1E8I,1B6E,1HYR,1JA3,1JSK,1KCG,1P1Z,1QO3,1YXK


Conserved Protein Domain Family
CLECT_NK_receptors_like
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cd03593: CLECT_NK_receptors_like 
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C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
CLECT_NK_receptors_like: C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs), including proteins similar to oxidized low density lipoprotein (OxLDL) receptor (LOX-1), CD94, CD69, NKG2-A and -D, osteoclast inhibitory lectin (OCIL), dendritic cell-associated C-type lectin-1 (dectin-1), human myeloid inhibitory C-type lectin-like receptor (MICL), mast cell-associated functional antigen (MAFA), killer cell lectin-like receptors: subfamily F, member 1 (KLRF1) and subfamily B, member 1 (KLRB1), and lys49 receptors. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. NKRs are variously associated with activation or inhibition of natural killer (NK) cells. Activating NKRs stimulate cytolysis by NK cells of virally infected or transformed cells; inhibitory NKRs block cytolysis upon recognition of markers of healthy self cells. Most Lys49 receptors are inhibitory; some are stimulatory. OCIL inhibits NK cell function via binding to the receptor NKRP1D. Murine OCIL in addition to inhibiting NK cell function inhibits osteoclast differentiation. MAFA clusters with the type I Fc epsilon receptor (FcepsilonRI) and inhibits the mast cells secretory response to FcepsilonRI stimulus. CD72 is a negative regulator of B cell receptor signaling. NKG2D is an activating receptor for stress-induced antigens; human NKG2D ligands include the stress induced MHC-I homologs, MICA, MICB, and ULBP family of glycoproteins Several NKRs have a carbohydrate-binding capacity which is not mediated through calcium ions (e.g. OCIL binds a range of high molecular weight sulfated glycosaminoglycans including dextran sulfate, fucoidan, and gamma-carrageenan sugars). Dectin-1 binds fungal beta-glucans and in involved in the innate immune responses to fungal pathogens. MAFA binds saccharides having terminal alpha-D mannose residues in a calcium-dependent manner. LOX-1 is the major receptor for OxLDL in endothelial cells and thought to play a role in the pathology of atherosclerosis. Some NKRs exist as homodimers (e.g.Lys49, NKG2D, CD69, LOX-1) and some as heterodimers (e.g. CD94/NKG2A). Dectin-1 can function as a monomer in vitro.
Links
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Statistics
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PSSM-Id: 153063
Aligned: 57 rows
Threshold Bit Score: 89.3137
Created: 21-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding surface [chemical binding site]
Evidence:
  • Structure:1KCG_B, human Nkg2d homodimer bound with Ulbp3, contacts at 3.5 A.
  • Structure:1P1Z_D, human Ly-49c bound with a MHC Class I ligand H-2kb, contacts at 3.5 A.
  • Structure:1QO3_C, human Ly49a bound with MHC Class I ligand H-2dd, contacts at 3.5 A
  • Structure:1YXK_B, human LOX-1 disulfide-linked dimer residues responsible for OxLDL binding defined by mutation analysis.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 #                   
1E8I_A      4 CSEDWVGYQRKCYFISTVK--RSWTSAQNACSEHGATLAVIDSEKDMNFLKrya---grEEHWVGLKKEp-gHPWKWSNG 77  human
1KCG_B      7 CPKNWICYKNNCYQFFDES--KNWYESQASCMSQNASLLKVYSKEDQDLLKlv-----kSYHWMGLVHIptnGSWQWEDG 79  human
NP_064369 102 CATKWRYHGDSCYGFFRRN--LTWEESKQYCTEQNATLVKTASQSTLDYIAer----itSVRWIGLSRQnskKDWMWEDS 175 house mouse
AAH29554   69 CDTNWRYYGDSCYGFFRHN--LTWEESKQYCTDMNATLLKIDNRNIVEYIKar----thLIRWVGLSRQksnEVWKWEDG 142 human
BAC39163  133 CPKGSEWYKDSCYSQLNQY--GTWQESVMACSARNASLLKVKNKDVLEFIKyk----klRYFWLALLPRk--DRTQYPLS 204 house mouse
NP_796129 132 CSSDWIAFGNNFYCVFRENs-KTWVESQSACEELNSHLVIIDSKAEVENLLlf-----eMDGWILHRMDgtnSSRLWGND 205 house mouse
NP_057595 137 CTEQWKWHGDNCYQFYKDS--KSWEDCKYFCLSENSTMLKINKQEDLEFAAsqsyseffYSYWTGLLRPdsgKAWLWMDG 214 human
AAS00605  133 CPRRWIWHKDSCYFLSDDV--QTWQESKMACAAQNASLLKINNKNALEFIKsqs---rsYDYWLGLSPEedsTRGMRVDN 207 human
XP_534891 131 CPKTWMWHEDSCYILKNSY--ETWQESVMFCSAQNASLLTIKNKSVLEFIKsn----rlYNYWLGLSPKy-dRDYQKLDE 203 dog
XP_585566 126 CPEEWMWHDDKCYLLHAYQrqETWQKSDEICSGYNASLLTIKSKSVLEFIKsl----klNNYWLRLSPRkdnTKYGNLDT 201 cattle

Feature 1             #                    # ##             
1E8I_A     78 KEFn-nWFNVTg------sDKCVFLKNT-EVSSMECEKNLYWICNK 115 human
1KCG_B     80 SILs-pNLLTIiem---qkGDCALYASSfKGYIENCSTPNTYICMQ 121 human
NP_064369 176 SVLrknGINLSgnt--eenMNCAYLHNG-KIHPASCKERHYLICER 218 house mouse
AAH29554  143 SVIsenMFEFLedg--kgnMNCAYFHNG-KMHPTFCENKHYLMCER 185 human
BAC39163  205 EKMf-lSEESErstddidkKYCGYIDRV-NVYYTYCTDENNIICEE 248 house mouse
NP_796129 206 IKIrntLMNDSek----knHSCHYLHGN-IFMPDECSAKKTYICEF 246 house mouse
NP_057595 215 TPFtseLFHIIidvtsprsRDCVAILNG-MIFSKDCKELKRCVCER 259 human
AAS00605  208 IINssaWVIRNapd--lnnMYCGYINRL-YVQYYHCTYKQRMICEK 250 human
XP_534891 204 TIFssnWFMRNtndv-nglMYCGYVDIP-FVYYIKCTARQRVICKK 247 dog
XP_585566 202 IFPl-nWFTRNtsvi-ndqMYCGYVYYA-TFYYIKCTETKNIICEK 244 cattle

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