Conserved Protein Domain Family
Vps55

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pfam04133: Vps55 
Vacuolar protein sorting 55
Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase. Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.
Statistics
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PSSM-Id: 461188
Aligned: 111 rows
Threshold Bit Score: 71.3883
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK42066       7 IIFLSAFLASGFLLILLSCAL-YN-N-YKPLWVIFIFLMAPLPNILANSiEAQR--DynfltfnDygnaqdlNL--SPLQ 79 
XP_015365473   1 M-SLAFAGSIGMTLVILACAL-PDlNsWWPFIVVIFYLLAPLPTMLMKRf---Ndy--------------sgSG--NANM 59 
Q8MMD0         7 LFICAFLTCIGVTFLILACAV-PTtKiFYPFFVLLFYVLSVLPVFIARRtTPGN------------------ET--NPKS 65  fruit fly
EAY11791       7 YIVIGIFGTIALVLFIAGCAI-TK-T-WWPLFGIIPATLSCIFGVSLSTkLGDDyve-------------dtEGcnIFTA 70 
XP_001320939   7 YIVIGIFGTIALVLYIAGCAI-TK-Q-WWPLFGIIPATLSCIFGISLSTkMGDDyve-------------dtEGcnIFTA 70 
EAY07081       7 YIALGVFLAIELALVIISCVL-DK-N-AYALIIIVPLCFAIICQFLADSySDGYheE-------G-----------LLTV 65 
XP_001330722   6 YIILGIALTLGVTLIIVGCVT-AK-N-AFALLELIPACVISFSYISYINkEDDSddD-------------------VITK 63 
XP_001565648   7 LIISAFCLVMGFLFLILGCTMvKKrN-AWPLMSLVLYCFTPVPFVLCGRgAGSDefGgdd-depL-----------DAFK 73 
Q4Q9Q1         7 LIISAFFLVMGFLFLILGCTVvKKrN-AWPLMSLAFYCFAPVPFFLCGRgADSDdfNdfd-depL-----------DAFS 73  Leishmania major
Q57ZB6         7 LVLSASLVVVAVVLSILACTVvAGsN-VLPLFSLLLSFITPLPFLFFGRsESTFddD-------------------GEIN 66  Trypanosoma brucei
EDK42066      80 EFSKFVTGLLIVSGVALPLSLYHC-GLIQLELFLMSVSGGFIVYGDIILFMWFFSSEV 136
XP_015365473  60 DLAVFITMGIVVSSFALPIIMARV-NAIAWTACNFTLCGNIVVYLTFIGFFLTLYQED 116
Q8MMD0        66 EFAHFLTAGMVLSAFALPIVLAHA-LVITWTASILTIISNIINYGTIFWYAMRDDEPY 122 fruit fly
EAY11791      71 DSVLFYLVCSVVSTIALNVVFWHA-GTINKKCFGFMIGGDVAVCIGFVVFMILYGKTE 127
XP_001320939  71 DSVLFYLLCSIVSCIALIAVFWHC-GTIDGICFGFMMGGDAATAIGLIAFIILWGKAE 127
EAY07081      66 DTINWFFGVAFAASIGIPLMLWHD-KLIKDIGLGLTLGAVVIQLISYWVFNCLKKKTD 122
XP_001330722  64 DFLIWLLTIAVVSIIALPCVLYHLeKIGKTVSLILDIIGCVAIFAGCIVVACLDREDD 121
XP_001565648  74 TIGLFIGGVLLMSGPGLALVLYHT-SVICGSALLLTLLSGVCFLGATVSLTVTTTHEE 130
Q4Q9Q1        74 TVGLFMGGVLLISGPGLAVVLYHT-SVICGLALFFTLLSGVCFITAGVSLTVADRGNG 130 Leishmania major
Q57ZB6        67 GFVVFLSGALAVSAPSLSIVLYHT-GYSSLGAFLLSLGSQVTLLGAAAFLQSGERQDE 123 Trypanosoma brucei
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