Conserved Protein Domain Family
DUF684

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pfam05075: DUF684 
Protein of unknown function (DUF684)
This family contains several uncharacterized proteins from Caenorhabditis elegans. The GO annotation suggests that the protein is involved in nematode larval development and has a positive regulation on growth rate.
Statistics
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PSSM-Id: 368277
Aligned: 16 rows
Threshold Bit Score: 352.029
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFO94761     133 KELGELKNQLTALSDKMSVHFNALESFMVKQEFYKNYTVAMKsMMSFMMDTTDGS-----KESVDLFKKIYDERRPQTLV 207
XP_003110711 128 KELGELKKQLTALSQKMTAHFDDLKSFIVEQNFYDKYTTSLTkLYMYMLDTLTHRt----KESVKTFEEIYRKNKPQELV 203
XP_002632441  62 KDLKEVKNQIRKLNDAMGSHFNDMKAFIVAHHFYTTIAVKASvLTKAMGDCSEAKdqkkhEASLKFFKEMYDKHSPLELA 141
XP_003093328  32 AELGNSKRDLKTLAEKIGQQFDDLKAFQVSLKFFENFTSTTSvLYRAMTDVTESNn---rEASERVFKRLYDRNHPFDLT 108
XP_002632439  61 KKLGDLKVDLKRLEESMKNGFDNLKAFILMQEFHNNIAVPAQvMCQFWTDCTGSDdqktrQDRVQVFKETYAKHSPLELG 140
CAP32424      60 KNLRDVRTEIKRLDDSMKKNFNDLKAFIVAQNFYNNIAVKAAiLCQFWSDITVTNdeksrESSVLFFREMYDKHSPVELS 139
Q9N2W4        15 SELKTLDKKIGELSHKMDALFGDLKSFITTSHFYMNEVATIKtLMKYMQDTMNNPc----KYTKELFRGAVTDNKPLWIA 90  Caenorhabditis ...
CAB07683      57 LKLIEIDKKLTQLSDKMSWEFDNLKAFIVENEFYADLAQTAStLMKFMQDTVKYPc----KDSYGIFRDVSQKSPPLQYA 132
EGT34352      69 EDVRELERRLRRLFEKSNETVGSLKYDIDNPNIMT-VFNASTiLFKYMLNTLRTPn----TLMFDNLRNEYKKKSPLHHA 143
EGT39496      78 elIDDLGKNVEALGDKVSLNLGEMKALITEINFFVRILSPAFkLMRYMRDCLHFPg----KDANENFLRAYKKTPPLKLA 153
EFO94761     208 YDMLAELELDDRNPLKLAMHGDNLQSKNTFKKWKDILEGALSQALFLEVYASGLfPEVGNYGTTKILEKIARYQQLVDQW 287
XP_003110711 204 YEMLAKLEQDSTNPLRWAMKGDHLQSKATFQKWKNILEGAISEALFLETYASGLlPDVGKHGINMILEKIGRFQEIVKKW 283
XP_002632441 142 KTLREMMDNEVTNPVKMAMTGDKFKTKRTFESWTKICSAVFTQLFVVEAFASGQyHDQESYRQDKISEEHAEFESLAKEW 221
XP_003093328 109 RTMMQMIGNDETNPLKIGMKADPLETKRTFSKWKDLFGSIITQLWLIECFAIGMnEPIDTYELEKIEEENSVLEHWIENW 188
XP_002632439 141 ETLMQLLSNEVTNFLKQAMSADTLMAEKTFTNCRNMIEAVFAQLWMLESFASGLvHDRDTYRPNKIYEQYERFEEVVKKW 220
CAP32424     140 ETLLQLLNNEMTNFLKSAMTADSLMTKEAFTTHRDIIGGVFAQFWMLESIASGLfHDGRTYRADKIAENFQWFEKCAKKW 219
Q9N2W4        91 EQMIIKLDQEETNPLKMAMNCDPLRPTETFEKWRKIIDGVLAQCLILETYQNGMfCDKNMIGPSRLKKQTEELQLKMNRW 170 Caenorhabditis ...
CAB07683     133 YKMISLLEQESTNPLKMAMKADPLRTSETFDKWRGIIEAVMAQFLFLETYINGLfWNKNMYGPNRLKDRITHLNHLMDSW 212
EGT34352     144 YNFTASIESDSTNPITYAMSLDRFKTKATFEKWSNFIDAILSQLLFMEAFCCGMfSNEDMYTADLLNNEIEGTNLRIEEL 223
EGT39496     154 YYLQSYLEQESTNPLKHAMDLEKIKHKTTFTKWEDIFARVMLQFMIIETFAKGLmKNKTEATLDKLIEATIKIFTQLGKW 233
EFO94761     288 DYHFW--TNENFWpKGVEKLVNDVHDDRNLKTKDEKMEVLWKGIESIHTQFKFYAVVVP--SEHIIRW--YKH------F 355
XP_003110711 284 DDYYL--NTDDFWpKGVQKLVDEVHENKSLSSKNDKIDEIWKGILSIHTNFKFYVVVVS--TDHIVRY--YKH------Y 351
XP_002632441 222 KEHYKt-NETRFWeHEVRPFVEDIQENNTSKSNVEKADLIRAQLDKILTNDIFYVVVMS------ASF--DHStvlregL 292
XP_003093328 189 KQDYL--NNAHFWpDKIRQFVGQIQDENVEKSNQENVELIKAGLEKILTDDLFYVMVFNekLVHSVVa----------nP 256
XP_002632439 221 EIEYQ--VGSSFWpDKVRQFVEGIQDNNEEKTSEEKAQMIKEGLDKMMTNDLFYIVVCR--------S--AYRcllaadP 288
CAP32424     220 EEEYT--AGDDFWpDKVRQFVEGIQDNNEEKTIAQKADLIKEGLEKIMTKDLFYVVVCR--------S--AYRcllaahP 287
Q9N2W4       171 AEEYR--QDHSYWdDGVLSLIHNVQDNNEGSENIR--NILTKELGKIMTNHKFYVIVYDfcDGSSEEYqfTSYs----yF 242 Caenorhabditis ...
CAB07683     213 RREYE----DSYWdTVVERMVHDIQDRYENSSNGEKSKMICDHLFAGLNRNCYYVIVYDpcAGY------DHHa----fY 278
EGT34352     224 KNRYK--NDDSYW-PHIKNFVHDVQDHNVHLGNISKSEILQNKLETILTNDAFFVLVYD--------HceESHrhafvyP 292
EGT39496     234 EKEYVdlTGPSFW-DEMRPWTENYLKNDSKLTNVVKADKIREKMETYFLRNSFYIIVFNt-SKKNQDY--AYHs-----H 304
EFO94761     356 EAQAIVS--DRNGFTIMVYRHTGKVVRTMSWLynyig---------ehlheERSDFMQ-------FNNWQSVRNHFSDDN 417
XP_003110711 352 EDQAITS--SREGFHIMVYRSARKQARDKRWLdqymf---------enmeeSRSETFQ-------FDHWQIVRNHLSQDN 413
XP_002632441 293 EHQHIHSa-NRGGCTVIVYQSKKARSSGA----------------------QVRELRKkaghfktVKHRKLE----SSWI 345
XP_003093328 257 NEQHINSs-NRGGCNVLVHRSKRGREASHeem-----------------hqFRADIEG-------YAREMESWSKNSHFV 311
XP_002632439 289 ADQTIASl-DRKHCNVYIFRSKKGRTASDaem-----------------kkFSEDMKKkfd--hiYRHRTEQNNRNAEWM 348
CAP32424     288 ADQTIESl-DRKASNVYIFRSKKGRTASDeem-----------------kkFSEDMKKkfd--hiYRHRWEQNNRNAEWM 347
Q9N2W4       243 KRNFKSSf-NRNGCNAFVLRSLRTQDCKR----------------------HEENLQRkl---qaALPMEYDYRFKLIDY 296 Caenorhabditis ...
CAB07683     279 GRDYIVSf-RRGGCNVGVFQSkty-------------------------dcVSQAVRNkfqhdalARVNEVNWNWSYADV 332
EGT34352     293 DSQGVTSf-NRGNCNVAVYRSRHWNTASEeek-----------------kkIRDEVEG-------LSNKRFPWSNNYREI 347
EGT39496     305 PILLIETflNMGGCDVIIYESIYGHGWTDenheerehledddqndpealtkIKAHVNS-------FHSGKLTYNKNLNDI 377
EFO94761     418 VEK-------IGKYTGtFVFIIAQSKSFIALKYS--RfLGNKGPGVHTfDATLTTT--GG 466
XP_003110711 414 IDK-------IGKYLGtFYFVVGQSSNHIASKFS--ImDGSDGPGCFTfSATLECS--DG 462
XP_002632441 346 SWTeahgwltGIEHCG-YIELVRSDHDVAVRCTS--AaWSQHGPGISF-QATFNRT--DR 399
XP_003093328 312 SWEqvrtwamRMRNCA-FMVVMQHDYYVAVESTG--RdIHEMGAGWWL-MGNYNMG--NM 365
XP_002632439 349 LDWqvrnwrgEMENCA-FMLTVRSKEYVAVRSTH--TdIRERGPGDWM-DGQYHAG--NI 402
CAP32424     348 LHSqvqkwrgEMENCA-FMLTVRSNENVEVRSTH--TdVRERGPGDWM-DGQYHRG--NI 401
Q9N2W4       297 AEKlc---krFGDECG-LVLIIRRNTTIFFGPVNwyLnEYSKRPGALI-EGFFEKTflGK 351 Caenorhabditis elegans
CAB07683     333 TKWlwq----niTNCD-LTVVIALYEHIWISYVY--YpSVPSEPGWSC-NICFDDG--EK 382
EGT34352     348 LEFid----gVAVHKAkLLAIIRKDRNIAIRVIN--C---ETGPGAYT-TVRAGND--NQ 395
EGT39496     378 FEKqilpfkeFNDTNSyFYALVFKDKKPEVRWAN--SpELEKGPGWWT-TVKIKDG--Sk 432
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