Conserved Protein Domain Family
SPG48
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pfam14764: SPG48 
AP-5 complex subunit, vesicle trafficking
This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterized by progressive spasticity in the lower limbs.
Links
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Statistics
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PSSM-Id: 464303
Aligned: 30 rows
Threshold Bit Score: 99.586
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFH59174      26 ASDPSILQSVKKLHGFCKLEKsdDLVARIYPQINKVFH------RSVASLSQSEsgtskglLLLAILQFFLDFGDM-VLH 98 
XP_001742355 256 FAFAALSEALLLLQELMRLDE--EFVVDAVPTLQRVLDrarcvgRAETALGWAN-------AELLCLRVLLSHDEKsTMI 326
EFJ20551      26 TADTSVRDAVERLNAMCKSEGneDLVTRVYPAMTKLFQ------RCCSSSTQRPst---alVALAILQFFLDHGET-VLH 95 
ERM93771      25 STDPSLLESVKKLYEMCKNENseDLIARVYSHMNKLFQ------RCIAAMSQAQtsn--glLHLAILQFFLDFGEV-VLH 95 
XP_009393334  39 ASDPYILQSVKKIYDIAREGGseELVARAYPQINKLFQ------RCVSALPQSQtsn--gvLLLTILQFFLDFGEV-VLH 109
XP_006352496  32 ASDPSVLNSVKSLCDLCRSEKseDLIARVYPHLNRIFQ------RCLSSISQSQtsn--glLLLAILQFFLDFGDV-VLH 102
CBI23948      29 ASDPNLLPSVRKLYELCKSEEseDLVARVYPQINKIFQ------RLVASVSQSRtsn--glLFLAILQFFLDFGEI-VLH 99 
EKC38143     289 LQNCCLLEVVNVLDMICKIEP--GHVARVFQEVRRLYQ------RLMHELDKPR-------LLIPVLQFFLNHGKS-VEH 352
EDV27902     358 LQFSCLVEVVTLMNNVCDCDP--SSIPALFNKVKRIY-------KQVLDVNKGR-------TLLAVIQFFINFGDT-VVF 420
XP_002595760  72 LQQACLTEVILLLDTMCQQNS--SLIPRVFPSIKRVYN------RIQNSPASSI-------NIINILQFLLHHSDA-VMY 135

EFH59174      99 DADPSLRTFFRSCLSREFSDSAVAEATCEFLVANQRKLLASfPNLLPQFFPLLLK 153
XP_001742355 327 DCLSALDDIFTQKHGRHMRDPYFAGALMALVTDFIDLLSAK--GIVDKYCPAIFK 379
EFJ20551      96 DADPSLRAFFRSCLVKQYADPAVAAATVAFLNHNKMKLLLSySSVLPQFFPLLLK 150
ERM93771      96 DANSSLRAFFRSCLSRQFAAPVVAESTLNFLFLNKTRFLNSfPSLLPQFFPLLLK 150
XP_009393334 110 DADPSLKAFFRSCLSREFADPVIAKATLDFLNLNKAKLLSSfPTLLPQFFPLLLK 164
XP_006352496 103 DADPNLRTFFKSCLSREFADPVVAEATLDFLNANKKKFSSSfPTLLPQFFPLLLK 157
CBI23948     100 DADPSLRTFFRSCLSREFADPVVAKATLDFLIWNKKKILTSfPTLLPQFFPLLLK 154
EKC38143     353 DPQEAYTLFFHKLLTQCYLDPAFSFDTITFIKDNLETLCHN-TNVLSTYFPNILK 406
EDV27902     421 DTKDALEFFFAKVLDTRFHNSFLAFDVVMFLIENQEKLCAN-TEVFTRYFPNILK 474
XP_002595760 136 DMGPALQHFFLKILDKQCIDQSLAFEATLFCLENMENLCNN-TSVLRKFFPCLLK 189
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