFSKYSRTMKMlgld------------ 1103
CAP23802      188 PFGLVTKHLTSAVKLLKHT--DKVSKWQDTIERIAKKADVIKEQKKMEDFMQRRLSVFTDAAA----------------- 248 
Q9XU60          3 PLGVLAKHLSHTLRLIKNK--RTTSKWEDTISRISEKASQIKQQKDMERRIRKQRGY----------------------- 57   Caenorhabditi...
EFP01901      177 PLGVLAKHLSHTLRVIKNK--RTTSKWGDTITRISEKAQKIKERKEMQRLLEKRMNVFTENGE----------------- 237 
EGT56201      176 PLGVLAKHLSHTLRLIKNK--RTTSRWEDTITRISEKAQKIKERKELEKLFQKRMNVFQEASE----------------- 236 
CAP25584        2 rIHLLAKHLSHTLRIIKNK--RNTSKWEDTITRISEKAQKIKKRKEMEKMFQKRMNVFTEAAEGl--------------- 64  
EFP02723      243 lddpiqMTNEIiqtSSESDKKIDAeELLKRFQD-----HPEDILNDDAQGLLNMTGQ-ETEAVLRIKLIRE--------- 307 
2_pfamImport   65 -ladnnTSDEQlenDS---KPVNMdEMFQRLQD-----HPEEILKNDAPRLLNMTGE-QSEAVGRIKLIRD--------- 125 
O76555        256 ---------------------------------kpvalKQAEMEDENNEIAKLMRKKeADEIRVPLKFLRK--------- 293  Caenorhabditi...
CRZ25494      254 ---------------------------------ekllaKELHISNHLLQGLDKNSMK-TKKTLEIIQLFKR--------- 290 
CAP22655     1104 ---pkqAFEKAvsfFLQCRTRIPNfDIIQGMSS-----LGEEIAD-SSNTTEPMSEE-ETALKKPLMMIRDgkfrvldfe 1173
CAP23802      249 --------------KMKQNKKLAKdDSLKEMNDleefiDNDQIRDVLRNRKEKITEQ-DKLLMIPMKMMRD--------- 304 
Q9XU60         58 --------------ELPEEKPVPLdKDVRELIDlekyiGDEDLKSMVRHKSGNLTEQ-DRAMLIPMRLIRG--------- 113  Caenorhabditi...
EFP01901      238 --------------NFEQLKS-PEdDEAKELIDlekyiDDDDLKSMVRKKAGNLTEQ-DRMMLIPMKLIRE--------- 292 
EGT56201      237 --------------DMKQ--SRILdHDAQELLDlekyiGDDDLKSMVRKKAGNLTEH-HRMMLIPMRLIRQ--------- 290 
CAP25584       65 ---------------------nPNdSDAQELMDlekyiRDDNLKSMVHKKAGNLTDQ-DRMMLIPMRLIRG--------- 113 
EFP02723      308 -----AVKLGLSLGGQNVSGFDQKSMKFASPRFFAIAPEEHKKENDTvsfireqdtceltcsfsqINILSPSLFSLHDEG 382 
2_pfamImport  126 -----AVKLGLSLGGQNVRGFDQKSLRFASPRFFAIAPEEHKRKDDT------------------VNILSPSLFSLHDEG 182 
O76555        294 -----AVKTALMLGGQNVTDFDQKTLKMVSPRMMSIVPE--QEDESL------------------FNLLSPSLFSLHDEG 348  Caenorhabditi...
CRZ25494      291 -----AIKLAMVLNGANGTKLENKTLRFGSPRLLSLVPD---NVNDQ------------------INILSPSLLSMHDKG 344 
CAP22655     1174 nkkssGVKLGMMLAGKNVSNFDERKISLMSPQFMSVLPD--EQANDT------------------VNLLSPSVFALHEKG 1233
CAP23802      305 -----AAKMSLGMTGYNTTDFDRKIVRIISPRIMSVIPQEEEAKNNE------------------IDVLSPSLFALHDDG 361 
Q9XU60        114 -----AAKLGLSMTGYNTTDFDRKVVRIFSPKLMSVVPESEEARKNE------------------IDILSPSLFSLHDDG 170  Caenorhabditi...
EFP01901      293 -----AAKLGLSMTGYNTTDFDRKVVRIFSPKMMSVIPTSDETKKDE------------------IDILSPSLFSLHHDG 349 
EGT56201      291 -----AAKLGLTMTGQNTTDFDRKVVRIFSPKMMSVVPTSDDAKKDE------------------IDILSPSLFSLHQDG 347 
CAP25584      114 -----AAKLGLTMAGQNTTDFDRKVVRIFSPKMMSVVPANEDEKKDEvgagysn----pytinfqIDILSPSLFSLHHDG 184 
EFP02723      383 SPDEQKTSLVKLLGDK----EGIDKDSFMDLLTELTGVADTVDDAAQKASRE-----SEGTLINVKGEEINVSRENL--- 450 
2_pfamImport  183 TQEEKSLSLPKIFDNTitqhDGAEKDSFMDLITEISGVADAVDDAAQKVARE-----SEGVLMKSDGAEISVSRENV--- 254 
O76555        349 EGIEKLTSLPHLLKKL----DNHGQNAWMDFIVEAAGVSDEVTKTEKVFREK-----KEKELRGTDGVPLYFTKENA--- 416  Caenorhabditi...
CRZ25494      345 KGLEALTSVPELLKAA----GNRDYEEWLSFIIEASGTTDAIHKLKEKNELDwlppgYKSMPRGIDGQPMFFTKENV--- 417 
CAP22655     1234 TELDQMLSLSKAMRFL----SENGHDEWMNLILEASGVTEAVEKMRVRNRREe-------------------TRNRVvpk 1290
CAP23802      362 SGVEKKASLGNLLGSLt---NNKDSQDFLDFIVEATGVNEAMERVEKKIGEYrr-lkDDAMGRGPEGQPLYFTKENV--- 434 
Q9XU60        171 TADEKEVSLQNLLGSLs---TNKDTSQLLDFIIEATGVDEAMERVETKIDE------SFGSERGPEGQPLYFTKENV--- 238  Caenorhabditi...
EFP01901      350 SEIEKEVSLQNLLGSLt---AHKDTSDLLDFIIEATGVDEAMERVETKIEE------SFHSERGPEGQPLYFTKENV--- 417 
EGT56201      348 SSIEKEVSLQNLLGSLt---ANKDTSDLLDFIIEATGVDEAMERVESKIEQ------SFQQERGPEGQPLYFTKENV--- 415 
CAP25584      185 SEIEKEVSLQNLLGSLt---ANKDTSDLLDFITEATGVDEAMERVEQKIEQ------NFQSERGPEGQPLYFTKENV--- 252 
EFP02723      451 TKVYGEeNYRKMKVLEKLHGMYTDE---------------QvsmMNHFNKSGYAIMTDKQRDMVYGSGAPFENKLTLEAG 515 
2_pfamImport  255 TRIYGEdNYRKMKVLEKMHGMYTEE---------------Q---MHHFNKSGYAIMNDKQREMMYGAGAPFENAQTMKAG 316 
O76555        417 TKILGNeEKSKIEVFEDLDKSYSEE---------------Q---KKKLNDDGFAFLTEKQMERLYGKESPYKHTKALKKF 478  Caenorhabditi...
CRZ25494      418 TEFDPE-LAREVELFENLTHSLTPK---------------Q---LTDFNTTGFSMMTPKQLTMFYGPQSPLNDSKALNFF 478 
CAP22655     1291 XXXXGEyETSKIDSMEALHKSMSAAqvlyrnwqlswsllfQ---MHEMNTTGFAIMTPFQISQFYGPRSPYNDSYAYKNY 1367
CAP23802      435 TEKYPH-EAKKIDMFEALDKTYSDE---------------Q---LKEMNRTGYTIMRHDQMDLIYGKGSVGENEKFLKTA 495 
Q9XU60        239 TANYPH-EAQKLEIFEALDRTYSTS---------------Q---LNEMNRTGYAIMRHDQMDLIYGDQSIAKNPKFLKQA 299  Caenorhabditi...
EFP01901      418 TAQ----ESKRIEIFEALDTTYSEN---------------Q---LKEMNRTGYTIMTHEQMDLVYGNYSIMENQKLLREA 475 
EGT56201      416 TEKYPH-EAKKIEIFEALDKTYSEE---------------Q---LKEMNRTGYTIMRHDQMDLIYGNKSVMRNLEFLERA 476 
CAP25584      253 TEKYPL-EARKIETFELLDKTFSME---------------Q---LREMNRTGYTIMRHDQMELIYGNNSVHKNPEFLNRV 313 
EFP02723      516 RNLTMPKAKKALHTVIQEIGKGNIKV 541 
2_pfamImport  317 QNLTMARAKRALHTVIHEIGKGNIK- 341 
O76555        479 KRL-RDDPEKYIEKDIRALAEAEkfr 503  Caenorhabditis elegans
CRZ25494      479 LSLSEDDMHRHILSDIRDMAKMNssl 504 
CAP22655     1368 RNIRRNDIPHMLENNIHRMAREEQAF 1393
CAP23802      496 KALSRPQIDRAIMSTIKDLAHEKVKF 521 
Q9XU60        300 KALSRAEIDRSIMSTIKDLAKEKVKF 325  Caenorhabditis elegans
EFP01901      476 KRMSRPEIDRSIMQTIDDLAKEKVKF 501 
EGT56201      477 KQLSRSEIDRNIMGTINDLAREKVKF 502 
CAP25584      314 KGMSRSEIDRNIMGTIGDLAKEKIKF 339 
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