Conserved Protein Domain Family
Sfi1

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pfam08457: Sfi1 
Sfi1 spindle body protein
This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.
Statistics
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PSSM-Id: 430007
Aligned: 31 rows
Threshold Bit Score: 474.091
Created: 23-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EED21482           355 ELEKKRQNSRTKRFFRHLENRAAKARDLYLMTKAFSHWAQLTSDELSKASAAREHILSIKYFNAWREIT-------AVNV 427 
O13652             203 MLKYFPRWVQKLRNIQSRIYSAGEAYRLILIGQMVNRWRQKTRERLHQKLRFQKNAFLLDVLLKWSALT-------VNWN 275  Schizosa...
EAA26776           513 ERERHEAEAEYEAWVDRMERRATRVYEVFTIQNMLNFWQDQAREELDRTAVARRHLVRKRAFDAWRAQH-------IQDE 585 
XP_006691266      1500 fARDARKRREHKEWVDKMERRANRVYEICTARDALARWQAAAKQERDRTAVARRHLVRKRAFEGWRDEH-------IRVE 1572
XP_003657393       284 qrlkAEAAAQYEAYVAKMERRATRVYEIFTIRTLLDHWQDQAREEIDRTAVARRHLVRKRAFEGWHAQH-------VEDE 356 
jgi:MYCTH_2130496  308 lrlEAERAAEHEAYVERMERRATRVYEIFTIHTVLAEWQERAQEELDRTAVARRHLVRKRTFEGWHAQH-------IKDQ 380 
Q2GUV2             292 LRIKAEEAAKYEAYVAKMEKRASRVYEIITIHNVFAEWQGRAREERERTAVARRHLVRKRTFEGWHAQH-------VEDE 364  Chaetomi...
EJT72042           532 KAESARREAENARLHERMMRRAARAADLSLLHKAFTHWRAAASHEAERTEIARRHLLRKKVFVAWSEKV-------SADR 604 
XP_003716757       621 aaETARQLVETARREERIMKRAERAYELSLLHKAFTHWWTAAHEEVERTEIARRHLLRKKVFDGWSQKV-------SADK 693 
XP_001585650       408 HLEAQQKLREIEERFVKLERRVDRARDRHLKHKAFTHWAAITREKVEITKVAQRQILRSRMFTAWKTQTeetekknKENE 487 
EED21482           428 MKAERFAIQKPLDGWRRKIQQIRTLDDHAIHAHEYNRKRKYLMMLLWNFyYEHRAPEWSDFRLMKGAFLSWIRALRRQRE 507 
O13652             276 RKHEYMLKRRVFTNWMSKRRRNESLIQKANVFFQHSVLAHSFKTWKANL-SIKNAATLYEKKVVFMSFNRWHANYESHVL 354  Schizosa...
EAA26776           586 TKARNFVLIHALQRWTAVALHQEVRRHVAEQTEERETMREGLMHWYRLQ-KGRVADDYAVFKAMKGSLTHWTSRTKDVQD 664 
XP_006691266      1573 NKVRKFQADHYLKKWGEAALENEVRKEVADQWRCRRLLKNSVNFMLKET-KERQADNVYANSLAKDALATWSEKARELQE 1651
XP_003657393       357 TKVQNFILKNALQTWTQVALHHEVRHEVAAHWHQQQLRKQTLHTMLEET-KERQADEFYAVNLAKQCLGTWAEKARDLND 435 
jgi:MYCTH_2130496  381 TKVKNFILNNVLQKWSQVALHHEVRREVAVQWHQQELCKRSFHTLWQET-KERAADEFYAVGLASHCLSIWVNKACEIQD 459 
Q2GUV2             365 TKVRNFILSNVLQKWSQVALHHEVRHEVAAQWHQQDLCKQSLHTMWEES-KRRLADEFYAFGLAGQCLDAWTDKARDTRD 443  Chaetomi...
EJT72042           605 TKVKAFAATGLLGAWSNALEQHREVKRFSAQMYPADLAKRCFTKWRREY-QSCAAELWYSVRLAEDCVHKWKHETSLCRG 683 
XP_003716757       694 YKAFNFAASGALLAWRTATKKQEEQEEVALQMRSRGLVKIAFAKLFRRH-QECVADAFNSTRLGQWAILTWSLELQSAAK 772 
XP_001585650       488 EKARKFQLRKFFGKLKAKKEEIDEKLNMASQVAKGNLLGRVFSKLAQEK-KVVEFTQRIDEKNKQRALSTWVEKTQAVSE 566 
EED21482           508 REAEIDHGLRQELLHATLKTWSYRLRSVEAAQLDADMGYRKKLLGDQMEVWRAQTRLQPAAIQIATKIDSRVLKTTLIQW 587 
O13652             355 DLQKAELFSQKAYYSIALHKWKLRIEELSDLMNKADDLYEVNLLQRMLVLWRRKATTYEKIDFWMDGHDVDIVKSAFFKW 434  Schizosa...
EAA26776           665 DHEVAIALDERLLLDEAVNIWQEEAEDLRYTGYKCRGYKVTRDCQIILADWHEQSRLLRTLRKFRAADERTLKWNCLEHW 744 
XP_006691266      1652 EGEVAAAVDKHVLLDEAVGIWREEADDQQVRARLGQRLLQLKQLKRGMDRWREKATLVRRLIELEQKRAAETKQEVLDTW 1731
XP_003657393       436 EYQVAVALDERLLLDEAVNIWHEELEVQQYDAYECTRQFLILGCRRDLEYWQEQARLSALLKQYRTKDEQDAKRQALDVW 515 
jgi:MYCTH_2130496  460 EYQVAVALDERLVLDEAVNIWLEEVDIQQYNAYECTRQWLVQGCRRDLDYWQEQARLSALLKQHNAKEEQALKRRVLEAL 539 
Q2GUV2             444 EYQVAVALDERLVLDEVVNIWLEEVDAQQYNAYEYTRQWLVLGCRRDLDYWQEQARLSALLRQYTGKQERDTIVRTLETW 523  Chaetomi...
EJT72042           684 LHAAAEADAVHSLRASSIGAWRSMSAETKASTVEASDRLEKRQLSGLLSTWHTQAMLESRLRRALVSREERIKTESLHVW 763 
XP_003716757       773 LWTAAEADASHMRQSNALSMWQSRRSDMFMFQSMASSLVLDHDAAAIFEFWRKQAKLESRFREFSNSQRKNMQAITLSTL 852 
XP_001585650       567 ATQLAEDERLLNVVTKTMDSWKEKTETQVVLNARAERAAKAKQLGSAFKKWRLEAQTAPAEKKVVASHNASLLKISLSIW 646 
EED21482           588 RLRTESVQHAKEADRLRVLRNTWTTWNDHLRCYALKERIDERLKKEAIYRWILAERYRLAQRIRDQRIQREAFAQFIFTV 667 
O13652             435 KNKFIKVDRNFELADTILQNTFLTKWRLAVRVKVVQEKRNKDRLIVTFRFWYYLMKAKSFQHKRDHRLLTIAWEAWKDNY 514  Schizosa...
EAA26776           745 QEEAEYARRDGLLADAVLLLNPVDTWKLELKLKLWNIREDEETLEDTLTHWFLEQRLALFQHHAASTTKKSTLSTWLDAT 824 
XP_006691266      1732 KEVSKGQKTQAEKADAFAAKEHVEHWDREMKLKLWRERDEHETKIAVVERWSNEEKLAWLKRRHDTQNKKNVLNTMLLAA 1811
XP_003657393       516 HSAFQNAKSEAGIADAFFLEDPVDHWEREMKLKLFIERDEYETKAAVLNRWALEEKLAWYQRYSETRVKREALDTFVAAA 595 
jgi:MYCTH_2130496  540 SIALRKVKRDTAVADAFLLTEPVDHWEREMRLKLFLERDELEMKAAVLEHWALEEKLAWYKGHLETRNKRQTLNTLFAAA 619 
Q2GUV2             524 NSISQDAKGEAAVADAFLLNEPLGHWEREMKLKLFIERDEFETKAATLEHWALEEKLTWYQGHLETRTKRQTLEAFFAAF 603  Chaetomi...
EJT72042           764 KLNLQAAGTQKQAAQRRSIQGFARHWVLELELKLFRENVDSLTLLSSTYQWVLESRSKLVRRFNRKSTQNSALLNLRAEY 843 
XP_003716757       853 VHASDLLQMLGTKADTMMLKDFAQHWLRELRLRDVSRRRDHDLLYNQLYEWLMEERYALFYRYSEYNRTAAALSDLRAIH 932 
XP_001585650       647 KLRTEQEKQATAIDHDKIKREAFTEWRHQTRLKRLRAISDDRAVAKASKTWRLETKCAVLQKEKKEETKSACLEVWFDRS 726 
EED21482           668 RDTSKELLQRENQYFRHYNEDLARSALDCWRNKLAVQRQREYAAMEFYVPRIEQEALTIWNSRHQHLQNLDKW----SRD 743 
O13652             515 QR-RIKLQKEAQELQLTRIQKIAKQYLIKWRISLLDIKELSIRAEKLHTTNEIIGVWNQWVVSYNRKVGM-------QQN 586  Schizosa...
EAA26776           825 QTSLSVCQRPESEADHFYSDHLLSSCFSTWFDASNAIFTPRHNANLICLYRTTKPCLDRWREALVSSTTRNAYyarkASK 904 
XP_006691266      1812 RKAQDERLRQEDDADALNEYYTQAGALNTWKKAHEKADIGRQNANLVNLYRTGKPAVDYWRERFRETSARGAYckrvADK 1891
XP_003657393       596 RRARTDRERHEQEAAYVDSFYTRAEAVDTWAAETDKMWKHYHNADLVNLYRTTRPCMDHWREQCHQSRARDSYyrrkADR 675 
jgi:MYCTH_2130496  620 RQARGERERHEEEADYVDAYYTQTEVLDTWIEGTDQMWKHRQNANLVNLYRTTRPCIDHWRERCQQSQARDGFywkrAEK 699 
Q2GUV2             604 TQARGERERHEQEADYVDTYYTQTEVVDIWLEETDEMWKQRQNANLVNLYRTARPCVDHWREHCQQSQARDGFyrrkADK 683  Chaetomi...
EJT72042           844 AKEKRRRKEHQALAKLCYKATIADAFIGAMSRQLGESQWMEEEARRADSAQVTAQAVQGWAAQTAEHEEMEDA----AQR 919 
XP_003716757       933 ESEKLRQRQLDLKSQRFRRRALLAPFVCLMRSQICHNDEAHKLAYGIDLRNVASSIIQAWTAAAGELESM-------AHD 1005
XP_001585650       727 QDTRSRRWEREEIARRHDNKTVAASVLRRWYVKMNDRAEIEARAADFQAPRILGQCFDSMRTQLQRIVKLNKV----ARA 802 
EED21482           744 AQFYF---ITTKFIKLWHNAALDASKKRRQEAYVKIRRKVKMNIAASALRVWYDKSRRMTNLHNQANELMQT---KLLIY 817 
O13652             587 ADLFFkrkTLRVVFEHWRYLRETNMLLRLENKVVDFREVQSEKLVLRCWNAWVARLLSVSQMLDTAELSTQKvvvRAYEA 666  Schizosa...
EAA26776           905 QSKRF---TIASVLDRWPFLAEQARRERMMTSLRSFRHSYKISLAQSCLSTWFNALLEADDLSADADALHLD---HNHSD 978 
XP_006691266      1892 SRKRS---LVKGVLEDWRINAKQARRDRLMSRLRQFRRQYKVDLAQSCLDKWQDAAADALDAKADADQINIE---YKRAD 1965
XP_003657393       676 HRARS---IVSSVLRKWPDIAETARRQRMMNSLRQFRRKYKVELAQECLGKWLDATAEAVEAGHDAHRANLY---YERED 749 
jgi:MYCTH_2130496  700 HRARS---IVSAVLEKWPAVAETARRERMMTSLRQFRRKYKVELAQECLGKWLDATVDALDAQHDARQTNLH---YKRED 773 
Q2GUV2             684 QRARS---IVSNVLDRWPAVAEATRRERMMTSLRQFRRSYKVELAQECLGKWLDATAYAFDAHHDARQANLH---YKRED 757  Chaetomi...
EJT72042           920 GAFYV---GAINCLHAWPRLAKAARQERLRLTYLAFRRNMKIERRAGCLAVWREATYNSAVTAWEFERRRQE---QLLDE 993 
XP_003716757      1006 ARLGAywtAAITCLEGWPSFAREVRRHRLATTYHAASRLRKERMATDAFVTWQEALHDKFVVTWESEAALQD---RQLHE 1082
XP_001585650       803 ANKFF---VMNSALKKWRQATQKSKREKRKTAYIQVRRNRKLYLAGDMFSRWRQKAQEKMALNEQALQFAQG---KTFII 876 
EED21482           818 STELVSRWREKTAKITQDTQDAEVYYHRQLAYHQLSRWMDECEIYRGLEEQAEVLDLIRISGVVSAQLRKLSLRIFQIRS 897 
O13652             667 -------WSFRYNHQKEIMSQADQFYNERLMRSAMVFWRYQLRAIKFYFNISDWKRREFNRQTLRNAFDAWHLLMFRVTS 739  Schizosa...
EAA26776           979 LYETLGYWSSIA----RRAQEMRETAADAELDTYLENWMDSAAEMREAEMDAEEWEAVGTMKGC---LQRWEHEALHLVA 1051
XP_006691266      1966 INDGLDHWRDSA----KRNEDINNIAADAELEVYTNKWQDRLDEHRENMQDAVDYDAEKTRAQT---MEKWEVQALQQKS 2038
XP_003657393       750 LNDCLDFWAETA----KKAQDIQQIAADAELEVYCGKWQAQLHEAQENMADAIEYDAEKTRRQC---WEKWEFQTLQQQS 822 
jgi:MYCTH_2130496  774 LNECLDLWNQAA----KRAEGIQQIAADAEVEVYCVKWQAQLQEAKENMQDAIEYDAEQTRKRC---WEKWEFQNLQNES 846 
Q2GUV2             758 LNDCLDLWVRAA----KRLENVQQIAADAEVEVYCEKWHAQLQEAKENMQDAVEYDAEQTRKRC---WEKWEFQNLQNES 830  Chaetomi...
EJT72042           994 MVDWLNDWIGET----NRMIGMGQTAVEVGTEAAVGAWRGAASRLEATWSDAAAYEAEAVATAR---LEDWELRLVTIRG 1066
XP_003716757      1083 TIDLMNTWIGET----NRMIVMSSVANQADLQVNVNSWRAIASGLENQETDAVIYDIERLRSAT---LEVWELELVKLRG 1155
XP_001585650       877 GMNSFDQWRART----EEVAELEPLWKEVVMRKFFNRWKDRTESLQVLNIEATLDFQERQQSDA---LRKWSLRTMQTRA 949 
EED21482           898 AAEMAESLHDRISRKHHRNMLRHWSAKV 925 
O13652             740 LVMQADRFHEQKKNKLLGKYFRKWLQRM 767  Schizosaccharomyces pombe 972h-
EAA26776          1052 KRNAVKALREREERRLAAGVLEGWWAVV 1079
XP_006691266      2039 KRHMADGMKDRYDKRVVRQILGDWQQKA 2066
XP_003657393       823 KRHMANTLQEKHERRLCGEVLYEWQQQA 850 
jgi:MYCTH_2130496  847 KRHMAATLQEKNERRVCRRILAEWQQKA 874 
Q2GUV2             831 KRHMAVTLKEKNERRVRRRILGEWQQKA 858  Chaetomium globosum CBS 148.51
EJT72042          1067 REHTASGLAEKNRKRLARQALGFWLGQl 1094
XP_003716757      1156 WTHTATELADKNKKKLARQALGFWLSQT 1183
XP_001585650       950 MANTAKELHDKNTRKGHRKMFNYWRQRT 977 
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