Conserved Protein Domain Family
Link_domain_KIAA0527_like
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cd03521: Link_domain_KIAA0527_like 
Link_domain_KIAA0527_like; this domain is found in the human protein KIAA0527. Sequence-wise, it is highly similar to the link domain. The link domain is a hyaluronan-binding (HA) domain. KIAA0527 contains a single link module. The KIAA0527 gene was originally cloned from human brain tissue.
Links
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Statistics
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PSSM-Id: 239598
Aligned: 3 rows
Threshold Bit Score: 165.488
Created: 10-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative hyaluronan binding site [chemical binding site]
Evidence:
  • Comment:These two HA-binding residues are found at equivalent sequence positions in TSG-6 and CD44 . None of the other HA-binding residues identified were found at equivalent sequence positions in the two proteins.
  • Comment:HA-binding residues were identified in TSG-6 and CD44 by site-directed mutagenesis.
  • Citation:PMID 9417085
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ##                                                                    
BAA25453     178 KLFVLesqnGSQGLQLEAARLSCKSRGAHLASADELRRVVQDCSFAVCTTGWLADGTLGTTVCSkGSGEQQIMRAVDVRI 257 human
CAG10003      30 RLFVLnlenSTGLMGFRGAEQACAALHARLASPAELRHAVVECFFSACARGWLYGGTVGTTVCN-VVAGALKAVDVKTEN 108 Tetraodon nigro...
XP_001521029 239 KLFTLepgnGSQGLDLPAARASCGSVGARLATAEELRRAVLHCAFTSCSGGWLADGTIGSTVCRpEGSEKHNPARGSVQI 318 platypus

Feature 1                       
BAA25453     258 EsnpvpgGTYSALCI 272 human
CAG10003     109 Ate--dfAHLNAFCI 121 Tetraodon nigroviridis
XP_001521029 319 ErnpipsRRYNALCI 333 platypus

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