2V3M


Conserved Protein Domain Family
Gar1
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pfam04410: Gar1 
Gar1/Naf1 RNA binding region
Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex. In humans, Gar1 is also component of telomerase in vivo. Naf1 is an essential protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1.
Links
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Statistics
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PSSM-Id: 461296
Aligned: 205 rows
Threshold Bit Score: 46.3279
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2V3M_F        30 ITPIGV--LKSAFE----------------NNIIIHatXSGe---KR-VLKEGSIFCL-EDRTLIGXLTEVFGPLQNPFY 86  baker's yeast
Q22HG7       170 LVELGQ--IMTIVD----------------DKIIIAtnNEMreaeKRiIVDLDNIIFN-EQKNIIGNVDDVFGNIKNPFY 230 Tetrahymena the...
Q587F8       201 VTTVSS--GNSNNS----------------WCMVVAdsVPGi-----fVLDCGTRVCL-PDGAVVGVVTAVMGPVNACVY 256 Trypanosoma brucei
Q4CNT7       128 ASVTGL--IARSS-------------------TVVAdnVSGa-----fVMDAGTRLCL-GDGSVVGVITTVMGPVSCCAY 180 Trypanosoma cruzi
Q5KH70       298 YAEAGTeqVTSVTGgptkkiskaeptftsaGTVVVRamQSRpgdfDDgWLEEGSILCW-EDGRVLGTVYETFGPLTSPFY 376 Cryptococcus ne...
XP_003138190 156 LKQFGK--IMNIVD----------------RLVVIEad------sNT-ALDFETVIFD-AERNAVGRVFDIFGPVVKPMY 209
EFN83891      31 CDLFGE--IIGIVE----------------ELVIIKp--rAe---KP-ALREETVLFIeQGQKTLGKIFDIFGPVKEPHY 86 
XP_002015303 291 CIELGK--VHSIVD----------------QLVLVSv--iPn---SM-LFDLDTVLFLeKGRKVLGEVFDVLGQVSDPLY 346
EDS28094     301 CKPVGH--VQSIVA----------------QIVIVQs--yAg---VE-LLNLDTVLFLeKGKRPLGKIFDVIGQVAAPMY 356
XP_001689281 291 CKPIGH--IESIVA----------------QIVLVQs--vAg---AE-LLNLDTVLFLdRGQRALGKIFDVIGQVNQPIY 346

2V3M_F        87 RIKLPDSK---KNlfDElkv-rlGEKAFI---VTPDAHWI 119 baker's yeast
Q22HG7       231 CVIIDKYTeemIAqkRLq----vGQKVYM---IEGYNKLL 263 Tetrahymena thermophila SB210
Q587F8       257 AILCNGDV---FSrlHAsgrleaGTGLHY---DLGAQHII 290 Trypanosoma brucei
Q4CNT7       181 AIVCLPAV---FGalCDggkltvGVDLCY---DLGEQSVI 214 Trypanosoma cruzi
Q5KH70       377 TVRLPPPPfpyPTpgSLa----tGTRLFYp-fNPSYRSFV 411 Cryptococcus neoformans
XP_003138190 210 AILFNd--------iKEasewkvGTAMYYapaASQFTHTV 241
EFN83891      87 TIRFNNVEh-----iQErqi-tvGTPVYYcp-dSCYTFFV 119
XP_002015303 347 CVRFNTNQq-----iQErgi-kiGDVVYCap-kTEHTQFV 379
EDS28094     357 CVLFNSRQe-----vISkgi-tvGTPVYCap-qTEHTQFI 389
XP_001689281 347 CVLFNSNQe-----iLTkni-ttGMEVFCap-rTEYTSFI 379
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