Conserved Protein Domain Family
Fes1
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pfam08609: Fes1 
Nucleotide exchange factor Fes1
Fes1 is a cytosolic homolog of Sls1, an ER protein which has nucleotide exchange factor activity. Fes1 in yeast has been shown to bind to the molecular chaperone Hsp70 and has adenyl-nucleotide exchange factor activity.
Links
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Statistics
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PSSM-Id: 462534
Aligned: 98 rows
Threshold Bit Score: 48.0024
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P0CN68                4 INELLRWSIANstapdtDASEQLQIRFNPnstqsgtstlhasdsgppdispastpgpvtpddgsslplppgtEVPvtkkE 83  Cryptoco...
ETN66378             16 LQGLLKFAM-------------EATKEED-------------------------------------------APQesrlQ 39 
WGS:AAQB:GK20262-PB  11 LQGVLKYAVENtp--tnSCDSPQNQQFES-------------------------------------------DSE----R 41 
XP_002021212         12 LQGVLKYAVAH-----------TTSPEAD-------------------------------------------AKPs---T 34 
XP_001958338         13 LQNVLKYTVQH-----------HDKNGTE-------------------------------------------PKEn---E 35 
XP_002030318         13 LQNVLKYTVQH-----------HDPNPEA-------------------------------------------APKl---E 35 
EEN64263             23 LEGVLRYAIentp-dnaGDTPVSPGPMDV--------------------------------------------------- 50 
CAG02713             15 LQGLLQLAVdag---saSEEPAPAEPMSE--------------------------------------------------- 40 
XP_006012969         16 LQGLLRLAVevg---veSQETSHPEPMSE--------------------------------------------------- 41 
NP_001016069         16 LQGLLQMAIeag---teSDSTPQMEPMSE--------------------------------------------------- 41 

P0CN68               84 DLTT-EMLDLI---LG---KGDSITMKEKMAFATDE-------NNSVEDRVEALDDFEMLIELIDNANNM 139 Cryptococcus neofo...
ETN66378             40 PMDE-ERRRFLenaLNsltVDVVKELEKAMQTLLDA-------SSSDEAKVEAIEIVTDYVQDVDAANDf 101
WGS:AAQB:GK20262-PB  42 NLFL-QKALKA---MT---TDVTKDLKTALAILDSN-------STDLDEKIESLEIIRDQIDDIDLANSf 97 
XP_002021212         35 DLDD-EKSRFLegaLNsltVGASIDFKTALEILDSP-------ETSTEEKKESLNHLRSHIDDIDLANSL 96 
XP_001958338         36 TPDV-EKSKFLeeaLTamtTDASKELKAALIVLEDG-------ESSLDEKKDSFEVIRSHIDDLDNANSL 97 
XP_002030318         36 TPDP-ERAQFLanaLNamtVDAAAALKAALVILNSE-------EASTDDQIESLDVIRSHIDDIDNAItl 97 
EEN64263             51 --NRrQWLGAAlqqFAqtaQDDVEQMKMCLQTLAeg------gEDHIEEKETAMEELMDLCCSIDNAQDl 112
CAG02713             41 --ERkAWLREAladVAkgqLDEVEQLKQCLAVLQQErkveeeeDDDVEEKESAFEMLSELCENLDNARdl 108
XP_006012969         42 --ERrNWLQEAmadAFqghLDEIQQIKQSLEVLRQEerveddeENE-ERKAYVLDLLADLCENLDNASdf 108
NP_001016069         42 --ERrQWLQQAmnsAFsgqADEVKMIKECLQELSNEtnsgeeeDGK----ERALELLADLCDNLDNASdf 105
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