6U42


Conserved Protein Domain Family
Enkurin

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pfam13864: Enkurin 
Calmodulin-binding
This is a family of apparent calmodulin-binding proteins found at high levels in the testis and vomeronasal organ and at lower levels in certain other tissues. Enkurin is a scaffold protein that binds PI3 kinase to sperm transient receptor potential (canonical) (TRPC) channels. The mammalian transient receptor potential (canonical) channels are the primary candidates for the Ca(2+) entry pathway activated by the hormones, growth factors, and neurotransmitters that exert their effect through activation of PLC. Calmodulin binds to the C-terminus of all TRPC channels, and dissociation of calmodulin from TRPC4 results in profound activation of the channel.
Statistics
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PSSM-Id: 464004
Aligned: 111 rows
Threshold Bit Score: 57.5829
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6U42_5R           134 GKVPMYLKRNKD-RVAKEKEHFTqylrmrEApeanahVS-------------QLSPEDRQQLVRHLKAKWGSVNTAYQGL 199
CBJ31034          285 GRVPEYLVSRQE-QWEREA----------DR------RKaeapdpscppgmkLMPEEERLQTLRQLQENESSCQSQLNKF 347
EEH52792          135 GEVPGYLLARKA-ELAEAA----------RV------KRemeershipvgmrVLPEEERVKTLEILRENREDTYEKLRSL 197
jgi:MICPUN_106619 193 GRVPDYLVERKL-ELAERE----------RE------RRekeelahippgmrVLPEDERLRTLEILAENRQDVEEKLLAL 255
jgi:THAPS_6663    201 GKVPCYITKRRA-KIEEAE----------QE------RRlaeqnappapglvLMDEAERLETLRVLEENEKKERDQLRKI 263
EFJ29085          139 GKIPAYLIRRKM-ELAFDA----------ER------KLleeeakslppgfvLMPDEEKQEVLKTLEENKVDLENKLRGL 201
XP_003721546      174 ARVPRYLQQRKA-ELAAEKEAIA------AE------AErqrqlslipagqrRVSEEEKADTLRQLDERQRELEGQLARI 240
Q38FI9            147 GIVPKYLLQRKA-ELAAQKEATQ------RE------AErqreiaryppghrLVSEEERKETLEKLAARRRELEMELHKI 213 Trypanosom...
Q4DJ24            128 GVVPKYIIQRKA-ELAAEKVAVL------RE------MErqkeiakyppghrPVTEEERKETLAKLASRRKELEYELHKI 194 Trypanosom...
EFC43675          188 GRVPQYIKDRKAiKHEKEQ----------KE------KEeqkkkdecppgmrLVSEEDRLETLTELEKSKREVQGAINKL 251
6U42_5R           200 SL-SVDSAVKKGRKEAMERELAEIERDIRTLER 231
CBJ31034          348 PL-VVQTPLLQRRVDDLNKKLKEIDEAKAIFSR 379
EEH52792          198 PF-KCETPSSKRTKAALEFRLAEIEDAQKVFSR 229
jgi:MICPUN_106619 256 PIaKDGTPVVHRRKAELEARLAEIEDAQRIFGR 288
jgi:THAPS_6663    264 PF-SMNAHRAARLREAIDHRLREIENAKRIFSK 295
EFJ29085          202 PL-VIETPSLLRSKIDMDTQLRETEDAIKRFSR 233
XP_003721546      241 PI-RFDTQSIQQRRRAIEEELRQIETTRNKYST 272
Q38FI9            214 PI-RYDTQSIKERRSKIENELSEIEAAERKFGS 245 Trypanosoma brucei
Q4DJ24            195 PI-RYDTQSIKARRNRIESELKEIDESERKFSA 226 Trypanosoma cruzi
EFC43675          252 PM-LCDTQFLQQKKNNMERKLQEIDEAIKIFSR 283
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