Conserved Protein Domain Family
rad1

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TIGR00596: rad1 
DNA repair protein (rad1)
All proteins in this family for which functions are known are components in a multiprotein endonuclease complex (usually made up of Rad1 and Rad10 homologs). This complex is used primarily for nucleotide excision repair but also for some aspects of recombinational repair in some species. Most Archaeal species also have homologs of these genes, but the function of these Archaeal genes is not known, so we have set our cutoff to only pick up the eukaryotic genes.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford Universit [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273163
Aligned: 5 rows
Threshold Bit Score: 1183.84
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAA28847   36 REKMYAQGGIFSITSRILVVDLLTNLLNPETITGMLVLHADRIVATSLEAFIFRIYRQKNKVGFLKAFSDNPDPFTVGFS 115  Neurospora crassa
AAB07689   86 RYEVYTQGGVIFATSRILVVDFLTDRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFC 165  human
P06777    203 RRKLYISGGILSITSRILIVDLLSGIVHPNRVTGMLVLNADSLRHNSNESFILEIYRSKNTWGFIKAFSEAPETFVMEFS 282  Saccharomyces cer...
Q24087    122 RERVYLEGGLQFISTRILVVDLLKQRIPIELISGIIVLRAHTIIESCQEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYS 201  fruit fly
CAA50599   90 REKSYLEGGIFAITSRILVMDLLTKIIPTEKITGIVLLHADRVVSTGTVAFIMRLYRETNKTGFIKAFSDDPEQFLMGIN 169  fission yeast
BAA28847  116 PLATMMRNMFLRKASLWPRFHVQVAQSLe----GKKKAEVIELEVPMTDSMREIQTAIMECVEISIHELKKENTG-LEME 190  Neurospora crassa
AAB07689  166 HVERVMRNLFVRKLYLWPRFHVAVNSFL-----EQHKPEVVEIHVSMTPTMLAIQTAILDILNACLKELKCHNPS-LEVE 239  human
P06777    283 PLRTKMKELRLKNVLLWPRFRVEVSSCLnatnkTSHN-KVIEVKVSLTNSMSQIQFGLMECLKKCIAELSRKNPE-LALD 360  Saccharomyces cer...
Q24087    202 HVERTMRNLFVKHLYIWPRFHESVRTVL-----QPWKIQSIEMHVPISQNITSIQSHILEIMNFLVQEIKRINRT-VDME 275  fruit fly
CAA50599  170 ALSHCLRCLFLRHVFIYPRFHVVVAESL-----EKSPANVVELNVNLSDSQKTIQSCLLTCIESTMRELRRLNSAyLDME 244  fission yeast
BAA28847  191 DWNLDSALTRNFDRMVRRQLEPNWHRVSWKTKQIAGDLTVLRGMLQSLLALDAVSFLQQLDt-IHAAHKPAPGTtrqtES 269  Neurospora crassa
AAB07689  240 DLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLE--SLRATEKAFGQ----NS 313  human
P06777    361 WWNMENVLDINFIRSIDSVMVPNWHRISYESKQLVKDIRFLRHLLKMLVTSDAVDFFGEIQl-SLDANKPSVSRky-sES 438  Saccharomyces cer...
Q24087    276 AVTVENCVTKSFHKILQAQLDCIWHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFMK--RYRSTEYALSN-----S 348  fruit fly
CAA50599  245 DWNIESALHRSFDVIVRRQLDSVWHRVSPKTKQLVGDLSTLKFLLSALVCYDCVSFLKLLDtlVLSVNVSSYPSna-qPS 323  fission yeast
BAA28847  270 PWLFSDAAQTIFETARQRVYSsk------------qKagPNSTIESLKPVLEEQPKWAVLADVL-EEIDRDLyfEPAVRD 336  Neurospora crassa
AAB07689  314 GWLFLDSSTSMFINARARVYHlpdakmskkekisekMeiKEGEETKKELVLESNPKWEALTEVL-KEIEAEN--KESEAL 390  human
P06777    439 PWLLVDEAQLVISYAKKRIFY------------------------KNEYTLEENPKWEQLIHIL-HDISHE---RMTNHL 490  Saccharomyces cer...
Q24087    349 GWTLLDAAEQIFKLSRQRVFN------------------G-----QQEFEPEPCPKWQTLTDLLtKEIPGDM--RRSRRS 403  fruit fly
CAA50599  324 PWLMLDAANKMIRVARDRVYK---------------E--SEGPNMDAIPILEEQPKWSVLQDVL-NEVCHETmlADTDAE 385  fission yeast
BAA28847  337 DSNGTILVMCADTDTCRQLRDYLQTmhirprtakkveevydpeedrPSGAFLMrrklRNYLNWKREFAQvnATLFSENqK 416  Neurospora crassa
AAB07689  391 GGPGQVLICASDDRTCSQLRDYITL---------------------GAEAFLL----RLYRKTFEKDSK--AEEVWMK-F 442  human
P06777    491 QGP--TLVACSDNLTCLELAKVLNAsnk----------------krGVRQVLLnk-lKWYRKQREETKKl-VKEVQSQdT 550  Saccharomyces cer...
Q24087    404 EQQPKVLILCQDARTCHQLKQYLTQ---------------------GGPRFLLqq-aLQHEVPVGKLSDnyAKESQTRsA 461  fruit fly
CAA50599  386 TSNNSIMIMCADERTCLQLRDYLSTvty---------------dnkDSLKNMNsk-lVDYFQWREQYRKm-SKSIKKPeP 448  fission yeast
BAA28847  417 ALSGAVDPrlPQARGRGGAPANKRRRvRGGGGGVgSNPSRHENGs-IVQHFEKPNEVADL-----MSeIQITEDdAGGQA 490  Neurospora crassa
AAB07689  443 RKEDSSKR--IRKSHKRPKDPQNKER-ASTKERT-LKKKKRKLT--LTQMVGKPEELEEE-----GD-VEEGYR-REISS 509  human
P06777    551 FPENATLN--VSSTFSKEQVTTKRRRtRGASQVAaVEKLRNAGTnvDMEVVFEDHKLSEEikkgsGDdLDDG---QEENA 625  Saccharomyces cer...
Q24087    462 PPKNVSS----NKELRREEVSGSQPPlAGMDELA--QLLSESET--EGQHFEESYMLTMT------QpVEVGPAaIDIKP 527  fruit fly
CAA50599  449 SKEREAS----NTTSRKGVPPSKRRRvRGGNNAT--SRTTSDNTd-ANDSFSRDLRLEKIl----LShLSKR---YEPEV 514  fission yeast
BAA28847  491 AEEIITFATADPLEDMDDYY---QLy--------dMQDLVViHA---YEGd--QD-EHV-------------------LE 534  Neurospora crassa
AAB07689  510 SPESCPEEIKHEEFDVNLSSd-aAFgi------lkEPLTII-HP---LLGc--SD-PYAlt---------------rvLH 560  human
P06777    626 ANDSKIFEIQEQENEILIDDgdaEFdngeleyvgdLPQHITtHFnkdLWAehcNEyEYVdrqdeilistfkslndncsLQ 705  Saccharomyces cer...
Q24087    528 DPDVSIFETIPELEQFDVTAalaSVp--------hQPYICL-QT---FKTe--REgSMAle---------------hmLE 578  fruit fly
CAA50599  515 GNDA--FEVIDDFNSIYIYS---------------------------YNGe--RD-ELV-------------------LN 543  fission yeast
BAA28847  535 EVKPKYIIMYEPDASFIRRVEVYRSS-HNDRNV---RVYFLYYGGSVEEQRYLSSVRREKDAFTKLIRERASMSIVmttd 610  Neurospora crassa
AAB07689  561 EVEPRYVVLYDAELTFVRQLEIYRAS-RPGKPL---RVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVP---- 632  human
P06777    706 EMMPSYIIMFEPDISFIRQIEVYKAIvKDLQP----KVYFMYYGESIEEQSHLTAIKREKDAFTKLIRENANLSHHf--- 778  Saccharomyces cer...
Q24087    579 QLQPHYVVMYNMNVTAIRQLEVFEAR-RRLPPAdrmKVYFLIHARTVEEQAYLTSLRREKAAFEFIIDTKSKMVIP---- 653  fruit fly
CAA50599  544 NLRPRYVIMFDSDPNFIRRVEVYKAT-YPKRSL---RVYFMYYGGSIEEQKYLFSVRREKDSFSRLIKERSNMAIVltad 619  fission yeast
BAA28847  611 sHGVEDPES-AFLRTINTRIA------------G--GGKLakATAQPPRVVVDVREFRSSLPSLLHGRSMVIVPCMLTVG 675  Neurospora crassa
AAB07689  633 -EEREGRDE-TNLDLVRGTASadvs-----tdtRkaGGQE--QNGTQQSIVVDMREFRSELPSLIHRRDIDIEPVTLEVG 703  human
P06777    779 -ETNEDLSHyKNLAERKLKLSklrk-----sntRnaGGQQgfHNLTQDVVIVDTREFNASLPGLLYRYGIRVIPCMLTVG 852  Saccharomyces cer...
Q24087    654 -KYQDGKTDeAFLLLKTYDDEptde----naksRqaGGQApqATKETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIG 728  fruit fly
CAA50599  620 sERFESQES-KFLRNVNTRIAgggqlsitnekpRvrSLYLmfICIKTLKVIVDLREFRSSLPSILHGNNFSVIPCQLLVG 698  fission yeast
BAA28847  676 DYILSPNICVERKSVSDLISSFKDGRLYAQCETMFQHYRNPMLLIEFDQNKSFTLEP----FADLSGSLRSvnpen-aga 750  Neurospora crassa
AAB07689  704 DYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTS----RGALFQEISS--------- 770  human
P06777    853 DYVITPDICLERKSISDLIGSLQNNRLANQCKKMLKYYAYPTLLIEFDEGQSFSLEPfserRNYKNKDISTvhpisskls 932  Saccharomyces cer...
Q24087    729 DYILTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKPILLIEFDQNKPFHLQG----KFMLSQQTSMa-------- 796  fruit fly
CAA50599  699 DYILSPKICVERKSIRDLIQSLSNGRLYSQCEAMTEYYEIPVLLIEFEQHQSFTSPP----FSDLSSEIGK--------- 765  fission yeast
BAA28847  751 qRLAVQKSCLLTLAFPKLRIIWSSSPYETAEIFERLKALEEEPDPVAAVRAGlgegeSPEDGVNEGKgavnggsTFNMEA 830  Neurospora crassa
AAB07689  771 -NDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAIT-----ADSETLPESE-------KYNPGP 837  human
P06777    933 qDEIQLKLAKLVLRFPTLKIIWSSSPLQTVNIILELKLGREQPDPSNAVILGtnkvrSDFNSTAKGL-------KDGDNE 1005 Saccharomyces cer...
Q24087    797 nADIVQKLQLLTLHFPKLRLIWSPSPYATAQLFEELKLGKPEPDPQTAAALG-----SDEPTAGEQL-------HFNSGI 864  fruit fly
CAA50599  766 -NDVQSKLVLLTLSFPNLRIVWSSSAYVTSIIFQDLKAMEQEPDPASAASIG------LEAGQDSTN-------TYNQAP 831  fission yeast
BAA28847  831 QEM--LGKVPGVTPKNIRNITAE-AENVREVANMEVEELGRLVG-REAAGKIVEFFKKDVLE 888  Neurospora crassa
AAB07689  838 QDF--LLKMPGVNAKNCRSLMHH-VKNIAELAALSQDELTSILGnAANAKQLYDFIHTSFAE 896  human
P06777   1006 SKFkrLLNVPGVSKIDYFNLRKK-IKSFNKLQKLSWNEINELINdEDLTDRIYYFLRTEKEE 1066 Saccharomyces cerevisiae S288c
Q24087    865 YDF--LLRLPGVHTRNIHGLLRK-GGSLRQLLLRSQKELEELLQsQESAKLLYDILHVAHLP 923  fruit fly
CAA50599  832 LDL--LMGLPYITMKNYRNVFYGgVKDIQEASETSERKWSELIG-PEAGRRLYSFFRKQLKD 890  fission yeast
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