4K6J


Conserved Protein Domain Family
WAPL

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pfam07814: WAPL 
Wings apart-like protein regulation of heterochromatin
This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Statistics
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PSSM-Id: 462278
Aligned: 61 rows
Threshold Bit Score: 144.752
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4K6J_A         16 HVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPL-NTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQ-- 92  
CBI35691      104 ataTLMETQEFGEMMEHVDEVNFALDGLRKGQPA-RIRRASLLSLLSICGTAQQRRLLRTQGMAKTIMDAVIGLSFDDsp 182 
F4I7C7        149 FTSTLLEAQEFGELMEHEDEVNFALDGLRKGHQL-RIRRASLSSLLSICASQHQRRSLRAQGISQSIIDAILVLSLDDip 227  thale cress
Q9C951         77 SNSTLMEAQEFGELIENEDEVNFALDGLKKGHKV-RIRRAALSSLLSICESQYQRRSLRALGISQSIIDAILGLCLDDip 155  thale cress
NP_001294626  217 HIKEANELRESGEYDDFKQDLVYILSSLQSSDASmKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALMDSPEDD-- 294 
EDV26103      227 HVRESHQCLEQGEDEQLADDIEYLLDGLNPSYPK-NLRCSSITALAKRCTESPFRMYIRAHEIIPKILDLLVDSPSDY-- 303 
ETN64005     1018 NVKNSHQMQEIGEFQEMDDDVEYILSALQPDNPV-STRCLSALQLATKCMKPAFKMHVRAHGVVTRFFRALSDAHQDA-- 1094
XP_015795049  127 RVKKAHQCAELGEREEFDGDIKFYLDGLSRVNNI-NTRCLSILGLANQCQRAEFRMHLRAHDDMPKIISALMDACSNP-- 203 
EDO34596      228 NVKKVSECLESGEDQEFFDDVEYLLYGLE-SSKV-STRCLSALDIMSRCTNGSFRVNLRAHGTISKIFNLLKDAGEYK-- 303 
XP_019848770  643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPL-LVRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLKDAQTHP-- 719 
4K6J_A         93 NLSLCTAALMYILSRDRLN-MDLDRAS--LDLMIRLLELEQDASsakll---------------------nekdmNKIKE 148 
CBI35691      183 S-NLAAATIFFVLTSDSHD-DYLLESPtcIRFLLELLKPPMSNAthgkapsigikllglrkdadplrdtnktidsSSTA- 259 
F4I7C7        228 S-NLAAATLFFALTADGQD-EHFMESPkcIKFLIKLLKPVIVTStegkprnigfkllsllkdvdaardpvkmddpSSSD- 304  thale cress
Q9C951        156 S-NLAAATLFFVLTTDGQD-DHFMESPnsIKFLVKLLRPVVSAStkvkprnigsrllsiikdvdaardaasmhdlSSCD- 232  thale cress
NP_001294626  295 LFALAASTVLYLLTRDFNS-IKIDFPS--LRLVSQLLRIEKFEQrpe--------------------------dkDKVVN 345 
EDV26103      304 QLATYTAALFFVLSEDRLI-MDLTDDL--LDVLLKLLQCPNQDHndtn-----------------------dailKSSLQ 357 
ETN64005     1095 GLALCTAAIMYVFSQDKLN-MDLDRDS--LELMLNLLgttsageqlag-----------------tagkvtndpqQKIRQ 1154
XP_015795049  204 NLALCTSALMYVYNQDRMT-MDIDPNA--LSLMLELLETR---Tdeee-----------------------dsvdKNYKE 254 
EDO34596      304 NLSLCTSAIMYILTQDRQF-IDFDKFI--LEMLIKFISVENSNDvdgse----------------------dieyNKYIH 358 
XP_019848770  720 ALKVALVTLSFVMTQSNVEpSELDKKC--TELLVMALSVKDQFLvspageeeppplegkaateykkitdkskallKKCSP 797 
4K6J_A        149 K-IRRL-CEtVHNKHld---------------------leNITTGHLAMETL------------LSLTSKragdwfkeeL 193 
CBI35691      260 --IVHKvQE-VLVSCkeiksssg---------ddngvgrpELSPKWIALLTMekacfstisledTSGTVRktg----gnF 323 
F4I7C7        305 --ILSRvQE-LLVNCkemrlnds---------yitettrpELSTKWVALLAMeracvskisfddTSGSVKktg----gnF 368  thale cress
Q9C951        233 --IIDRaQE-ILVNCkelrlids---------ykiermrpELSTKWVALLVMekaclskisfddTSGTVKksg----gmF 296  thale cress
NP_001294626  346 M-VWEVfNS-YIEKQevggqkv-----------sfdmrkeSLTPSSLIIEAL------------VFICSRsvn---ddnL 397 
EDV26103      358 N-ISLScKD-YLkah-----------------------vdSLNGKALALACI------------FNLVCSrna----vwL 396 
ETN64005     1155 R-VKELcDE-IKGSGkakphiigsegdsssgsssnssdghRISAATLAMESL------------LSLTSQrag----ewF 1216
XP_015795049  255 K-VKKLcDE-MKTKGhgkf-----------------lnsnNITAGKLALEAL------------LGLTSKrag----ewC 299 
EDO34596      359 R-IKSIlNE-RNRLIpgty-----------------felhDISTFSLARESL------------LSITTErvg----pwF 403 
XP_019848770  798 LlIHAKySD-SSNTNetvdi---------------slqpsTLSLGELATECF------------LSLTSSmnts--vssL 847 
4K6J_A        194 R----LLGGLDHIVDKVKECVdhl----------------srdEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIaY 253 
CBI35691      324 KekfrEFGGLDAVFEVAMNCHstlegwlk------hgspsirdAKDDANLQSLVLLLKCLKIMENAAFLSKDNQSHLLgM 397 
F4I7C7        369 KeklrELGGLDAVLEVVMDCHavmerwve------ydalsvqeKKDNLHKQSLMLLLKCLKIMENATFLSTDNQNHLLgF 442  thale cress
Q9C951        297 KeklrELGGLDAVFDVVMDCHtvmeswvt------hdtlsvedIKDDLNKQSLMLLLKCLKIMENATFLSTENQIHLLrL 370  thale cress
NP_001294626  398 KsellNLGILQFVVAKIETNVnli-----------------adNADDTYS--ILILNRCFRILESSSVFHKKNQAFLIsH 458 
EDV26103      397 KdkvrSIGILDVICDLVIDHKynl-----------------emNPKANRIIVLREVELCCRILETVTFLNKENQDYVIgW 459 
ETN64005     1217 KdelrKLGGIEHLIKTVSECYesvpe------------raadwHPEAIAK--LRKIERCLRVLNNVCVFNRANQAFLLeH 1282
XP_015795049  300 KeelrNLKGIDFLCNKTIDESnslir------------ddivwEEEIVDKGLLHKIERTLKVIENVTFMNQENQNYIIeY 367 
EDO34596      404 KeevrSLGALDHIIDTISESVnwvieek---------gsipegDQNMQAK--IIRIDKCLKLLENVTYQNTSNQTYLLhY 472 
XP_019848770  848 KedlrTLGAIDVIANRAIALTrqctgyltsgqeeegkeeeereGEEREVDVHFMKLFRQLKLLENILCMSKGNQSYLTmF 927 
4K6J_A        254 KDSQ------------LIvSSAKALqhceeliqqynraedsicladskplphqnvtnhvgkavedcMRAIIGVLLNLTND 321 
CBI35691      398 KGKGncngsrlsfiklIL-SIIKTL---------------------------------------------SGLSLSKSSS 431 
F4I7C7        443 KKCLgshdsrmsftelTI-SVIKML---------------------------------------------SGLHLRGGFS 476  thale cress
Q9C951        371 NKSMgshesrlsftelMI-SVIKIL---------------------------------------------SGLQLR---- 400  thale cress
NP_001294626  459 RSNIl-----------IS-SLAKFLqvildrvhqlaee--------------------evkkyisclalmCRLLINISHD 506 
EDV26103      460 KGYTl-----------VG-NVSRIFslcvekimsqdkn-------------------tainedsacllasVRLLLNITHE 508 
ETN64005     1283 RDGLl-----------VQ-LLARIYrqldreipfhptddht-------------pkeavgvvvrelhqpiLHMLITLTHS 1337
XP_015795049  368 QGGKf-----------IY-RCIDLIkylknsiifmte----------------------sqsqlstllsiLRVLTNLTSE 413 
EDO34596      473 QKGLl-----------AR-SLSRSLikihlikptycttrk----------------aslpghsagsllnaFKLFLNLSND 524 
XP_019848770  928 DGSIf-----------IS-EISKFLvllgdyliskdl------------------strhtcivtetLLGTLRVFLNITHD 977 
4K6J_A        322 N-----EWGSTKTgeQDGLIGTALNCVLQV-PKYLPQEQRFDIRVLGLGLLINLVEYSARN 376 
CBI35691      432 TisideKSRNISDgiSHDSQVDCMADYKGTv------TDS----VCVLESNGNLFVnysrk 482 
F4I7C7        477 SpntnnVNSHYSNggNHDSVLEANRKVTNEvVTISSDTYS----TVGSISTRNGSVSQRSQ 533  thale cress
Q9C951        401 --------AHRNEkhPHPQPHLASAVKKGFvTIISSDTCS----TTGFSSIKSLSVSKRNQ 449  thale cress
NP_001294626  507 N-----ELCCSKLgqIEGFLPNAITTFTYLaPKFGKENS-YDINVMMTSLLTNLVERCNAN 561 
EDV26103      509 N-----EIGCKQVgrDKSTIKAAMECIDEI-HEKVDDVRRFDLVILALGLLINLVESNKES 563 
ETN64005     1338 Fdd--qAPGATLVgqQPEMIDITMQILLRI-ARYVPSRCVFDLNLLALTLLLHLARPSEQN 1395
XP_015795049  414 S-----SEGCFKVgsFTGLFQLLLECLFEL-PSFTVPDSRFDLIVLLLCLEINFVEYCVNi 468 
EDO34596      525 S-----EEGSNLIgqQEGFLSTLLFSVLQL-PQYYEASQRFDLHVLGLGLLINLVEHSKQN 579 
XP_019848770  978 N-----ALASYRVgeQEKIIDSICNFTFKL-AQSVPVIQQFDILVLCLSLLINLLEESSTN 1032
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