1ONE,1OEP,1E9I,1PDZ,1TE6,1IYX,1W6T


Conserved Protein Domain Family
enolase

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cd03313: enolase 
Click on image for an interactive view with Cn3D
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.
Statistics
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PSSM-Id: 239429
Aligned: 91 rows
Threshold Bit Score: 484.678
Created: 9-May-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:1ONE_A; yeast enolase with bound Mg
  • Citation:PMID 8605183

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                              #                                      
1ONE_A      4 KVYARSVYDSRGNPTVEVELtte------kgvFRSIVPSGASTGVHEALEMRdgdkskwmgkgvlHAVKNVNDVIAPAFV 77  baker's yeast
NP_962067   6 SVVARQLLDCKARPLVEVEIttdt-----ghvGRGAAPTGTSVGAHEAFVLRdgdptryrgrsvhRAVAAVRDEIAPALT 80  Mycobacterium aviu...
AAB84550    7 DVRVRKILDSRGNPTVEVDVitw------ngfGRAAAPSGASTGSREVAAFPsgg--------vdEIITEVEDIISSELI 72  Methanothermobacte...
NP_558864   5 DAWIRKVFTGRGDVTVEVELtvedsvtgdvlvTRAAAPAGASRGAHEVLYFPegg--------vdAALAAFEKLVAPEIV 76  Pyrobaculum aeroph...
O29133      5 DVHYRVVFDSRGNETVECEVvag------evvAKAMAPSGASTGSGEAVVVSp------------YRYEEIEEEVSKAII 66  Archaeoglobus fulg...
NP_280046   6 AVRYRPILDSRGNKTVEAEVttdd-----ggfGRAAAPSGASTGEHEAVELPv-----------gEAIAAGRERIAPRLE 69  Halobacterium sp. ...
NP_148623  10 RVWGLQVLDSRGNPTVKAYVklag-----gslGWGIAPSGASRGEREAVELRdgggkw-rgkgvsRAVSLLNTVVAPRLE 83  Aeropyrum pernix K1
NP_377144   9 KIKGYQILDSRGNKTIRVKIetyg-----gisETGDAPAGASKGSREAIELRdkdg------gvtRAVELVNTLINDSLR 77  Sulfolobus tokodai...
CAD25889    9 DIKPRMILTSRGRPTVEVDLits------rgvHRSSCPSGASKGSKEAVELLdggefy-ngrgveTVINNINQLVVKKMC 81  Encephalitozoon cu...
NP_394341   7 EIKVRKVLDSRGNFTVEADVtvp------ngfGRTSAPAGASTGETEVIAFSksg--------idASIQFFESKVKRSLI 72  Thermoplasma acido...
Feature 1                                                                                     
1ONE_A     78 kanIDVKDQKAVDDFLISLDGTANKSKLGANAILGVSLAASRAAAAEKNVPLYKHLADlsksktspYVLPVPFLNVLNGG 157 baker's yeast
NP_962067  81 g--AELDDPRSLDRVMIELDDTPDKHRLGGNAIYSTSIALLRAAAAAAGTPTYTYVGAllgl-tppTTVPMPSFNMINGG 157 Mycobacterium aviu...
AAB84550   73 g--MDAVDLQDIDLVLKEIDGTENLSSLGGNTVVAVSMATAKAAASSYNMPLYRFLGGnl-----aTSIPYPLGNMINGG 145 Methanothermobacte...
NP_558864  77 g--LDVTEPYSTDGKLEEVDGTQRFEKIGGAVAIATSFAAAEAGAASLGVPLYSFIGGay-----aRRLPLPLGNVIGGG 149 Pyrobaculum aeroph...
O29133     67 g--MSVFDQESVDEALRELDGTDNFSRIGGNFAITASLAVAKAAAEILGLPLYAYVGGvf-----aKELPYPLGNVIGGG 139 Archaeoglobus fulg...
NP_280046  70 g-rEFAGDQRGVDAALHAADDTTDFSAVGANVAVATSMAAAKAAADVLGVHTYQHLGGal----rgRNFPVPLGNVLGGG 144 Halobacterium sp. ...
NP_148623  84 g--VDARRQAQIDRLLIELDGTPNKSRLGGNTTTALSIAVSRAAAAQARLELFQYLGGag-----aRRLPIPLLNVINGG 156 Aeropyrum pernix K1
NP_377144  78 d--FDVRNQLGIDQTLIRMDGTPNKSRVGGNTTIATSIAVAKTAAKAMGLEIFQYIGGpr-----vRYLPIPLLNILNGG 150 Sulfolobus tokodai...
CAD25889   82 eleCNVGDQQAIDNYLLGLDGTKNKSRIGGNGITALSTAFCKMGAAYSNMRVDEFISGitt---fkRGIPVPHFNVLNGG 158 Encephalitozoon cu...
NP_394341  73 g--FNALDQSGFDKLLTDIDGSGNFSNLGGNLATALSMSVAKAAAQSLGIPLYRYVGGi------rSTIPRPMGNVIGGG 144 Thermoplasma acido...
Feature 1                                                                                     
1ONE_A    158 SHAGGa-lALQEFMIAPTgaktfAEALRIGSEVYHNLKSLTKKrygasaGNVGDEGGVAPNiqtaEEALDLIVDAIKAAG 236 baker's yeast
NP_962067 158 RYGDVe-qSFSEFLVVPYraesiQAAVEKGVSLFEVLGEVLAEhlgrtpLLASSYGYIAPSgd-pHAVLELLAEAVERAG 235 Mycobacterium aviu...
AAB84550  146 AHAGKnapDIQEFLVVPVgaediTEAVFANAAVHKRIRELIQKkdpsfaGGKGDEGGWVPSls-nGDALEIQATACEEVT 224 Methanothermobacte...
NP_558864 150 KHSRGlgpDIQEFLAMPLnppdiYTAVYTNVEIHKRVLKYILKvdtsftGGKNDEGAWTPRis-sTTALKILREAAREVS 228 Pyrobaculum aeroph...
O29133    140 RHAEGs-tSIQEFLVIPVgaktfFEAQRANAAVHKQLKKIFKErg--ifAAKGDEGAWAAQis-dEQAFEILSEAIQRVE 215 Archaeoglobus fulg...
NP_280046 145 AHAADa-tAIQEFLVAATgapsvRQAVFANAAVHQRVKDRLDDdg--vpAAKGDEGAWAPSid-dATAFDVVAGAAAEVA 220 Halobacterium sp. ...
NP_148623 157 VHAGNe-lDFQEFMIIPYgfesfTEAMRAAVETYGELKSLLKDrygasaVNVGDEGGFAPPmrsaEEALKTLVDAVEKAG 235 Aeropyrum pernix K1
NP_377144 151 LHAGNe-lKIQEFIIIPLsfdsfHEALYAADEVYKQLKGIITEkygklyTMLGDEGGVAPPlsktEDALDLVYTAIKNSG 229 Sulfolobus tokodai...
CAD25889  159 IHSGNe-mSVQEIMVAYQhd-slESNIESGCVLYESLKRVISEkygalyTSVGDEGGFAPPikklEEGLDLILEASRRCN 236 Encephalitozoon cu...
NP_394341 145 KHARNg-tSIQEFLVSAQgs-tfLESAYINVLVHRRIGDMLSDkfkdisIGVGDERTWSVNls-dEEAFEILNEAVKEIS 221 Thermoplasma acido...
Feature 1                #                                                 #                  
1ONE_A    237 HDg--KVKIGLDCASSEFFKDgkydldfknpnsdkskwLTGPQLADLYHSLMKRYP-IVSIEDPFAEDDWEAWSHFFkt- 312 baker's yeast
NP_962067 236 CAd--VMAFALDCASSEVCDNgsatya------fnggrVTAEALIDYARALSQEFP-MLFIEDLLDGDDWAGFTKAVqtv 306 Mycobacterium aviu...
AAB84550  225 DElgvEVRPSLDLAASEFWDPeiekyvy----rqenvqKDTGEQIEFVKEIIETYD-MYYVEDPLHEGDLEGFAELTslv 299 Methanothermobacte...
NP_558864 229 GElgvEVGIGVDVAASSLWNGekyvyk------negveRDPREQFEFIAKLIEEYD-LVYVEDPFHEEDFQSFAELRdrf 301 Pyrobaculum aeroph...
O29133    216 DElgvKVRMGIDVAATELWDGeryvy--------sdrkLTTEEQIAYMAELADRYD-LLYIEDPLHEKDFEGFAELTkq- 285 Archaeoglobus fulg...
NP_280046 221 DEfgfDVRLGLDLAAAERYDGdeyvf--------gddrRSTAAQIEYVAGLVSEYD-LAYVEDPLDENDFEAFAELTdrv 291 Halobacterium sp. ...
NP_148623 236 YQpgsEIALGIDAAASQLYSNgrysv--------egksLSREELLSLYQRLVEQYP-IVYLEDPFSEDDYEGFKAAVdal 306 Aeropyrum pernix K1
NP_377144 230 YEd--KIVMGIDAASSDFFNGsqyei--------dgkkLSPDEMIDYYIQLASRYP-LLYIEDPFNENDFERFSILQqkl 298 Sulfolobus tokodai...
CAD25889  237 RT---DMKIAIDFAANGFMRDgkyel--------dgetYTTKSLGERYIEILKEYPqVYSLEDPFSERDYDGWIWLNaev 305 Encephalitozoon cu...
NP_394341 222 SEkkvKIYTGVDFAADSLYENgkyvy--------khttKSRDEQIDYAISISKDFG-VYYIEDPMYDTDFDGFAEITari 292 Thermoplasma acido...
Feature 1             #                                                                       
1ONE_A    313 -agIQIVADDLTVTNPKRIATAiekkaADALLLKVNQIGTLSESIKAAQDSFAAgWGVMVSHRSGETEDTFIADLVVGLR 391 baker's yeast
NP_962067 307 -nrSIIVGDDLIVTNRDRLRRAvetsaVDGFILMPNQVGTIAEALDCFEYASQNgLLAIPSGRSGGVIDDVVMDLAVGLG 385 Mycobacterium aviu...
AAB84550  300 gdrCMICGDDIFVTNREILREGiemgaANAIIIKPNQIGTLTDTYLTVKLALENrYTPVVSHRSGETTDDTIAHLAVAFG 379 Methanothermobacte...
NP_558864 302 -kdRLIVGDDLFVTNPERIKKGgkigaATGVIIKPDQIGTLLRAHQAVSAAREFgMRVIVSHRSGDTEYKTLAHIAVGFG 380 Pyrobaculum aeroph...
O29133    286 -vkCMVCGDDIFVTNPEIIKKGievgaANTVLIKPNQNGTLSGTAKAVKIAKDNgYSVVVSHRSGETEDETLAHLAVAFN 364 Archaeoglobus fulg...
NP_280046 292 gdeTLVCGDDLFVTNTERLQRGidagaANSILVKPNQIGTLTDAVDAIELATRNgYDAVVSHRSGETEDTTIAHLAVATD 371 Halobacterium sp. ...
NP_148623 307 steTIIVGDDLLVTNPQRVKEAsalkaVTGLLVKVNQVGTLTEALEAIQAARDRgIVHIVSHRSGDTEDTFIADLAVATE 386 Aeropyrum pernix K1
NP_377144 299 -kkTIVTGDDLFTTNIEYLKKGiekssAKGTIVKPNQIGTLSETFEYIEFAKKNsIKIIVSHRSGETEDSFIADLAVGVQ 377 Sulfolobus tokodai...
CAD25889  306 gkkINIVGDDLTVTDPQLVRDAgarrmCNTLLVKPNQVGTVSETVEAIRIARKCgMKIMVSHRSGETDDHFISDLSVGVG 385 Encephalitozoon cu...
NP_394341 293 gdrSLIVGDDLYTTNPDRIRKGvekksTNAVLIKVNQIGTLSAAREAVAVATFAgMKNIVSHRSGETTDDFLAHLSVAFG 372 Thermoplasma acido...
Feature 1                                
1ONE_A    392 TGQIKTGapaRSERLAKLNQLLRIEEE 418 baker's yeast
NP_962067 386 APLQKNGaprSGERIEKLNFLLRAAEG 412 Mycobacterium avium subsp. paratuberculosis str. k10
AAB84550  380 APLIKTGa-iGGERIAKLNELIRIQEE 405 Methanothermobacter thermautotrophicus str. Delta H
NP_558864 381 AEVIKTGi-mGGERTAKLNELIRIGDY 406 Pyrobaculum aerophilum str. IM2
O29133    365 AKLIKTGv-vGGERISKLNELIRIEEL 390 Archaeoglobus fulgidus
NP_280046 372 APFIKTGa-vGGERTAKLNELIRIADE 397 Halobacterium sp. NRC-1
NP_148623 387 ALMIKTGapaRGERTSKYNRLLEIENI 413 Aeropyrum pernix K1
NP_377144 378 SDFIKTGapaRGERTSKYNRLLEIEND 404 Sulfolobus tokodaii str. 7
CAD25889  386 AEYIKSGapcRGERVSKYNQLLRLYEY 412 Encephalitozoon cuniculi GB-M1
NP_394341 373 STFVKTGv-iGGERVAKLNEIARIEEC 398 Thermoplasma acidophilum DSM 1728

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