6WSL,6QBY


Conserved Protein Domain Family
Vasohibin

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pfam14822: Vasohibin 
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Vasohibin
This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.
Statistics
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PSSM-Id: 434242
Aligned: 14 rows
Threshold Bit Score: 384.403
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WSL_C         7 VPFFVNRGGLPVDEATW------------ERMWKHVAKIH-PDGEKVAQRIRGATD--LPKIPI---------------- 55 
XP_002109112   8 VNFYINRGGFPIQQEYW------------HKLWKHTKRHHsAKGEEAENQIRGNRS--LSKVPV---------------- 57 
XP_002130486  20 VPFYINKNGFPVDDKTW------------EKMWRYAGKIY-PDAKSRMEKIKNNEN--LNKIPV---------------- 68 
XP_005160797  60 VPFFVNRTGFPIESVTW------------ERMWSHVAKVH-PDGQEMVDRIRNATL--LPKHSV---------------- 108
1_pfamImport   1 VLFYVNRTGFPIEDPTW------------DRMWSHVAAVH-PEGQEMVDRIRNAAY--LPKHPV---------------- 49 
XP_004082381  29 VPFYVNRGGLPVDEETW------------ERMWRHVARIH-PNGEGLAKEIRSAAD--LPKIPI---------------- 77 
XP_003200451  64 VPFIINRGGLPVNEETW------------EQMWRHVARIH-PDGEQLARRIRGTRD--LPKIPV---------------- 112
XP_003128707  55 IPFFVNRGGLPVDEATW------------ERMWKHVAKIH-PDGEKVAQRIRGATD--LPKIPI---------------- 103
OCA25839      43 APFYVNRGGLPIDEPTW------------ERMWQFVGKTH-PDGEALVRRIREAQD--LPRVPA---------------- 91 
XP_004991332  55 YDAMYRDETFPMTDASWatfvhtattrfkQATAQLAASTHtQQSKDTNDKHSASDGvlQPDVPAnvdemlklggavldvk 134
6WSL_C        56 PSVPTFQPS-TPVPERLEAVQRYIRELQYNHTGTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPT 134
XP_002109112  58 PIAPTITPG-MTTEERIICIQNYISDLHYNFTGLQFFEIKKSRPMSGLMEIAKDMIKESLPIKCLEAVILSIYFTCGLEG 136
XP_002130486  69 PTVPVIPAR-LPTKQCLKLVQNYISSLQYNHTGTQLFEIRKSRPLAGLMDKAKEMIREALPIKCLEAVILAIYLTNGIQN 147
XP_005160797 109 PSVPNFKPS-MSVPDWLHAVQNYMRNLQYNHTGTQFFEIKKTRPLSGLMETAREMIRESLPIKCLEAVILGIYLTNGLTS 187
1_pfamImport  50 PSVPTFRPS-MSVPDWLVAIQNYMKALQYNHTGTQFFEIKKSRPHSRLMETAREMIRESLPIKCLEAVILGVYPTTHYLK 128
XP_004082381  78 PSVPSYQLT-TTIPQRLEAIQKYIRELQYNHTGTQFFEIKKSRPLTALMDIAKEMTREALPIKCLEAVILGIYLTNNMPG 156
XP_003200451 113 PSVPTFQPS-ISIAHRLEAIQKYIRDLQYNHTGTQFFEIKKSRPLTALMDIAKEMTRESLPIKCLEAVILGIYLTNSMPS 191
XP_003128707 104 PSVPTFQPS-TPVPERLEAVQRYIRELQYNHTGTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPT 182
OCA25839      92 PSVPSFHVG-ATVPERIEAIQRYIRELQYNHTGTQFFEIKKTRPLTGLMDLAKEMTKEALPIKCLEAVILAIYLTNSIAG 170
XP_004991332 135 PPQPLQQLTsGNVADALKETQRFLWRLQYNHTGMQFFPVKKYLPLTRLMELGRLICRTCLPIKCLEAVIVALYLLLPFEN 214
6WSL_C       135 LERFPISFKTYFSGNYFRHIVLG--VNFAGRYGALGM-SRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQS 211
XP_002109112 137 LDRFPISFKSCFNSHHHRHVVLG--IHYSGRYGALGL-SRRRTLMYKPLIYRSLMDLIQQYKTSYEECYHELEKVKIGLP 213
XP_002130486 148 LDRFPIGFKSIFQGHRYYHVVLG--VFYNGKYGALGL-SRRKDLMDKPLAFKSLFDLIESYNEAYYKYTHQLKKVRIGGI 224
XP_005160797 188 VERFPISFKTQFSGHHFHHVVLG--VYCNGRYGTLGM-SRRTDLMDRSLSFRTLSELVFDFEDSYRRYQHTMKKIKIGLY 264
1_pfamImport 129 TLNFTTPQTSRCSSSSIESILIShqCHHTFSHGLVGLgSKVSDLVTSCATFQVTSLIQFSFVDSYLSYQHTLKKGGSALY 208
XP_004082381 157 VERFPLSFKSQYSGNHFYHIVLG--VYSGGRFGALGM-SRREDLMFKPMEFRTLTDLVQEFEGAYRGNWHTLRKVKIGQY 233
XP_003200451 192 VERFPLSFKTQFSGSHFRHIVLG--VHSGGRFGALGI-SRRQDLMYKSLQYKTLSDLLLDFQEAYRGHWHTLCRVRIGHY 268
XP_003128707 183 LERFPISFKTYFSGNYFRHIVLG--VNFGGRYGALGM-SRREDLMYKPPAFRTLSELVLDYEAAYSRCWHVLKKVKLGQC 259
OCA25839     171 LERFPISFKTQFSGGCFRHIVLG--LHWGNHFGALGI-SRRDDLMYKPLKHRTLSDLLADFQDAYSKCWHTLRKVKIGRY 247
XP_004991332 215 LHRIPISFKSRFCGHTYQHIVLG--VHVNGKFGALGL-SRRQHLMYKPCRYNSLAALIREYEQRYEEVGHTLVRVRVGRP 291
6WSL_C       212 VSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERHARDMR 251
XP_002109112 214 VDHSVHSCEPIKWKHVAINYKKSSTDNVRKALEKFSKQIK 253
XP_002130486 225 VLHDMCSQEKIQWGILAVGYSHTSYVERQRQFGRYSRDMR 264
XP_005160797 265 VPHNPHVFQPIEWNYLVINASKQGREDMRKELEKHGRDMR 304
1_pfamImport 209 VPHDPHVCQS-HRKHLVLNAARLGPQEMRKELEKARPRHL 247
XP_004082381 234 VSHDPHSVEQIEWKHSIIDIDKMSKEELRKELERHTRDMR 273
XP_003200451 269 VSHDPHSVEQIEWKHSVLDVDKLTREELRKELERHTRDMR 308
XP_003128707 260 VSHDPHSVEQIEWKHSVLDVEKLGREDLRKELERHARDMR 299
OCA25839     248 VSHDPHSVEQIDWKHSVLDVQELGTEGLRRELERHSREMR 287
XP_004991332 292 IPPSRHSTQAIPWRHLILVMKRLGEEDLRSACERYMRQLR 331
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