Conserved Protein Domain Family
DUF747

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pfam05346: DUF747 
Eukaryotic membrane protein family
This family is a family of eukaryotic membrane proteins. It was previously annotated as including a putative receptor for human cytomegalovirus gH but this has has since been disputed. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.
Statistics
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PSSM-Id: 398815
Aligned: 109 rows
Threshold Bit Score: 199.658
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESS29572                 3109 LAPADVCALVRFSLLVASVSLFLL--V-DT------SRVYHYIRAQPFMKLYVVFNMLELFEKMWRSLGRDIFDALMRTT 3179
EFC49106                  345 vnesVLFDLVKFFCLVINIILIMQ--TtDY------SLLYHYIRGESILKLYVIGNMLDVFDKLCSSFGLDSQIALLYSS 416 
WGS:AAFB:cds.EHI_100500A  120 iHYKRIYDILMYLSTLFCVIIIYQ--V-DI------GFVYHYIRAESVLKLYALYNALGMLNSLLSAFTFDIHSSLLISI 190 
XP_001614494              700 LSFPEYSGLIRMSLILICIYIFSF--V-DT------SRIYHYIRAQPFMKLYVVLNMLEIVERLLRSLGKDLIDNMIRTF 770 
CAX64442                  785 LSFPEYSGIIRLSLILICIYIFSF--V-DT------SRIYHYIRAQPFMKLYVVLNMLEILERLLRSLGKDLIDNMIRTF 855 
Q4N5K5                    220 ITLTEVCGCVRFLVLLATVYIFSF--I-DT------SKVYHNIKAQPIMKLYVLFNMLEICERLCRSFNRDIMDSLVKTT 290  T...
XP_001609992              259 ITPIEACGFARFAAMLFAIIILSR--I-DT------SRVYHNIRGQPFFKLYVIFNMLEICERLCRSFGRDCIDTLMRTT 329 
Q4QIS9                    122 wrrcELRDIITLLVLTIT--LGSYwvA-DLattqlySYLYHAVRRTSFIKVVMIFSILDVADKILSSFSQDSLEVLYAAV 198  L...
Q4D3C1                     83 fPRLERRDIVALVLIVVG--MLTYcsL-SLyathlyAYLYHVVRRTSFIKLVMVFNILEVVDRLLSALSQEVIEVLTISV 159  T...
Q582A2                    164 vHRFERRDAVALVLIVVG--VLTYtlL-SFktvelyAYLYHAVRRTSFIKLMMVFNILEVADKLLSALSHEATEVLTACV 240  T...
ESS29572                 3180 Vqllsrpvqassastadegeentetaerkeetrssvlafphtwkrhqreseegrvcrdeggrnrkeaegreekrrghrqe 3259
EFC49106                  417 Kqfvng-------------------------------------------------------------------------- 422 
WGS:AAFB:cds.EHI_100500A  191 K------------------------------------------------------------------------------- 191 
XP_001614494              771 Iriinlrsyvyivrnhytskegereaggvpgmaehgsggvpsggvspggalqggkkatfpaaspttttngattggpstqa 850 
CAX64442                  856 Iriinlrsyiciirnnynekssinsnsnyinyvhndnygvnsyiyknkdnnnelitfdntrhinvftnknkdnllnnnnn 935 
Q4N5K5                    291 Inifiiqfnntnvssarvnfqkpdsqkcqlgnngnksflnsht------------------------------------- 333  T...
XP_001609992              330 Vkiyklcsnfslrssnalamlnatkrmksgiamdhfmtkkykssvvisnfarveqmatptmrrvtvdvagysertis--- 406 
Q4QIS9                    199 Ddeyayrcahrcqtkpaagdtpmnraa----------------------------------------------------- 225  L...
Q4D3C1                    160 Qnwdkkhpqhpr-------------------------------------------------------------------- 171  T...
Q582A2                    241 Gdwrgaaqtcge-------------------------------------------------------------------- 252  T...
ESS29572                 3260 eekenesafrsredrerelefiiggenkesssegssaflkcradvrttpetdetngrllktedgdeemeresrlfsvfre 3339
EFC49106                      --------------------------------------------------------------------------------     
WGS:AAFB:cds.EHI_100500A      --------------------------------------------------------------------------------     
XP_001614494              851 ehypetnatptrehpnqgeapp---------------------------------------------------------- 872 
CAX64442                  936 nmnymn-------------------------------------------------------------------------- 941 
Q4N5K5                        --------------------------------------------------------------------------------      T...
XP_001609992                  --------------------------------------------------------------------------------     
Q4QIS9                        --------------------------------------------------------------------------------      L...
Q4D3C1                        --------------------------------------------------------------------------------      T...
Q582A2                        --------------------------------------------------------------------------------      T...
ESS29572                 3340 stgqageeafvephallkrhtwagdferecwtflahtevhdsprispksrgetsqdagesqafkqtspvhagkatsqmaq 3419
EFC49106                      --------------------------------------------------------------------------------     
WGS:AAFB:cds.EHI_100500A      --------------------------------------------------------------------------------     
XP_001614494                  --------------------------------------------------------------------------------     
CAX64442                      --------------------------------------------------------------------------------     
Q4N5K5                        --------------------------------------------------------------------------------      T...
XP_001609992                  --------------------------------------------------------------------------------     
Q4QIS9                        --------------------------------------------------------------------------------      L...
Q4D3C1                        --------------------------------------------------------------------------------      T...
Q582A2                        --------------------------------------------------------------------------------      T...
ESS29572                 3420 sqlpsfsgpyhsspsrssrshsahsashsssrsssascvgrrgtlrhsaghldaagflsprspavllvasssasvacsve 3499
EFC49106                      --------------------------------------------------------------------------------     
WGS:AAFB:cds.EHI_100500A      --------------------------------------------------------------------------------     
XP_001614494              873 ---------------------------------------sddqaaskpagicpvgndaqdvemcrsevssaprhnhipsq 913 
CAX64442                  942 -------------------------------------------------------ymykdsviknkheyengyvtnmdkd 966 
Q4N5K5                        --------------------------------------------------------------------------------      T...
XP_001609992              407 ----------------------------------------------------------------qsetthpysnagtsdl 422 
Q4QIS9                        --------------------------------------------------------------------------------      L...
Q4D3C1                        --------------------------------------------------------------------------------      T...
Q582A2                        --------------------------------------------------------------------------------      T...
ESS29572                 3500 apaqeaagslnirrgregasgegpgerreqekadperrastacsrssrasgklsvqtgveWNKWML----WVAQYLLVLA 3575
EFC49106                  423 --------------------------------------------------------ilndRSGSWKefghMTVMFIFHMI 446 
WGS:AAFB:cds.EHI_100500A  192 ------------------------------------------------------------NKKMSD----SILFFILTVF 207 
XP_001614494              914 nqnqnqnanqnqnpnqlspnereknkidclknnkdkdkdkdkdkddqtnkkfkipifypfYSILIK----FIVQYIFVLT 989 
CAX64442                  967 ifsnnfymnnirhhadsfyyqnelnsfnlnknkennvrffnnendkkknnkskisilfpfYSVVLK----FTIQYIFVLA 1042
Q4N5K5                    334 -------------------nntqnhpnksvnrrssldsegfvpgnktesllsscrnhvdgFNIYYK----FVFLYCFVVL 390  T...
XP_001609992              423 sdkerpiktlsfvgddldlhlnhsedspekhsfvlkdlsatldtiadtvcpdstreledsGNAYLE----FILRFLLVTI 498 
Q4QIS9                    226 --------------------------------------------fggacagrddagyanarqhtppsrwlLAGSAIAACI 261  L...
Q4D3C1                    172 -----------------------------------------------------------pevlfthslwlPVGSAILSVV 192  T...
Q582A2                    253 ------------------------------------------------------------qcerfaatwlPVLSAVVAVV 272  T...
ESS29572                 3576 YVLVHTCMHLIRVLSLNIAINSSESAMFLIVVTNNFGEIKSSVFKKFSPTTLYSIVAADVVERFQLCCDAFIVSLKLATA 3655
EFC49106                  447 YLYVHSIVQLIRIVTLNAALNSSNYTLLTMIISTNFVELKGSVFKRFTKENLFQLASSDVVERFEIFWFTILIFVQNTLR 526 
WGS:AAFB:cds.EHI_100500A  208 ITLLHSFNLFFYIMALNVAINSKGHALLALLVSNNILELKSSVWKRMFPENVFQVLCADILELFELFSFVILLSLSNFGY 287 
XP_001614494              990 YILTHAFAHLIRFLSLNIAINSSESTMFLILVMSNFTEIKSTVFKKFSKTSLFTIVASDAVERFYLFIDAFLVLLKMSTA 1069
CAX64442                 1043 YILIHAFMHLVRFLSLNIAINSSESTMFLILVMSNFTEIKSTVFKKFTKISLFTIVASDAVERFYLFIDAFLVLLKMSTA 1122
Q4N5K5                    391 TITFHAFIHLVRVLILNIAINSPEYTMFLVLITNNFGEIKSSVFKKHTQLSLFIIFASDAVERCHLVLDGLLVFFKMSTS 470  T...
XP_001609992              499 YIIFHSFMHLLRVLILNIAINSSDSAMFLLMVTNNFAEIKSTVFKKFNETSLFTIVATDAIERFHLCFDGMIVFFKMCTV 578 
Q4QIS9                    262 STSCHSLSLLLHVVTLNVAINAEGNSLLALLVGNNFTELKSVVLKKNTPESLQSVCALDALERMQYVVFFLVMLLHHMHE 341  L...
Q4D3C1                    193 CVAAHAVTLLLSVVTLNVAVNAEDRLLLALMVGTNLSEVKGAAYKKYNRESLLQVTAADAVERFKFLLFVLVMALQHMHE 272  T...
Q582A2                    273 SVAAHAVVLLLSVVTLNVAVNSEGNLLLTLIVSSSLSELKGAVYKKHNRESLYSVAAADAIERVKFLLFVLVMVMQHMHE 352  T...
ESS29572                 3656 a------------------------------SPRATSLAAVCSWLCGVFLLEIAVDWVKFLYLVKFNNIQATAFDEYQHV 3705
EFC49106                  527 tivdstsgpvegvdlndfetmtnlegssslfSFLDDKLEEFGHIFIFMICAEILVDTLKHTFVSKFNSIHPSTFRMYTLK 606 
WGS:AAFB:cds.EHI_100500A  288 yew--------------------------diESNPDLLISMIYSLFLILLAEVIIDSLKHMFIGKFNNIPLSIYDKGKFV 341 
XP_001614494             1070 -------------------------------YRTQNSFFSISSWLIIILLLEVGVDWCKHSYLLKYNKLDSDSLNKYFHT 1118
CAX64442                 1123 -------------------------------YRTQNSFFSISSWLIIILLLEVGVDWCKHSYLLKYNKLDSESLNKYFHT 1171
Q4N5K5                    471 -------------------------------RRNLNSYISVFSWLFLVYGIEVLIDLVKHSYLIKFNKLLSETFEKYDSV 519  T...
XP_001609992              579 -------------------------------QSPWQAYLQVSRWLSKMLVLEVLIDYFKHSFLLKFNKIGGELFKRYTEV 627 
Q4QIS9                    342 -----------------------------------RFTDFAVADVFVILCVEVAIDFVKHLFVFRFNGIPPSMFRAYSQL 386  L...
Q4D3C1                    273 -----------------------------------RFHVLDIADMLLVFLGEVFVDFTKHLFVAKFNGISLSVYRTYAQL 317  T...
Q582A2                    353 -----------------------------------RFCGLDFADTLFVLLSEVAVDFTKHLFVAKFNGISLSVYRSFTQL 397  T...
ESS29572                 3706 LLADVLlsrvpqaqrhl------------lpdgnfkvpcrGMYAFSHIPTRRIGFMELPIVTLIIACLP----------- 3762
EFC49106                  607 LCDDLIshsdsakkse---------------ttsvvvssfFHNTNRSKVARRLGFLEGPLITHTLRMIM----------- 660 
WGS:AAFB:cds.EHI_100500A  342 LLNDLIstqdg-------------------------lfkiPSLDSTSTSARRLGMPAVPLSVLFICFGL----------- 385 
XP_001614494             1119 LLADVLisrtpnnniyy------------mntssfevpckNIFCFAHIPTRRLGYMSMPVVTLIVCSLPrwvlheggskw 1186
CAX64442                 1172 LLADVLisrtpnkniyy-------------mkdsfavpckNIFSFSHIPTRRLGYMSMPVVTLIVCSLP----------- 1227
Q4N5K5                    520 LIADRLlsrslynlrsl-------------tfyklkvpckCSFSFSHISSRRLGFISSPIVTLIISTIP----------- 575  T...
XP_001609992              628 LIGDILlsrslrnlhml-------------vrfdfrvickGVYSFSHIPARRLGFMSSPIMTLIVCNIP----------- 683 
Q4QIS9                    387 ALLDLScetvlwrlpslevvasgsgsgvatrmeeaaelltPAFGFAPKNVKRNGFDAIAYAALLLWSCE----------- 455  L...
Q4D3C1                    318 TILDMAaetvlwrlgdnihirc--vdepqlhvdnvktllsASDGFFPKYVKRTGYIPVPYAALLLWSLY----------- 384  T...
Q582A2                    398 TLIDMAaetvlwrlthiraccv---dsalydsqdlrkllrPSDGFFPKYVRRTGFVPVPYAALLLWSFS----------- 463  T...
ESS29572                 3763 -------------------------VVSWTSP-----------------------------STLVYALLGWLCLFVSKVL 3788
EFC49106                  661 -------------------------EVMLPWLfhfvavlgysnnwdsletliaipslskviYPIIITLLGFLCLFLLKLL 715 
WGS:AAFB:cds.EHI_100500A  386 -------------------------ETIPPSH-----------------------------FNLLFIISLLLILYLFKIL 411 
XP_001614494             1187 dpdsrcmgrqsdyiyahnnlsspplRLNYLYNi----------------------------SHFSFALSIW-------II 1231
CAX64442                 1228 -------------------------RLNYLSNi----------------------------SLFSFALSIWICLFLFKII 1254
Q4N5K5                    576 -------------------------KMGFHISp----------------------------KILIISAFSWLSLFFVKIT 602  T...
XP_001609992              684 -------------------------YIRSRLTv----------------------------TRFVTALLIWTALFFLKVT 710 
Q4QIS9                    456 -------------------------RVAGYLLw----------------------------QAPLVCVLLVLILALLKLM 482  L...
Q4D3C1                    385 -------------------------PFVSMMLl----------------------------RAPLLFALSLAILVLLKIL 411  T...
Q582A2                    464 -------------------------PIAHALFr----------------------------NAPLLLLLVLVAVMLLKVF 490  T...
ESS29572                 3789 LSLMIVAFATKRRR 3802
EFC49106                  716 ISITIIGHAAKnlc 729 
WGS:AAFB:cds.EHI_100500A  412 LAIALRYLAFTEVT 425 
XP_001614494             1232 LSVMIVSYTISEKK 1245
CAX64442                 1255 LSIMIVSYTISEKK 1268
Q4N5K5                    603 TSILLTGYCIKKKD 616  Theileria parva
XP_001609992              711 LSILLLSYGIKKRR 724 
Q4QIS9                    483 LSSIVYGMCARftl 496  Leishmania major
Q4D3C1                    412 LSELIRGVATRFvv 425  Trypanosoma cruzi
Q582A2                    491 MSELIHSVSMRFVv 504  Trypanosoma brucei
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