3EXE


Conserved Protein Domain Family
PDH_E1_alph_y

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TIGR03182: PDH_E1_alph_y 
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pyruvate dehydrogenase E1 component, alpha subunit
Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase]
Statistics
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PSSM-Id: 274473
Aligned: 35 rows
Threshold Bit Score: 473.597
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EXE_A        50 REDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPT-DHLITAYRAHGFTFTRGLSVREILA 128 human
WP_011141528  17 RPEALVLYRDMVLGRTFEDTCAQMYYRGKMFGFVHLYNGQEAVSTGVIKAMRPD-DYVTSTYRDHVHALSKGVPARSVMA 95  Gloeobacter vio...
WP_010996861  19 KEEGLLLYEDMTLGRFFEDKCAEMYYRGKMFGFVHLYNGQEAVSTGVIQAMRPGeDFVSSTYRDHVHALSAGVPAREVMA 98  Nostocaceae
WP_011132922  21 RETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVIGAMKRKhDWFCSTYRDHVHALSAGVPSFEVMS 100 Prochlorococcus...
WP_011690378  14 SDHARHLLRQMLRVRRLEEQCVELYSAAKIRGFLHVYIGEEAVAAGVMSTLAPD-DAVVATYREHGHALLRGVPAGAILA 92  Arthrobacter sp...
WP_011189337  16 PAHARQLLYQMVRIRRFEEKAAELYTKMKIRGFLHLYIGEEAVAAGVSAALEPE-DASVGTYREHGNALARGISAGAIMA 94  Desulfotalea ps...
WP_011462714  15 KPFALSLLSDMLRIRRMEERAAELYGQQKIRGFLHLYIGEEAVAAGALRALSAD-DKVVATYREHGHALLHGLKMDTIMA 93  Albidiferax fer...
WP_011176278  23 PQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQS-NWYATSYRCHALALLLGATPNELMA 101 Candidatus Prot...
XP_471066     75 REEALELYEDMVLGRIFEDMCAQMYYRGKMFGFVHLYNGQEAVSTGFIKLLNQA-DCVVSTYRDHVHALSKGVPARSVMA 153 Oryza sativa (j...
WP_009896301  20 KDFALVLLRDMLRVRRLEETCAQLYGAGKIRGFLHLYIGEEAAGIGALHALEPD-DNVVATYREHAHALVRGMDMGVLMA 98  Burkholderia th...
3EXE_A       129 ELTGRKGGCAKGKGGSMHMYA--KNFYGGNGIVGAQVPLGAGIALACKYN-------GK-------D--EVCLTLYGDGA 190 human
WP_011141528  96 ELFGKATGCSKGRGGSMHLFSaeHNLLGGFAFVAEGIPIATGAGFTAVYK-------GT-------D--QVSACFFGDGA 159 Gloeobacter vio...
WP_010996861  99 ELFGKATGCSKGRGGSMHMFSaeHGLLGGYAFVAEGIPVAAGAAFQSKYRrevlgdpNA-------D--QVTACFFGDGA 169 Nostocaceae
WP_011132922 101 ELFGKATGCSKGRGGSMHLFSkeHHLLGGYAFIGEGIPVALGSAFSSKYK-------KEvvgdnqsD--SVTAAFFGDGT 171 Prochlorococcus...
WP_011690378  93 EMYGHVEGCCRGRGGSMHLFDagTRFYGGNAIVAGGLPLAVGLALADKMS-------GR-------S--RVTVCFFGEGA 156 Arthrobacter sp...
WP_011189337  95 EMYGKQEGCSRGRGGSMHIFDdkTRFYGGNAIVGGGLPLAVGLALADKMQ-------GK-------K--RVTCCFFGDGA 158 Desulfotalea ps...
WP_011462714  94 EMFGRQDGCSRGRGGSMHLFDraHHFFGGQAIVGGGLPLATGLALADKLL-------KR-------R--ALTACFFGEGA 157 Albidiferax fer...
WP_011176278 102 ELYGRATGNAKGRGGSMHFFT--DRLLGGFGIVTGQVPIATGAAFALKYK-------GNk------N--EVAVCFMGDGA 164 Candidatus Prot...
XP_471066    154 ELFGKATGCCRGQGGSMHMFSepHNLLGGFAFIGEGIPVATGAAFAAKYRhevlkqsSP-------DglDVTLAFFGDGT 226 Oryza sativa (j...
WP_009896301  99 EMFGKREGCARGRGGSMHLFDrqTRLFGGNAIVGGGLPLAAGLALAEKMQ-------AG-------K--RVTACFFGDGA 162 Burkholderia th...
3EXE_A       191 ANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYK-RGDF--IPGLRVDGMDILCVREATRFAAAYCRS 267 human
WP_011141528 160 TNNGQFFECLNMAALWNLPVLYVVENNLWSIGMYHHRASSVIEIYK-KADAfgIPGVRVDGMDVLAVRAVAKEAIERARA 238 Gloeobacter vio...
WP_010996861 170 ANNGQFFETLNMAALWKLPIIFVVENNKWAIGMAHDRATSDPEIYK-KASVfnMVGVEVDGMDVLAVRAVAQEAVARARA 248 Nostocaceae
WP_011132922 172 CNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWR-KASAfgMHGEEVDGMDVLAVRGAAQRAVERARA 250 Prochlorococcus...
WP_011690378 157 VAEGAFHESLNLAALWQLPVLFCCENNLYAMGTALARSESQTDIAL-KAAGyeIASWSADGMDVIAVEEAARRAVDAVRA 235 Arthrobacter sp...
WP_011189337 159 VSEGEFHESMNLAALWNLPVLFICENNLYAMGTALERSQSVTDLTR-KAVSyrIAASAVDGMDVLAVEAAANEAVNAVRS 237 Desulfotalea ps...
WP_011462714 158 VAEGAFHEAMNLAALWRLPVLFCCENNLYAMGTALARSESQTDLCL-KAASygMEVMTVDGMDVVAVHEAVRFAAQKVRE 236 Albidiferax fer...
WP_011176278 165 VPQGSFHESLNLASLWNLPCIYVIENNQWGMGTAIQKAVSVKRLAEdKASGynMKAYTLDGMDFFNCYGGFAQIHQEVLQ 244 Candidatus Prot...
XP_471066    227 CNNGQFFECLNMAQLWKLPIVFVVENNLWAIGMSHLRATSDPEIYK-KGPAfgMPGVHVDGMDVLKVREVAKEAIERARR 305 Oryza sativa (j...
WP_009896301 163 VAEGVFHESMNLAALWRLPVLFCCENNLYAMGTALERSESQTDLCA-KAASygMRVSSADGMDVVAVHDAAKDAVEYVRG 241 Burkholderia th...
3EXE_A       268 GKGPILMELQTYRYHGHSMSDPGvSYRTREEIQEVRsKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATA 347 human
WP_011141528 239 GGGPTLIECTTYRFRGHSLADPD-ELRDPAEKEFWR-KQDPIPRLAAFVREQELASAEELKAIDQEIRAEIDDAVLFAEE 316 Gloeobacter vio...
WP_010996861 249 GEGPTLIEALTYRFRGHSLADPD-EMRSKAEKEFWF-SRDPIKKLAAYLIEQNLADEAELKAIERKIQDVIDDAVKFAES 326 Nostocaceae
WP_011132922 251 GEGPTLLECLTYRFRGHSLADPD-ELRAEEEKEFWA-KRDPIKKLANQIIEGNFAQEEELKSIEKKIDLEISESVKNALD 328 Prochlorococcus...
WP_011690378 236 GGGPHFLELRTYRFRAHSMFDPE-RYRDKAEVSRWM-ERDPIDTLRTALEAAGQLSAKDWKSIQQDVDTEVDAAVEFAEA 313 Arthrobacter sp...
WP_011189337 238 GQKPYFLECRTYRFRAHSMFDPE-LYRSKAEVDKWK-KRCPIDSFVKRLKKQDLLSDGDMEKLERQVAREIEEAVAFAEN 315 Desulfotalea ps...
WP_011462714 237 ASAPMFVELRTYRFRAHSMFDPD-LYRAKQEIEAWK-TRGPVHTFTARLKLQGILSEDEFLALDASAQAEVEAAVAFAEG 314 Albidiferax fer...
WP_011176278 245 RQRPVLVEVVTERFKGHSISDPG-LYRAKDTLKQIM-AKDPILALQAVLIKKGILTEDMVKQMNKENREKIIEAMSFAEN 322 Candidatus Prot...
XP_471066    306 GEGPTLVECETYRFRGHSLADPD-ELRRPDEKSHYA-ARDPITALKKYIIEQNLATESELKSIEKKIDDVVEEAVEFADA 383 Oryza sativa (j...
WP_009896301 242 GAGPMFVELRTYRFRAHSMYDAE-LYRQKAEVDEWK-ARGPIHTFTARLKAEGKLTEDEFAALDADANAEVARAVAFAEA 319 Burkholderia th...
3EXE_A       348 DPEPPLEELGYHIYS 362 human
WP_011141528 317 SPEPPIDELYRFQFA 331 Gloeobacter violaceus
WP_010996861 327 SPEPDPSELYRFVFA 341 Nostocaceae
WP_011132922 329 APEPPSNELTKYIWA 343 Prochlorococcus marinus
WP_011690378 314 GTPEPLEDLTRFVYS 328 Arthrobacter sp. FB24
WP_011189337 316 GTWEPVEDLTRFVYS 330 Desulfotalea psychrophila
WP_011462714 315 SNWEPVEDLLRDVHT 329 Albidiferax ferrireducens
WP_011176278 323 SPWPDPQTLEEDVFA 337 Candidatus Protochlamydia amoebophila
XP_471066    384 SPLPPRSQLLENVFS 398 Oryza sativa (japonica cultivar-group)
WP_009896301 320 GEWERVEDLAKDVYT 334 Burkholderia thailandensis
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