3CUE,1WC8,3KXC,2CFH,1WC9


Conserved Protein Domain Family
TRAPPC3_bet3

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cd14942: TRAPPC3_bet3 
Click on image for an interactive view with Cn3D
Bet3-TRAPPC3 subunit of the TRAPP complex
Bet3 (also known as TRAPPC3) subunit of the trafficking protein particle complex (TRAPP). Bet3 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. TRAPPC3 has also been shown to be additionally important for membrane fusion during the formation of vesicular tubular clusters (VTC). In its core, Bet3 forms a hydrophobic channel that also contains a conserved acylation site.
Statistics
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PSSM-Id: 271345
Aligned: 70 rows
Threshold Bit Score: 157.672
Created: 14-Jan-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:TRS31 interface [polypeptide binding site]
Evidence:
  • Structure:3CUE; Saccharomyces cerevisiae TRAPP membrane-tethering complexes; contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ##### ### ##  #                #   #  ##  ##  #                                 
3CUE_D        26 NTELFTLTYGSIVAQLCQDYErd--fNKVNDHLYSMGYNIGCRLIEDFLARTa---------------------LPRCEN 82  baker's yeast
EEH57426      26 NAELFTLTYGAIVRQVLADYEdc--vPEANAKLDAMGRSIGGRLIEEFNAKNe---------------------QQRCVD 82  Micromonas pusi...
EST43645       1 MDQFTSLFYGAIVSQILEDVQd---pVETTKILHKLGQQMGEKMADYYFTMVlln----------------nqdLPQCKQ 61  Spironucleus sa...
CCO14571     100 NSELFSLTYGAFLVQLLRDANgd--aSFVNAKLRGIGKSIGNRLIEEYLAKMmntggggngvgngsyyggsnnaADSCKT 177 Bathycoccus pra...
XP_001708729   5 NAEFFAVTYGAIVTSLLEELHd---pGMVTKELDRMGFNIGQRCVDEYLANS----------------------SSICTK 59  Giardia lamblia...
EER03982      35 NAEVLALLYGATVRQLLVDFEgd--fDKVNKELYRMGTDIGARLVDEFLIKSr---------------------APPCQD 91  Perkinsus marin...
Q57UH5        23 SAEFFAITYGALVQQMITDLPqaddvEVVNQQLDTMGRRIGSRLVEEYSARSg---------------------APACRT 81  Trypanosoma brucei
XP_001419409  22 NAELFALTHGAFVRQILRDHEdd--vECANAALERVGRAMGARMVEEFLSRTna-------------------sGGACAT 80  Ostreococcus lu...
EPY40125      31 SAEFFALSYGALVRQLIDQLPqdedvNSVNQQLEMIGQRIGARLVEEYSVRSg---------------------GPPCKT 89  Angomonas deanei
AGG11549      25 SAEFLAISYGALVQQMLVDHGns--vEEVNDQLLVMGSRIGARLIEEYCVRSg---------------------APPCKL 81  Trypanosomatida...
Feature 1                      ## #                                                #             
3CUE_D        83 LVKTSEVLsKCAFKIFLNITPNITNWShn----------------------------kDTFSLILDENPLADFVELPmda 134 baker's yeast
EEH57426      83 FRDTCETIaGVALRMFLGVGGHCADWNad----------------------------hTSCLVVMETNPLADFVELPery 134 Micromonas pusi...
EST43645      62 FIQTSDGV-VQYLSFILGVSCIVSSQEe------------------------------LSYQIKLEENPFESFVKVPnql 110 Spironucleus sa...
CCO14571     178 FREVMENVaFVGFRMFLNARCRLVDWSsnsssngssgntpttndnstsnmnsnsssshESVTLAIEDLSLADFVELPeky 257 Bathycoccus pra...
XP_001708729  60 FHHTATGV-LGGLKMFLGCASGTITGCep---------------------------ecSAYTIFVENNPLEKYVKLPaql 111 Giardia lamblia...
EER03982      92 FRDACEVMsKVALKMYLGVTGDCVDWDnst--------------------------egRKCRLVLPVNPLNDFVELPmel 145 Perkinsus marin...
Q57UH5        82 FAQAADAVaIVGIKMFLNVNATVQPAEes---------------------------ggDTFTLTFADNPLALFVELPegp 134 Trypanosoma brucei
XP_001419409  81 FEEAMEMTtRVGLKMFLNVDAKTRDWSee----------------------------rDECVIEMESNPLAEFVELPgky 132 Ostreococcus lu...
EPY40125      90 FTDCAESVtKIGLKMFLNVNATVSAVKds----------------------------aDTFSIRFHDNPLNIFVELPpek 141 Angomonas deanei
AGG11549      82 YSQAAESVaLVGLKMFLNVAAEVEAVRdt---------------------------esNTYSITFASNPLSLFVELPegi 134 Trypanosomatida...
Feature 1                                #                                                       
3CUE_D       135 ----------------mksLWYSNILCGVLKGSLEMVQLDCDVWFVSDILrgd------------------sqTEIKVKL 180 baker's yeast
EEH57426     135 -----------------rdLSYGQMLCGVIVGALEQVQTRATCEWEKDALrgg------------------dgFAMRVTL 179 Micromonas pusi...
EST43645     111 -----------------tgLCYSTVIPGAISGALKAVGWSATSSIIQKDSs----------------------WIIDVKR 151 Spironucleus sa...
CCO14571     258 ----------------tnsLSYCEVVCGVVEGALESVNVRVKVHFVKDGLrsdlsssyvgqtqeservvknckFALRVTS 321 Bathycoccus pra...
XP_001708729 112 -----------------drLVYSQIVCGAIRGALSLIGYNVTVELIPAHNamv------------------hpLHLRVEL 156 Giardia lamblia...
EER03982     146 rrpasttaaaggtdhpgpiLYYSNILCGVIAGAMEQLRINVAVQFESDVLlgd------------------eiSVISLEL 207 Perkinsus marin...
Q57UH5       135 v---------------rqrLWYSNVICGVIVGALSMVGFIAEATFVRDTLrgd------------------atNEILLSF 181 Trypanosoma brucei
XP_001419409 133 -----------------gdLSYCNALCGAIRGALETVRVRTTCAFESDPLrge-----------------gerFAIRVKL 178 Ostreococcus lu...
EPY40125     142 n--------------mrerLWYSNVLCGVLKGALGLVGYQTDVHFMKDTLrgd------------------pvNEITLRF 189 Angomonas deanei
AGG11549     135 v---------------aekLWYSNILCGVVQGALWQVGLHSEVRFVRDVLrgd------------------atNEIEIRF 181 Trypanosomatida...
Feature 1          
3CUE_D       181 NR 182 baker's yeast
EEH57426     180 VG 181 Micromonas pusilla CCMP1545
EST43645     152 TS 153 Spironucleus salmonicida
CCO14571     322 LG 323 Bathycoccus prasinos
XP_001708729 157 QN 158 Giardia lamblia ATCC 50803
EER03982     208 LE 209 Perkinsus marinus ATCC 50983
Q57UH5       182 KG 183 Trypanosoma brucei
XP_001419409 179 LE 180 Ostreococcus lucimarinus CCE9901
EPY40125     190 IG 191 Angomonas deanei
AGG11549     182 NG 183 Trypanosomatidae sp. TS-2013

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