Conserved Protein Domain Family
7TM_GPCR_Sri
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pfam10327: 7TM_GPCR_Sri 
Serpentine type 7TM GPCR chemoreceptor Sri
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Links
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Statistics
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PSSM-Id: 313539
Aligned: 51 rows
Threshold Bit Score: 257.088
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O17360     7 F-CPRECPAHYEPIIHSIGVVSTVFNVFGIYLTLAKSKKNTNYRFCQLYVQITALITEFDISIVNPAYFFFPMIGGMNCG 85  Caenorhabditis elegans
CAP26389   7 VtVDVNTPNILLTFYRIHGVFALVFNILGVVLIMKNPRIVRLYRGFMLNMQILSLLADAQTTLLMQPVYIFPIIGGYTNG 86 
O62176     5 PpCPSEIPTYYPLTLHIIAGISIPINFIGFYLVWFQSPKMLGYKYCLCYLQFASFLTEMHMSFICPGYYFFPLTGGFNTG 84  Caenorhabditis elegans
O45372     5 PpCPSEIPTYYPLTLHIIAGISIPINFIAFYLVWFQSPKMQGYKYCLCYLQAASFITEIHMSFLCPGYYFFPMIGGYNTG 84  Caenorhabditis elegans
O18113     3 ApCPEIIPFYYTTTLHVIATISVPINLIGLYMVWFQSPGMQGYKYCLCYMQTVSFLTEIHMSWICPGYYFFPMVGGYNTG 82  Caenorhabditis elegans
O18110     3 ApCPPTIPAYYTLTLHIIGAISLPVNAIGFYMVWFQSPGMFGYKYCLCYMQTASFVTEIYMSWVCPAFYFFPMVGGYNTG 82  Caenorhabditis elegans
O45314     3 ApCPETLPAYYMPTLHVIGAISIPMNVLGFYMVWFQSPGMQGYKYCLCYMQSVSMLTELYMSWICPSYFFFPLAGGYILE 82  Caenorhabditis elegans
Q22358     3 ApCPETLPNGYLLTLSIIGGISIPMNLLALYMIWFQSPGMHGYKYCLTYMQVASFIVEINVTWLVPAYHFFPLTGGIAAG 82  Caenorhabditis elegans
O45759     3 ApCPATIPDGYLLTLDIIGGGSLSMNFLAMYMIWFQSPGMHGYKYCLTYMQFASFLVEFNLTVLVPAYYFFPLTGGIAVG 82  Caenorhabditis elegans
Q9XX84     3 ApCPEAPPDGFLLTLHLIGGISLLMNLLTMYMIWFESPGMHGYRYCLTYVQIVSFLVEFIMAVVIPIHIFLPMKGGITLR 82  Caenorhabditis elegans

O17360    86 -KMREVqvkFGITSHICITFFTFILCLQVPALLTCFIYRHQVAAKCSpdKTWSLSK----FHLYSILFIYHIFPCLIAFS 160 Caenorhabditis elegans
CAP26389  87 -VWWNV---FRMSSHLQMGIFLLLLYLQVASIVCAIVTKYHVVSNIGntTNRP-------LLFWNFVIFYHCCAFLIFGI 155
O62176    85 ---GQF-----ISSHLSITIYTFIFSFEVPSTLLCFIYRHTSSQNIS--KKTNPSSksklYLEKASLILTHLFPFSSAFC 154 Caenorhabditis elegans
O45372    85 ---VEF-----ISSHTSMSIYVFIFAFELPSALLCFVFRHNAAQNIS--RTAPNKK----YFKTFTLFLTHLFPFAAAFC 150 Caenorhabditis elegans
O18113    83 eFFGQF-----ISSHLSMSLWVGVFCFELAAGLTCFVYRHNAAAQIN--QTYSSKL----YLDKFLLFLTHLFPFFTGIS 151 Caenorhabditis elegans
O18110    83 eFFGQF-----ISPHMSMSIWVGIFCFELSAGLTCFVYRHNAAVQIN--QNQSSKM----HFNKLLLFITHIFPFFTAIS 151 Caenorhabditis elegans
O45314    83 eNFRRF-----VSTHASLTIWVFIFCFVLSAALTCFVYRHNAAAQIN--QDYSGKM----YFEKLLLVLTHIFPFFTGFG 151 Caenorhabditis elegans
Q22358    83 eIIRKF-----VSNHTGVTIWIFLFCFLLPASLLCLFYRHNAASKIN--QSGSNNL----YLEKLVMILTHIFPFLTAFG 151 Caenorhabditis elegans
O45759    83 eVVRKY-----ISNHMGLTIWMFMFCFVLPASLSCFIYRHTAASQI---QNNASKF----HLKKLVMILTHIFPFLTALG 150 Caenorhabditis elegans
Q9XX84    83 eGFRTI-----MSNQMALTIWIFLLCLVLPASITCFIYRHNAASQINenSNSSTKY----SHKTLAMILNHIFPFLTAFG 153 Caenorhabditis elegans

O17360   161 LYHSGLSKDEKNYSMHMNYPGCIHSLdDF-TFDFYDYQvnPTFIAFGILISVYYVMAGVIGFGLAWRTGQVLNRYRYIMS 239 Caenorhabditis elegans
CAP26389 156 FCMSYLTKEQAVDLVKIKFPNAMNIF-TVeNVEIYDMEvnKWMIMTTMIIAM-LTSSILISLYFSIRLLKTLRSKRLVIS 233
O62176   155 MWNSKITSRQKQNFVKNNWPQCSSWL-ELeAFEVYNYEsnQWLAALGAVVFGTILLSYSYAMTLGIHTMTILRKVRKSMS 233 Caenorhabditis elegans
O45372   151 MWNSNLTNQQKQDFVEENWPQCTQWL-KFfAFEVYDYMlnPWLAVVGIGAVALVFMVYGYGLGLGTHTMMILQRFRKSMS 229 Caenorhabditis elegans
O18113   152 MWYSKLTYQQKFEYVRQNFPQCLSWL-AFdGFEVYDYHlnKMMAVTGVGAFAYVFIIAWYCFYLGVHTMIILQRLRQHMS 230 Caenorhabditis elegans
O18110   152 MWNSSLTYQQKYDFVKKNYPQCLFWM-AFdGFEAYDPHqnPWMFVTGIGALIWVFFIVWYCVYLGVHTMIILQRLRQHMS 230 Caenorhabditis elegans
O45314   152 TWMSQLTYEQKYDYVRQNYPQCLSWM-AYdGFEAYNWQvnTWIPVAGLGGIGWVFVVASYCLYLGVHTMMILQRLRAHMS 230 Caenorhabditis elegans
Q22358   152 TWNCQMTFAQKYEYLSQNYPECLFWL-ASdRFEAYDYKmnPWIVSTAAAAITFLVITASYGGYHGIHTMIILQRLRAHMS 230 Caenorhabditis elegans
O45759   151 TWNCQMTFDQKYEYVRKNYPQCLFWL-EFdRFEAYDYQvnPWIVRTACAAIGFLMISTCYGIWLGVHTMVILQRLRGHMS 229 Caenorhabditis elegans
Q9XX84   154 TWQCQNTTEQKYEYVRQNYPQCLFWV-ANdNFEAYDYHenPWIIRTVGAGIGFLVVSSAHGAFLGVHTMIVLQRLRSHMS 232 Caenorhabditis elegans

O17360   240 ARTYQLHKSSLITLTTQVSGPTLVLgIPVFVVYVIVASQMTQLHDLAATAPFFISAHSAVTTSCLIMTTANYKNLF 315 Caenorhabditis elegans
CAP26389 234 ARSFRGHQIAVTSLMAQATIPFIVIiIPIGTIVYFFVHIVPNSQGISNIMMAIYSFHSSLSTAVMIISTPQYRKMI 309
O62176   234 RQTYQMHKNALFSLVMQIVIPGVFIiVPLSICMFVIITEEVSLQELATDTMFLVGSHSMCSSAVMILSNPKYRCVL 309 Caenorhabditis elegans
O45372   230 RQTYQQHKTALFSLVMQLLIPGVLIiVPLGVCMFVVVTGEVGLQEVATNTMFLVGSHSMCSSAVMISSNPRHRKYL 305 Caenorhabditis elegans
O18113   231 SQTFQMHRAALISLAMQMVIPGVFIiVPLDICMTVVITETVALQEFATDTMFMVGSHSMCQCSVMLLSNSTYRRVL 306 Caenorhabditis elegans
O18110   231 SQTYNMHRAALFSLSMQMALPGGLIvIPKNIMLFIVIGEATHLQELATNMTFLMASHSMCQCSTMILSNSVYRRIF 306 Caenorhabditis elegans
O45314   231 PQTYQMHRTALISLTMQMVIPGMLLtTPLYMILVVIMTNSLAFEELASTFSFLMSSHSMCQCFVMVMSNGVYRRVL 306 Caenorhabditis elegans
Q22358   231 VQTYQMHITALISLALQMLTPSVFA-VPVYVWVTVVLTNAIDLQGIVSWSPCLMSTHSILMSSVMIVTNATYRRVL 305 Caenorhabditis elegans
O45759   230 VQTYQMHLTALISLGLQMATPTVFI-LPVYMFVAVIVTDAVDMQRIVSWAPCLMSTHSMLLVTVMIMSNASYRKVL 304 Caenorhabditis elegans
Q9XX84   233 VQTYQMHRTALISLAMQMVCPCVFI-FVVYFYALVAWIDDVELQVYISRCPCIMSTHSLLLCTVMIMSNKNYRQVL 307 Caenorhabditis elegans
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