5F5S,5F5T,5NRL


Conserved Protein Domain Family
PRP38

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pfam03371: PRP38 
PRP38 family
Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.
Statistics
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PSSM-Id: 460901
Aligned: 135 rows
Threshold Bit Score: 132.566
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5F5S_A        12 HSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTA----------ELVVDKAME-LRFVGG-VYGgNIkp-tpFLCLTLK 78 
XP_002179852  41 LPLWGAPDSFHFNPLLLRNTVRSLYFQKCCEKLLDw---------NAVVDEIYYeVKYLQPfALDksp---stAFCLLLR 108
XP_001417208  18 nAAKTTGRTHGVEAVLRQNVVNSEYYR-KLCRSATgtvdgegmdfMSLVDEIYElVDHVEPwMSGnARga-stGFCILFR 95 
XP_003057645  20 gqalDNGKSYNMEKVLRTNILASDYFS-QLVKMNDf---------YELVDEIYNeVDHVEPwMSGnARgp-stAFCLLYR 88 
EDP06100       1 mEIHGSNTTFNLENVLRQNILSSDYYKGTCSELSNc---------SDIVDEIYEsVDHVEPwMSGnARgp-stAFCLLHR 70 
EFN52225       1 meqYGNQTTFNLESVLLQNIKRSQYWEKRAKDIADw---------SELVDEIFEtVDNVEPwMSGnARgp-stAFNLLYR 70 
EDO08447     159 LDM-TNSSTYNMNTLLLNNILNSDYYK-SLSTMTSh---------HSIIDELAQyADHVEPyCKTaTRvp-stLFCCLHK 226
ESS30588     141 vEM-TDSTTYNVNALLRSNILSSEYFK-SLHELKTv---------PEVVDEITQyAQHAEPyCSGsSRap-stLFCCLYK 208
Q8IM21       173 LEM-TNTTTYNVNTLLRNNILSSEYFK-SLIPIKTf---------KEVVDEIHSyADHVEPyCIGsNRap-stLFCCLYK 240 Plasmodium falc...
EFC45362      48 INVWGNSSTMNITPYLYKKVLASPYFK-SLYEYKTy---------HEVLDLIKN-IKYIHPfTDGdTNaepsiAFSLLFK 116
5F5S_A        79 MLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGe------------FELMHV 146
XP_002179852 109 LLTLRVTNHQMELTLKHTDSPYIRGIGFLYLRYAGPPEQIWSFIESSLQDEEelvie-------------aghrGKRSTI 175
XP_001417208  96 FCEKELSDKEIWHLLRHGDSPYIRAIGFLYVRYVKNGRELLRWCEEFFDDAEkfsp---------------spgGKEVTM 160
XP_003057645  89 LFTMEIEDNEVKHLINHGDSPYIRALGFLYVRYARDPKEFGRWFDEFLRDEEefsp---------------sphGKSVTM 153
EDP06100      71 LFTLKLSAKEVKGMLDHKDSPYIRAVGFLYLRYVGDPKTLWSWVAPYVKDQEkfsp--------------sgpnEKEVAM 136
EFN52225      71 LCQLKPDVRQVRQMLDHVDSTFIRAIGLLYLRYVCDPRQLWDWFRNYVRDEEICKAGLLSLlftqefepsppglGRTVTI 150
EDO08447     227 LFTLRLTERQMEDLIDCTKSPYPRCCGFLYLRFVLPSDQLWAWFEPYLMDEEtfvm--------------svnpTRKTTI 292
ESS30588     209 LFTMKLTTKQLEQLLDYSDSPYVRCTGFLYLRYVHPPEKLWKWYEQYFLDDEvfaa--------------ssdtKRTTTM 274
Q8IM21       241 FFTMQLSEKQLKSLIENKDSCYIRACGFLYLRYVHSPANLWMWFEPYLLEEDefsi--------------scdkRRKVTI 306 Plasmodium falc...
EFC45362     117 LHTLKLSYKQLKGMLQKDMSTNTKAMALLYVRFAVQPDEMWDYFRDFVNDENntv----------------niyTKRISL 180
5F5S_A       147 DEFIDELLHSERVCDI--ILPRLQKRYVLE 174
XP_002179852 176 GQFVRSLFSSRDFYGT--SLPRLPIQTERD 203
XP_001417208 161 GTYVRDLLLEQHYFET--IFPRIPEVARRE 188
XP_003057645 154 GAFVRDLILDQYYFET--IFPRIPEVSRRa 181
EDP06100     137 GDYVRDLLLSQYYFET--IFPRIPKPVQDQ 164
EFN52225     151 GAFARDILLDQFYFET--IFPRVPKPggad 178
EDO08447     293 GKFCESLLVEDRYFNT--VLPRLPSRFKNM 320
ESS30588     275 GEYVESLIMEDKYFNT--VLPRLPVKVKnl 302
Q8IM21       307 GEYVQSLLSDDKYFNT--VLPRLPIKIKNV 334 Plasmodium falciparum 3D7
EFC45362     181 GEFVRSLITNQKLFGSqcILPILPANLVrr 210
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