Conserved Protein Domain Family
GT33_ALG1-like

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cd03816: GT33_ALG1-like 
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins
This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.
Statistics
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PSSM-Id: 340843
Aligned: 18 rows
Threshold Bit Score: 585.389
Created: 15-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P16661        36 STKKRIIiFVLGDVGHSPRICYHAISFSKl-GWQVELCGYVEDTLPkiissDPNITVHHMsnlk----rkgGGTSVIFMV 110 baker's yeast
XP_962115     37 GKGVVVHvLVLGDIGRSPRMTYHALSIAKh-GGKVSLIGYLETPPHpsllaSPSITIHALpppp---vrpaRIPFLLFAP 112 Neurospora cras...
XP_001249105  40 KASISVQiVVLGDIGHSPRMQYHAESVAKh-GGRVTIIGYQTSPPKpellsNPLVSIVALppppkmlqtknKVLFPLLAV 118 Coccidioides im...
XP_662950     42 EPKTTVQvLVLGDIGRSPRMQYHALSIARg-GGHVDIIGYSESEIHpdvssHPNISVVPIpphpsvlqtsnKVLFLFVAP 120 Aspergillus nid...
XP_001421765   1 MTKRRTAlVVLGDFGRSPRMQYHALSLARdaDRAVDVVCYSGTPPIda-lsREDAVTMRYvvgcr-wrwltRVPLALALG 78  Ostreococcus lu...
AAP49524       2 GKRGRACvVVLGDLGRSPRMQYHALSLARqaSFQVDIVAYGGSIPHeavlnHPSIHIHTMaqprf-iqyfpKILYPVTLL 80  thale cress
XP_504760     37 RKRKRTIvLVLGDLGRSPRMLYHARSLARs-GHKVDLCGYDGAKPFdeilnNDLIKIHHIplil----ntrKLPFVVFGI 111 Yarrowia lipoly...
XP_001482713  50 GNRKSIAiIVLGDLGHSPRMCYHSLSFSKl-NYYVSLCGYLQSEPSdeileDVNIDIKAIpmv-----enhGLPFLLFAI 123 Pichia guillier...
AAW41187      46 HLHHTATvLVLGDIGRSPRMMYHSESLARh-NWRTFMVGYAETPPTsalleNPMVHLLGLkepp---kmvgLLPWILRAP 121 Cryptococcus ne...
NP_983757     60 TKSRRIAiYVLGDLGHSPRICYHARSFSAa-GWEVELCGYLEEQPPkdlldDPRVTIRALpga------snAGKSLGQTA 132 Ashbya gossypii...
P16661       111 KKVLFQVLSIFkll--weLRGSDYILVQNPPSIPILPIAVLYKl---tGCKLIIDWHNLAYSILQLKFkgnFYHPLVLIS 185 baker's yeast
XP_962115    113 FKVLHQFVCLFall-sytLPPSQWLLVQNPPSIPTLLIASLVCrl--rSTKLLIDWHNYGWTILSSTRg--PRHPLVYIA 187 Neurospora cras...
XP_001249105 119 LKVLQQTWFLWsal-vyrSKPAQWMLIQNPPTVPTLVMAQLACwl--rNTRLIIDWHNFGYSILAMKLg--PRHPMVKFL 193 Coccidioides im...
XP_662950    121 LKVLFQVIALWwil-ayhTKPAKWLLIQNPPSIPTLAIASLVCff--rQTRLVIDWHNFGYTILALKLg--DTHPLVKVS 195 Aspergillus nid...
XP_001421765  79 TRVAAQCAHLFwil--mtMQRCEEMLIQNPPCVPTFLVCGIVCra--rRTRLVVDWHNFAYTLFGMKRg--DASATTRML 152 Ostreococcus lu...
AAP49524      81 LKAFIQFTMLLwfl-fvkVPAPDIFLVQNPPSVPTLIAVKWASsw--rRAAFVVDWHNFGYTLLALSLg--RNNLLVSLY 155 thale cress
XP_504760    112 LKVIRQHWLLIsll--ykLRGADYLLVQNPPSIPTLGVVRFYNlflstRTKVVLDWHNFGYTILALKLp--ETHPMVKFA 187 Yarrowia lipoly...
XP_001482713 124 EKICMQVVSLFsll--feLRGIDYIMIQNPPSMPLLLISIIFVklfsrNTKIIIDWHNLNYSILNLKYn-nENHPLVRFL 200 Pichia guillier...
AAW41187     122 IRIIYQVFSVIhtciwrvPCNTEILLVQNPPSIPTLALAQFICla--tKTKLIIDWHNTGYSILGLRVg--EGSRLVRIA 197 Cryptococcus ne...
NP_983757    133 RKVVLQTCHIVrql--weLRGCDYILIQNPPSIPLLPIVAIFKvl--tRTRLILDWHNFAYTVLQLRVg-rFLHPLVLVS 207 Ashbya gossypii...
P16661       186 YMVEMIFSKFAD-YNLTVTEAMRKYliqsfhlNPKRCAVLYDRPASQFQPLAGDISRqkaltt----------------- 247 baker's yeast
XP_962115    188 KLYECLFGRLGD-HNLTVTHAMARQlrlppyrIRGPITAVHDRPAEIFKPMWWGKARqdvler----------------- 249 Neurospora cras...
XP_001249105 194 RFHEMTACRFAT-AHFCVSKAMARMlqq-einLVAPILVLHDRPPELFQPIVREDEKfaflts----------------- 254 Coccidioides im...
XP_662950    196 KWYENVFCRSAV-AHFCVTNAMASVlkk-efdLQAPILPLHDRPASHFRPILDEQERksfll------------------ 255 Aspergillus nid...
XP_001421765 153 KWYERTQGKMWGdAHVCVTKAMGNFlek--ewKIEGARVVEDRAAERFREAAREATTpedal------------------ 212 Ostreococcus lu...
AAP49524     156 RWSENHYGKMAT-GSLCVTKAMQHEld---qnWGVRAKVLYDQPPEFFRPALLEERHelfcrvrkdlchpigvydfisre 231 thale cress
XP_504760    188 KFYEGFFGGRAF-VHLCVTVLMGQAmrktfgmSGRRIVPLHDRPAFHFKPLSESEKLdvl-------------------- 246 Yarrowia lipoly...
XP_001482713 201 KLYEMILGRFAF-YNLTVTKRMKRFlvsdfgmNSKKISTLHDRPASSFKPLQELETTkmdi------------------- 260 Pichia guillier...
AAW41187     198 KWFESTFGQTAY-AHLFVTKALQEFlir-ewdLKGRTSVLHDRPPTHFHRTVPMIQHelfsrllpelkpslpps----hl 271 Cryptococcus ne...
NP_983757    208 YAVEFLFSRMAD-YHITVTAAMKDYlvqsfllPARRIAVMYDRPGEQFRPLPAGERGaalae------------------ 268 Ashbya gossypii...
P16661       248 --------kafiknYIRDdfdtekgdkIIVTSTSFTPDEDIGILLGALKIYENSYVKFDssl------------pkILCF 307 baker's yeast
XP_962115    250 --------vlpaeqRDLVpsimegntkLIVSSTSWTRDEDFGILLDALVAYAADPVSETt---------------pVLAI 306 Neurospora cras...
XP_001249105 255 ---------lpetnNFVKayragrqceLLVSSTSWTPDEDFSIFLDALCQYSTHAATVDanl------------pdLYVV 313 Coccidioides im...
XP_662950    256 ---------slpeaAPMRrsieegntkVIVSSTSWTPDEDFSLLIDALCRYSEVSSTTKphl------------paVLAI 314 Aspergillus nid...
XP_001421765 213 ----------drflRGTHenmtknkprFIVSSTSWTPDEDFGVLLDAAVAYDARKRAKGdhask--------sypdIVII 274 Ostreococcus lu...
AAP49524     232 lenqelnetlfttkFNADislkqnrpaLVVSSTSWTPDENFGILLEAAVMYDRRVAARSkgsetaeiseeqhhypnLLFI 311 thale cress
XP_504760    247 -----------rdfKETLyddmtadhkIIVSSTSYTPDENFNILLDALALYDESKLDLPp----------------LRVI 299 Yarrowia lipoly...
XP_001482713 261 ----------lnshPLFQditgvdkykILVSSTSFTPDEDFNILLDALKYYDSSEKNEP-----------------LLLI 313 Pichia guillier...
AAW41187     272 dtndpthtafteisSEGLavlkhtrpaLIISSTSWTADEDFSLLITALDLYQSAVDSGSal-------------pkLVVL 338 Cryptococcus ne...
NP_983757    269 ---------pfirgYIPAgfdvqrgdtILVTSTSFTLDEDINVLFGALKIYESAAAKFDttl------------prILLF 327 Ashbya gossypii...
P16661       308 ITGKGPLKEKYMKqve----eydWKRCQIEFVWLSAEDYPKLLQLCDYGVSLHTSSSGLDLPMKILDMFGSGLPVIAMNY 383 baker's yeast
XP_962115    307 ITGKGPQKEMYLAqiaeltksgqLPNVSIVTAFLPFEDYAKLLACADLGVCLHMSSSGVDLPMKVVDMFGAGLPVAAFCG 386 Neurospora cras...
XP_001249105 314 ITGKGPLQRTYLRaiaaltaegkLRKIHIQCAWLTIQDYAKLLACSSLGVCLHTSSSGVDLPMKVVDMFGAGLPVVAWDR 393 Coccidioides im...
XP_662950    315 ITGKGPQRDIYVErisrlqkegkLSKVTICTAWLSTGDYARLLASASLGVSLHTSSSGVDLPMKVVDMFGSGLPVVGWSK 394 Aspergillus nid...
XP_001421765 275 ITGQGPRKTMYEKkin----elaLEHVAFRTVWLDAADYPRALANAHLGVSLHTSSSGLDLPMKIVDMFGASLPVAAMRY 350 Ostreococcus lu...
AAP49524     312 ITGKGPEKEMYEEkik----rlnLRHVAFRTMWLAAEDYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCSVSY 387 thale cress
XP_504760    300 ITGKGPMMPEFLAkve----klqLKRVSIRTAWLEFADYPRILGAAHLGVSLHESSSGYDLPMKVVDMFGCGIPVVSVDY 375 Yarrowia lipoly...
XP_001482713 314 VTGKGPLKQAFRErvkd---lrfLKKVIVKTAWLSVEDYPVVLAIADLGVSLHTSSSGIDLPMKIVDFFGCGIPVISLDF 390 Pichia guillier...
AAW41187     339 ITGKGALRAPFENivksr-eiskWKDITVRCVFVPAQEYPPLLGCADLGVSLHTSSSGKDLPMKVVDMFGCGVPVLAKDF 417 Cryptococcus ne...
NP_983757    328 VTGKGPLKGKYMEevr----nykWERCTIHFLWLSAEDYPRLLQLCDFGVSLHTSTSGLDLPMKVLDMFGSGLPAFVMDY 403 Ashbya gossypii...
P16661       384 P-VLDELVQHNVNGLKFVdRRELHESLIFAmkd-------------adlYQKLKKNVTQea-------enRWQSNWERTM 442 baker's yeast
XP_962115    387 YeSFGELVKEGVNGRGFEtYGELSIILKILlspe-----------gsgeLEVLRKGAVKeg-------arRWDEEWDAKV 448 Neurospora cras...
XP_001249105 394 YeAWPELITEGVDGKGFGsAEELSRHLIDLlged------------rsqLQWLRQGARNas-------krRWDDEWDPVA 454 Coccidioides im...
XP_662950    395 FrAWPELVTDGVNGKGFGsPSELAEQLVELlgn-------------penLNMLRAGAQDas-------afRWDDEWAPVA 454 Aspergillus nid...
XP_001421765 351 A-VIGELVQEGVNGVLFAdATELAAMFAKLlrgd-----------erltLRALKHGAAKwg-------eqTWDDHWKRCA 411 Ostreococcus lu...
AAP49524     388 S-CIQELVKDGKNGLLFSsSSELADQLLILfkgfp---------gncdaLMSLKAGAMEtgs------sgRWATEWEDCA 451 thale cress
XP_504760    376 A-ALSELVKTNTNGVAVKgHVEMGNTFMSLfsn-------------rgkLDNIKRGAMIes-------rnTWDQTWVKTV 434 Yarrowia lipoly...
XP_001482713 391 P-AIDELVKHDYNGVVVT-GKDQAKVICQHlehlf---------rdqekLNRLKNGAIEes-------htRWNENWNRVM 452 Pichia guillier...
AAW41187     418 Q-CISELVKDGENGKVFGtGEELGEQMIDIlssfpsseklddlkgyfdrMNTPRRRATLptadvgedewsNWDDNWDNVV 496 Cryptococcus ne...
NP_983757    404 P-AIGELVQDRVNGLRFTtRRELEQCLIFAikd-------------ehtRKVLKENALLes-------knRWHQSWASAM 462 Ashbya gossypii...
P16661       443 RDLK 446 baker's yeast
XP_962115    449 AKIM 452 Neurospora crassa OR74A
XP_001249105 455 GEFL 458 Coccidioides immitis RS
XP_662950    455 GKLF 458 Aspergillus nidulans FGSC A4
XP_001421765 412 LPVF 415 Ostreococcus lucimarinus CCE9901
AAP49524     452 KPLI 455 thale cress
XP_504760    435 GPLF 438 Yarrowia lipolytica CLIB122
XP_001482713 453 KPRF 456 Pichia guilliermondii ATCC 6260
AAW41187     497 YNGI 500 Cryptococcus neoformans var. neoformans JEC21
NP_983757    463 SELQ 466 Ashbya gossypii ATCC 10895
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