Conserved Protein Domain Family
Vac7

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pfam12751: Vac7 
Vacuolar segregation subunit 7
Vac7 is localized at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.
Statistics
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PSSM-Id: 432760
Aligned: 31 rows
Threshold Bit Score: 402.094
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE07881     392 TVETETVTSIPNVALGP-SAAQGVNGSLRTKPSSETIR-PKKEKKKTTRKQTPvTPGATTSKADIFEAKVASAVDEANTS 469 
XP_012743371 338 TVETETVSSIPQVAVGGgTGTV--NGSLRTKPSSETIR-PKKEKRKTTRKPQSvQNGVASSKADIFEAKIASAVDEANSS 414 
XP_011394761 411 TVEAETVTSIPQVALAPgGGVQPSSLSLRTKPSTETIRpPKKEKKRTARKQPNmTAGTASSKADIFEAKVASAIEETNSS 490 
KLU91220     355 TVETETVTSIPQVSVAP-AGMQGSNGSLRTKPSSETIR-PRKEKKKPSRKQQMvQSGAASSKADNFEAKIASAVDEADTS 432 
EQB58164      84 IVETETVSSIPQVALAPaAKLEPGTGTLRAKPSTETIR-PKKEKKKTSRKQPTvNPGNASSKADIFEAKVASAVDEANTS 162 
XP_013937827 299 TVETETVSSIPQVALTVgPKADGMNGTLRTKQSTETIK-PKKEKKRS-RKQPv-TSGNGSSKADIFEAKIANAVDEANTS 375 
XP_006665550 327 TVETETVASIPQVPINTsSKADGPNGTLKTKHSTETIK-PKKEKKKTVRKQSNvHTGTSASKADNFEAKIASAVDEANTS 405 
EEU45157     323 TVETETVPSVPQVALATgPKSEGPNGTLKTKQSTETIK-PKKEKKKTTRKQPAvNTGNASSKADIFEASIASAVDEANTS 401 
CCU77868     265 TVETQTVSSIPQIAVCSgGSGN--GGSIRTKQSNETIR-PRKDKKKATRKLPSvTAGTASSKADIFEAKVASAVDEANSS 341 
XP_001593574 339 TVETETVSSIPQIALATgAGGLGANGSLRAKQSTETIR-PRRDKKK-SRKAPSvASGTASSKADIFEAKVASAVDEANSS 416 
EPE07881     470 DSEETFVYDSNPADGRDRPhRFHHSRTPSATSLSQA--DR---SGmRS-IHSIMEgg-------gPSgGVTVKKSMKFVN 536 
XP_012743371 415 DSEETFVYESNPPD-HERP-RRFHSRSPSTTSMASQs-QAdlrPGpPSrLANTLDg--------sNGhSVAMKKSMKFAS 483 
XP_011394761 491 DSDETFVYDSNPPD-HPRP-PRYHSRTPSAASMVSQm-NR---ADmRS-IHSAMMn---------VEqPIGVKRSMKFVN 554 
KLU91220     433 DSDETFVYDSNPPDVRDRPhNRFHSRTPSATSMASQv-DR---NGmRS-IHGVMDvgyghalppaPGsAIAAKKK-KFSN 506 
EQB58164     163 DSEETFVYDSNPPDV---ErRRYHSRTPSATSMISQa-DRagaLGmRS-IHEALQ----------VNtAAGLKKSMKFVN 227 
XP_013937827 376 DSEETFVYDSNPPDVGDRAtRRFHSRTPSATSIVSQg-DR---PNlRS-IYGIMD-----------NhVPAPKKSMKFSN 439 
XP_006665550 406 DSEETFVYDSNPPDGTDRTvRRFHSRTPSATSMASQppDR---QNvRS-IYGVMEa--------aGHhGPVPKKSMKFVN 473 
EEU45157     402 DSEETFVYDSNPPDGNDRAgRRFHSRTPSATSMASQa-DR---QNlRS-IYGIMEg---------PGpAHGPKKTMKFVN 467 
CCU77868     342 DSEETFVYESNPPDVNDRP-RRFHSRTPSAASMVSQidQR---CGvRA----IME----------SHqSVIMKKSMKFAN 403 
XP_001593574 417 DSEETFVYESNPPE-QERP-RRFHSRTPSATSMASQidAR---NGlRS----MMDn---------GShSVAMKKSMKFAN 478 
EPE07881     537 TfGNTsSNDSGM-GDDETNKaatiRGVT-GS---GrGTARlhH--HV-GRFGLgggaKNGHQSILDHE-SPFPVSTasrl 607 
XP_012743371 484 Sf-APlPPTSDAaTDDDAAQ----RALGt-----GrGTIRh-H--HI-GRWGRnn-nTSSHGSLFDAE-SPFPHATkpsk 547 
XP_011394761 555 Sy-NPsINESVG-GEEDGKStt-gRSTA-GS---ArGTSGrhH--HY-GRWGRng-gGNGHASLFAEQ-SPFSGANsgnn 622 
KLU91220     507 TyNPGlAAENLGlLIDEDGGs--aRGSGsGS---GrGATAarHphHI-GLWGRs---gNGHTYLFDNDsSPFLGSQrpri 577 
EQB58164     228 Tf-NSnGAESLG-ADDDGKGs--gRSAGvGS---GrGTGRhhHhnHF-GRWGRh--pGNTHPSLFDNE-SLFPNAArskm 296 
XP_013937827 440 TyGNGaIDGGVLtGDEDGRGt--gRSAG-GS---GrGTVRqhH--HI-GRWGRq--pGNGHASLFDNE-SPFQNTPrpki 507 
XP_006665550 474 Tf-NGsGTESLTpGEDDGKAt--gRSAG-GS---GrGTARhhH--HI-GRWGRq--pNNSHLSIFDND-SPFANTTrakp 540 
EEU45157     468 Tf-TSnGNDNLTvGDEDKASn---RGGGsGS---TrGTARhhH--HI-GRWGRq--pGNGHPSLFDNE-SPFPNAArtkl 534 
CCU77868     404 Sy----ATNGTDpLISDEAV----KGTIrGSngiGrGTTQh-H--HLnTRWGRn--iGNSYYQTIDNE-SPLLHAAtsnp 469 
XP_001593574 479 SsYNSaPQEMSTeDDGKGTS----RSNL------GrGTAh--H--HF-SRWGRn--gGNGHASLFDNE-SPFPNAAkskf 540 
EPE07881     608 kmlsggsgggvssggptsypsgrtGGPTSPRASGGSMSGRSGGTYSQKRGYGSTGghhfgYDMDdttPGQAgSDERTPLM 687 
XP_012743371 548 fgn--------------sasmrqsSRPTSPRVGANG--RGVNGNGTVRKGGFAHA-----YDIDd--GAGA-DDERTPLI 603 
XP_011394761 623 n-------------------srpsSGVNSPRYLSR-----SGPHAKSSRGT-HLSv---gYDLDd-nATGA-DDETTPLI 672 
KLU91220     578 sga--------------ggsarnsPAPPSPRFG-GSVSS-ARGTGGGKRGS-HLTpa-vgYDLDd-tTTEA-DNERTPLI 637 
EQB58164     297 sa----------------nnsrqsSGPPSPRVASSA---RGGPHALGKRSSIQMAr----YDADdttTTGA-DDERTPLL 352 
XP_013937827 508 a------------------nsrhsSGPPSPRNHPS-----MRGPLSSKRSAIHMSs---sYDLDd--TTGA-DDERTPLL 558 
XP_006665550 541 pt----------------sasrnsSGPTSPRNHHS-----PRGQLSSKRSALQMSs---iYDMDe--NTGA-DDERTPLI 593 
EEU45157     535 ag----------------ansrnsSGPPSPRNAHS------NRNFGHKRSAMQMSs---nYDMDd--TTGA-DDERTPLI 586 
CCU77868     470 pr----------------isprtlSRPTSPRISIS-------RLTNNKKKSTPGTl---rCDLQd-----SvSNERTPLI 518 
XP_001593574 541 sa----------------hpsrqgSRPTSPRVVNSA----RMSNANGKRTSPISSg----YDLDd-----AaDDERTPLI 591 
EPE07881     688 gtASLRgTVRGNNrtsRRHH--MSLRALEQQsy--------hhHPPASFLNRFASCLVLTVMLMLVISGAIGFMFATSQP 757 
XP_012743371 604 gsGT-R-STRSRH---RRNPptSS------Q------------QRQRNSRSPFGACLILGVMAVLVFSGALALLLGTAQP 660 
XP_011394761 673 qsGTVR-SSRSAR---SRRNglHSLRSMESGt----------yRQPPSFLNRFASCLVLTVMLLLVVSGAIGFMFATSQP 738 
KLU91220     638 --HTAR-SARTRRg--NRYH--HSLMADHQQraavaayrqhqrRHQPSLLNRMASCLVLTVMLLLVVSGAIGFMFATSQP 710 
EQB58164     353 t-STVR-SARRTR----RHP--ANLRNLESQs----------yRQQPSYLNRFAACLVVTMMLLLVITGAIGFMFATSQP 414 
XP_013937827 559 --DNGR---RGGRf--RRGP--HNLRQAEAQt----------yTRRSSYLNRFAACLVLTMMFLLVITGAIGFMFATSQP 619 
XP_006665550 594 --GTAR--YRSGRn--RRGP--HNLRQAESQt----------yTRRSSYLNRFAACLVLTMMFLLVITGAIGFMFATSQP 655 
EEU45157     587 --GSIR-SGRSQRn--RRGP--HNLRQAESQt----------fTRRSSYLNRFAACLVLTMMFMLVITGAIGFMFATSQP 649 
CCU77868     519 --PAAR-KNKAFRs--RRYN--TSLRQLEHQa----------tRRSQTFLSRYGGCLFLILFVLLVILGAIGFMYATTQP 581 
XP_001593574 592 p-STIR-SARSSR---IRRGnaPSSRHIEHQ------------RQSRSFFARFAGCMFLSLLILLVVAGAVVFLFATTQP 654 
EPE07881     758 LDDIELVKISNVIASEQELMFDLMVRAHNPNVVVVTVDSADMEVFAKSPHAGTDS 812 
XP_012743371 661 LGGVRIAALRDVLASKTELLLDVDVVARNPNVFAVGVDKLDISVYAKSRYAGDEA 715 
XP_011394761 739 LTDIELISMDHVVASEQELMLDLTIRAKNPNVVVVVVDAADIEVFAKSPHAGTDS 793 
KLU91220     711 LTGMELIKISNVIASEQELMFDMMVKAQNPNVVLVIVDSSDLEIFAKSPYAGSDS 765 
EQB58164     415 LTDIELVSIKNVLASDPELMFDLTVKAHNPNIVVVSIDQANLEIFAKSPHAGTDF 469 
XP_013937827 620 LSDIEIVSIHNVVTSEQVLMFDVTVKAHNPNVVVVTIDHANLEIFAKSEYGGADS 674 
XP_006665550 656 MAGIEIVSIQNVVTSEQVLIFDLSVKAHNPNIVLVTVDHTDLEIFAKSDHGGTDS 710 
EEU45157     650 MTGIEITAIHNVVTSEQVLMFDLTVKAHNPNIVVVTIDHANLEIFAKSEYTGTDS 704 
CCU77868     582 LVNLKVISLKNIIASEQDLLFDIEARARNPNLVSVTIESTDIAVFALSKYSCCDl 636 
XP_001593574 655 LANVKVLALKNILASEQDVIIDLQVIAQNPNLVAVTIDSMDMVIFAKSKYAGTDS 709 
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