1O94,1EFP,1T9G,4KPU,5OL2,5OW0,6FAH,7KOE,7QH2


Conserved Protein Domain Family
ETF_beta
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cd01714: ETF_beta 
electron transfer flavoprotein (ETF) beta
The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is a heterodimer, consisting of an alpha and a beta subunit, which binds one molecule of FAD per dimer. A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit is distantly related to and forms a heterodimer with the alpha subunit.
Links
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Statistics
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PSSM-Id: 467487
Aligned: 67 rows
Threshold Bit Score: 179.268
Created: 2-Nov-2004
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 33 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:interface with ETF alpha subunit
  • Structure:1O94: Methylophilus methylotrophus electron transfer flavoprotein alpha/beta-subunit interface, contacts at 4A
  • Structure:1T9G: Homo sapiens electron transfer flavoprotein alpha/beta-subunit interface, contacts at 4A
  • Structure:6FAH: Acetobacterium woodii ETF FixA/FixB subunit interface; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # #                ##                                                 
1O94_C         1 MKILVAVKQTAALEedfei-----redgMDVDEDFMMYDLNe--WDDFSLEEAMKIKESsdt-dvEVVVVSVGPd----- 67  Methylophilus m...
5OW0_B         1 XQIVVLAKVVPDYEvpsad-----felvGNRAHPRYTRXIGl--YDENAVELGVQLKEKlg---aDLTVVSYGRn----- 65 
Q46908         1 MNILLAFKAEPDAGmlaekewqaaaqgkSGPDISLLRSLLGadeQAAAALLLAQRKNGTp----mSLTALSMGDe----- 71  Escherichia coli
AAD37460      18 LRIVVCVKYVPDATgdrr------faddLTLDREDVDGLLSe--LDEYAVEQALQIADGad--daEITVVTVGPe----- 82  Streptomyces gr...
P60566         1 MKIITCYKCVPDEQdiav------nnadGSLDFSKADAKISq--YDLNAIEAACQLKQQaa--eaQVTALSVGGka---- 66  Escherichia coli
WP_009990241   1 MNIIVGFKIVPDDQmik---------vvGDKLNTDAPLKVSt--YDKNAIEEAIRLKEKfg---gKVTGITVGN------ 60 
WP_010865514   2 PDIAVLVKASLNPDmari-------gpdDSVDLNSIPLKISd--IDRNAVEEAVKLKEKlggklyAVSVLTWGPvkl--- 69 
WP_011009491   1 MKIAVLVKTALDTGqlr---------irDSVVIEETPLKISd--IDRNAVEEAVKLKGQdk--ayAVTVLKWGPlqk--- 64 
WP_012308881   1 MEVVVCVKLAYDETqip--------iegDKLLLEKAPVKVSd--IDKNAIEEAVRIKEKfgg-svTVISVVTGP------ 63 
WP_012309680   1 MDIAVLVKQSLDVQqlai------dsrtGKIYLDEAPTKAGd--IELNAAEEAVRIKEKvg---gKAVAIMLSYfgssgr 69 

Feature 1                                         #                          #######  ##  ## ####
1O94_C        68 ---RVDESLRKCLAKGADRAVRVWDDaaegSDAIVVGRILTEVIKKEa--PDMVFAGVQSSDQAYASTGISVASYLNWPH 142 Methylophilus m...
5OW0_B        66 ---DDVQFLRKALAXGADKVVLVEGDs---DDPYVIAANLKDAIDRQg-tVDLILAGRQSSDXDRGVVPGVLAGXLDLPF 138
Q46908        72 ---RALHWLRYLMALGFEEAVLLETAadlrFAPEFVARHIAEWQHQNp--LDLIITGCQSSEGQNGQTPFLLAEMLGWPC 146 Escherichia coli
AAD37460      83 ---DAKDALRKALSMGADKAVHVEDDdlhgSDVMGTSLVLAKAVEKAg--YDLVICGMASTDGVMGVLPALLAERLGVPQ 157 Streptomyces gr...
P60566        67 --lTNAKGRKDVLSRGPDELIVVIDDqfeqALPQQTASALAAAAQKAg--FDLILCGDGSSDLYAQQVGLLVGEILNIPA 142 Escherichia coli
WP_009990241  61 ---NDRKSIREALAMGVDEVIAILVKd---PDVYVTAMAIAENVKTLn--PDIILFSEMTTDSGTSALPAYVSELLGLPY 132
WP_010865514  70 rnkDLRLAVQEALAKGVDEAIVVADDeltpGDQTTTAKAIKAALEKHgvkPELILAGEATIDEVTSQVPGRLASLLGYKY 149
WP_011009491  65 kvqEAENVLREALAMGLDEAYLIADEkllnASHVATAKAIAAVVKKIg--ADLVLAGEATVDNYTGQIPARVAAELGWPV 142
WP_012308881  64 ---YDETILNEALAMGADKAFIVEGIg--gTNPARTAKAIAEVIRKMgikYDLILCGEGSSDQYSCAVAPMLAEYLSIPS 138
WP_012309680  70 rlkEAREALTRLLAMGIDEALLLLSNq--yMDTYSAAKLLSEEIRGK---YQLVLAGEGSEDNFSGVLPARVAAELGWPY 144

Feature 1         ##               ###    ####### #                                           
1O94_C       143 AAVVADLQykpGDNKAVIRREleGGMLQEVEI-NCPAVLTIQlgINKPRYAs--LRGIKQAaTKPIEEVSLADIGLS 216 Methylophilus meth...
5OW0_B       139 VPQACSVEs--VDGGWKISQIt-ETGKRLLKLsGKGVLSITSvpENVPRIPa--VKAIFAAkKKPVEKLPEIGTGKX 210
Q46908       147 FTQVERFTl--DALFITLEQRt-EHGLRCCRV-RLPAVIAVRq-CGEVALPvpgMRQRMAAgKAEIIRKTVAAEMPA 218 Escherichia coli
AAD37460     158 VTLLSEVAv--DGGVVTGRRDg-DTASEQLEA-SLPAVVSVTdqSGEARYPs--FKGIMAAkKKPVESLDLDDLGLD 228 Streptomyces grise...
P60566       143 VNGVSKIIs-lTADTLTVEREl-EDETETLSI-PLPAVVAVStdINSPQIPs--MKAILGAaKKPVQVWSAADIGFN 214 Escherichia coli
WP_009990241 133 ISNVKSLKi--EGNKVVADRGm-VSYLETVES-SLPIIVSVGgeINTPRIPs--VKQIMESsKKPVKEVKFDAQSKV 203
WP_010865514 150 LSFVRKLDv--DNGRIIAERDl-EDYIEVVEA-SLPAVVSVTqeINEPRPPt--LLQIRRAaRKPVKEYSASELENV 220
WP_011009491 143 ITYVRELKv--EGGKIIAKRDl-EDHVEVVEA-PLPSVVSVTreINQPRIPt--LLAIRAAmKKPVNKLTLADLGLD 213
WP_012308881 139 ITFAGKLEi--EGNVIRGERLl-ETGYELVET-ELPAVVSVTseINEPRIPs--VLQIMKAgKKEKISVKSSDLNLE 209
WP_012309680 145 LSYATSIEv--NGDEIKVTRSl-EDYDEVVSL-KLPAVISVTqeINQPRIPt--VLHIMKAsKKPIVQKEVQATVEP 215

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