Conserved Protein Domain Family
NPBW
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pfam15180: NPBW 
Neuropeptides B and W
The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.
Links
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Statistics
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PSSM-Id: 464547
Aligned: 19 rows
Threshold Bit Score: 110.557
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EGW04445      18 LLPLLLV--LLLPLPAGAWYKHVASPRYHTVGRASGLLMGLRRSPYLWRRAL-GGAVGPLSRdt----------lVPGPV 84 
Q8K1M5        24 PLLPLLLllLLLPLPASAWYKHVASPRYHTVGRASGLLMGLRRSPYLWRRAL-GGAAGPLVG-------------LPGQM 89  Norway rat
ALD51507       9 PVLVVSL--LAAGGPSEAWYKQAAGPSYYSVGRASGLLSGIRRSPYVRRAEPePADSDEPADen---------afAQLTA 77 
XP_003450170   8 ALPIVVIsvLVACSPTEAWYKQVAGPTYYSVGRASGLLSGIRRSAYVRREEPhHADTDESATnn---------vfSEIPA 78 
XP_005989170  11 ALVCVAIslLISCQPSEAWYKQATGPSYYSVGRASGLLSGIRRSPYIRRSES-ETGTETGDTtgn--------nlVSEPR 81 
XP_006635208  11 ALVVAAIsmLISCHPTAAWYKQATGPSYYSVGRASGLLSGIRRSPYIRRSEP-EAMAESGEStgnf-----mtemGSQAR 84 
NP_001120841   8 VLVFVAVsiLISSHPTDAWYKQSTGPSYYSVGRASGLLSGIRRSPYVRRSEG-ESALDSGETpgvsnsvlaelssSNSGR 86 
Q4S001         8 TVVCVAVslLISGDLVEAWYKQSTGPSYYSVGRASGLLSGIRRSPYARRSESeETMLDSEDApgn--------svTPENR 79  spotted green p...
XP_027873560  10 AVVCVGVslLISCQSVEAWYKQVTGPSYYSVGRASGLLSGIRRSPTVRRAESeETVMDSGEAagn-------nliQETNK 82 
XP_004066211   8 AVVCVGVslLVSCHSAEAWYKQSTGPIFYPVGRASGLLSGIRRSPYVRRAESeEVLADSKEAaen-------svtHDASR 80 

EGW04445      85 TGStlPLLPSPVQELWETRRGswraglpvyePRSPRDLERARQ--PEQSLSLRSWISAE 141
Q8K1M5        90 ARSa-lLLPSPGQELWEVRSRsspaglpvhaTRSLRDLEGAGQ--PEQSLSFQSWTSAE 145 Norway rat
ALD51507      78 QNFilKTMPVCIKDISPDLQS----------CE-LQEITGSFKckADIFLTLDSADCGG 125
XP_003450170  79 SSSilKTMPVCIKDITPNLQS----------CERIQDIKASFRckADVFLSLDSSDCEA 127
XP_005989170  82 QTAilKSMAICVKDISPNLQS----------CELLQDGMNTFQckADVYLSLDSQDCMN 130
XP_006635208  85 QTAflKNMAVCVKDISPNLQS----------CELVQDGMSTFQckADVYLSLDSQDCVN 133
NP_001120841  87 QTPvlKNMAICVKDISPNLQS----------CELLQDGSSSFRckADVFLSLDSLDCFT 135
Q4S001        80 QISllKSMAICVKDISPNLKS----------CELLRDGTGTFQckADVFLTLDSLDCLS 128 spotted green pufferfish
XP_027873560  83 QISvlKNMAICLKDISPNLKS----------CELLQDGTGTFQckADVFLTLDSLDCLS 131
XP_004066211  81 QISalKDMAICVKDVSPNLKT----------CELLRDGTGTFQckADVFLTLDSLDCLS 129
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