Conserved Protein Domain Family
DUF19

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pfam01579: DUF19 
Domain of unknown function (DUF19)
This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins. It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges. The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.
Statistics
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PSSM-Id: 426332
Aligned: 89 rows
Threshold Bit Score: 66.3403
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_505282     33 CTl-GDGLKALSCIF---RMQD----FLEKIDALDLDNKeE-TNDFKGSCDSLH-------NCFDALDCQTsstdheTSD 96 
Q17932        27 CTlqDIQSVQQNCEPfanELNS----YNDDYDGKILPDDi--IGNMTDLCSSVI-------KCYGEYECQE------SAN 87  Caenorhabditis ...
EGT31025     265 csteillkIQQECGPaqkKLEV----LIEKYDGQVPPEEv--IEEMDVMFQNLT-------TCYAAFNCTQ------SIK 325
XP_003115946  34 CTteQVLAVQQKCDLlakEVDG----YLEDYDGEISTDEv--MKNMTELYEKVT-------NCYSQFGCKE------AVE 94 
XP_002648888  24 CTpsDRQIAQDKCGAieeLLDS----YFEKYDGQIPPEDv--KENMTDLYKNIM-------ECYEMIGCQE------ALE 84 
EFO95439      30 CTpkELVVAQGKCSKyvnDLIV----LTEEGDTK--------SRNVTDACKSVTvmlqpgsSCFGGIQCAE------AEK 91 
EFO95287     216 dngvtedSKVGKCAPvvdELVT----LLSRRTFEEFSEH---YQNANETCSRVK-------DCFKSIGTPE------AQK 275
CAP25345      26 CNd-EELSKMERCIPrtdYLQM----VMRYYEDENQPVEn--YKDAALYCTNIL-------DCLAPLNCRE------AEP 85 
XP_003116172  30 CStlQDLVEFGACLPlisKLKR----YVEQHNSEPPSEH---VENMTLLCEKTT-------SCLSRVQCKQ------GIE 89 
CAP25347      30 CRdeEKLSISL-CAPiieVINQypklYTDRIHDP------MyYQNLEKLCQEAK-------GCVSDLNCSE------ADA 89 
NP_505282     97 ISGMIKTYCDTIIYISTKFVECSDKLE-E-KS-------SQCFENWDPFPNdieketdqkkkeemRKSACQNFFGKDNCL 167
Q17932        88 YKKKFERECAEMKISNARVKECMLEIYgAiFEd-----tYNCTKNFDWLAKd-------------PVTKRNAYLSGKDCF 149 Caenorhabditis ...
EGT31025     326 YRQYLTKKFSEIRIHNLDINGCMLEFYgAlYEg-----tYNCTLGYEWFSTd-------------LLTKRNAYISGKSCF 387
XP_003115946  95 YNAKLEREASDRKVFNTGIKDCMLEFYgAiYEg-----sYNCTAGFDWFSKd-------------SAVKRDGFIKGRSCL 156
XP_002648888  85 SKMNFEVEFENWSIFNTGIKDCMAEFYgAiYEe-----rYNCTNEFEWFSTd-------------PSTKRDAYLNGKSCF 146
EFO95439      92 SKRTYEQKCDKLEFTNNDVASCMSMFYnTvYSk-----kENCTEDFDYFSRd-------------MRIKRESYTAGKSCF 153
EFO95287     276 LQQSYQVVCDRLDFTFTELISCVNKFYeNeR--------KEGNKYSDFVSKn-------------LTVKREAFTSKKEMF 334
CAP25345      86 MKLEFETVRENLEYKMLELKPCLARFFtRtYLiqh-srnSSCLKDYSFLDKd-------------LTIKSDEYIEGEACF 151
XP_003116172  90 AKIVLDAACDIVKYRDSQLQLCIVGFFkKvYLaremmneTSCFKYNDFLEKd-------------MAKRSEAYTNGKQCF 156
CAP25347      90 LRNDIDKVCSYSLFFYAENQKCLQKFHqKaYVank-tedSSCYAKFPSFQNe-------------MDKKYKTFMEGEECF 155
NP_505282    168 KEEIVSSCSEGEWIGFRDHFVSLSNITK------QCD 198
Q17932       150 MEIVTNDCSNSSVMYFSSQYEHFVDLISikpdgePCV 186 Caenorhabditis elegans
EGT31025     388 LEIASNECSNATINYLKTDYEPLVDIMTtrpngpECQ 424
XP_003115946 157 IEIATNECSNKTLNYLNSDYESFVDLMTvkpsgpPCE 193
XP_002648888 147 FEVTSIECSNSSQNYLTTNYNKFVDLLTqkpdgpACE 183
EFO95439     154 FKTINKTCNATSVAYLEKNYEKLLDVLTipsdgdACS 190
EFO95287     335 LKFAESKCFKREINYLALNYEKFVDFLTtestddRCK 371
CAP25345     152 LNTIKSLCGTDAMEYYTKNYQKFVTTIStepedaKCS 188
XP_003116172 157 MDYVKESCNESSIEFFSKNYEKFVTTMTaepivknck 193
CAP25347     156 MNHIEENCNDTSRKFFVKSYNYLVEYmtnkpeirtcd 192
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