Conserved Protein Domain Family
RING-H2_RNF214
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cd16477: RING-H2_RNF214 
RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins
RNF214 is an uncharacterized RING finger protein containing a C3H2C3-type RING-H2 finger, suggesting it may have E3-ubiquitin ligase activity.
Links
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Statistics
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PSSM-Id: 438140
Aligned: 6 rows
Threshold Bit Score: 88.339
Created: 31-Jul-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #             # #  #  #            #  # 
Q8ND24       656 KLCLMCQKlvqpselHPMACTHVLHKECIKFWAQTNTNdtCPFCP 700 human
EOB08698     427 KLCLMCQKlvqpgdlHPMACSHVLHKECIKFWAQTNTNdtCPFCP 471 mallard
CDQ77868     256 KLCLMCQNhvevdsqHPMSCAHTVHKDCISVWLQSSKNntCPFCP 300 rainbow trout
XP_005988216 656 KLCLMCQEivqlndvHPMACSHTVHKECIKFWAQSNKNssCPFCP 700 coelacanth
XP_007906977 586 RLCLMCQKvvrgnevHPMSCSHIVHKECIKYWAQSNKNsaCPFCP 630 elephant shark
XP_018081370 735 KLCLVCQTfvqpsdlQPMSCSHAMHRECIRCWAPNNQYncCPFCP 779 African clawed frog

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