2CU0


Conserved Protein Domain Family
IMP_dehydrog

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TIGR01302: IMP_dehydrog 
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inosine-5'-monophosphate dehydrogenase
This model describes IMP dehydrogenase, an enzyme of GMP biosynthesis. This form contains two CBS domains. This model describes a rather tightly conserved cluster of IMP dehydrogenase sequences, many of which are characterized. The model excludes two related families of proteins proposed also to be IMP dehydrogenases, but without characterized members. These are related families are the subject of separate models. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Statistics
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PSSM-Id: 273546
Aligned: 11 rows
Threshold Bit Score: 631.69
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CU0_A        14 GYTFDDVLLIPQATEVEPKDVDVSTRITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNMGIEEQVEQVKRVK 93  Pyrococcus hori...
O14344        36 GLTFNDFLILPGYIDFVPNNVSLETRISRNIVLKTPFMSSPMDTVTEDQMAIYMALLGGIGVIHHNCTPEEQAAMVRKVK 115 Schizosaccharom...
O58045        14 GYTFDDVLLIPQATEVEPKDVDVSTRITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNMGIEEQVEQVKRVK 93  Pyrococcus hori...
P06981         8 ALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVK 87  Escherichia coli
P21879        10 GLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNIPVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVK 89  Bacillus subtil...
P47996        19 SYTYDDVIFLPHFIDFSTDAVSLSTRLSRRVPLSIPCVSSPMDTVSESHMAAAMASLGGIGIVHYNCGIAAQASIIRQAK 98  thale cress
XP_001465126  27 GLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHIPIVSSPMDTITENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVK 106 Leishmania infa...
WP_010915551  13 ALTFDDVLLQPGHSEVMPGETDVRTRIAGDIDLNVPILSAAMDTVTEARLAIAMAQAGGIGVIHRNFSPAEQAEQVRQVK 92  Mesorhizobium loti
WP_010900646  12 GFTFDDVLLIPMRTAVEPKNVVVSSRISRHIQVKVPIVSSPMDTVTEDAMAIAMARYGAIGVIHRNQPREKEVEMVKRVK 91  Thermoplasma ac...
AAD10256      16 SYTYDVIICMPGYIDFALSDIDLTNNMTDNITLKTPVISSPMDTVTGHKMSIALALSGGLGVIHNNMSIEKQIEEVKKVK 95  malaria parasit...
WP_010902714  48 ALTFDDVLLRPAESRVEPDDADVATRVSTNVELEVPVLSAAMDTVTESRLAIAMAREGGLGVLHQNMDTDRVVAEVERVK 127 Halobacterium s...
2CU0_A        94 RAERLIVE--DVITIAPDETVDFALFLMEKHGIDGLPVVEDE--------KVVGIITK---KDI--AAREGKL--VKELM 156 Pyrococcus hori...
O14344       116 KYENGFIL--DPVVFSPQHTVGDVLKIKETKGFSGIPITENGkl----rgKLVGIVTS---RDVqfHKDTNTP--VTEVM 184 Schizosaccharom...
O58045        94 RAERLIVE--DVITIAPDETVDFALFLMEKHGIDGLPVVEDe--------KVVGIITK---KDIa-ARE-GKL--VKELM 156 Pyrococcus hori...
P06981        88 KHESGVVT--DPQTVLPTTTLREVKELTERNGFAGYPVVTEe-------nELVGIITG---RDVrfVTDLNQP--VSVYM 153 Escherichia coli
P21879        90 RSERGVIT--NPFFLTPDHQVFDAEHLMGKYRISGVPIVNNEed-----qKLVGIITN---RDLrfISDYSMK--ISDVM 157 Bacillus subtil...
P47996        99 SLKHPIAS--DAGVKFPEYEITSLDAFGPS---SFVFVEQTGtmt---tpKLLGYVTKsqwKRMnyEQREMKI--YDYMK 168 thale cress
XP_001465126 107 AYRNGFIS--KPKSVPPNTPISNIIRIKEEKGISGILVTENGdp----hgKLLGIVCT---KDIdyVKNKDTP--VSAVM 175 Leishmania infa...
WP_010915551  93 KFESGMVV--NPVTIGPDATLADALSLMRTYSISGIPVVENGgtgghktgRLVGILTN---RDVrfASDPAQK--VYELM 165 Mesorhizobium loti
WP_010900646  92 REETIIIR--DVYTISPETPIEVARTLMATRNIAGLPVVKDd--------KLVGIVTK---RDLefVK-KGSS--VSDVM 155 Thermoplasma ac...
AAD10256      96 RFENGFIF--DPYTFSPEHTVADVLETKNRVGYKSYPITVDGkv----gsKLVGIITG---IDYlyLTNKSMK--IGDIM 164 malaria parasit...
WP_010902714 128 RADELVIDreNVVTAAPEQTVEAVDEMMDRSDVSGAPVVDDDd-------TVRGIISA---TDIrpYLEVGESdaVREAM 197 Halobacterium s...
2CU0_A       157 Tk-E-VITVPESIEVEEALKIMIENRIDRLPVVDERGKLVGLITMSDLVARKKYKNAVRD---ENGELLVAAAVSP--FD 229 Pyrococcus hori...
O14344       185 TprEeLITTAEGISLERANEMLRKSKKGKLPVVDKDDNLVALLSLTDLMKNLHFPLASKTs--DTKQLMVAAAIGTrdDD 262 Schizosaccharom...
O58045       157 T--KeVITVPESIEVEEALKIMIENRIDRLPVVDERGKLVGLITMSDLVARKKYKNAVRD---ENGELLVAAAVSP--FD 229 Pyrococcus hori...
P06981       154 TpkErLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKD---EQGRLRVGAAVGAgaGN 230 Escherichia coli
P21879       158 Tk-EeLVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKD---IHGRLIVGAAVGVtgDT 233 Bacillus subtil...
P47996       169 ScdSsDYCVPWEIDFEKLEFVLEDKQKG-FVVLERDGETVNVVTKDDIQRVKGYPKSGPGtvgPDGEWMVGAAIGTreSD 247 thale cress
XP_001465126 176 TrrEkMTVERAPIQLEEAMDVLNRSRYGYLPIVNENDEVVNLCSRRDAVRARDYPHSTLD---KSGRLICAAATSTrpED 252 Leishmania infa...
WP_010915551 166 Tr-EnLITVKENVDQDEAKRLLHQHRIEKLVVVDKQGNCVGLITVKDIEKSQLNPHATKD---AQGRLRAAAATSVgdDG 241 Mesorhizobium loti
WP_010900646 156 Vr--dVITAPENVDIDEAIEILHKNRIEKLPLVDSSGHLVGLITAKDIITRQKFPDASRD---SEGQLMVGAAVGP--FD 228 Thermoplasma ac...
AAD10256     165 T--TdVVTGSYPINLSDANKVLCDEKKSVLPIVNKNNELIALVCRNDMHKNRIFPHASKS---QNKQLIVGASISTreHD 239 malaria parasit...
WP_010902714 198 T--DeVITAPEDITARDALELMYEHKIERVPIVNDEQHLVGLVTMQGILERREHGSAARD---QNGRLRVGVAVGP--FD 270 Halobacterium s...
2CU0_A       230 IKRAIELDKAGVDVIVVDTAHAHNLKAIKSMKEMRQK-VDADFIVGNIANPKAVDDLT--FADAVKVGIGPGSICTTRIV 306 Pyrococcus hori...
O14344       263 RTRLALLAEAGLDAVVIDSSQGNSCFQIEMIKWIKKTyPKIDVIAGNVVTREQTASLIaaGADGLRVGMGSGSACITQEV 342 Schizosaccharom...
O58045       230 IKRAIELDKAGVDVIVVDTAHAHNLKAIKSMKEMRQK-VDADFIVGNIANPKAVDDLT--FADAVKVGIGPGSICTTRIV 306 Pyrococcus hori...
P06981       231 EERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKyPDLQIIGGNVATAAGARALAeaGCSAVKVGIGPGSICTTRIV 310 Escherichia coli
P21879       234 MTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETyPELNIIAGNVATAEATRALIeaGADVVKVGIGPGSICTTRVV 313 Bacillus subtil...
P47996       248 KERLEHLVNVGVNAVVLDSSQGNSIYQLEMIKYVKKTyPELDVIGGNVVTMYQAQNLIqaGVDGLRVGMGSGSICTTQEV 327 thale cress
XP_001465126 253 KRRVAALADVGVDVLVLDSSQGNTIYQIAFIKWVKSTyPHLEVVAGNVVTQDQAKNLIdaGADGIRIGMGSGSICITQEV 332 Leishmania infa...
WP_010915551 242 FERAERLIDAGVDLLVIDTAHGHSQRVLDAVTRAKKLsNSVRILAGNVATAEGTQALIdaGADAVKVGIGPGSICTTRIV 321 Mesorhizobium loti
WP_010900646 229 LDRAVEVEKAGADFIVVDTAHADNENVLSSLKKMRKQ-ISVDIVAGNIATAQAAEDLIscDVDGLRVGIGPGSICTTRIV 307 Thermoplasma ac...
AAD10256     240 LERANQLIKNMIDVICIDSSQGNSIYQIDTIKKIKSAhPDIPIIGGNVVTSQQAKNLIdaGADVLRIGMGSGSICTTQDV 319 malaria parasit...
WP_010902714 271 TERATAVDEAGADVLFIDCAHAHNLNVIDSAREIKAS-VDADVVVGNVGTREAAEAVVd-FADGIKVGIGPGSICTTRVV 348 Halobacterium s...
2CU0_A       307 AGVGVPQITAVAMVADRAQEYGLYVIADGGIRYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGS 386 Pyrococcus hori...
O14344       343 MACGRPQATAIAQVAEFASQFGIGVIADGGIQNVGHMVKSLSLGATAVMMGGLLAGTTESPGEYYVREGQRYKSYRGMGS 422 Schizosaccharom...
O58045       307 AGVGVPQITAVAMVADRAQEYGLYVIADGGIRYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGS 386 Pyrococcus hori...
P06981       311 TGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGS 390 Escherichia coli
P21879       314 AGVGVPQITAIYDCATEARKHGKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGS 393 Bacillus subtil...
P47996       328 CAVGRGQATAVYKVCSIAAQSGIPVIADGGISNSGHIVKALVLGASTVMMGSFLAGSTEAPGGYEYTNGKRIKKYRGMGS 407 thale cress
XP_001465126 333 LACGRPQGTAVYKVAQYCASRGVPCTADGGLRQVGDICKALAIGANCAMLGGMLSGTTETPGEYFFKGGVRLKVYRGMGS 412 Leishmania infa...
WP_010915551 322 AGVGVPQLSAIMSAVETAHKSGVSVIADGGIKYSGDLAKALAAGASAAMIGSLLAGTDESPGEVYLHQGRSFKAYRGMGS 401 Mesorhizobium loti
WP_010900646 308 AGVGVPQLTAISDVAEAAKDSGIPVIADGGIRYSGDIVKAIAAGADAVMLGSMLAGTEESPGQEMIINGRKYKAYRGMGS 387 Thermoplasma ac...
AAD10256     320 CAVGRAQGTAVYHVSKYAHTRNIKTIADGGIKNSGNIVKALSLGADFVMLGNLLAATEESCSEYYFENNVRLKIYRGMGS 399 malaria parasit...
WP_010902714 349 TGSGMPQITAVSQVADVAAPAGVPVIADGGIRYSGDAAKAIAAGADAVMLGSYFAGTDEAPGRVITMNGKKYKQYRGMGS 428 Halobacterium s...
2CU0_A       387 LGAMM------KGGAERYYQGGym-------kTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIRELKE 452 Pyrococcus horik...
O14344       423 IAAMEgtgvnkNASTGRYFSEN----------DAVRVAQGVSGLVVDKGSLLRFLPYLYTGLQHALQDIGTKSLDELHE 491 Schizosaccharomy...
O58045       387 LGAMM------KGGAERYYQGGym-------kTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIRELKE 452 Pyrococcus horik...
P06981       391 LGAMS------KGSSDRYFQSDn--------aADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRT 455 Escherichia coli
P21879       394 VAAME------KGSKDRYFQEEn----------KKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKDLRALRE 456 Bacillus subtili...
P47996       408 LEAMT------KGSDQRYLGDQ----------TKLKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASSLQSAHG 470 thale cress
XP_001465126 413 LEAMSq----gKESGKRYLSEN----------EAVQVAQGVSGNVVDKGSAAKLIAYVSKGLQQSAQDIGEISFDAIRE 477 Leishmania infan...
WP_010915551 402 VGAMA------RGSADRYFQAEvr-------dTLKLVPEGIEGQVPYKGPVSGVLHQLAGGLKAAMGYVGGRDLADFRE 467 Mesorhizobium loti
WP_010900646 388 IGALT------TGLSDRYSKLGn-----------GFIAEGVEGAVPYRGRVDEVLFQLVGGLRTGMGYVGAATIEDLKR 449 Thermoplasma aci...
AAD10256     400 MEAMYnk---gFNSKSRYLVDErkneytdeniDEIKVSQGVSASLVDKGSVLNLIPHLFKAVKHGFQSMGIRNIPELHS 475 malaria parasite...
WP_010902714 429 VGAMQ------SGGSDRYLKDDd--------eDEEYVPEGVEAATPYKGSLASELHQLVGGIQSGMGYVGAESIPAFKA 493 Halobacterium sa...
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