Conserved Protein Domain Family
TFP_LU_ECD_GML
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cd23555: TFP_LU_ECD_GML 
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins
GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467085
Aligned: 11 rows
Threshold Bit Score: 137.122
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q99445        29 LRCHDCAViNDFNCPNiRVCPyHIRRCMTISIRINsRELLVYKNCTNNCTFVYAAEQPpea--pgkIFKTNSFYWVCCCN 106 human
XP_021515376  42 LQCKTCSTiNTFVCHAhKLCPdGQRRCATVAVRVNsRELMVYKDCIRDCTFVYKVHQPaavgggrrLPGTNSFYYVYCCA 121 Mongolian gerbil
OBS64274      70 FRCYICAStNTFNCFEpRTCTsSQKFCLIVALRMNsRELLVHKNCIDICSFTLAEPPPad----rkISQHFNFYYTMCCR 145 desert woodrat
NP_034546     47 LTCHKCYIsNTFSCPKlSECPsNLRRCMTVSFRVNiRLLYVLKDCTKDCTFIYREHVPpel--prvLKDVKNFYFVMCCS 124 house mouse
NP_001070493  24 VQCHECIVkNTFHCPVkRTCPyDIRRCFTVSMRLNsREILVYKNCTFNCTFLYRAEEPpetprrktTHRFNSFYWVHCCG 103 cattle
NP_002057     29 LRCHDCAViNDFNCPNiRVCPyHIRRCMTISIRINsRELLVYKNCTNNCTFVYAAEQPpea--pgkIFKTNSFYWVCCCN 106 human
NP_001170995  47 MRCHSCQEhNTFYCPHiHYCDmDIRRCLTVAIRVNlRLLYVYKHCTKDCTFIYRRHVPpel--prvLKDVKSFYFVLCCG 124 house mouse
XP_006830920  76 VVCHSCAVlNTFTCNTfQTCDyNTRRCMIVAIRLNlRNLLVYKGCAFNCTFTYASQQPpea--prkITRKNNFYYVHCCG 153 Cape golden mole
XP_028617046  47 IKCNTCELeNTFQCEHhVDCHeNIRRCLTLAIRVNlRLLYVYKDCTKNCSFVYHSQVPpes--prlLRSVKSFYFVLCCS 124 Grammomys surda...
XP_004469731  72 MKCHVCYNiNSFYCPVhRDCLpDIRFCLIVSIRLDsRTLLVYKNCTNNCTFVYPFEQPrpt--ariSPTKPVFYFVRCCS 149 nine-banded arm...
XP_006879502  66 VVCYSCSLvNTFSCIAeMTCEkEVRRCMTVAIRVNsREVLIFKNCTKNCTFVYKEEEIppaspgrkITKTTNFYFVNCCN 145 Cape elephant s...

Q99445       107 SMVCNAGGP 115 human
XP_021515376 122 GNDCNIVGP 130 Mongolian gerbil
OBS64274     146 GTFCNVGGP 154 desert woodrat
NP_034546    125 SITCNVGGP 133 house mouse
NP_001070493 104 SNMCNFGGP 112 cattle
NP_002057    107 SMVCNAGGP 115 human
NP_001170995 125 SVVCNEGGP 133 house mouse
XP_006830920 154 VNRCNFGGP 162 Cape golden mole
XP_028617046 125 GTFCNEGGP 133 Grammomys surdaster
XP_004469731 150 GMTCNEGGL 158 nine-banded armadillo
XP_006879502 146 SMRCNSGGP 154 Cape elephant shrew
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