3HM5


Conserved Protein Domain Family
SANT_DAMP1_like

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pfam16282: SANT_DAMP1_like 
SANT/Myb-like domain of DAMP1
This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structual similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA binding site.
Statistics
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PSSM-Id: 465084
Aligned: 103 rows
Threshold Bit Score: 104.861
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3HM5_A         5 YPFARFNKTVQVPVYSEQEYQLYLHd-----------DA----WTKAETDHLFDLSRRFDLRFVVIHDRYDHQQ------ 63 
XP_003344892 128 SSFAKFNVRVSVPQYSEDQYNTNLKh-----------PD----WTKEETDYLLELAKDFDLRWPIIWDRYEYAPqqpege 192
SZF05769     121 STFVKFNVKPKIPKYDGNIYDLKLQh-----------PD----WTKQETDYLFSLVDDYDLRWPIIWDRYAYEPpsaets 185
ESW97176     108 YNFAKYNTSLDIPSFSKEEYDEKLK-------------DlsedWTFEETKFLFDLAKDYDLRWAVVYDRYEFHN------ 168
Q752S6       108 SSFAKYDQKLTLPEFTEGEYQEFMAqaa------kgaNSdaptWSYEEVQYLFDLCRRYDLRWHIVYDRYMY-------- 173 Eremothecium go...
XP_003644484 108 NTFSKYNQKLTIPEFSKEDYEEFMSgshdkasskesgDDtiqvWEYDEVKYLFDLCKKYDLRWYIIYDNYSY-------- 179
XP_002553847 107 SSFSKYNTKLTIPAFSEEEYLSFMGytt-------pgSNplkeWDYEEVQHLFDLCRKYDLRWFIIQDRYEG-------- 171
Q6CSS3       110 SSFAKFNQHLTIPSFDEQEFQQFMN-------------GnnseWKYGEVQYLFDLCRNYDMKWFVIADRFNYN------- 169 Kluyveromyces l...
CCD27406     117 SKFAKFNTHLSIPSFTREEYASFMNlkdn-----nesADasstWAFEEVIYLFDLCKLYDIRWFIINDRYLFVDsn---- 187
CCC67084     114 SNFTKYDIHLSIPEFSEEEYNSFMNpqtkstesnetdNKpehkWSYVEILYLFGLCRRYDLSWFVIYDRYNF-------- 185
3HM5_A        64 ----------FKKRSVEDLKERYYHICAKLA 84 
XP_003344892 193 ipdgmavvpaPKPRTMEDLKARYYEVAAKMM 223
SZF05769     186 qe-ncsdtpkPTTRTMEDLKDRYYKVASEMM 215
ESW97176     169 ----------DKHRSLEDLKERLYSVSAKLL 189
Q752S6       174 ----------DESRTMEDIREMFYTVCQKYF 194 Eremothecium gossypii ATCC 10895
XP_003644484 180 ----------DEKRTLEDLKEAFYKVCKAYF 200
XP_002553847 172 ----------KLFGTLEDLKDAFYTVCHRYF 192
Q6CSS3       170 ----------GTERKLDDLKEMFYTVCQWYF 190 Kluyveromyces lactis NRRL Y-1140
CCD27406     188 --------gkRSDRSVEDLKEMFYKVSKNYF 210
CCC67084     186 ----------GEEKSLEDLKEMFYEVCRKYF 206
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