Conserved Protein Domain Family
Gp-FAR-1
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pfam05823: Gp-FAR-1 
Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Parasitic nematodes produce at least two structurally novel classes of small helix-rich retinol- and fatty-acid-binding proteins that have no counterparts in their plant or animal hosts and thus represent potential targets for new nematicides. Gp-FAR-1 is a member of the nematode-specific fatty-acid- and retinol-binding (FAR) family of proteins but localizes to the surface of the organizm, placing it in a strategic position for interaction with the host. Gp-FAR-1 functions as a broad-spectrum retinol- and fatty-acid-binding protein, and it is thought that it is involved in the evasion of primary host plant defence systems.
Links
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Statistics
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PSSM-Id: 399080
Aligned: 20 rows
Threshold Bit Score: 129.74
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFP04375      49 AYKQFMPSYVWEPIEKITEEQKTQAVKMVNDyHAGqf-ePKNYDELIAIIKKSYPALAAPYETMYGKYKEQVAKLGPKGQ 127
P34382        33 EYKSLIPAEVSEHLKSITPEEKAILKEVAKG-YKD----FKSEDDFLNALKEKSPTLHEKASKLHQIVKDKVNALNDEAK 107 Caenorhabditis ...
P34383        33 EYKGLIPAEVAEHLKAITAEEKAALKELAQN-HKE----YKTEEEFKAALKEKSPSLYEKAGKLEALLTAKFEKLDATAQ 107 Caenorhabditis ...
Q9XUB7        33 EFKELIPAKVTEYLKSITTEEKAAIKEFIKSvMGG----NKSVEELSADIKERSPSLYAKVEKLDVLLRTKLAKLDPAAL 108 Caenorhabditis ...
PDM63167     346 SFPQFVPDEILALLKEISSDEKHQIIGVVNElGSGkiaePKTVDAALALIKSRTPRLYGRLQKMNETFTQQFQKLRPATR 425
2_pfamImport   1 PYKEYVPDYVWSAIDGLTDEQKTQVVQMVNDyHDGkf-ePKNYEDYLAIMKKSYPAIAGTYETMHTKYQAQVDTLGPKGQ 79 
Q21152        51 EYKQFMPSYVLEPLDNITDEQKTQAVQMVNDyHAGkf-ePKNYDEYIAIMKKSYPALAGPYETMYNKYKEQVAKLGPKGQ 129 Caenorhabditis ...
KAF8358535    29 EYKDLIPAQAKEFLTGLTEEDKKILKEVAAN-YAN----YKTEDEALNALKEKSPALFEKAEKLHLMLKEKLDALNAEAK 103
PDM63694      29 EYKDLIPAQAKEFLTSLTDEDKKILKEVAMN-YKE----YKTEEDALNALKEKSPALYEKAQKLGNYLKEKLDALNPEAK 103
PDM76114      30 EYKDLVPAQAKEFLTGLTDEDKAVLKEVAKN-FDS----YKTEDEFLAALKEKSPSLHEKAEKLGKLFKEKLDALNPEAK 104

EFP04375     128 EYANNVSvpifnhskPDILQLEAQMYADASPD---RVVWACHIFNNAKKAVSDAKAlllddseadKIDQAFPEAVTFLHS 204
P34382       108 AFVKKAI--------AEGRKIHAQYLAGEKPSldtLKTTAKTHIEAYKGLSQDAKD---------SIAKEFPILTGFFKN 170 Caenorhabditis ...
P34383       108 ALVKKII--------AKGRELHQQYLAGDKPTldsLKELAKGYIAEYKALSDDAKA---------TITAEFPILTGFFQN 170 Caenorhabditis ...
Q9XUB7       109 ALFGKVI--------AQGLSFRQQFHAGYQPTpemVKKLFKGYIAEYKTLSENAKA---------TITDEFPIVVEFFQH 171 Caenorhabditis ...
PDM63167     426 ---NKVIdwgkllfqNFNKKLDDEIEAKMQPL-----KVVSTIFNSYNQQTPELRA---------DFRSVFPKIAALFES 488
2_pfamImport  80 EFAKQ---------------TEAQVFADASPD---RIVWACHIFNGAKSLISNAKAllldadeadKIDAAFPEVVTFMNS 141
Q21152       130 EYCNG---------------LEAQMYTDASPD---RVVWACHIFNNAKSAVSGAKAllqddseaaKIEEAFPEAVKLLNS 191 Caenorhabditis ...
KAF8358535   104 KFAEEII--------GEARAIQAQIVSGNKPTladLKAKVVAGVEKYKALSPEAKS---------DIEKQFPITASVFKN 166
PDM63694     104 KFAEEIF--------GDARKIQAAVIAGNRPSldeLKAKAVEIVNKFKALSDEAKA---------DIEKQFPITASVVKN 166
PDM76114     105 KFAEEIF--------GDARKIQAQVVAGNKPTideLKAKVVAIVGKFEELSAEAKA---------DIEKTFPITSALVKN 167

EFP04375     205 KEFD 208
P34382       171 EKVQ 174 Caenorhabditis elegans
P34383       171 EKIQ 174 Caenorhabditis elegans
Q9XUB7       172 EKIQ 175 Caenorhabditis elegans
PDM63167     489 DFIK 492
2_pfamImport 142 KEFE 145
Q21152       192 KKFE 195 Caenorhabditis elegans
KAF8358535   167 EKFQ 170
PDM63694     167 EKFQ 170
PDM76114     168 DKFQ 171
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