1JFI,4WZS


Conserved Protein Domain Family
HFD_Dr1
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cd22905: HFD_Dr1 
histone-fold domain found in protein Dr1 and similar proteins
Dr1, also called down-regulator of transcription 1 or negative cofactor 2-beta (NC2-beta), is a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. It forms a heterodimer with DRAP1. The association of the Dr1/DRAP1 heterodimer with TBP results in functional repression of both activated and basal transcription of class II genes. Dr1 can bind to DNA on its own. Dr1 is a component of the ADA2A-containing complex (ATAC) that has histone acetyltransferase activity on histones H3 and H4.
Links
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Statistics
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PSSM-Id: 467030
Aligned: 68 rows
Threshold Bit Score: 107.653
Created: 31-Aug-2020
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1JFI; Homo sapiens NC2 beta subunit forms a heterodimer with NC2 alpha, contacts at 4A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ####  #   ## ###        ###  #  ##  ## ####  ##  #             ####  #       
1JFI_B        11 DDDLTIPRAAINKMIKETLPn-----vRVANDARELVVNCCTEFIHLISSEANEICNKs----eKKTISPEHVIQALESL 81  Homo sapiens
XP_002683223   6 REDLTLPKQTIVKIIKEHLGes----iKCAADTRELIVECCVEFVQMIAAESNSICESd----kRKTIAGEHVTEALRRL 77  Naegleria grube...
XP_005829259  19 IVKISNTAATVFRTIKDVLPeg----yRCSSETGNLIMECCMEFMRMISDETSQLCAKe----gKSTIGADHVLKSLESL 90  Guillardia thet...
XP_029654459  11 HDDVSISQLAVNKAIKDIMPd-----lKLSTQCKSFIRDCCTTFVHSVAAEAAKICDKa----kRKTINEEILLEAVKNI 81  
KAA8909072     6 KEANSFPKATIQNLIKACLPsd----cRASPEFRDLVNECCVEFVKMLTTEANEIVDQe----gKKIIAPQHLVKALKEL 77  Sphaerosporella...
XP_013753488   2 NEDLKLPQRTIDNVIRATLEgmdlgdiKCHKEARELLNECCLEFVHLVGSEAHEVCERs----tKKVINPNHVFKAMEDL 77  Thecamonas trah...
PRP79837      65 EKEFSLPRTRLLEVIKSAMPegf-hppAAKDYTMQLMNDACIEFMQLVASQAMVEHSKgnpkteKVSITPKHVLNALRNL 143 Planoprotosteli...
KII70316      20 SSEKRLPKSVIVKALRGGLGg-----aKLESDTRELIYTICEEFVKHLVSITLEQSDKv----nKKVLAPEHVFAALKEM 90  Thelohanellus k...
CCI47222     715 MPNGMLSRSTIEEHLSQRLPse----yRITTDTIDYINECVTEFVRITAEEANRLAELgas-keQFRVQESHLITAANNL 789 Albugo candida
OSX73753      12 AEEVALPKATVNKFVNEIAGgl---dmRLTSETRELLAEVCTEFVQMLSAEANDLCEAd----kKKTITPGHILRAMEKL 84 

Feature 1              #  #   #   #                                                   
1JFI_B        82 G--FGSYISEVKEVLQECKTVALKRRKASSRlenl----------gipEEELLRQQQELFAKARQQQAE 138 Homo sapiens
XP_002683223  78 G--YSEYLGLVNEAHNQHKVESSRHNNASKKlkns----------gktEEELISEQHKLIAQSRARLIG 134 Naegleria gruberi strain N...
XP_005829259  91 G--FHAWRKDLDAALSSHKEVLITTRLFYTQnlk------------dlQEETQDEQEPNVEQWAEVRKS 145 Guillardia theta CCMP2712
XP_029654459  82 G--FPEFSADARVHCNANDIFESKKLRKKGLlens----------eltIDELLKLQTELFDQEEEMRED 138 
KAA8909072    78 G--FGEYAAAAQKAGAEANRDILQKRRERRQsmler-------tegldDQQLLKEQAELFNAARERLEG 137 Sphaerosporella brunnea
XP_013753488  78 GfaNTEVLKRSRDALGAHKARDAKRPKLTHTkrkk----------hepTAEDIARQKALFAQAKARQLA 136 Thecamonas trahens ATCC 50062
PRP79837     144 D--YKEYAETAKRELNLDEGRTTSRQPTKRLkktkadmeregealraeQEALRVEQEKLFAQAREKMNQ 210 Planoprotostelium fungivorum
KII70316      91 G--YDQHIMKLTEFTQDYNQKMSDRKKKIKLlrdgf-------knsgtRQSLVNEQADLIQAAEERRKE 150 Thelohanellus kitauei
CCI47222     790 A--LHTLLPDVESQRQTNRQIQNTKRKRDRAkm-------------sgSEELIVEQKKLFELASNKAKS 843 Albugo candida
OSX73753      85 G--LERYQKDVQDDFARHKEDEKQHPKGKNGgwssmk------asgvtDEELQRQQQQLFEMARSGPAA 145

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