Conserved Protein Domain Family
SUR7
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pfam06687: SUR7 
SUR7/PalI family
This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.
Links
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Statistics
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PSSM-Id: 399580
Aligned: 93 rows
Threshold Bit Score: 53.1047
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001526385   6 FRAIIIFFSLACLILSCFAIAGSYkNANYLT-STYLINFHLDgldlrqiistsigsgsrkikradttatatatvstgttf 84 
Q59WV0         4 AFIALLILLIVCWVIQLLPVIAVP-FTTPDA-NIYLSYYNNY-------------------------------------- 43  Candida albican...
XP_001523872   4 SLLALLVLCLICWIIQLLPVISVP--LTPLSsKIYLSCFENF-------------------------------------- 43 
EDO15727       3 rfsLMMSVAILMTISLVFHIIPNI--TTPVIdHLMLSQLDGI-------------------------------------- 42 
Q6FU42         3 lfdLRTLLAILVSICVVFQAFPLA--TVPLNkNLILGQYMGY-------------------------------------- 42  [Candida] glabr...
EDN64452       5 IHIVVFLLAITTI----FEILPLI--TVPVTkYLSLSSFRNH-------------------------------------- 40 
Q759Y2         5 MSVVEWLLLGSTTLALLFQSFATF--SVPLSnGVTLSHFNGY-------------------------------------- 44  Eremothecium go...
Q6CUG3         1 -mlVKIVLVVLLTLALVFECFSTI--SVPITiGLYISEYNGY-------------------------------------- 39  Kluyveromyces l...
Q6CXZ7         1 mshFKIVFLTSLSLALVFELFNTI--SVPITsHLFISEYNGY-------------------------------------- 40  Kluyveromyces l...
O74472         5 SATPSLILLVIAIV---FFVLAIC--TPPLAnNLTLGKYGDV-------------------------------------- 41  Schizosaccharom...

XP_001526385  85 stssntglattvasqveawanaasgltsssttdasdiisaiadvldnlsalelgladvySTSFWGYCrgektgnsttatt 164
Q59WV0        44 -----------------------------------------------------------KFGVFGIC------------- 51  Candida albican...
XP_001523872  44 -----------------------------------------------------------TFGVFGIC------------- 51 
EDO15727      43 -----------------------------------------------------------QFGVFGWC------------- 50 
Q6FU42        43 -----------------------------------------------------------HFGVFGWC------------- 50  [Candida] glabr...
EDN64452      41 -----------------------------------------------------------YYGLFGWC------------- 48 
Q759Y2        45 -----------------------------------------------------------KFGVFGWC------------- 52  Eremothecium go...
Q6CUG3        40 -----------------------------------------------------------RFGVFGWC------------- 47  Kluyveromyces l...
Q6CXZ7        41 -----------------------------------------------------------KFGVFGWC------------- 48  Kluyveromyces l...
O74472        42 -----------------------------------------------------------RFGVFGYC------------- 49  Schizosaccharom...

XP_001526385 165 sssssssstssssnssvlkwmdnnfDNSDVNYTWCSA-P-KVGfFFDpve--ilkEELNRTIDGKsvdsqsddisqlsqt 240
Q59WV0        52 ----------------------------NVERHICSK-P-SIGyPSTnstfyaydNDESFGTGGIv-------------- 87  Candida albican...
XP_001523872  52 ----------------------------DERSGKCSD-A-RIGyPSSnssnfvlqDNYDGVV------------------ 83 
EDO15727      51 --------------------------NTKGHSMGCSGlSiGYRyPQS--------SLLALKFR----------------- 79 
Q6FU42        51 -------------------------FVDKGVTIACHC-------KFRpd----siETYKYTDQLL--------------- 79  [Candida] glabr...
EDN64452      49 -------------------------VRGQNQELMCTK-M-KIGy-----------DSTDVDSSGHvl------------- 77 
Q759Y2        53 ----------------------------DTTHTHCTP-L-KLGySAE--------DGFLFAGQDEl-------------- 80  Eremothecium go...
Q6CUG3        48 ----------------------------KVDRSVCSP-I-RIGySKD--------DILLFNEQEYl-------------- 75  Kluyveromyces l...
Q6CXZ7        49 ----------------------------KVDGSICSP-I-RMGySLD--------DILLFNDNEYl-------------- 76  Kluyveromyces l...
O74472        50 ------------------------------LNSNCSK-P-LVGy--N--------SDYLDEHA----------------- 70  Schizosaccharom...

XP_001526385 241 ykselkqlidnlslldlnLPGNLQNDLKTLNNLTKAGFALMIITSVLSFI--SIVV--QLMGC-Cvsp------------ 303
Q59WV0        88 ------------------LPSDVRYTISK-------LLVVHVVAFCFSSL--LLIVifGLIII-Lffkyiktkkdlegiq 139 Candida albican...
XP_001523872  84 ------------------LPSDVKYTISK-------LLVVHVVAFCFSSLlmTVIC--LLFALeSvdrw----------- 125
EDO15727      80 ------------------LPSGIRYSVTRL-------LVVHPIALVFVFV--LWLM--SLCLF-Iekl------------ 117
Q6FU42        80 ------------------FPSLYKVTIST-------LLVVHPVSFAFTCI--LWIM--ALIIR-Lsrf------------ 117 [Candida] glabr...
EDN64452      78 -----------------tLPSNSKVVVSNL-------LVVHPISLAFTGT--LLIL--AVIIM-Vtpl------------ 116
Q759Y2        81 -----------------sLPTQAKYSLSKL-------LVVHPLALCSMVV--LWLM--VVLSQ-Cyk------------- 118 Eremothecium go...
Q6CUG3        76 -----------------hLPNHAKYALSN-------LLLVHVLAFVCVTI--LWVF--GMLTC-Frci------------ 114 Kluyveromyces l...
Q6CXZ7        77 -----------------hLPNHAKYALSK-------LLLVHVLSFVCVLV--FWLF--AILIC-Ikwl------------ 115 Kluyveromyces l...
O74472        71 -------------------KDGFRTSVI-VRQRASYGLVIVPVSACICLI--STIM--TIFAH-Igai------------ 113 Schizosaccharom...

XP_001526385 304 ---------------------------dnCC---------------------------LSFLNFMLQVLVFLAAIIGAGL 329
Q59WV0       140 lndssheitihsdeednnnnnidntnhnnKRasvtink-------------tifdltpFLNLMLVFTFFSVLTTLLAFLA 206 Candida albican...
XP_001523872 126 --------------------------ryqMKprqeieseeereereqreenekrdltpYLNMMLILTIMSVLTTLLAFLA 179
EDO15727     118 --------------------------gtsTS---------------------------YTLGVALLSLPTFLMSLLAFLV 144
Q6FU42       118 ---------------------------grCPi--------------------------FILSAATWSLAAFLLALLSALV 144 [Candida] glabr...
EDN64452     117 ---------------------------gdSPe--------------------------MLLFTALFSLPTFMLCLLCFLV 143
Q759Y2       119 ---------------------------hsDR---------------------------RLTIIILWSFLTYMETLLCFLV 144 Eremothecium go...
Q6CUG3       115 ---------------------------ktSRr--------------------------MLIIAVLWSMLTFMVTLLGFLI 141 Kluyveromyces l...
Q6CXZ7       116 ---------------------------ntSKs--------------------------VLLFAVGWSMVTFMVSLLGFLI 142 Kluyveromyces l...
O74472       114 ---------------------------arSPg--------------------------FFNVIGTITFFNIFITAIAFVI 140 Schizosaccharom...

XP_001526385 330 VTGCYVFVRkqinnnlsefgiksfLSINFYAfaFSAAVAALLVVIF 375
Q59WV0       207 DILLFT------------------PNLSYLG--WLQLIPIVSMALV 232 Candida albicans SC5314
XP_001523872 180 DILLFT------------------PNLSYLG--WIQLIPIISMALI 205
EDO15727     145 DLLLFV------------------PTVCWPA--WMVLIVTIFIAIC 170
Q6FU42       145 DLLLFV------------------NKLKWPG--WLVLASVPLMAIC 170 [Candida] glabrata CBS 138
EDN64452     144 DILLFISKL------------------DWPG--WLMLAATISVALC 169
Q759Y2       145 DVLLFV------------------PYLDWPG--WLMLVSAVLVVFS 170 Eremothecium gossypii ATCC 10895
Q6CUG3       142 DILIFS------------------SHVTWCT--WLTLASAFFTVLS 167 Kluyveromyces lactis NRRL Y-1140
Q6CXZ7       143 DVLMFA------------------SHVTWSS--WLMLVSAFFVALS 168 Kluyveromyces lactis NRRL Y-1140
O74472       141 CVITFV------------------PHIQWPS--WLVLANVGIQLIV 166 Schizosaccharomyces pombe 972h-
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