Conserved Protein Domain Family
Ureidogly_lyase
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pfam04115: Ureidogly_lyase 
Ureidoglycolate lyase
Ureidoglycolate lyase (EC:4.3.2.3) is one of the enzymes that acts upon ureidoglycolate, an intermediate of purine catabolism, releasing urea. The enzyme has in the past been wrongly assigned to EC:3.5.3.19, enzymes which release ammonia from ureidoglycolate.
Links
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Statistics
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PSSM-Id: 427721
Aligned: 42 rows
Threshold Bit Score: 161.615
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0U7M7         9 SIRIPIELLTPTAFAQFGVIVENpTtslsa---klpiPQRipp--peSVNANQGSATKYLDVSHMSNLYsla-pskKPAR 82  Parastagonospor...
O13843         3 AKKIYAQALTDEAFAPFGSVVQQkD------------DVK-------MVSANGGTAKKYLKVSESIQNYeks-ssaSTRK 62  Schizosaccharom...
Q74ZI4        14 PPMIVPVPITAAAFEPYGSLMSH--------------SDQlag--caARNANQGTAVKVHAGTTRCLLGs------AVRE 71  Eremothecium go...
Q6CLX4         1 MQCIPVVPLSITAFEEFGSIVSPdE------------EVRrld--ssQKNANQGTAIKLLQVSHIENQFpq---slKVKN 63  Kluyveromyces l...
Q6BHQ1        11 IGTVIAEPLTPEAFAPYGGVISA-D------------HQIks---vtSTAANYGTAVKIHKVAPIVNNFkdc-psgKEAT 73  Debaryomyces ha...
XP_001383536  11 IPAITAEPLTPEAFAPFGGVISA--------------DHQien--aaSSSANYGTATKIHKVAPIVNNYdkc-psgVVAT 73 
Q6C2M0        10 TRSVFVKPLTIDNFAPFGGVMSL--------------EHQqr---peDVGANYGTATKIKDVSPVTNNFaya-pskQPAR 71  Yarrowia lipoly...
Q5BDA0        11 SLSITPEPLTRDAFAPFGTAVIPpLprsvttapnplsSHPkhplvtfPVAANQLSALKYSPISPLINNYpsqcpsnQPSE 90  Aspergillus nid...
Q7RW83        13 dmVVDAVPLELEAFKPFGDAVANpQpnlhpamaakanD-Tagm-pfdAIVANQGTAIKYQHVSRIENLYdqa-psgRTGV 89  Neurospora crassa
KIS70774     418 DKFVAAVALTTDAFSRYGAVIDGp-------------SVHnaddakaFKIVNQGTAKKYLNLAEIINNYpt----qAAAK 480

Q0U7M7        83 AVMNMFVC-APRELRphepsesmpsswgdleldddddlggnfrrqlLDVGILERHPFTTQTFVPMGLsPAekh--tqYLV 159 Parastagonospor...
O13843        63 GVWNFFST-HPSVHPande------------------------haaFQISVLERHPFTTQTFIPMCRsSDeq----aYLI 113 Schizosaccharom...
Q74ZI4        72 PAWHLFRSfVPPQLRcalatsp------------------tphvlrHPVPVLEQHPFTSQTFVPIGQgSGp-----vYIV 128 Eremothecium go...
Q6CLX4        64 PSCNLFRC-FPKGALqkrfalvds--------------dgslkkyqHEIKVLEKHPFSTQTFIPMGRdIKsg---yaYLV 125 Kluyveromyces l...
Q6BHQ1        74 ANWNIFRCsFPKNSIvteak----------------------nelvYKAKVLERHPFSTQTFIPMGL-ELsr---nsYLV 127 Debaryomyces ha...
XP_001383536  74 ANWNIFRCtAPKHLIsdyg-----------------------tykrYTSKVLERHPFSTQTFLPMGQdLHkv----sYLV 126
Q6C2M0        72 SIWYGFRC-SPPNHLtstkn----------------------sqstYTCKVLERHPFSTQTFVPMGRnKDdq----aYLV 124 Yarrowia lipoly...
Q5BDA0        91 ARMSMFSC-FPRTLRavtstgegk--------------vggaqkvvFDVGILERHPYTSQTFSPLGLsSDdks--ayYLV 153 Aspergillus nid...
Q7RW83        90 AVSNMFTC-ASRALPrrleag--------------------verevFPVTVLERHPFTSQTFVPLRA-DPqs----rYLV 143 Neurospora crassa
KIS70774     481 TNIHVYRCdAAASLP-------------------------------FQVKLLERHRFTTQAFIPM---VPiggkqqgFLV 526

Q0U7M7       160 IVAP--TLpasasrrntgrpppyptphverkkslkdifararpspystestpppssfsrlpasarpkgpglPDLKNLRAF 237 Parastagonospor...
O13843       114 AVAPnaPDg-------------------------------------------------------------mPDWNQTQAF 132 Schizosaccharom...
Q74ZI4       129 VVARpsARg-------------------------------------------------------------ePDLLTLRAF 147 Eremothecium go...
Q6CLX4       126 VTALpdKNg-------------------------------------------------------------ePDLLTLQAF 144 Kluyveromyces l...
Q6BHQ1       128 IVAK--SDkdtl-------------------------------------------------------ptslPEPSSVRAF 150 Debaryomyces ha...
XP_001383536 127 IVAAndPHsga---------------------------------------------------------qvlPDPSTVRAF 149
Q6C2M0       125 IVAKtgTDg-------------------------------------------------------------lPDVNTLEAF 143 Yarrowia lipoly...
Q5BDA0       154 IVAP--TLlgqtatarte-------------------------------------------agesvsirdpPNLSKLRAF 188 Aspergillus nid...
Q7RW83       144 VVAP--NLspsaqdqqlpvpssr---------------------------------ppgtianrelpgrglPDLKGLRAF 188 Neurospora crassa
KIS70774     527 VVAQ--NGqd-----------------------------------------------------------drPDLNTLAVF 545

Q0U7M7       238 VANGAQAVTYGAGTWHAPMIVIGd--RPIDFVVVqf---aNDVgLE-----DCQEILLKPnHSAAE 293 Parastagonospora nodorum SN15
O13843       133 VAKGAQGVTYSAGVWHAPMVTIG---KETMLAAFny---eNGVaED-----DCQVQSTES-PIEVF 186 Schizosaccharomyces pombe 972h-
Q74ZI4       148 VCAGTHAVTYAPGVWHAPMIAAAp-qDYVDFLSLthvlddPQQpEA-----DCVEHSYTPdPLQLA 207 Eremothecium gossypii
Q6CLX4       145 LCKSNQAVTYGAGVWHAPMIVVGe-eEYLDFTVIinelhdHNQlQY-----DLEERFYDS-QLSLN 203 Kluyveromyces lactis
Q6BHQ1       151 ICKGNQSITYGQGIWHAPMVVIDedpPHIDFAVLi----hENG-VDn---eDVEECYFEP-GFNIK 207 Debaryomyces hansenii
XP_001383536 150 VCKGNQSVTYGAGTWHAPMVVIDeetAHIDFAVFih---eNGVaDE-----DCQECYFKP-GFSIN 206
Q6C2M0       144 EARGDQAVTYGVATWHAPMVVLH---KPIDFGVFih---eNSVpEE-----NCQEVYFEP-GVNVE 197 Yarrowia lipolytica
Q5BDA0       189 VASGEHAVTYGPGTWHAPMVVVGe--CKVDFVVTqf---vNGVaAE-----DCQEVCFGE-GIVVD 243 Aspergillus nidulans
Q7RW83       189 IATTDQAVTYGAGTWHSPMVALGpadKAIDFFVFqf---aNEVsVE-----DCQEVLFGPsTitvr 246 Neurospora crassa
KIS70774     546 LATTEQAIQYHAGIWHHPMIALGd--QPTDFACI------VNE-SAtqpqlDCDE---------VE 593
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