1FFX,3J6E,2XRP,3HKB,3RYC,4I4T,4DRX,1Z2B,3DU7,1FFX,1JFF,1TUB,1SA0,4FFB


Conserved Protein Domain Family
alpha_tubulin

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cd02186: alpha_tubulin 
Click on image for an interactive view with Cn3D
The alpha-tubulin family
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.
Statistics
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PSSM-Id: 276955
Aligned: 91 rows
Threshold Bit Score: 522.099
Created: 5-Feb-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Comment:In alpha-tubulin, N-site (non-exchangeable) buried at monomer-monomer interface within dimer
  • Structure:1FFX_C; Bos taurus tubulin binds GTP, defined using 4.0 A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##  #                                                        #         
1FFX_C         2 RECISIHVGQAGVQIGNACWELYCLEHGIqpdgqmpsdk-tigggddsfnTFFSETGAGKHVPRAVFVDLEPTVIDEVRt 80   cow
CAK92911       2 REILQFHVGQAGIQIGNTAWELLCLEHGIqpdgsap--------ssqnlqVLFSESQTKANVPRAAFFDDDPLTINSLNr 73   Paramecium tet...
CAI38965       2 REIISLHIGQAGLQIGNSLWELFCLEHSIqpdgtvptdr-ileglnsnvdSLFSLSQYGRYVPRAIFFDEDPTTINAIKn 80   Paramecium tet...
XP_001425659   2 REIISFHFGQSGAQLASPLWELYCLEHGInldgsvsnns-eiqendtnreILFSETQNNRYVPLAYIADDDDYSIDQIKn 80   Paramecium tet...
GAA36344      20 GELVQFFIGQYGLQVGNAVWELACAENGLdcsgspqdks--fplddhgvqTLFSQTPSGKFVPRCALIDTEPTVIDEIRi 97   Clonorchis sin...
KFG48527       3 GEVVTVQCGQAGLQLGFAFWELLLAEHGLtyegtqgkhn-vpegcqnnvdCFFYEAHTGRSVPRSAMIDLDNSAESLTGw 81   Toxoplasma gon...
CDJ00233       3 KELITFHIGQCGVQSGLHFWEQLIYEHEIgpdgysqvky-mnseevlepfGFFNVMRDDRYVPRTIFVDTDPTTIEEAKn 81   Echinococcus m...
EER17108       2 REVITCHLGQAGCSVGQKVWELFCIEHGIepdgtmpsde-svgsmedpfnTFFHETPSGQHVPRTLFMDTDPSDITSSGt 80   Perkinsus mari...
CDI99033       3 GELVQIFVGQGGAQIADACWELFTQEHFItpsgepsaclcgqeqgdcdgsAFFSLTQRGFFVPRTLIVDTEPSVLDEIRm 82   Echinococcus m...
EUB59866       2 KELCTFFIGQAGVQAASAVWEMLCLEHGVcrdgtiqyep-tlqehrelntVFEQLTPHEKYVPRAILADLEPSVIDEVRd 80   Echinococcus g...
Feature 1                                    #                                            ####   
1FFX_C        81 --------GTYRQLFHPEQLITGKEdAANNYARGHYt---iGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGF 149  cow
CAK92911      74 --------GPLKKVLNQNLIKLFKDdASSIWASKKItqydeKDRSSRAADEIVRKMLEAADAASAIIIYHSLAGGFGSGF 145  Paramecium tet...
CAI38965      81 --------GPSRGLFNRSYIHQCQKeSGGCWARSFGti--mNQEGEEKIADKIRKQVESCDGLQGIMLYHSVGGGFGGGF 150  Paramecium tet...
XP_001425659  81 --------GQLKKLFSTKSLQEFKGdSGSIWISSYK-----SAQASENFRNQIHQLLDKCDSLQGIMIYHSVSGGFGGSY 147  Paramecium tet...
GAA36344      98 --------GHYRSLFNPQNLVSGWEdSASNFARGYYr---nARKILQPTLEVTRRLVEACDDLQSFVFHQSHTGGTGSGF 166  Clonorchis sin...
KFG48527      82 --------SPIRRLFDDEFSVSHKEdASSNFARGYIs---vGPSVLSAANDVIRRQAEMCDSLQSFFVCRSLGGGTGSGL 150  Toxoplasma gon...
CDJ00233      82 --------ALLRSLFNPRCFFNGKEeAASNFARGRFi---lGADLIEPIIDRIRQEVEATDNCQGFIVNHSIGGGTGSGL 150  Echinococcus m...
EER17108      81 kheilgprCKWRNLYNPEQVMGYKQdCRSNFFEGRTqa--iEYHIVDEMMDRLRKEADKCSNLAGFFTFRSFGGGTGSGI 158  Perkinsus mari...
CDI99033      83 --------GVYRNLFQPSSLISGCEdSASNFARGYYg---aPCSLIDASYNSIRRLAEACDLLHGIIFYRTYGGGTGSGL 151  Echinococcus m...
EUB59866      81 --------GAYKGLFNPETLLAGMEdAAGNFARGYYt---lGGKVVGALINSMRRMIEKCDNFEGTMTFSALGGGTGSGL 149  Echinococcus g...
Feature 1                             #                                      #                 # 
1FFX_C       150 TSLLMERLSVDYGkkSKLEFSIYPAPQVSTAV----VEPYNSILTTHTTLEHsDCAFMVDNEAIYDICRRNLDIerPTYT 225  cow
CAK92911     146 TCKLLQLLNDETAktTKLTVSVFPSTKQDQLFtqpiVEPYNTILTLPTLSELsDFNILYDNAAMYKVCQNQLDFetPNFS 225  Paramecium tet...
CAI38965     151 TSKILDLLSSDLEkvTKATVSVLSSNHSLQSSl---IEPYNSLLTIKYLKEKaDMSIMLENQALFKVANQQLDIdnPNFS 227  Paramecium tet...
XP_001425659 148 ASYLLNEFEDDFSkvIKSTVSMLSSDQNSTSTi---VEPYNSVFTINQLKQYsNFNIFIDNSALSQVCERQLEIdwANFG 224  Paramecium tet...
GAA36344     167 TASLLENLHDEYTkkIRFSISLLPSDAMSTCI----VEAYNTLLSCHVPNQYiDFTILTDNKALLTACVERIGIwkPTMY 242  Clonorchis sin...
KFG48527     151 GSLLLEGIAEQFGkkYILDSFVWPFNSQTSSV----VEPYNAVLATPTICAHsSAALLVDNTALFNISRNLLNVesVFHS 226  Toxoplasma gon...
CDJ00233     151 TVRIMEHLTNEYCkaISIQFPIFPSEYLSTTV----VDPYNAVLHCGFNVPNsNMTVMMDNSAIMGLLSRHLQIekPTVV 226  Echinococcus m...
EER17108     159 GCELLEALREQFEkkVILEPVLYPSAEYSSSA----VEPYNCLFATAYSKAVcDLSLMLDNQAAYKLCRDQLAVknPTFY 234  Perkinsus mari...
CDI99033     152 GCRLLQHAADEFCkiSRMDFGVIPGVTLSSGP----VEPYNAVLATQVPVEHvNLVSLVDNMALQRICSCLLKIykPSFT 227  Echinococcus m...
EUB59866     150 LSMFQERACLEFAgrRMLQFSIVPSDQMAIGP----VEVYNCMHHLYHSSDFcDLNIFLDNSALFNICTKELAVvrPTYT 225  Echinococcus g...
Feature 1          #                                                                             
1FFX_C       226 NLNRLIGQIVSSITASLRFD-GALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLS--VAEITNACFEPANQM 302  cow
CAK92911     226 HLNYMIAQTISSISQSIRFR-GTKLVDFNDMRTNLITTPKQQFLWTSYSPFIYTDQQHLKKPN--LQNITESLFDDNGHL 302  Paramecium tet...
CAI38965     228 TINRMIAQLISSVTQSSRFN-GSKFVDLIEMRMNVVPEPDFQFLHASYAPFINIDKQNTELTN--LQQITNSLFDQRSSF 304  Paramecium tet...
XP_001425659 225 ILNKMIAQMIASITSTQRLN-SENFVDLQDMYQNLVLLPELQFLHTSYAPFIQRDQQNSSSVN--LLQISQALFNEAGSF 301  Paramecium tet...
GAA36344     243 HLNRVQAQVVSGVVSPLLFK-SQLSAGLPELLTNLVPYPEAHLIIGSLSPLRGGINTNYEALS--CCEITEQAFRTQNQL 319  Clonorchis sin...
KFG48527     227 NLNHLVAQVLSATTLSTRFE-GTLNSTIEHTLVNTIPYPELKFLTASLAPLTNLKKYQFERAS--TKDITIECVLPSRCF 303  Toxoplasma gon...
CDJ00233     227 FLNRLIAQIQSNFFCGFHYNgDPICSTMEEVITNLIPFPELHYVYVRHAPIVAARRHDYQTHNnpPEDIVKAALKPQFNT 306  Echinococcus m...
EER17108     235 HLNRLISQVVSACTTSLRFE-SMINASLLEIIHNIVPTPVYRYPIVALSPVRHASRHKHESFS--TKDIVIDLFEPRSFL 311  Perkinsus mari...
CDI99033     228 SLNRILAQCMSGLTSTFRFP-GPTTITMMDLYTNLVPYPDAHFAMIGFAPLFDLETACKGQVD--TTQLTESVFAPENQL 304  Echinococcus m...
EUB59866     226 TVNRVIGPLVAGLTASVRFK-CNINGTISEFLTNLIPFPAIHYPMITFVPFCTDMEAERSRYT--TPILTRMVFKPDYRT 302  Echinococcus g...
Feature 1                                                                                        
1FFX_C       303 VK--CDPRHGKYMACCLLYRGDVV--PKDVNAAIATIKTKr-----tIQFVDWCPTGFKVGINYEPPTvvpg----gdla 369  cow
CAK92911     303 LS--FNRLTHKYLGSSLFFKGDCP--LPELNYVIKQIKQSe-----eIRFAEGTQVAYQTCVSMAQPCtlpn----ypfa 369  Paramecium tet...
CAI38965     305 IN--YNHKTVKYMAANLFFRGDCP--WGEVKSVVESLKQSp-----nIQFAEFAVPTFQIAISDKAPIpfpn----seqg 371  Paramecium tet...
XP_001425659 302 IK--FTPNPSQYFGVNLFYRGDCP--YSDLQSTINELKNSk-----cINFADWVPINYQVAMSSKSTVqfhn----aelg 368  Paramecium tet...
GAA36344     320 LSs-PAAYQPTYLSCCLLYRGGVT--AKHINNAIIKLKKSg-----nLPWVDWCPTGFKVAVSNQPMTvvps----scig 387  Clonorchis sin...
KFG48527     304 AS--IDYSKNRSIACHIMYRGDVT--PRDVQEGVAAVKEHg-----tLRFVDWIPTGLKCSMNSRLMCvspe----sela 370  Toxoplasma gon...
CDJ00233     307 LSa-DKYTRSKIITTVLSFRGVAAgwQRTLASTILQSKMNq-----sMNIVDWCPTGVKVAVHAVPPLkpvpe---scit 377  Echinococcus m...
EER17108     312 CDvgPTLRLNRYLSVCVLILAMMEg-RVDALQAINTLCNPkasyrtaLRFLPWIESGFKVGVVGVPPSipltgngepfma 390  Perkinsus mari...
CDI99033     305 VHq-HGEEVNMYLTCCLFYRGNAS--VRDVNTCIDEMRSSn-----rLPFVDWCPTGFKVGISYQPMTtiea----srig 372  Echinococcus m...
EUB59866     303 VT--AMLDEGVTLATCLTYRGHHS--VFEILQTLEGMREEr------ANIVDWCPTAFKVAYTPQPPVlipg----mgpe 368  Echinococcus g...
Feature 1                                                                            
1FFX_C       370 KVQRAVCMLSNTTAIAEAW-ARLDHKFDLMYAKRAFVHWYVGEGMEE-GEFSEAREDMAALEKDYEEV 435  cow
CAK92911     370 KYSKTACMLAHSTGVLQSF-ESLKKRFSTLYSKRAFVSWYVGQGLEE-GQFSESNESLQQIIELYKGK 435  Paramecium tetraurelia
CAI38965     372 RSNKAVCMIANSSAIGIPL-FRIRRNASTLYSKRSHVHWLVGEGREE-GEIQEALDTVKSFIINYRQV 437  Paramecium tetraurelia
XP_001425659 369 RGNKTACLVANSTRILNPL-KNIQSRFKNLYQKKCFLHWFLKNSQIDeSQFVNGLDFFSSLLSNYEQS 435  Paramecium tetraurelia str...
GAA36344     388 QTDCSLLMLHNSTRIIPAL-SHVLDEFRMLFSRRAFVHWYTTEGMDE-AQFIEASLSLAQIRDEYIQI 453  Clonorchis sinensis
KFG48527     371 PAFQSCCMLANNTGITSLL-EKTLADMYKMFNKRAFVHWFVGEGLEE-GEFLEASERLQRTIDDYHES 436  Toxoplasma gondii GAB2-200...
CDJ00233     378 ESPTNLTMIINGTVTTQRAlQTINAQFNRLYERRCFVHWFVGEGMEE-GEFTEASGAVREVIDQYKNA 444  Echinococcus multilocularis
EER17108     391 RCDRQGCVLANTTAVRTMF-LRQYKKFLQLFYHKSYVWQFVDANGEM-DMFYEAKEIVRTIIDDHEAL 456  Perkinsus marinus ATCC 50983
CDI99033     373 PSDTSVMALHNSTLFRTPL-HELTQAVETLLKRNAFLHWYKAEGIER-DEIENALGGLKKLEADYNSF 438  Echinococcus multilocularis
EUB59866     369 KITRSLVMITNSTAISEVF-SRAEIAFLNLFSKRAFLHWYVGEGMEM-EEFTDALEKVRNTAADIIAL 434  Echinococcus granulosus

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