1MSV


Conserved Protein Domain Family
SAM_decarbox

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pfam01536: SAM_decarbox 
Adenosylmethionine decarboxylase
This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes. In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine. The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.
Statistics
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PSSM-Id: 460243
Aligned: 93 rows
Threshold Bit Score: 336.427
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1MSV_A         4 AHFFEGTEKLLEVWFSRQQPDA-Nqg-----sgDLRT-IPRSEWDILLKDVQCSIISVTKTDKQEAYVLSEASMFVSKRR 76 
EFH59249       2 tTEFEGVEKRLEIVFRKEED-------------SLREvLTEEVWHDILRSIDCWIVDKLLTASVDSYLLSASSLFVFDDR 68 
XP_009115932   4 DERFEGVEKRLEIVFSPTAG-------------KLREkLTQNLLEQILTDVKCHIVSHKLEEKVDAYLLSTSSCFVYDDR 70 
NP_001306788   9 AIGFEGFEKRLEISFVEPGLFAdpn------gkGLRS-LSKAQLDEILGPAECTIVDNLSNDYVDSYVLSESSLFVYSYK 81 
EEF47640      10 AIGFEGYEKRLEISFFELGMFVdpe------gkGLRS-LSKAQLDMILGPAECTIVDSLSNENVDSYVLSESSLFVYPYK 82 
Q9LSU6         5 ATGFEGFEKRLEISFFETTDFLdpq------gkSLRS-LTKSQLDEILTPAECTIVSSLTNSFVDSYVLSESSLFVYPYK 77  thale cress
VDD19418       5 AIGFEGYEKRLEVSFFEPSLFLdth------gkGLRA-LPKSQIDEILAPAECTIVSSLSNDELDSYVLSESSLFIFPYK 77 
XP_006338297   7 AIGFEGYEKRLEICFFELGNSYgp-------gcGLRS-LSKDQLDEILTPAACTIVSSLANDEVDSYVLSESSLFVYAYK 78 
Q8T1E3        26 SDGFEGPEKKLDIRFGPISKGSvKsiagspskvGLRT-IDKEKWQTVLDSARCTIISQTSNDHMDSYVLSESSLFVYPRR 104 Dictyostelium d...
Q587A7        25 ERSFEGPEKRLEVIMRVVDGTHvS---------GLLA-HDDDVWQKVIDAICAHIVSREFNEYIRSYVLSESSLFVMKDR 94  Trypanosoma brucei
1MSV_A        77 FILKTCGTTLLLKALVPLLKLARDYSGfDSIQSFFYSRKNFMKPSHQGYPHRNFQEE----IEFLNAIF--PN----GAA 146
EFH59249      69 LIIKTCGEIKLFQAITKILGLS----K-RTPVGVKFTRGTYFWPERQPEPHGNFPSE----VSELRRNF--LElddtVTA 137
XP_009115932  71 VIVKTCGETEIFKCMESLMGLTDH----QNVVSVVYTRGDFFWPERQPFPHNDVTEEnkefVKLLEKLTklKP----MKA 142
NP_001306788  82 IIIKTCGTTKLLLAIPPILRLA-ETLS-LKVQDVRYTRGSFIFPGAQSFPHRHFSEE----VAVLDGYF--GKlaagSKA 153
EEF47640      83 IIIKTCGTTKLLLAIPPILKLA-DALS-LNVKSVRYTRGSFIFPGAQSYPHRSFSEE----VAVLDDYF--GKlgagSTA 154
Q9LSU6        78 IIIKTCGTTKLLLSIPHILRLA-DSLC-LTVKSVRYTRGSFIFPGAQSYPHRSFSEE----VALLDDYF--GKlnagSKA 149 thale cress
VDD19418      78 IIIKTCGTTKLLLSIEPLLRLA-GGVS-LEVKSVRYTRGSFLCPGGQPFPHRNFSEE----VSVLDGHF--AKmglsSVA 149
XP_006338297  79 IIIKTCGTTKLLLSIPPILKLA-DALN-LKVKSVRYTRGCFIFPGAQPYPHRHFSEE----VAVLDTYF--GKlgagSNA 150
Q8T1E3       105 AMIKTCGTTTLLHLIAKMVQVG-KECG-LEVEMVVFSRKNLNQPSKQVFPHCSFSDE----VNFLNKIF---D----GQA 171 Dictyostelium d...
Q587A7        95 VILITCGTITLLNCVPLICEAVSTVCG--EVEWVSFMHKNYSFPWEQKGPHLSMAEE----FKTLRSHF--PS----GQP 162 Trypanosoma brucei
1MSV_A       147 YCMGR--MNSDCWYLYTLDFPES-RVISQPDQTLEILMSELDPAVMDQFYMKD----GVTAKDVTRESGIRDLIP-GSVI 218
EFH59249     138 EFGTD---EKHKFHIFAAaasg---ssvSDGVTVEILMTGIEKSKASVFFkds-----giPGSMTSASGIDQIFP-ESSI 205
XP_009115932 143 LCMGT---GNKKWHVLGGfsgds-ltsqGDFVTVEMSMRGLDREKAKVFYeke----nvTKTTMTEESGICYIFP-NAII 213
NP_001306788 154 VIMGSp-dKTQKWHVYSAsags--vqsnDPVYTLEMCMTGLDREKASVFYkte----esSAAHMTVRSGIRKILP-KSEI 225
EEF47640     155 YVMGGl-hSPQKWHVYSAsahs--tyccDCVYTIEMCMTGLEREKASVFFksq----saSAAVMTVDSGIRRILP-NSKI 226
Q9LSU6       150 FVMGGsdNNPQRWHVYSAssteesavcdKPVYTLEMCMTGLDNIKASVFFktn----svSASEMTISSGIRNILP-GSEI 224 thale cress
VDD19418     150 YLMGDd-dETKKWHVYSAsapaknsngdNNVYTLEMCMTGLDKDKASVFFkne----ssSAGSMTDNSGIRKILP-QSQI 223
XP_006338297 151 YVMGNa-dKQQNWHVYSAsaesadannmNPVYTLEMCMTNLDKKKASVFFktq----ssTAAEMTEVSGIRKILP-ESNI 224
Q8T1E3       172 YVMGD--VNKDHWNLYIADFRKN-PTLQRTEQTFEVMMHDLDETVMKQFFKRE----GVSAWDTTVNSGIADLLP-GSMI 243 Dictyostelium d...
Q587A7       163 FIFGP--IDSDHYFLYFHsdvv--qpscSDDAQLSMTMYGLDRNQTKHWYsdkmlptgpETAVIREATGLSEVVDdSWIL 238 Trypanosoma brucei
1MSV_A       219 DATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNL-SQ----TSYDDLIRKVVEVFKPGKFVTTLFVNQSS--- 290
EFH59249     206 CDHEFPTCGYSMNGVVGSNSVYTIHVTPEEGFSFASFEVCGcET----HSLEKLVQNVLSCFNPSTFTAVLHTRS----- 276
XP_009115932 214 DAHAFDKCGYSMNGIEGK-GISTIHVSPEDEGSFASFESFGyDFkn-eKKFEHVIPTVLKCFSPKQFTMTVYSTVp---- 287
NP_001306788 226 CDFEFEPCGYSMNSIEGA-AVSTIHITPEDGFTYASFESVG--YnpktMELGPLVERVLACFEPAEFSVALHADVATkll 302
EEF47640     227 CDFDFDPCGYSMNAIEGA-AISTIHITPEDGFSYASFETVG--YnpeeVNLNQLVERVLACFQPSQFSIAVHANVADkql 303
Q9LSU6       225 CDFNFEPCGYSMNSIEGD-AVSTIHVTPEDGFSYASFETVG--YdlkaLNFKELVDRVLVCFGPEEFSVAVHANLGTevl 301 thale cress
VDD19418     224 CDFEFEPCGYSMNSVEGD-AVSTIHVTPEDGFSYASFEAVG--YdfttMDLSHLVSRVLTCFEPKQFSVAVHSSVAQksy 300
XP_006338297 225 CDFDFDPCGYSMNAVEGP-AISTIHITPEDGFSYASFEAVG--YdfraVDLSAMIERVLSCFRPAEFSVALHCDIPGkel 301
Q8T1E3       244 DDFQFDPCGYSMNGLLNE-FYWTIHITPESHCSYVSFDTNV-AL----ADYNQLLAKVLNVFKPGRFTAALYAEDGApc- 316 Dictyostelium d...
Q587A7       239 HDLQYEPCGYSINAIRGS-EYQTIHITPEEHCSFASYETNT-CA----LNYSKCICGVLRVFDPERFSVIVFIDPDSavg 312 Trypanosoma brucei
1MSV_A       291 -KcrtvlaSPQKIE-------GFKRLDCQSAMFN--DYNFVFTSF 325
EFH59249     277 -----------KLElldlnieGRICKEKDCKNLGs-YGTMTYlsf 309
XP_009115932 288 --------LEGNEPelkvdlkGYKCLEEKIHKLDn-GGSVVYQSF 323
NP_001306788 303 eRicsv------------dvkGYSLAEWSPEEFGe-GGSIVYQKF 334
EEF47640     304 vQtcal------------dvkGYCRGERSFEELGm-GGSIVYQKF 335
Q9LSU6       302 aSdcva------------dvnGYFSQERELEELGl-GGSVLYQRF 333 thale cress
VDD19418     301 dHsgls-----------vdleDYGCRETTVESLGeeRGTVMYQRF 334
XP_006338297 302 yTesgl------------dviGYVSGEKTTEVLGk-GGSLTYLTF 333
Q8T1E3       317 gDpyt--afdVNVP-------SYAIQNKTVHGFDg-GYDVVVSNY 351 Dictyostelium discoideum
Q587A7       313 k----syhSGGTIGvepeyypNYEAHHRTVNEYTp-GHWVLKVNY 352 Trypanosoma brucei
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