4CRN,3AGK


Conserved Protein Domain Family
aRF1/eRF1
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TIGR03676: aRF1/eRF1 
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peptide chain release factor 1, archaeal and eukaryotic forms
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. This model identifies both archaeal (aRF1) and eukaryotic (eRF1) of the protein. Also known as translation termination factor 1. [Protein synthesis, Translation factors]
Links
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Statistics
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PSSM-Id: 274719
Aligned: 25 rows
Threshold Bit Score: 452.126
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4CRN_X        10 EIWKVKKLVQSLEKARGNGTSMISLVIPPKGLIPLYQKMLTDEYGTASNIKSRVNRLSVLSAITSTQQKLKLYNT-LPKN 88  baker's yeast
O29048         5 MMYEFKRKLEELEKYKGRGTELITLYIPPDKNIADVSNQLRSELSQASNIKSKQTRTNVLAGIEAILNRLKHFRK-PPEN 83  Archaeoglobus f...
Q5JGK6         7 EMYELKKKVEELKSYRGRATELVSLYIPAGYDINKVMQQLREEYGTAQNIKSKSTRKNVLGALERAMQHLKLYKQ-TPEN 85  Thermococcus ko...
Q9HKR2        11 RRYEFKRALEELSKLHGRGTELISLYIPPDKQISDVVAYLRDEYSTSSNIKSKSTRKNVLAAIESIMARLKYYKT-PPPN 89  Thermoplasma ac...
Q8ZU81        15 SAVELRAFVNLLKKFKGYATTLITLYINAERPIPDVVNLLRSEWSTAANIKDKTTRTHVQDTLERIINNLKGEAK-APEN 93  Pyrobaculum aer...
Q9YAF1        13 SKRELARLLKELKKWSAPATVLLSLYIPPGRPLSDVMTLLRQEYSITDNIKLKRTRQAVKRALSAAMDRLQMLTS-TPPN 91  Aeropyrum perni...
Q97W96         9 NKQELKALIKELKKWKAPATVLLSLYIPPGRPIPDVVNLLRQEYSIAQNIKLKRTRDAVLSAIGAAIDRLNKIPK-IDGN 87  Sulfolobus solf...
WP_011752190   6 ERYKLEKLVEELKKKEGRGTELVSLYIPAGRPISDVLNTLYYEYSTASNIKDRVTRHHVLDALATIINRLKLFRE-TPPN 84  Thermofilum pen...
WP_011321865  12 QKYEFQKVIEELDEYSGSGTQLVSIYVPEDRQISDVVQHVTQEHSEAANIKSKQTRTAVQDALKSLKDRLKYYDTfPPDR 91  Natronomonas ph...
3AGK_A        13 SKRELARLLKELKKWSAPATVLLSLYIPPGRPLSDVMTLLRQEYSITDNIKLKRTRQAVKRALSAAMDRLQMLTS-TPPN 91  Aeropyrum pernix

4CRN_X        89 GLVLYCGDIITED-GKEKKVTFDIE-PYKPINTSLYLCDNKFHTEVLSELLQADDKFGFIVMDGQGTLFGSVSGNTRTVL 166 baker's yeast
O29048        84 GMVIISGVVNIN--GKEKHITEIIE-PPEPVPLYKYHCDSKFYLDPLKEMLTEKKLYGLIVLDRREATVGLLKGKRIEVL 160 Archaeoglobus f...
Q5JGK6        86 GLALFVGNVSEQE-GVSDIKLWAIV-PPEPLNVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGLLRGKRIEVI 163 Thermococcus ko...
Q9HKR2        90 GFVFFEGHIATRG-DQTEMYTKIIE-PPEPITTFMYKCDSEFHLEMLKTMLEEKEIYGLIVIDRKEATVGFLNGTRIEVV 167 Thermoplasma ac...
Q8ZU81        94 GMAVFAGFHMINQ-GNYEWVYYVVI-PPQPINTFKYICDTAFHTELLEDQLHAGVVYGIVVIERGEAVIALLKGGQWEVV 171 Pyrobaculum aer...
Q9YAF1        92 GLVLFCGEDMSTG----KFECFMFS-PPEPIRVFYYRTDKRFITDFLEDMVEDNNAIGIIIVERDQATIGLLKGARLEVL 166 Aeropyrum perni...
Q97W96        88 GLVLFCGENF----DTEDFKCFMFS-PPDKVPLFFYRTDKEFHLEFLEDMVEDTAVYGLIIVERDEATIGLLKGARIEIL 162 Sulfolobus solf...
WP_011752190  85 GLIVFAGYVAGDVpGREKMEVHLIE-PPQKLNVWLYRCDSRFYTEILEEMIRVKEVYGLIVIERDEAAIAILRGKSLEVV 163 Thermofilum pen...
WP_011321865  92 GMVLFSGAVDAGG-GQTDMVTEVLEsPPDPIQSFRYHCDSHFLTEPLQEMLGDKGLYGLVVLDRREANVGWLKGKRVEPV 170 Natronomonas ph...
3AGK_A        92 GLVLFCGEDMSTG----KFECFMFS-PPEPIRVFYYRTDKRFITDFLEDMVEDNNAIGIIIVERDQATIGLLKGARLEVL 166 Aeropyrum pernix

4CRN_X       167 HKFTVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAEVAVQNFITNDKv-nVKGLILAGSADFKTDLAKSELFDPRLAC 245 baker's yeast
O29048       161 DWDTSMVPGKHRQGGQSSVRFERLREIAIHEFYKKVGEMASEALLPYKDk--LIGILIGGPSPTKEEFYEGEYLHHELQK 238 Archaeoglobus f...
Q5JGK6       164 DELTSNVPGKTRAGGQSARRYERIREQETHEFMKRIGEHANKAFLPLLEkgeLRGIIIGGPGPTKEEFVEGDYLHHELRK 243 Thermococcus ko...
Q9HKR2       168 DNVQSQVPSKHHQGGQSSRRFERLIEIAANEFFKKVGEIANNAFMPKIKd--IRAIFLGGPGATKEYFFEKDYLRNEVKE 245 Thermoplasma ac...
Q8ZU81       172 KSVEFFVPGKHHAGGQSANRFKRQTEHLAEAFYKMVAEEANKIFLQIPT---LKGIIVAGPGPTKEDFLEEGGLDYRLKD 248 Pyrobaculum aer...
Q9YAF1       167 KELEGFVPGKHKMGGQSQRRYERIIEQMVDEFFKKVGEEASNLLVPLAEkgvLKGVIVAGPGLAKQEFVEGNYLDYRLKK 246 Aeropyrum perni...
Q97W96       163 EEIEGFVPGKHMMGGQSQRRIDRIIDEMYHNFLKEVGEKVNAYFMPFVQngkMKGVLLGGPGYAKEDFYKEDYVDYRIKN 242 Sulfolobus solf...
WP_011752190 164 DELTAGVPGKHRSGGQSARRFERIIEQLVHEFYKRVGEHANKIFLPLKDe--LRGIIIGGPGFSKKEFAEGDYLHYELRQ 241 Thermofilum pen...
WP_011321865 171 KSASSLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAEMADDLFVPKRHe--MDGILVGGPSPTKDEFLDGDYLHHELQD 248 Natronomonas ph...
3AGK_A       167 KELEGFVPGKHKMGGQSQRRYERIIEQMVDEFFKKVGEEASNLLVPLAEkgvLKGVIVAGPGLAKQEFVEGNYLDYRLKK 246 Aeropyrum pernix

4CRN_X       246 KVI-SIVDVSYGGENGFNQAIELSAEALANVKYVQEKKLLEAYFDEISQ-DTGKFCFGIDDTLKALDLGAVEKLIVFENL 323 baker's yeast
O29048       239 KVL-GLFDVGYTDESGLYELVEKAKDVLQEVDIIREKNLMQRFLKEVAR-D-GLAAYGEEEVRRYIELGAVDTLLLSEDL 315 Archaeoglobus f...
Q5JGK6       244 KVI-GVVDISYHGEYGLRELVEKASDILKDHEAVKERQLIQEFFKHLVK-DTGMITYGEKEVRKALELGAVDKLLISEGY 321 Thermococcus ko...
Q9HKR2       246 KIK-DLFDVGYTDESGLRELVEKASESIKDMKISKEKDLMNRFLREVRKpDGGLAIYGEQAIRDALEQKMVDLLLISEGL 324 Thermoplasma ac...
Q8ZU81       249 KIL-AIVPACCANEYGVMEAIRNAQEQLKESEYVKAKEVMDKVMYYAVK-KSEYLVYGRERALKALEMGIADIIVIAEEL 326 Pyrobaculum aer...
Q9YAF1       247 ILApELVDVAYQGLQGLKEAVMKAEKVVEAQMYRDAVNAMEEFKLHLAK-GTGMIVYGEKDVEAALEMGAVKTLLIHE-- 323 Aeropyrum perni...
Q97W96       243 LILqPLIDVSDQGEVGLREMIMKAEDLLKNQQYIEVEKLLEELKYHLAK-DDGLIIYGKEQIKKAMEIGAIEAIVIHEDS 321 Sulfolobus solf...
WP_011752190 242 KIL-GLFDVGYGGVSGLYELLEKSKDLIKDVQFMKEREAVNQFLYHLAR-DTGLAVYGEAEVREALQLNAVEKLLLSEDL 319 Thermofilum pen...
WP_011321865 249 MVL-GKFDISYTDESGLYDLVDAAEDVLAETEVMKDKAEMEEFFEQLH--DGQKATYGFDATRQNLMMGSVDRLLISEDL 325 Natronomonas ph...
3AGK_A       247 ILApELVDVAYQGLQGLKEAVMKAEKVVEAQMYRDAVNAMEEFKLHLAK-GTGMIVYGEKDVEAALEMGAVKTLLIHE-- 323 Aeropyrum pernix

4CRN_X       324 ETIRYTFK-DA-EDNEVIKFAEPEAKDKs----fAIDKATGQeMDVVSEEPLIEWLAANYKNFGATLEFITDKSSEGAQF 397 baker's yeast
O29048       316 RYERVKYRcPK-CGKEVEVTVREGIEKPp-----fCEEDNVE-MEEVERRDIVLELSELAESTGAKVEFLSTESEEGEML 388 Archaeoglobus f...
Q5JGK6       322 DKVRVRAKcNN-CGWEELKTMSEGEFHVykkqltHCPKCGSQ-NITFEKWDVAEELIKMAEESGADVEIISLDTEEGQQF 399 Thermococcus ko...
Q9HKR2       325 RKVRYTYRcPT-CQAELTLNQEPNEWPV-------CEKDGTP-MELVAEDDFIEDLYRLAKESGAQVEIISDQSEEGKLL 395 Thermoplasma ac...
Q8ZU81       327 ------------------------------------------------GEDAVLEVIMKAEEKGIKVEVVPRGVEESKTL 358 Pyrobaculum aer...
Q9YAF1       324 ------------------------------------------------SREDLEEWVEKAKSSGAQVIVVPESLAEAEWF 355 Aeropyrum perni...
Q97W96       322 ------------------------------------------------TDKELEKLAQDAENYGVKVFVVGDEVPEAEWV 353 Sulfolobus solf...
WP_011752190 320 EKIRVRAKcTS-CKHEFEATLHSESEVAq----lKCPKCGGE-VEIIENRSVVEELAELAEKTGAEVVLVSTQSAEGKEF 393 Thermofilum pen...
WP_011321865 326 RKDVVTFDcGSrEEYELIDRRADTPDH-------TC-EDGSE-GEAVEREDAIDHLMELAEQRGSDVKFISTDFEKGEQL 396 Natronomonas ph...
3AGK_A       324 ------------------------------------------------SREDLEEWVEKAKSSGAQVIVVPESLAEAEWF 355 Aeropyrum pernix

4CRN_X       398 VTGFGGIGAMLRYKV 412 baker's yeast
O29048       389 YKAFGGIAAILRFKP 403 Archaeoglobus fulgidus DSM 4304
Q5JGK6       400 YKAFGGLGAILRYKI 414 Thermococcus kodakarensis KOD1
Q9HKR2       396 KQAFGGMAAVLRFIR 410 Thermoplasma acidophilum DSM 1728
Q8ZU81       359 MQAFGGYVALLSTPV 373 Pyrobaculum aerophilum str. IM2
Q9YAF1       356 LKTFGGLAGILRFRI 370 Aeropyrum pernix K1
Q97W96       354 KKTFNGIVGKLRYRL 368 Sulfolobus solfataricus P2
WP_011752190 394 FKTFGGIGAILRYRL 408 Thermofilum pendens
WP_011321865 397 LTAFGGIAGILRYST 411 Natronomonas pharaonis
3AGK_A       356 LKTFGGLAGILRFRI 370 Aeropyrum pernix
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