1ICN,2MM3,1P6P,1LFO,2CBR,1EII,1MDC,1PMP,3PP6,2A0A,1FTP,1O8V,1VYG,2POA,1VYF,5XN9,5Z4G,5IBO


Conserved Protein Domain Family
FABP
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cd00742: FABP 
intracellular fatty acid-binding protein family
Members of this family are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner. They protect and shuttle fatty acids within the cell and are involved in acquisition and removal of fatty acids from intracellular sites. They include cellular retinol-binding proteins (CRBPs) which participate in the cellular uptake of vitamin A in the form of free retinol, cellular retinoic acid-binding proteins (CRABPs) which participate in the metabolism of vitamin A and retinoic acid, and bind all trans retinoic acid, but not retinol, and FABPs similar to FABP3 which plays an important role in fatty acid transportation, cell growth, cell signaling, and gene transcription.
Links
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Statistics
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PSSM-Id: 381183
Aligned: 114 rows
Threshold Bit Score: 63.761
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
ligand binding
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:ligand is bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on cytosolic fatty acid-binding protein family members with structure
  • Structure:1PMP; Bos taurus P2 myelin protein with bound oleic acid, contacts 4A
  • Citation:PMID 7683727
  • Structure:1EII; Rattus norvegicus cellular retinol-binding protein II with bound retinol, contacts 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #            #  ##  #     ##  #     # # #       # # #       # # #       #      
1ICN_A         1 AFDGTWKVD-RNENYEKFMEKMGinVVKRKLGAh-dNLKLTITQEGn-kFTVKESsn-frNIDVVFElgVDFAYSladgt 76  Norway rat
1PMP_A         3 KFLGTWKLV-SSENFDEYMKALGvgLATRKLGNl-aKPRVIISKKGd-iITIRTEsp-fkNTEISFKlgQEFEETtadnr 78  cow
CBY39297       8 NLAATWKQT-GQENIDKQLEAAGlgWAKRKIAVn-lSTTVTFSFPDddtFHVDFVtk-vmSKKEKFSisKVTKHKnflde 84  Oikopleura dioica
XP_002127813   4 AVAGNWTLD-RSENYDDFLKAAGmnSIKRAMAVk-lGGSLSIENVGg-kLKVKSVng-pkTKEREMPigADFDDEgpggg 79  Ciona intestinalis
XP_002115178   5 NVIGKWKLVrSDENFENYMTQIGigKVGRAWRKk-yKPTQIIVKLGn-kMAIRTTng-lfVNLAEFElgEELTEKtvkge 81  Trichoplax adha...
XP_002115009   9 PICGKWKLD-HSENFEEYLKAAGvgAIKRQLAKrtsHIEQTIKCLDgnkVAIKIWsr-vlTKEDTYVidEAIDEEtlege 86  Trichoplax adha...
EKC34000       9 KFGGTWKME-SEENIAKYLEAMGvgFLMKKMASa-mKPTMVIEVQGd-eVVVTRKtp-ikDLHSRHKlgEETDIVehd-r 83  Pacific oyster
XP_002115010   9 PLVGKWRLD-RTENFDDYLKATGinIIKRQLAKktsHVEQTIQCQEsnkVYIKIWsr-vlTKTDTYIlgEEIDEEllege 86  Trichoplax adha...
EKC34001       7 KFEGNWECI-KKENVEKFLEAMGvnLIKRKAAAq-fNPKLSISVGDg-cVKVVRKmp-ikEITNEFKldDEIDVKddd-h 81  Pacific oyster
CBY24365      10 KFEGSWKQI-ESHGLDEFLSASGigWMKRKMATk-cNPVDQIQISGe-kLTISYTavgviSGSNTYNigGSAKIKnylde 86  Oikopleura dioica

Feature 1                       # #             # #      # # #          # #  
1ICN_A        77 elTGTWTMEg---NKLVGKFKrvd-ngkELIAVQEISGNELIQTYTYeg--vEAKRIFKK 130 Norway rat
1PMP_A        79 ktKSTVTLAr---GSLNQVQKwn---gnETTIKRKLVDGKMVVECKMkd--vVCTRIYEK 130 cow
CBY39297      85 dvESELFVEd---GHLVMVTKggs--pgEIRTVRIVEGDKLTIKTTVvkknvTGIRTFER 139 Oikopleura dioica
XP_002127813  80 saRGRWVEEg---DTMVGTFKtek--gkTFVMKREIVGGQLVQTMDFdg--vVCKRYFNK 132 Ciona intestinalis
XP_002115178  82 vvKTTYTFEgddeQTLTSTSNgsk--hgILKTERVVEGSEMVHTLTIcd--iVCKRYYKK 137 Trichoplax adhaerens
XP_002115009  87 kvKGTMTFDg---TKLTNTMAgtk--ksPAYTIRYIEGDNLVHEFHYsg--tTCKRFYNR 139 Trichoplax adhaerens
EKC34000      84 kyKSTMSFSd---GKILINNVpaddkgkPNTLTREVAGDKLTQTYTVed--iVATVSFRK 138 Pacific oyster
XP_002115010  87 kvKGTMTYEd---GKLLDSIKgs---kkPCFNSRVMEGSQMVHFLADte-rsRHLVIFNK 139 Trichoplax adhaerens
EKC34001      82 kyKAKLTYSg---GKMTLCLRavdgkskDNTIVREIEGDNLVQTATCng--vTAKTTFKK 136 Pacific oyster
CBY24365      87 evDAECVLEd--dDKIVLIMRggs--lgEVRITRVIKDGKLHVEQKImeknvVASRVFGR 142 Oikopleura dioica

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