Conserved Protein Domain Family
MDM31_MDM32

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pfam08118: MDM31_MDM32 
Yeast mitochondrial distribution and morphology (MDM) proteins
Proteins in this family are yeast mitochondrial inner membrane proteins MDM31 and MDM32. These proteins are required for the maintenance of mitochondrial morphology, and the stability of mitochondrial DNA.
Statistics
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PSSM-Id: 429828
Aligned: 68 rows
Threshold Bit Score: 505.161
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011109321 254 KEELLAAASNAWDRLRIRFKWLTIRQIRPFNMDEI-SAFFSWIILGNLAWIILGTTTFFSIGIWLVNTV------FAQ-- 324
XP_719380     88 KATLLSQANSGLSRMLIHLKWPLSRNTNTTSTWDMtSAFISWLVMGNILWIILGTTTFGLTLMYSLHYLdslvgkFSDdk 167
XP_003030532  12 REAMLNAASGFWERLRIHWRWMALRSFRKFNADDF-SAFLTWFVMSQTIWILVGTTSFLSAVFWLANSL------SLQ-- 82 
ESK93861     150 RDDFLRLADGFWQGLRIRFKWFTIRSFRKFNADDI-SGIVTWILMSQTIWILIGTTTFFSVVFAIANSL------RLQ-- 220
EKM80591      11 RDEFLSVATGFWQRLNIRFKWFTIKSFRKFNADDI-SAFVTWFLMSQTLWIFVGTTTFFSVIFAVANSL------RLQ-- 81 
EAU91730     186 REDFLNVATSFWQRLRIRFKWFTIKSFRKFNADDI-SAFITWFLMSQTLWILVGTTTFFSVIFAIANSL------QLQ-- 256
EGN99928      70 RDDFLRVATGFWQRLRIRFKWFTIRSFRRFNADDI-SAFITWFLMSQTLWILVGTTTFFSVVFATANSL------RLQ-- 140
EKM54190     127 RDDFLNAASGFWQRMRVRFKWLTIRSFRKYNADEI-SAFITWFFMSQTLWLFVGTTTFFSVFLITVNSL------RLQ-- 197
EMD37322      11 RDDFLKAANGFWQRARVRFKWLTIRSFRKYNADEI-SAFITWFLMSQTLWLFVGTTTFFSVLFATANSL------RLQ-- 81 
EPT04549     112 REDFLNAANGFWQRARVRFRWLTIRSFRKYNADDI-SAFVTWFVMSQTLWLFIGTTTFFSVIFATINSL------RLQ-- 182
XP_011109321 325 ---------------EHLAKVVGNYLTQEMGMKVVFES-AIVPRWKDGCISFKNVFISRR-PG---IlKGAGIEKGSSSV 384
XP_719380    168 ettdklnqtksktstNVMSYLIGGIISFGIGVDLNFEKgSSLPELKDGKLRFKNVGIVSH-------------------- 227
XP_003030532  83 ---------------HYIAKALSDYLTRGTDIMIVFES-AIVPKWRDSKLCFKNVYISRG-PHtteQeKKRQDEKRAQSD 145
ESK93861     221 ---------------NFIARGISDYLTSETGVTVIFES-AIVPKWKDSRISFKNVYISRR-PV-------------SMQT 270
EKM80591      82 ---------------HYIARAISDYLTSETGVIIIFES-AIVPKWRESRISFKNVYVSRRlPEt------------AARK 133
EAU91730     257 ---------------HYIARAISDYLTSETGVTIIFES-AIVPKWKDSRISFKNVYVSRR-PAdsdIgSP------LGTP 313
EGN99928     141 ---------------ENVARAISNYLTAETGVTIIFES-AIVPKWKDSRISFKNVYISRR-PRs-----------dVTPS 192
EKM54190     198 ---------------ENVARAISDYLTAETGIHIVFES-AIVPKWKDSRISFKNVYITRR-PDv------------VNKV 248
EMD37322      82 ---------------EYVARAISDYLTSETGITIIFES-AIVPKWKDSHISFKNVFVSRR-PLdleT---------VRQR 135
EPT04549     183 ---------------EYVARAISDYLTSETGITIIFES-AIVPKWKDSRISFKNVYVIRG-PKgpeMa--------RARS 237
XP_011109321 385 AAAAAAAAAFS-ESHSG----------TADE---------EDDGNYTQFDLTVDTVNVTISLAKWMNGRGLLVDVDMKGV 444
XP_719380    228 ----------------------------------------DGNNKHVKFKGTVEAMDITLSFNKWYEGNGLIYDLELYGL 267
XP_003030532 146 GEEGEPGHPPQmAGKVPeq--------------------lLEEYNYTMFDLNVDSVDVTLSLWRWLDGKGLVKDAVVKGV 205
ESK93861     271 QQKKLKEHQSAlGYDVAhhpayhhiedDDDElpf----ppEEECNYSMFDLNIGSIDVTLSLWRWLDGKGLIESAAVKGV 346
EKM80591     134 IQRKRSEHLTAaGYDVSnhpgyhqlneDDDEdavp-ieldKQDTNMSLFDLNIDSVDVTLSLWRWLDGKGLVEDAVVKGV 212
EAU91730     314 PNEERSRNMAGvGYDVGnhpayhrvgeEDEDnadgfrpleDEDYNYTMFDLTIDSVDVTLSLWRWLDGKGLVEDAVIKGV 393
EGN99928     193 TEKKVTGHKAAiGYDVSghpayhytgdEEEEitl---dhsDDDLNYSMFDLNVDSIDVTLSFKRWLDGKGLVEDAVIKGV 269
EKM54190     249 RADRNTGYHYAtGYDVSnhpanhgfmyDEEDsile--elpGEDTNYSMFDLSVDTIDVTLSFTRWLEGKGLVTDAVVKGV 326
EMD37322     136 RSLRNAGYKAAvGYDVSnhpsnhslaeEDDDmmle--dhsNDDVNYSMFDLSVDSIDVTLSFTRWWQGKGLVTDAVIKGV 213
EPT04549     238 DAMFHAGHKVAvGYDVSnhpsfhsigeEEDDdgpn--aphDEDLNYTMFDLTVDSIDVTLSFARWWQGKGLVVDAVVKGV 315
XP_011109321 445 RGVVDRTHLRFDP--DVDPRSYRH---KHAPGDFE-------------------LDHFKLEDLLVTVYQTGGFRPFHVSI 500
XP_719380    268 NGKLYKSRSPSPPvaNTTKKSYRFnenIHYQYDLDhnveeiasgsssiidnnytFDHVKIHDSYLEIYEEQSSTPIKINI 347
XP_003030532 206 RGAIDRRSIHWDPenPLNPADFRH---KSQPGDFE-------------------LESLQMEDVLVTVYQPDAFRPYTASI 263
ESK93861     347 RGVLDRRSVRYDPdhPLDPALFRH---ESHPGDFE-------------------LESLQLEDVLITVHQPGGFRPYTASI 404
EKM80591     213 RGVLDRTNVYWDPdnPLDPALFRH---KFVPGDFE-------------------LESMQLEDLLITVYQPGSFRPFTASI 270
EAU91730     394 RGVVDRRNVFWDPdnPLDPAAFRH---KYQPGDFE-------------------LERLQLEDVLVTVYQPGEFRPYTASI 451
EGN99928     270 RGILDRRSVFWDPehPLDPAAFRH---TPQPGDFE-------------------LELLQLEDVLITVYQPGDFRPYTASI 327
EKM54190     327 RGVLDRRFVHWDPenPLDPASFRH---QARQGDFE-------------------LESFQLEDLLVTVYQPGSFRPFTASI 384
EMD37322     214 RGVLDRRSVTWDPdhPLDPAAFRH---IAQPGDFE-------------------LESLRLEDVLITVYQPGGFRPYTASI 271
EPT04549     316 RGVLDRRNVFWDPdhPLDPVLFRH---ESQPGDFE-------------------LESLQIEDLLLTVYQPGGFRPFTASI 373
XP_011109321 501 FSCDLPQLRKRWLFYDFLSANHVSGSYDDSLFTLHPRQThgPVNPVSGQIDAQegaiyPWKKTSRFRIDGLRFDHLN--- 577
XP_719380    348 FSCDLPKLRGDKLVLDFFNANNASGAINDAMFTLHKRQN--LDPENK-----------NQDKLIRFKLDAIDLGEINk-- 412
XP_003030532 264 FRADFPIFRKQWLFYDFLSADSIVGQFDNCLFSLHKPQS--IGRTNEADTRDS-----DWARMSRVRIDGVNIDHLQr-s 335
ESK93861     405 FRADIRTFRKRWLFYDFLCAENIVGQFDNCLFSLHKPQS--IGRTTEMDLQDG-----EWARMSRIRIDGVNIDHLQa-s 476
EKM80591     271 FRADIQQFRKRWLFYDFLCAENVVGQFDNCLFSLHTPQS--IGRTTEKDLEDG-----EWARMSRLRIDGVNIDHLQnst 343
EAU91730     452 FRADIRTFRKRWLFYDFLAAENVVGQFDNCLFSLHKPQS--IGRTTEKDLEHG-----DWGMMTRIRIDGVNIDHLQn-s 523
EGN99928     328 FRADMRNLRKQWLFYDFLCAENVVGQFDNCLFSLHKPQS--IGRTTDQDLKDG-----KWSRMSRIRIDGVNIDHMQn-s 399
EKM54190     385 FRADIRTFRKQWLFYDFLSAENVVGQFDNCLFSLHKPQS--IGRTTEQDLKDG-----QWARMSRLRIDGVNIDHLQh-m 456
EMD37322     272 FRADIRTFRKQWLFYDFLRAENVVGQFDNCLFSLHRPQS--IGRTTDQDLKDG-----QWARMSRFRMDGLNVDHLQa-m 343
EPT04549     374 FRADMRTFRKQWPFYDFLAAENVVGQYDNCLFSLHRPQS--IGRTTEQDLQDG-----KWARMSRFRMDGLNVDHMQa-m 445
XP_011109321 578 RGYEGPLSWIVSGNLDIIADIHFPE-DS-AE-GISKFMHDMMEKMETSITARReklTDmisgtdglsyenisgiigaavg 654
XP_719380    413 YDPNSKFNWIINGKAEVIADITLPE----EQdDLNESITEVLTKMFTNMFQTA---DMsqt------------------- 466
XP_003030532 336 TSSDGPFSWITSGKVDAVLDIKFPH-DPeDElPFQLILGELADAISEHIPGQQ---QHipg------------------- 392
ESK93861     477 TTMEGPVSWITSGKLDAVFDIKFPQ-DP-GDgTLSAILEEITDAITTTVLSNT---PDpilqr----------------- 534
EKM80591     344 TTMEGPISWITSGKVDAVLDIKFPR-DPnGDlHLNAILGEIADAITTSISSNM---NEqeshper--------------- 404
EAU91730     524 TTMEGPISWITSGKVDAVLDIKFPR-DPqDGlALNAILEEIADAITTSLTNSQ---ETedtrr----------------- 582
EGN99928     400 TTQEGPISWITSGKVDAVLDIKFPR-DPeDDfPLNALLGEIADALSTAASVSL---LNerip------------------ 457
EKM54190     457 STQEGPISWITSGKVDAVLDIKFPR-DYsDDsPFNTLIGEIADAITTAATSAV---AErip------------------- 513
EMD37322     344 TTQEGPISWITSGKVDAVLDIKFPReDPeEG--FEALLGELADAISTAASSVA---LDrip------------------- 399
EPT04549     446 TTQDGPFSWITSGKVDAVLDIKFPR-GPtDElQINALLGELADAISTAASSVA---ASaeri------------------ 503
XP_011109321 655 ltegdgavanamaleddgnyttailhddlfddlgntlRSTNMADTSVVSKPTTASIQMDQAS--DNQKFMMIDLHLEMND 732
XP_719380    467 ----------------------------------sedSLLKDAISAIYHTFRKPEETAKP----AENSYVMVNVKMKLYD 508
XP_003030532 393 -----------------------------------qrELAKPPLSAPDSDGIE-----------RAEPCVVIDIDLRFRD 426
ESK93861     535 --------------------------------ipgqrELAKPPLSAPESE-------DAADRvgNTEPKVVIDIDLRFRD 575
EKM80591     405 ------------------------------kripgqrELARPPLSAPDDNMYEGTGANSGEE--EEELKIIVDMDLRFRD 452
EAU91730     583 --------------------------------ipgnrELAKPPISPPSLELLE----SVAKE--DEKRKVVVDIDLRFRD 624
EGN99928     458 ----------------------------------gqrELAKPPLTAPQSD-------DFTED--DDTPKVIIDIDLRFRD 494
EKM54190     514 ----------------------------------gqrELAKPPLSAPSDQTAMPADS-------AEHPKIIIDIDLRFRD 552
EMD37322     400 ----------------------------------gqrELAKPPLSPPSDEEDA----RRPQH--EDKPRLVIDIDLRFRD 439
EPT04549     504 ---------------------------------pgqsRLAKPPLSAPSDRDST----QLAET--AGEPQVVIDIDLRFRD 544
XP_011109321 733 TRAAIP--LFTQ-D-LSYKNNALMRPIIAYINSQRTIIPINCRMVKRVTEFDGSWTLFDSGLMDDLSSEVYDAFVKDIAD 808
XP_719380    509 LKASLPqvLPRTnNgIPFISLTDLRSLISFINTENQPITIKSTVIEKITDLSNIQHLGQTKMFDYIMGDAYEELTNLVRD 588
XP_003030532 427 VKASVP--IFTN-D-ISVANNALIRPIVAFMNANHTLVPIRARVVKDLSEFDGAWTV--TGLMDDISDKIYNALAYHVTQ 500
ESK93861     576 VKAAVP--IFTN-D-LSYVNNALIRPIVAFMNANRTLVPIHCKVVKPLNDFEGAWTMWETGLMDEISLKIYDALAYHVAQ 651
EKM80591     453 LKAAVP--IFNR-D-LSYVNNAFIRPIVAFMNANRTLVPIHCRIVKKLSDFDGSWTMWESGLMDEISIKTYDALAYHVSQ 528
EAU91730     625 LKAAVP--IFTS-D-LSYVNNALIRPIVAFMNANRTLVPIHCRIVKDLSDFDGSWTMWETGLIDEISLNVYEAMAHHVSQ 700
EGN99928     495 LKAAVP--LFAS-D-LSYVNSALIRPIVAFMNAHRTLVPIHCRVTKNLSDFDGAWTMWETGLMDEISEKTYDALAHHVAQ 570
EKM54190     553 LKTAVP--LFTA-D-LSYANNALIRPIVAFMNANRTLIPIHSRVVKDLSNFDGAWTMWETGLVDDIGAKVYEAMAYHVTQ 628
EMD37322     440 LKAAVP--IFTN-D-LSYVNNALIRPIVAFMNVHRTLVPIRCHVVKDLSEFDGAWTMWETGLMDSIALKVYEAMAYHVTQ 515
EPT04549     545 LKAAVP--IFTN-E-LSYTNNALVRPIVAFMNANRTLIPIHCRVVKPLSDFEGSWTLWETGLMDIISLKVYEAMAYHVTQ 620
XP_011109321 809 ADIKKRRIRAVGLWSLQVFMNAFLAAM 835
XP_719380    589 D---ARRIINEKSWSNSIATQLLLLGL 612
XP_003030532 501 ANMNK-RLKTVGLWSVQMTASAVLSAl 526
ESK93861     652 ANMNR-RIKTVSVWSLQMTASAVLSAL 677
EKM80591     529 SNMNRQRIRTVSLWSLQMTANAILSAL 555
EAU91730     701 SAMNRQRMKTVSWWSLQMTASAIISAL 727
EGN99928     571 VNMNR-RVKAVSIWSLQMTASAVLSAL 596
EKM54190     629 ANFNR-RVKAVSAWSLQMTASAILSAL 654
EMD37322     516 ANFNR-RIRAVSSWSLHMTASAILSTL 541
EPT04549     621 ANFNR-RLKVVSAWSLQMTASAVISAL 646
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