7A46,4HWA,6ZYD


Conserved Protein Domain Family
MS_channel
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pfam00924: MS_channel 
Mechanosensitive ion channel
Two members of this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.
Links
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Statistics
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PSSM-Id: 459999
Aligned: 35 rows
Threshold Bit Score: 125.407
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7A46_D 530 RNALAVIISTITIMIVLSEIGVN---IAPLLAGAGALGLAISFGSQTLVKDIITGVFIQFEN-GMNTGDLVTIG------ 599 Escherichia coli
P0AAT4 142 QGIKLIGAILVGILMISLLIGQS---PAILISGLGAMAAVLMLVFKDPILGLVAGIQLSAND-MLKLGDWLEMPk----- 212 Escherichia coli K-12
O05781  87 SWVSIVLIYVVVVYEVIDVLPVP---VGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEK-QYGFGDLVELSmvg--s 160 Mycobacterium tubercu...
Q55987 385 KGMVTVVISASGLLTALIILGIP---TGSVVAIGGLLALAISFGAQSLVKDLVDGFLVLAED-QYAIGDVIDVG------ 454 Synechocystis sp. PCC...
P72735 524 KGGISVLLTILGILGTIWLFGIN----PLVLASFGGVAFVLAFLGRNVVEDMLNGTLILWTD-RYAIGDVVQIG------ 592 Synechocystis sp. PCC...
P73148 472 RGINLVVCIFTAFVFSLSLFDVP---VATVLAGAGIIGFAVSFGSQNLIKDLIAGISNLMSD-AFAINDFVLIG------ 541 Synechocystis sp. PCC...
Q58111  81 NYIFKYLVYVCVTLMIFGVIYQN---VSSLVVSVGLIGAAVTYALQKPILNFAGWIIILYTR-TIKIGDRIFIKnmgagd 156 Methanocaldococcus ja...
Q55882 107 PFCKALILLFTISYLLNLFFNLS---EGNLLALTGTIAVALGFAFKDYISSIIAGVVALFEA-PYRVGDRIQIG------ 176 Synechocystis sp. PCC...
O14050 443 GKLDRVGLGVVGIIAVLTFISFLdtsFATILAAFGTTLLSLSFVFSTSAQELMSSIIFLFSKhPFDISDVVIVN------ 516 Schizosaccharomyces p...
P71915 115 VDVARFALIGIGLAVILSYIWGVr--VGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQ-PFRIDDWLETP------ 185 Mycobacterium tubercu...

7A46_D 600 --PLTGTVERMSIRSVGVRQDTGAYHIIPWSSIT--TFANFVR----GIGSVVANYDVDRHEDADKANQALKDAVAELME 671 Escherichia coli
P0AAT4 213 -yGADGAVIDIGLTTVKVRNWDNTITTIPTWSLVsdSFKNWSGmsasGGRRIKRSISIDVTSIRFLDEDEMQRLNKAHLL 291 Escherichia coli K-12
O05781 161 peNAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIV--KSVNLSK----DWARAVVDIPVPTSADLGRVNEVLHQECEHARH 234 Mycobacterium tubercu...
Q55987 455 --FAAGGVENLNLRVTQLRSAGGELVTIPNSAIT--QVKNLTR----SWSRANLSVNVAYDTDPVKAINVLRQVGEDLYN 526 Synechocystis sp. PCC...
P72735 593 --DVFGLVENMNIYITQLRGPEGRLSTIPNGKIS--VVQNLTK----DWSRAEFIVEIDQSSNVDKALNLIRVVSEQMRE 664 Synechocystis sp. PCC...
P73148 542 --EFEGVVEDTNLFVTRIRCPNGDLVTIPNGAIG--TVCNQTK----DWSRVDYSVMVAADADPKKAIAVLQQVALGLYH 613 Synechocystis sp. PCC...
Q58111 157 vfDIDTQHIYLSELTTDTFEPTGRVLIIPNSYIFtaSIENLTKg--sPYIWDNIVVHFTLNSNINKAEKIVFESADEVIG 234 Methanocaldococcus ja...
Q55882 177 --DHYGEVTGYGLRGICLQTPDDNNVTIPHNKTWtePISNANGg--nLEAQVATSFYFDHSVD---VEQVIRILYQAAYS 249 Synechocystis sp. PCC...
O14050 517 --NIKYEVVSLSLLFTVFRTMGGSTVQAPNSLLNtlFIENLRRs---QPQSETITIVSPFATDFKQLERLRDLLLTFVKE 591 Schizosaccharomyces p...
P71915 186 --TARGRVVEVNWRAVHIDTGSG-LQIMPNSMLAttAFTNLSR----PAGAHECSITTTFSTS-DPPDKVCAMLNRAASA 257 Mycobacterium tubercu...

7A46_D 672 NEEIRGl---------------------------------------------iIGEPNFAGIVGLSNTAFTLRVSFTTl- 705 Escherichia coli
P0AAT4 292 KPYLTSrhqeinewnrqqgstesvlnlrrmtnigtfraylneylrnhprirkdMTLMVRQLAPGDNGLPLEIYAFTNTvv 371 Escherichia coli K-12
O05781 235 DSLLGEl---------------------------------------------lLDEPTVMGVERIEVDTVTLRLVARTl- 268 Mycobacterium tubercu...
Q55987 527 DPEWHDk---------------------------------------------mLAVPDVLGIDSLTHEGMTITIWIQTa- 560 Synechocystis sp. PCC...
P72735 665 DPLWQEk---------------------------------------------iLEPAAILGVDDIASKGIRLQVWIKTq- 698 Synechocystis sp. PCC...
P73148 614 DPWWHPk---------------------------------------------mLQAPELKGIEEVSHQGILIRIWLKTl- 647 Synechocystis sp. PCC...
Q58111 235 NLMRELyekwskr----------------------------------kylisrKLSDKPVVRVGITRSSFYIKALYLVn- 279 Methanocaldococcus ja...
Q55882 250 SRYTQL-----------------------------------------------SIPIVVVMKEHIWGTEFKLRSYPMDa- 281 Synechocystis sp. PCC...
O14050 592 NERDFRp----------------------------------------------IIDLNVSDFSTLDSLKFTVTYYYKS-- 623 Schizosaccharomyces p...
P71915 258 LPHVK--------------------------------------------------PGVVPATIARGAAEYRTTVRLTSp- 286 Mycobacterium tubercu...

7A46_D 706 pLKQWTVRFALDSQ-VKKHFDLAGVR 730 Escherichia coli
P0AAT4 372 wLEYESIQADIFDH-IFAIVEEFGLR 396 Escherichia coli K-12
O05781 269 pGKQFEAGRQLRVL-VIRALTRAGIV 293 Mycobacterium tuberculosis
Q55987 561 pAQQWSVGRELRFR-VRQALTENNIE 585 Synechocystis sp. PCC 6803
P72735 699 aGQHWPVGREFRLR-MKKAFELAGIA 723 Synechocystis sp. PCC 6803
P73148 648 pGEQWDVARELRLR-VKVAFESQEIA 672 Synechocystis sp. PCC 6803
Q58111 280 vYEKAKIRSEINKRiLEKVNKENDVK 305 Methanocaldococcus jannaschii DSM 2661
Q55882 282 -RDEFAYQTDLIRR-AKRAFGQQGLP 305 Synechocystis sp. PCC 6803
O14050 624 --NWQNVSLQCVRR-NKFMCALKNAI 646 Schizosaccharomyces pombe 972h-
P71915 287 -ADEGPTQATFLRW-VWYAARREGLH 310 Mycobacterium tuberculosis
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