2VEQ,2QUQ


Conserved Protein Domain Family
fungal_TF_MHR

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cd12148: fungal_TF_MHR 
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fungal transcription factor regulatory middle homology region
This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.
Links
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Statistics
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PSSM-Id: 213391
Aligned: 2168 rows
Threshold Bit Score: 36.2685
Created: 6-Sep-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2VEQ_A     63 LQKDQSFQLMNFAMENLGALYfgs-----------------igDISELYLRVEqywdrradk--------nhsvdgkyWD 117  baker's yeast
EAA60634  167 PALQKLIPTKEQTAEMLVCTYdwlqmvhamlp-qpsvpssrqeILDRYEEMCGpg----------------------vDI 223  Aspergillus nidul...
CAP81126  187 PPLEDMNKIVNASFHCLVWKDhfpel------------fdrhaDRLVFNENCRdnlvapae---------vakvlmclSI 245  Penicillium chrys...
CAP93696  168 EPPEELSIPKDLAQQLIDYYYsfshfegf-------kipleksFLASIPDLLKiphvq---------------ldctcQI 225  Penicillium chrys...
EED14840  215 PPRGDLRRIRDLAANWWSVWHymfpevpe-------pdrstlmGERDYFEIPKspg-------------------evaKF 268  Talaromyces stipi...
EEU48915  149 PTDLAKTWVENYFEHMPACMFlglf---------------errVIQMIPDIIDl------------------------PH 189  Nectria haematoco...
EGU80153  187 PSAEDMKIIMSVPVESSQIIRamtcap----------pkergsRLPSPSSLLRlppr-----------------gahpVL 239  Fusarium oxysporu...
EGX88874  128 PSQPELDRIVASQACTALLLNgivcepy---------eghldtHTACLGQATQrpdpa----------------tahpAL 182  Cordyceps militar...
EHA24739  258 PHPNTTALILTKGRFFSLPFEtcrsplr--------dqsavcsGLEQSGDVFRlpystsh------------piqfaqKL 317  Aspergillus niger...
GAA89144   80 KCIQAIEVAMREISELDNVETekpkasptitketahkwielyyDTYQFEGFRIpfekefilslpdllhnphvhldptiRI 159  Aspergillus kawac...
2VEQ_A    118 ALIWSVFTMCIYYmpveklaeifsvyplheylgsnkrlnwedgmqlvmCQNFARCSLFQLKQCDFmah----pdIRLVQA 193  baker's yeast
EAA60634  224 IALASWLLTLAITaqqvpqggespds----------pskgyhrridfaRTVSDAVESLVLAHDRLvg------tFQGLGM 287  Aspergillus nidul...
CAP81126  246 SAVHAPSEFDFNTltvpf-------------------------kpqkfSDQCIEMVDRLIVRDDNfa-----atLPGIEC 295  Penicillium chrys...
CAP93696  226 IYHTVLLQGMVTKpealprr---------------------gtlirilYQKCVSLSEDWLKNVKDt-------pADFFAA 277  Penicillium chrys...
EED14840  269 LLCHLMCIDQLPAdfdynsle-------------------rpivpneyGDDCVNAIDRLIINDEDlc-----gtLPSLEA 324  Talaromyces stipi...
EEU48915  190 IHVDPVILVIYYTvmyhgcslk------------------asntsvvgIDYMNASYLGCLRAIPLwereasgsiTDLLAA 251  Nectria haematoco...
EGU80153  240 VARKMLVLATFLQgtlissekhle--------------klstsyenimARIVKVAHDHVTCNDDLis------sLEGIEC 299  Fusarium oxysporu...
EGX88874  183 VARNAMLLVTLLDslppaas---------------------arstalqDRLYAAAARLVAAGHEHma------sLHGLES 235  Cordyceps militar...
EHA24739  318 IQLALGLQQLDLAsclhpqlq--------------------leqkwstGDSARRYVDLAVSHVTSqdal--vdsLDGLDT 375  Aspergillus niger...
GAA89144  160 VYYNVLFQGFLVDpdpyhn------------------------rgaivEFLCRSCMDLTESWLARikd----tpADLFAA 211  Aspergillus kawac...
2VEQ_A    194 YLILAtttfpyDEPLLANSLLTQCIHTFKNFHVDDfrpllnd------------dpvesiAKVTLGRIFYRLCGCDYlqs 261  baker's yeast
EAA60634  288 CIHFIrlqmgrGNAQKGWLKLRHLIALAELMGLPKavqlarikk--------pngpaeeaERNEKMQLWNLICTVDRlsg 359  Aspergillus nidul...
CAP81126  296 QMLLHrvhltdGRLRKAWLVIRRAIEFAHLAGMHLstkvp---------------rpgdsLYQRRLKIWCSLATSDRfls 360  Penicillium chrys...
CAP93696  278 LTLMSlfl-ecCNIDLSWKALAQACRISKALGYFSvdetpsegdnqlstepgslphqaevERNRKRFEFWHILRTDClfr 356  Penicillium chrys...
EED14840  325 ILLLSkwytslGRPRKAWLMTRRGIELAQLAGLHIstardp--------------hpedtLYNRRLKLWTMLGLNDRflc 390  Talaromyces stipi...
EEU48915  252 LCVTRvaa-efFDYDLAWRMFKHACESCQALNLHNldgddad------------atflgdKCDDERRGFWEVIQIDLffr 318  Nectria haematoco...
EGU80153  300 IMLEGlyenyaGNLRRSWLAARRAVMIAQVLGLNKgivpp----------------svrgATVEPGDLWFRVINLDRylc 363  Fusarium oxysporu...
EGX88874  236 HLMETaylatrGNLRRAWLVNRRGMSLAQLAGLPTsa---------------------atAAARSDYVWFRLVCSDRhls 294  Cordyceps militar...
EHA24739  376 LLLQAryhlnsGELRSAWLIFRRALSIAQLIGLPSrn---------------------eqAGSRAESLWVQLVYNDRfls 434  Aspergillus niger...
GAA89144  212 FFMMSmsl-eaCNSELSWRIVAESVKISRALGYFSvdadqptpgqqivrpggppnpeseiEKNRMRFEFWHLLRTDCvfr 290  Aspergillus kawac...
2VEQ_A    262 -gpRKPIALHTEVSSllqhaaylqdlpnvdvyREENSTEVLYWKIISLDRDLDQYLNkssk-----------------pp 323  baker's yeast
EAA60634  360 lliNLPPYTRRYQLRnade----------livNGVVQASVYMNRLMDVSPKIHDLEDlsaseg------------pttkl 417  Aspergillus nidul...
CAP81126  361 lilGLPYGISDQFFLpqm------------eqRLNSNLSAPEEYVSRIGIITGHMVDrnqdp--------------skmt 414  Penicillium chrys...
CAP93696  357 mcfGKPTLIPAGSWKvnf------------pdPTINGIDHESSRFIQIHFIASMRLAlivmkyldwv-----degkdpdp 419  Penicillium chrys...
EED14840  391 lilGLPYGIQENIYRpq-------------veRRLRTESPNMESYCLQLSLIMGPIIdrnqqd------------panms 445  Talaromyces stipi...
EEU48915  319 lvlNTPPAITNNPWKvn-------------lpWLDADSGPPLQGIQSTAFLASSRVSlviarffamld--dpknttkpei 383  Nectria haematoco...
EGU80153  364 lmlGLPQSAPDEPVGn----------------LDALDSYSANRKMQHLCSIACARLLsrrts--------------gifd 413  Fusarium oxysporu...
EGX88874  295 lllGLPQATTENAFAt----------------PAALEALPPLERFERIMVVACSLILqrngag-------------qagd 345  Cordyceps militar...
EHA24739  435 lmlGLPCAVKDLELLn----------------WQALDTYPPLRKLYRIHSVIAARIIvrnvrlqhcnllsqrqldttydh 498  Aspergillus niger...
GAA89144  291 lsfGKPALITDGSWTvnf------------pdPSITGVDHASTRFIQIHFFASMRLTlvlikyldlv-----dsepdvdt 353  Aspergillus kawac...
2VEQ_A    324 lKTLDAIRRELDIFQYkvdsleed-----------------frsnnsrfQKFIALFQISTVSWKLFKmyliy-------- 378  baker's yeast
EAA60634  418 yTSALEIIREARDLASqtpsswwaidt------------tndlrpdhivQFMHYCLVMKAHLPVALRqdr---------- 475  Aspergillus nidul...
CAP81126  415 lEATLRLDQELQDSWEsmpshfqaaepch-------yekrehyiervplQFMLKLLRAFLHLPLMLQsph---------- 477  Penicillium chrys...
CAP93696  420 vSHDATIDSFIDEVQLilsdwdaegllqm-------atnhvdmwfcvdvLLSTYKMLIVLYQSKKCN------------- 479  Penicillium chrys...
EED14840  446 iAETLKVEQEMETQARsmpdhfwqeqpprh------kmstdeavervmlPFMFHYMRATLHLPFMLQshg---------- 509  Talaromyces stipi...
EEU48915  384 mAKTEELCLEMQQIFDewqlnewmadap---------ekeqdiwvvvdvLFTGYTSIIYMFRKMSLLd------------ 442  Nectria haematoco...
EGU80153  414 qSLTREIDKLLRDACTsmpaqwwimpnlssh---yeladkiretlrfndHFMQYHLLLQLHMPYLLKveg---------- 480  Fusarium oxysporu...
EGX88874  346 lDTTYEIDTTLQRAAAmltpqwwlvtpptlarlegsgaaafyettrlmnQFMYHHLLVQLHLPYILLpat---------- 415  Cordyceps militar...
EHA24739  499 yGVTRGINDELRKSARsvpidcwkvptlnnt---msdtdkmdrismlvtQMHQYYLVILLHQPYLLLqlsnhtyfspsai 575  Aspergillus niger...
GAA89144  354 pQYDRTIDGLIAEVQTimsdwspeelltt-------ttnrmdtwfcvdiLFSSYKMLIVFYQAKKCNq------------ 414  Aspergillus kawac...
2VEQ_A    379 ydtadSLLKVIHYSKVIISLIvnnfha----kseffnRHPMVMQTITRVVSFISFYQIfves------------------ 436  baker's yeast
EAA60634  476 ---teEYLYSRLACIDACESVaqryhfirqklpsgffTLRMLDLQAFGAMAALLLLSHtspfpdhr----------tfqv 542  Aspergillus nidul...
CAP81126  478 ---epQFRPCHTIAIQSAREGlvlykvl--rsnikpyLCKMIDFMAFTLCLLLIIHLQgysdenpd----------qske 542  Penicillium chrys...
CAP93696  480 -----QSHILPSQAVEISRKSvktfqsllassahafwGVSLILFHQFIPFFILCLDVIgn-------------------- 534  Penicillium chrys...
EED14840  510 ---nrSYRFSQQAALESSRNAmraynrlrsegmmspyVCRLIDFQAFSVAMLLIINLIgysedspn----------hspe 576  Talaromyces stipi...
EEU48915  443 ----sTSPRPPTTDLDIPESPivedac----rhiinlLSQLLVIYPYVETMTTLFGAYrcfvayayl---------ansi 505  Nectria haematoco...
EGU80153  481 ---geEWKYNKLTAVTASREIlsrfvsir-sipqsryHCRGTDLIAFMSCTALTIAHIlcderhkrieeq---gfhfltq 553  Fusarium oxysporu...
EGX88874  416 --adaRMDCSRMTVANAARSIlmrfisfh-gspasvsYCRAIDFFAFIASTTLCLVHIearrqqhlaraggfsrlqplvh 492  Cordyceps militar...
EHA24739  576 spilpDYSYSRHVVVPASREVlsrclef--rnirpilSYRGLEHKAFVAAVALLLSHIlghrsgsen---------vleh 644  Aspergillus niger...
GAA89144  415 -----DSQFLPYHTVDIARKSlqmsrsi---msssthPYWGISLILLHQFVPLFIVSMnmi------------------- 467  Aspergillus kawac...
2VEQ_A    437 -aavKQLLVDLTELTANlptif------gsklDKLVYLTERLSKLKL 476  baker's yeast
EAA60634  543 dkprIERVVTQIIELMEekskdgvgadfaergAKTLRALRSLLQQDA 589  Aspergillus nidulans FGSC A4
CAP81126  543 qdeeDWDMVKKVIGILGqaatel----ggsvaAESANILRAIHDTKD 585  Penicillium chrysogenum Wisconsin 54-1255
CAP93696  535 ---pDHANLEEDLVSIGwisdy-----vemviKERVELKPVIIIIKS 573  Penicillium chrysogenum Wisconsin 54-1255
EED14840  577 qdekDWALVDETTEVIRhaaaep----agtvaRQSLLILEGISSNVD 619  Talaromyces stipitatus ATCC 10500
EEU48915  506 lqseDPQSYMKDVESLErlgnqsa--llargqKDIVPLVRAMQTINE 550  Nectria haematococca mpVI 77-13-4
EGU80153  554 qrlsDRGLIEQVLEIAQdglrrt----nddisKRLMTLLHYLLAIED 596  Fusarium oxysporum Fo5176
EGX88874  493 qrhsDRALLQSLLDIVAgmtqtg----pdpiaKRISSILTPLLEIEL 535  Cordyceps militaris CM01
EHA24739  645 qrpqDLAMIQQAIDTLDelctsnd--pnrdsaIQTRNLLSKLLSIEA 689  Aspergillus niger ATCC 1015
GAA89144  468 -gspECENAEADLDLVSwfnnfvvtaaqerseLKPLSIMMKAMTIAS 513  Aspergillus kawachii IFO 4308
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