3LPZ,5BWK


Conserved Protein Domain Family
GET4
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pfam04190: GET4 
Golgi to ER traffic protein 4
In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.
Links
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Statistics
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PSSM-Id: 461217
Aligned: 137 rows
Threshold Bit Score: 94.9438
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3LPZ_A        51 WAAAVDILASVSQTLLRSGQGGSGGDLAVLLVDTFRQAGQRV--DGA----SRGKLLGCLRLfQPGEPv-RKRFVKEMID 123 Chaetomium ther...
XP_001995963  63 FEDCLDLLYDGAQKLIERQQESSAADLCLLLVDTLEKRPQTD--NDTdnfqWIPRLGDLIRDlSPSTVe-RETLIHRVVK 139
XP_002072727  62 YQDCLNLLFDGAEKLIAKDQHSSAADLALLLIDTLEKRGSLP--GDNnf-yWVPRLGSLIRGfSPTTVe-RDTFIQRVVK 137
Q9VN19        58 YQDCLELLFDGAQQLIAKEQESSAADLCLLLVDTLEKRGPQA--EDTdnflWVPRLGALIRGlNSATVe-RETLIQRTIK 134 fruit fly
Q16KN0        53 YEELLDLLYQGALTLLSHEQNTSGADLGLLLVDTLEKSKTVA--EGAe--kWMQKIALLLSKiPQNVVe-RETLLVKAVK 127 yellow fever mo...
ETN61032      55 YDELLELLYSGAVTMLDHLQYGSGADLGLLIIQTLESAETTNlpAEE----WMKRLGELIGKiKPCVNe-RETVLEKAIK 129
EKC25941      46 YAEAASLLYHGALTLKKYDQISSFTDLCSLLIELLNQSETPV--SED----IIEKIITLFKEmTPNSEe-RQTFVVSAVH 118
XP_001640454  46 YQDAIELLHNGTLLFFKYKQMGSGTDLAMLMLDCLKAGKDTI--DSE----CLQKIISIFKAfDPEADtdRQEFIQKALR 119
XP_018645653  44 YQEALKYLKLGSEFLLDNEQWESGTELACLVLDVYSQSETVL--TES----HLDEICELLIRmCPGEE--RTRFVHKALH 115
XP_311026     56 YADVLELLYDGALTMLEHEQYSSGADLGLLIIQTLEKAGSTV--ETPe--qWIKRLAELVSKiKPTVVd-REALLDRAMK 130 Anopheles gambi...

3LPZ_A       124 WSKKFGd-YPAGDPELHHVVGTLYVEEGEFEAAEKHLVLGTKESpeVLARMEYEWYKQ-DESHTAPLYCARAVLPYLLVA 201 Chaetomium ther...
XP_001995963 140 WSIGVH--GHFGHPMLHKLIANVFWTEENIEAARHHYLLCQDGS--LCGYVLIMISERkGFRSEVDLFVVQVVLQQLSLE 215
XP_002072727 138 WSSGLH--GKYGHPVLHKLIAHVYWADGNVELARHHYLLCQDGS--LCGRVLIEISVSkGFRSEVDLFLVQAVLQQLSLK 213
Q9VN19       135 WSTALH--GQYGHPVLHKLIAHVFWTEGNIESARHHYLLCQDGS--LCGRVLIEISQSrGFQGEMDLFLVQAVLQQLSLK 210 fruit fly
Q16KN0       128 WSASVSk-SQVGHPLMHKLIAQIMWNEDNLAQARHHFLLSKDGS--GCGHMLIQLSQTkGFPSEMDLFIAQVILQQLCLK 204 yellow fever mo...
ETN61032     130 WSGTVAq-SPMGHPLMHKLIAQIMYNENNLPQARYHYPLSRDGF--SCAFLLIELSQAkGYAGEVDLFVAQMVLQLLCLK 206
EKC25941     119 WTMKVSaeHKRGHPDLHQKLGLSFWEEKNYVQARYHLVHSQDGK--NCALMLVECHVQkGFPNEVDLFIAQAVLQFLCLR 196
XP_001640454 120 ITADKDpsQKFGSTDLHHMCARIYWQEKNYGESRYHFLYTQDGF--QCASMLVEFATTkGFKSEQDLFVTQTVLQYLCLQ 197
XP_018645653 116 LLQK----QKDLLAVFNGYLARVLWQEGSFSEARLRIMLSSNGY--AAGVFLVALHQRyGLRSEIDLFLAQAVLQFLCMK 189
XP_311026    131 WSGSLVs-SPTGHPLMHKLFAQILYREGDLTLARRHFALAKDGV--SCGFLLIEISCAkGFPGEVDLFVAHTVLQQLALK 207 Anopheles gambi...

3LPZ_A       202 NVRAANTAYRIFTSALVEDNKGltvqnigsqsAelrifpsLPLLNFISMLLLSVQKGSPD--LFRQLKSKYEANLNElNG 279 Chaetomium ther...
XP_001995963 216 DRKSADDTFSEYTRYHPKLLRN----------Efp---fkEPLLNFLYFLLRLIEA--KSalGFRALRKLYDPSLKR-DV 279
XP_002072727 214 DQRTAEVMFYEYTRYHPKILRH----------Efp---frEPLVNFLYCLFRLIDT--KSvnGFRALRKLYDPSLKR-DT 277
Q9VN19       211 DRKTAEDTFTEYTRYHAKLLKH----------Efp---ykEPLVNFLYFLFRLIDA--KRvaGFRALRKLYDPSLKR-DT 274 fruit fly
Q16KN0       205 ETSTAAETFATYTKYHPKIACS----------Epp---fiTPLLNFIFFLLRAIEANQRKliVFRTLCELYKPSLER-DP 270 yellow fever mo...
ETN61032     207 ELTVATETFATYIKFHPRVACT----------Dpp---faRPLLNFLFFLLQAIEQEGRKyaMFRALCDLYKPALER-DP 272
EKC25941     197 NKDTAQVAFVKYTENHPDVQSGpp--------------yvHPLLNFLWFLLLAVEG--GRvaVFSILCEKYQTSINR-DP 259
XP_001640454 198 NSSTASIVFFKFTNKHPDFSGpp---------------fqQPLLNFVWLLLMAIERQGPLs-MFTVLCEKYQPSIER-DP 260
XP_018645653 190 QISVAILTFYTYTRRHPRLEPGppf-------------adFPLLNFLWFLMLAIEKKCSLa-VFSVLCEKYSPQLNR-DS 254
XP_311026    208 EPATAASTFATYCKFHASIACT----------Epp---faMPLLNFLHFLLALVEQNNRMyaTFRALCELYKPSLDR-DP 273 Anopheles gambi...

3LPZ_A       280 IWDTALELIAEMYFGIQRPRQ----SNPLLDMMGSLF 312 Chaetomium thermophilum var. thermophilum DSM 1495
XP_001995963 280 SFNKYLTKIGMIYFDEQ-PEPvhagPTGLGGMFGDIF 315
XP_002072727 278 SFLKYLTKIGIVYFDEQ-PEVphsgPSGLGGMIGDIF 313
Q9VN19       275 SFLKYVAKIGVLYFDEH-PEAahsgPPGLGGMFGDIF 310 fruit fly
Q16KN0       271 SYEKYLQKIGMIFFEASQPQRpq--sEGMGGIFGNLL 305 yellow fever mosquito
ETN61032     273 SYDKYLRKIGVMFFGASQPEQsr------sYAFGDLL 303
EKC25941     260 SYREYLDQIGQLFFGLPPPPKqs------qGFLGNLL 290
XP_001640454 261 TYKQYLDRIAQLFFGLPPPQPt-----GLQGIMGDLV 292
XP_018645653 255 SYLKYLDKIGQLYFGVKPPAN------EMNNFFSRIM 285
XP_311026    274 SYEKYLQKIGVKFFDGSRYEQrn-------fMFSDLL 303 Anopheles gambiae str. PEST
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