2KMU


Conserved Protein Domain Family
RecQL4_SLD2_NTD

?
cd22289: RecQL4_SLD2_NTD 
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins
RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.
Statistics
?
PSSM-Id: 412085
Aligned: 32 rows
Threshold Bit Score: 54.5585
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2KMU_A          4 ERLRDVRERLQAWERAFRRQRGRRPSQDDVEAAp-EETRALYREYRTLKR 52   human
XP_029849079    5 NNTQELKAKIKAWEKKFATEFGRKPTSADIKESp-PDVLGAYIKYWKTKR 53   black-legged tick
XP_029650704    2 EKLKNLKMALKTWEAKFLKENGRKPNSEDIGLSs-ENIRNAYSRYYKLKK 50   Octopus vulgaris
Q75DR2          7 GELDVLKVQLKTWERQFLEENGRSPIKEDIKAH--PEIRRKYKEYTSLKK 54   Eremothecium gossypii ATCC 10895
Q6CK38         21 ASMDALKIEIKLWERAFEKEHGRLPEKDDIKKD--KEVKRKYKQYAQLKK 68   Kluyveromyces lactis NRRL Y-1140
XP_002130892   11 LPFMDLKVKIKMWEITFAKQHGRKPGKNDISTD--AIARDMYIKYAKMKK 58   vase tunicate
Q6C7D7          1 MDIQTLRSEIKAWERAYADKHGRKPTPKEVKADpiAKKYHLYNKFKKAES 50   Yarrowia lipolytica CLIB122
O14216          8 KQISSIKALLKKWEHEYVHTNNCKPSKEDVKKQ--PEIALLYKQYYELKR 55   Schizosaccharomyces pombe 972h-
Q6BXN9          5 ESITQLKQAIKVWEHEFQRSNNRIPSRSDIKVD--PKVYELYKTYKVLKA 52   Debaryomyces hansenii CBS767
Q6FME9          3 MDVQQVKLKIKRWEHAFIAEHNRPPDKDDIRPL--TEMKQLYKLYSVLKS 50   [Candida] glabrata CBS 138
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap