4WW9


Conserved Protein Domain Family
CGI-121

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pfam08617: CGI-121 
Kinase binding protein CGI-121
CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.
Statistics
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PSSM-Id: 462537
Aligned: 149 rows
Threshold Bit Score: 59.0916
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4WW9_B         19 FEQVKNA--KEI-------RSKM--S--Elst----sfAFIDPRLVCSGEQMYSAIYKTLIEVK------YN---KMRTR 72  Saccharomyces ...
EFJ05709       16 FDGVSNS--GEL-------LASL--QagTlsp----evALFNASLVPDLFPVLASAHRTLLSQS------RG---NLVTR 71 
Q4DY70         12 YHDVRDA--ASL-------HEQFkkRsi--------saAVIDSAYIMSRLHLVVALHRISSAPLiighddCQpkmTRKST 74  Trypanosoma cruzi
XP_001329122   16 FENIGDP--QTI-------NDYI-----Kanq---ppvALIDARTIISLAHVQVAILNMRTIQE-------------RDQ 65 
XP_002259700   19 FKNVTNA--KELlrvynekTQAVdpdm-------rrffLLLDGQLIFSDNHILHSLYRAYHNA--------------LTK 75 
Q8I3Y9         20 FKNVVNS--KDLlesytksMN-------DnicyindffLLLDSNLVYNENHILHSIYRAHHNF--------------QSK 76  Plasmodium fal...
XP_677530      20 FKNVTNS--KDVleiynkqSDDI-----SssdqqnkffLILDSQLVFNEGHILHSIYRGYHNF--------------KTK 78 
Q4UGL2         65 FNSIKTP--KSIldfn-------------------vlfLVLRPSLILSVDHLLHSVARALTNVL-------------SSK 110 Theileria annu...
jgi:Mvol_0160  19 ILGIKNAvvNNE-------IFQL-----Nkkf----efQMINADYIATIEHIKHAILQAM-----------------TKK 65 
Q18DI5         16 FVSIVDKieKGT-------GATI---------------QAFDARYIVNQKHIKRAIECADRARR-------------RNN 60  Haloquadratum ...
4WW9_B         73 N-LNS----ECVLCLSPTSNISDAFLKFGIK--DD-SSQLICLKFhtnt---ddvdKEQLRTIMTSIVK-G-QEI-EFND 138 Saccharomyces ...
EFJ05709       72 T-LHS----ELVYNFSGSKHITESLRRCGIS--SGtSY-VLVVQFd---------cPAEKENEVRKLIQ-G-REI-SLEE 131
Q4DY70         75 ArTAR----DVFAALSHTRNLYRVLEHLTCS--ET-TRAVVIVLSap---------tEEDVAAVLDIVQgVrHGLlSLET 138 Trypanosoma cruzi
XP_001329122   66 T-QSKsiylEILRCLSPDGRLNGALKFCAIQ--KD-TTAVIAITFedefpsipglsDPKTFDQFLANPK----------- 130
XP_002259700   76 KrVTRnivlEVFFFLSAHENINECLKQYQIR--DS-SSSVIYVGVni---------pRDEVHSFTNLIC-G-QST-SVDD 140
Q8I3Y9         77 KrITKniflEILFLLSPHENINECVKQYQIK--ND-SSSVIYVGIni---------sKDQVDMFIKSVQ-G-DQA-DFNE 141 Plasmodium fal...
XP_677530      79 KkITKniilEIFFLLSSHENINECINQYKMN--EN-STSIIYVGVnm---------pNDQMIEVTKIIQ-G-KSA-NFDE 143
Q4UGL2        111 P-VSSnfttEVAFMLSGSSSVGKSLERVLLSknDK-SSPALILTLsq----------nKSRDSILDIINgVqDDIsNLDK 178 Theileria annu...
jgi:Mvol_0160  66 N-ISNnfwvEILVRASATRQIATAIKLLGAK-----SGDVCLICNde-------etANIIIDKIGGIVQ-K-NSVeFLDV 130
Q18DI5         61 N-IARdrsiEMLLYAAGRRQITEALE-IGVS--SGlNRIVVAIDGgn-------------eIEAAKSIEsN-----TLDT 118 Haloquadratum ...
4WW9_B        139 d---nLSRFYDEALIRKIYKLSDDFkpQDVNG-LSRALVDAIQLRG 180 Saccharomyces cerevisiae S288C
EFJ05709      132 -----LAKRADTALIQKHFKVPPLE--LEISS-LTDAVTSRIAARD 169
Q4DY70        139 y--------RDEAAVREFYGVG-----ESEAAaLEVTIVNRLATSD 171 Trypanosoma cruzi
XP_001329122  131 ---------TDFDKIKKAFKLSd---aMLATYsHEQLVITTLSVLA 164
XP_002259700  141 -----IRFLHDEKQIMQNFKCT------GEVAnLERFIYHTIASKK 175
Q8I3Y9        142 -----LSFLHDKKKILENFKCD-------NMDnLERFIYHNIASKK 175 Plasmodium falciparum 3D7
XP_677530     144 -----ISSLHCEKKILEHFNTD--------INnIDRFIYHNIASKK 176
Q4UGL2        179 yt--------kVDDLTKEFKIT--QeeLKLPGgLEASILCRIGVKR 214 Theileria annulata
jgi:Mvol_0160 131 pndvnNEK---FKKIVELYGLKn----VNSSKeLVKRVLEEIAIIE 169
Q18DI5        119 padevLGS-YDPDLVQPYFDIT-ANeiDVVNGdTESLVLERVALLA 162 Haloquadratum walsbyi DSM 16790
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