Conserved Protein Domain Family
HAUS5

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pfam14817: HAUS5 
HAUS augmin-like complex subunit 5
This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.
Statistics
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PSSM-Id: 464332
Aligned: 21 rows
Threshold Bit Score: 550.804
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004234704   7 PEAILEWLQKEMGYQplgsyaassKAAMPTIDSLRKICRGNMI----PIWNFLL-NRVKSEKTVEKVHRNILVHGRDdg- 80 
XP_003440037   7 VQDLKRWATEEFGLS---------PDRLPNDSYFKTLCVGTGK----SIWKYVI-QHVFQQRNVRIMRGNLQWYKSLqd- 71 
2_pfamImport   1 --ELKRWATEEFNLP---------PDSLPNDGYFKTLCIGTGK----SIWRYVI-QHVFQQRNVRVVRGNLQWYKVLqdk 64 
XP_007245836   5 FQEVKRWATEELQFP---------PPKLPHDSYIKTLCVGPGA----SIWKYVI-KHVYHERNVRLMRENLQWYKVVqdk 70 
NP_001007439   5 SQELKRWAVEELELP---------ASRLPDDGYMKTLCVGPGA----SIWKYIT-QHVYKERNVRVVRGNIQWYKVLqdk 70 
XP_008119149  13 AQELRRWAAEEMELP---------PGKIPPESALRRMCSGQCA----EIWKHVI-RHVHHQRNVKKIRGNLLWYRQMeet 78 
XP_003466669   7 ARELGRWAAEEMEVP---------AIARASESTLRRLCLGQGA----DIWAYIL-QHVRSQRNVKKIRGNLLWYG----- 67 
O94927         7 ARELGCWAVEEMGVP---------VAARAPESTLRRLCLGQGA----DIWAYIL-QHVHSQRTVKKIRGNLLWYG----- 67  human
XP_011613152   7 VQEVKRWAKEEFSLP---------PDSLPNDGYFKTl----CVgtgkSIWkYLIhHVFQ-QRNVRIMRGNLKWYKLLqd- 71  torafugu
XP_005800582   7 VKELKRWATEEFNLP---------PDSLPNESYLKTLCVGTGK----SIWTYMI-QHVFQQRNVRIMRGNLQWYKTLqdk 72  southern platyfish
XP_004234704  81 nGngnvnavdsgrskgrrkekvgvvrdsgsgssssvglasAENSR---EFALQERDLAEKEVERLRQIVRRQRKELKARM 157
XP_003440037  72 ----------------------------------------keAEG---QSEAAKRKDLQKKIEQLKEEISHLDSQMSVTE 108
2_pfamImport  65 eL--------------------------------------KHAEG---QSDAAKQRELQSKIEQLRAEISHLDSQLSGTE 103
XP_007245836  71 eL--------------------------------------KQVEG---QNKDAQRLQLQREIEELQAELSQLDHKISSAE 109
NP_001007439  71 eL--------------------------------------KQLKN---QNNDARKLELQREIDALQTELSQLDTKITRVE 109
XP_008119149  79 eG--------------------------------------KFNGL---QAEKECRKQLVQGIARLREELQNIDLQIESAQ 117
XP_003466669  68 ------------------------------------------HQD---SPEVRRKLELETTVSRLKAEIQELDQSLELME 102
O94927        68 ------------------------------------------HQD---SPQVRRKLELEAAVTRLRAEIQELDQSLELME 102 human
XP_011613152  72 kE----------------------------------------FKQaedQSATAKKRELQRKMEQLRAEISLLDSQISGTE 111 torafugu
XP_005800582  73 eL--------------------------------------MQSES---QSEAAKRKELQTKIEQLRHEISHLDSQIRGTE 111 southern platyfish
XP_004234704 158 LEVSREEAERKRMLDERSNYRHKQVMLEAYDQQCEEAAKIFSEYHKRLSYYINQARNVKRssvdssaevvttfqaNEKD- 236
XP_003440037 109 EQMATQDNSISRTWAQVEDGQRRELLLQAFRQRCISSRKYLSDDVQQISVHCQALEQMAR---------------KAEIe 173
2_pfamImport 104 EQLATQEQSISRTWAQVEDSRRRELLMQAYRQRCILGRRVLSADTQKVNGHCQALEELAR---------------KAEIe 168
XP_007245836 110 DQLTNEEKNVGRHWELYEESRLRELMLDSFRQRCADERNSLIEDTQKISTKRQALDQLSK---------------KAEVk 174
NP_001007439 110 DQLAAEEQSLNRNWDGFTESRCRQILLDCFRQRCSEDRNALLEDTRVIGDQRQSLDELAK---------------KAEVk 174
XP_008119149 118 RELVADEVTLETAQEKIRDAKRRTLLLKAYSTQVMAEHQLLHGKVMQMKGRLEQLEAMKR---------------KAQTt 182
XP_003466669 103 RENETQDMATEQALQSIRDTQHRALLLRAQAGAVRRQKVGLRDLTQWLQNQLKCLQDVER---------------KAKVd 167
O94927       103 RDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLRRLQDMER---------------KAKVd 167 human
XP_011613152 112 EQLATQEQSIDQTWAQVEDSHRRELVLQAFRQRCIMGQKLLRDDASKIEEHCQALEQMAK---------------KAEIe 176 torafugu
XP_005800582 112 EQMATQEQSINRIWVQIEENQTRELLLKAFRQRSVSNRKVLSDDVQKINYHCLVLEQMAR---------------EAETe 176 southern platyfish
XP_004234704 237 -VYSTSKGTKSSe----dVILIETTWERDIRKACECLAMQMAEKIRNSFPAYEGNGIHMNsllqaaklgidldgdlPDEV 311
XP_003440037 174 vLF-DKSSCNRDndnlnvKVATEAQVLRDVRELCDDRVHFYQSLQECESKTQHSAATHMT----------------REQR 236
2_pfamImport 169 vLFDDKPPSSRDvdnldsQGAAEAQVLRDVRELCDDRVHFYQSLQESELKTANSAAKHIT----------------REQR 232
XP_007245836 175 lVFGSSDGGNTG-------MAAEPLVLRDIRELCNERVLFFRSLQDSMLKATSEFTPA--------------------QR 227
NP_001007439 175 lVFGPSDQSDNE-------AGADPLVLKDVRELCNERVHFLQCLLEGELKANPSTQFT------------------RDQR 229
XP_008119149 183 vVLGKTAVSGF--------PSLEPEVLRDVQEACQLRFQFLKTLFERSISGNFPKGMS------------------EEQL 236
XP_003466669 168 vTFGPLASAA---------LAVEPVVLHDVRAACTLRAQFLQNLLMPQAREGNVQSPH------------------DDHF 220
O94927       168 vTFGSLTSAA---------LGLEPVVLRDVRTACTLRAQFLQNLLLPQAKRGSLPTPH------------------DDHF 220 human
XP_011613152 177 vLFDKSSSCSEGdtl-nsKSAAEAQVLHDVRELCDQRVHFYQSLQESELKSAHPAAKLMT----------------REQR 239 torafugu
XP_005800582 177 vLFGDEPSNLNS------KAVAVPQVLRELRELSEDRVHFFQCLQESEAKTQHSAPKSMA----------------REQR 234 southern platyfish
XP_004234704 312 RDAIVSCLKS---------PPQLLQAINAYAQKLKTTITREIEKVDVRADAEILRYKYENDRVMDAsSPDVTSPLHyqly 382
XP_003440037 237 TAVFQYWLSAvenmlgaypPNHVLSALLYLASREQKVLEEKLSSLDVTRDVTALQFRYESDHLLDM-SAEEENELP---- 311
2_pfamImport 233 TAVFEYWLSAvenmlcgypPNHVLSALEYLASREQKELEEKLASLDVAQDVSALRFRYESNHLLDV-STEEDNDLP---- 307
XP_007245836 228 NAAYQHWLSAvqdvlhshpSNQVLLALQTLAAKQHTALEEKTAALDVEDDVSALGFRYESNHLLDV-SMEEEQDLP---- 302
NP_001007439 230 HAVIQHWTSAvenvlrshpPNQVLSALQALTSRHQVALEEKITALNLERDVSALGFRYESDHLIDV-SSELEE-LT---- 303
XP_008119149 237 NRSYQHWLSIaekvagshpPKHILLALEHLALQSTHQLQELTSNINILRDVEALKFRYNSGHLEDV--SYPANDLP---- 310
XP_003466669 221 GASYHQWLSTaetlltnhpPGHVLAALEYLAAEREEEIRSLCAG-DGLDDMEKSRPQALT-------PTDSSRALP---- 288
O94927       221 GTSYQQWLSSvetlltnhpPGHVLAALEHLAAEREAEIRSLCSG-DGLGDTEISRPQAPD-------QSDSSQTLP---- 288 human
XP_011613152 240 AAVFQAWLSAvedllncypPNHVLSALEYLASREKKELEEKVASLDVTQDVKALRFCYESNHLLDM-SADEDNDLP---- 314 torafugu
XP_005800582 235 TAVFQYWLNTaeevlssypPSHVLSALQHLAVTEQKALQDQLASLDVAQDVAALRFRFESDHLLDI-SAEECDELP---- 309 southern platyfish
XP_004234704 383 gngkiggdtsskgSQNQLLERQKAHVQQFlatedaLNKAAEARKMSQQLLKRLQGTDDAISTHSLAIGGTSKSMSSLKQl 462
XP_003440037 312 -------------PVKTLLEAAWEEVEQS------LVELAQTRSRVQQLKNQLQTRKKDAELEVSSIRDELQDDSLALS- 371
2_pfamImport 308 -------------SVKTLLEDAWEEVEQS------LVELAQTRSRVQQLQSQLQARKKTAELEVSGIAD--------RS- 359
XP_007245836 303 -------------PVRSLLQSAWEDVEQC------YMQLTEVRSRARQLQADLSALMKQMQLRILGQDD--DADPIARS- 360
NP_001007439 304 -------------PVRSLLQSAWEEVEQS------YFELAQTRSRRRQMETELTALIRKAE-----ATH--KTDSVSRC- 356
XP_008119149 311 -------------DVRSLMQEGWSKCEML------HIEQISLHAQEKRLLAQLEGVVQEMHRQLSDGSE---NSILVRA- 367
XP_003466669 289 -------------SMVHLIQEGWQAVGAL------MAQRRTLLKEHQVLTGRLQGLVEEVERLSLGPSK--------RK- 340
O94927       289 -------------SMVHLIQEGWRTVGVL------VSQRSTLLKERQVLTQRLQGLVEEVERRVLGSSE--------RQ- 340 human
XP_011613152 315 -------------SVKTLLQAAWEEVEQS------LVELSQTRSSVQQLQHQLQMLRKEANLEVSGAIEDLHNDTLALS- 374 torafugu
XP_005800582 310 -------------PVQTLLEAAWVEVQQS------FTELSRTRSRIQQLKTLLKSHKAEAELEVSGIAD-----ENLNK- 364 southern platyfish
XP_004234704 463 eleVWTK-----EREAAGLKASVNTLMSEIQRLNKLCAERKEAEDSLRKKWKKIEEFDARRSELESIYSALLKASMDAAA 537
XP_003440037 372 ---ALEV-----ELQCVMQAAARDYIRDRCIQLDQHAQSRQEALRSLRSQWQSILDFRQLVLLRQEQIRGLIKGNSTAKT 443
2_pfamImport 360 ---ALEV-----ELQCVMQAAARDQIRDRCIQLDLHAKSRQEALRKLHSQWQSILDFRQQVVLRQKHIRGLIKGNSTAKR 431
XP_007245836 361 ---VFEL-----EVQTVRQAAVRDSVREQCAQLQLQSRARHEALQSLQAQWQSIMDFRQLVDVRQEHIRSLIKANSTIKT 432
NP_001007439 357 ---VFEL-----EMEAVKQVSVRDSIRDQCVQLQQQARQGQDAIRALQTHWQTVMDFRQLVNRRQEQIRSLIKGNSSVKA 428
XP_008119149 368 ---VFEL-----ELRVVRLQGYRNGLLDGCQELEKVVRTRREELQGLQTKRQRILDFRHLVNEKQQHIQLLIKGTSYIKS 439
XP_003466669 341 ---VLML-----GLRCCGLQAELRALCTQCQELEDVSGHRQLLLRELQTKQQRILHWRQRVGETQEHIRLLIKGNSASKT 412
O94927       341 ---VLIL-----GLRRCCLWTELKALHDQSQELQDAAGHRQLLLRELQAKQQRILHWRQLVEETQEQVRLLIKGNSASKT 412 human
XP_011613152 375 -----SV-----ELQCVMKAAARDYIREWCIQVNQRARSRQEALRNLQNQQQRILAFRELVAVRQEHIRGLIKGNSVAKT 444 torafugu
XP_005800582 365 ---SLalstleveLQCVMQAAARDHIRERCIQLDQHARNRQEALRSLRSQWQSILDFRELvALRQEQLRGLIKGNSSAKT 441 southern platyfish
XP_004234704 538 FWGQQPLAAKEYSSSTIIPACTVLVDLSHSAKDLIEQEVSAFyqtpdnTLYMLPSTPQALLESMgvggstgpevvaaaek 617
XP_003440037 444 QLIHLHRELEEFIQAKLMPQFEDVTAAANSLRNAVSKEARQM------GAVSLLSLDRRTIEGM---------------- 501
2_pfamImport 432 ELICLHTELQEFVQGKLVPQLEVVTTAGGTQRNSISREARQF------GTISLLALDRRTVDGM---------------- 489
XP_007245836 433 ELTRVHSELRQFVQENLSPQFGGVVQAATGLRNSVSQEGKQF------NSVFLAALDRRIIDS----------------- 489
NP_001007439 429 ELTRVHEEVGQFFKDELSPQFVTVIGASSGQRNSVSQGAKHF------SCVSLAALDRRVMKGG---------------- 486
XP_008119149 440 QLRKDQAEIQDFIEMKLLPQAHQVELETQKLYDRVNREVQQF------GAIALPCLLRRRLPGS---------------- 497
XP_003466669 413 RLGRSPGEVLAVVQQKVIPASEAVAPQSQELLRCLEEGAQHL------PHILLSPLLRHSPEGL---------------- 470
O94927       413 RLCRSPGEVLALVQRKVVPTFEAVAPQSRELLRCLEEEVRHL------PHILLGTLLRHRPGEL---------------- 470 human
XP_011613152 445 ELKCLHAELQEFVQGTLVPQFENITTAANNLRNSISKEVKRF------GTVSLPSLDRRTVEGM---------------- 502 torafugu
XP_005800582 442 QLISVHRELQEFIEEKLVPQFEDVIGAANNLRNSVYKEAKQF------GTVSLLALDHRTTDGM---------------- 499 southern platyfish
XP_004234704 618 naailtaragARDPSAIPSICRISAALQYPAgldasdaGLAAVLESLGFCMKFrgSEASILEDLEKAINLVHTRRDLVES 697
XP_003440037 502 ----------QRIPASWLSIHRLQSP------------TFSSLCQSLAFPLYK--APEELCSRSRSQQLELRFLRQLLQL 557
2_pfamImport 490 ----------QRIPASWLSIHRLQSP------------TFSSLCQNLAFPLYR--APEELCSHACAQQLELRFLRQSLQL 545
XP_007245836 490 ----------ERIPLEQLSLNRVNSP------------ALQTICRSLSTPMYM--APEELCSQTVSQKLELRFLRRLLQL 545
NP_001007439 487 ----------QRAPAAQLSIHRIQSL------------AFHKLCESLSFPMYM--APEELWSQAVTRRLEFRNLRRLLQL 542
XP_008119149 498 ----------KYIPAHELSIHRMSRIAPAEYr------AFLNVCSGAAFPLYK--APEQLLFHMSDLKKMIFRLRAQLGS 559
XP_003466669 471 ----------KPLPTILPSIYQLHPASPKGF-------SLIALSHILGLPAGK--GPELLLPKAASLRQDLLFLQDQQSL 531
O94927       471 ----------KPLPTVLPSIHQLHPASPRGS-------SFIALSHKLGLPPGK--ASELLLPAAASLRQDLLLLQDQRSL 531 human
XP_011613152 503 ----------QRIPASWLSINRVKSP------------TFSSLCQTLAFPLYR--APEELCAHARSLQLDWRFLHQILKL 558 torafugu
XP_005800582 500 ----------HRVPASWLSIHRLQAS------------NFRSLRESLEFPLYR--APEELCFQLLSQQLELRFLRELLQL 555 southern platyfish
XP_004234704 698 GRALLDHANKAQNEYER-TTNYCLSLAADQEKTATENWLQELDVAIGNAKHCLdEECKYVRGLVDEWWEQPASTVVDWVT 776
XP_003440037 558 HSATLQKIKKEADQLEAsDQKALLSRVMEEDQKLLKSLVPRVRGLTHRCAQGL-SYGDQVKTAISYWWERPAQHVLPEVS 636
2_pfamImport 546 YAVTSQKIQKETELLHAsDQKALLSRVLEEDQKLLDALVQRVRCLTQRCTQGL-SYGVQVKTAISYWWDRPAQHVLPDVN 624
XP_007245836 546 LSDSLANTQRRTAQLPAsNQQALLQRVKAEDAEVLQSLLPRVRELTQRCTKGL-AFGDQVNTAIAHWWEQPGQFALPEMQ 624
NP_001007439 543 FSDSAADLQKRAAQLPSpDQQTLLQRVKMEDEEILQTLLPRARELMHRCSKGL-LYSEQVKTAITHWWDQPAQFALPEME 621
XP_008119149 560 KQQALAKLQHQLDEAPEpNVQALVEEVQTHDREQVRELLPRIQRLTEQCKCHI-ERWHEVQGTVDAWWEQPGQFALPSER 638
XP_003466669 532 RSRDLLCMKTSLP--LGpSTQEVLQIQASQEKEQKESLGQALKRLENVLKQAL-ERIPELQGVVGDWWEQPGQAALSEEL 608
O94927       532 WCWDLLHMKTSLP--PGlPTQELLQIQASQEKQQKENLGQALKRLEKLLKQAL-ERIPELQGIVGDWWEQPGQAALSEEL 608 human
XP_011613152 559 YSAVLQETQNEAELLPAsDQKALLSRVQEEDQKLLKALIPRVRSLAQHCDKGL-SYGVQVKTAISYWWEKPAQHVLPEVS 637 torafugu
XP_005800582 556 YSATLQKVEKDSELLHAsDQKALLSKVREADQKLLKSLLPRARGLTNHCAQGL-SYGAQVKTAISYWWDKPAQHVLPELS 634 southern platyfish
XP_004234704 777 VDGQNVAAWWN 787
XP_003440037 637 KGGLTFQQWLQ 647
2_pfamImport 625 KGGLTFQQWLQ 635
XP_007245836 625 QEGLTFQQWLQ 635
NP_001007439 622 REGLTFQQWLQ 632
XP_008119149 639 RHGLTLQQWLE 649
XP_003466669 609 FQGLSLMQWRL 619
O94927       609 CQGLSLPQWRL 619 human
XP_011613152 638 KGGLTYQQWLQ 648 torafugu
XP_005800582 635 KGGLTFQQWLQ 645 southern platyfish
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