3S4W,7AY1


Conserved Protein Domain Family
FancD2

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pfam14631: FancD2 
Fanconi anaemia protein FancD2 nuclease
The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
Statistics
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PSSM-Id: 464225
Aligned: 9 rows
Threshold Bit Score: 2285.08
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3S4W_B          1 SHNSHEVEENg-sVFVKLLKASGLTLKTGENQNQLGVDQVIFQRKLFQALRKHPAYPKVIEEFVNGLESYTEDSESLRNC 79   house mouse
XP_013001742   35 SHASNEVEEN---VFVKLLKTSGLILKTGENQNQLVVDQIVFQKKLFQSLKKHPSYPKVIEEFVSGLESHIEDHDTFRNC 111 
7AY1_B         39 SHIANEVEENd-sIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNC 117  human
XP_023353940   34 SIGQNEIVENd-sTFVKLLKTAGVTLKTGEKQNQLAVDQVIFQKKLSQALRKHSSYPKAVEEFIGGLESYIEDRDCFRNC 112 
XP_008103225   35 SVPQDGVIELs-sVFGQLLKSAGIILKAGERQNEIAVDGAIFQKKLHQALRKHPSYPQVVEEFITGLESHIENRDQFRNC 113 
XP_005166084   35 SSVQDSCQd---sVFVQFLKESGVTLTPGSTANEIAVDQVIFQKRLQQRLRKSPRFPNIIQEFISALETYIEDPERFRNC 111 
XP_011472951   34 EAVAVETNe---sVFAVFVRKAGVTLKHDAQSNEIAVDQVVFQKRIQQQLQRSPQFPAIIQEFITGMEAHIENPDTLRVC 110 
XP_005469603   34 EAAPEETNq---cVFVDFVRVAGVILRPGGMPNEIGVDQVVFQRRIQQQLQKSPRYPGIIQEFITALESYMENTDRFRNC 110 
XP_015202792   35 PTAQHATQHAgesVFAQLVRGAGIALRQGRTPNEITVDQAMFHGRLQRSLRKHPHYPNVIKEFITGLESHIEDQEKFKNC 114  spotted gar
3S4W_B         80 LLSCERLQDEEA----SMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESENRDGINMARLIINQLKWLDRIVDG 155  house mouse
XP_013001742  112 LLPCERLQDEELrcegSTGTSYSKSLIKLLLGIDILQPAIIKTLFEKLPEFLFVKVNSDGISMPRLIISQLKWLDRVVDS 191 
7AY1_B        118 LLSCERLQDEEA----SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDG 193  human
XP_023353940  113 LLSCERLQEEET----SMVTPYYKSLIKLLLGIDNLQPAIIRILFEKLPEFLYESTNNDGLNMPRLIINQFKWLDRIIDG 188 
XP_008103225  114 LLPCVPVQNQEAs---NAVHSYCESLIKLLLGIEILQSTVIKLLFEKVPEFFDESVGSDGLNLPRLIVNQLKWLDRIVNS 190 
XP_005166084  112 LLPCVPAPTSQQd---TNSSSYQESLVRLLLGIEMLQTLVINTLFEKLPEFMFEGASEDGLNVPRLIVNQLKWLDRIVDG 188 
XP_011472951  111 LLPCVPQTSDGH------ISSFQESLLRMLLGVEMLQTLIINILLEKVPEFMLDSTGDGGLSFPRMIINQLKWLDRILDA 184 
XP_005469603  111 LLPCVPQSSNGDs---SSVSSFQESLLRMLLGIEMLQTSIINTLLEKLPEYMLDSTSDGGVSIPRIIINQLKWLDRVVDA 187 
XP_015202792  115 LLPCVPRSSDGEs--sTAVTSYQESLIKMLLGIEMLQPSVINTLFEKLPEFMYDGVGDDGLNIPRIIINQFKWLDRVMDS 192  spotted gar
3S4W_B        156 KDLTAQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELGELLVQNTSLTVPILDVFSSLRLDPNFLSKIRQLVMGK 235  house mouse
XP_013001742  192 KDLTAKVMQLIGIAPECLQHDFITSLPEILGDSQHADVGQELSVLLVESTQLTVPILDVLSSLQLDPDFLSKVRQLAMGK 271 
7AY1_B        194 KDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDK 273  human
XP_023353940  189 KDLTTKIMQLISIAPVTLQHDLITSLPEIIGDSQHGDVAGELSDLLVKNTMLTVPILDVLSSLRLDPKLLSKVRHLVMTK 268 
XP_008103225  191 KELLSTIMQMICVSPLSIQHDIITSLPEILEDAQHSEVARELSSLLKEKTELTVPILDALSSLNLDLGLLSEVRQSIMVT 270 
XP_005166084  189 KDLSSKLMQMVSVAPVEIQRDIITSLPEILEDSQHGDMAKELNGLLQQNTQLAVPILDALSSLNLSSTLLSEVREAVMGT 268 
XP_011472951  185 KGLSLKLMELVSVAPVEVQRDVITSLPEILDDSQHNDVGRELNCLLLERTQLTVPILDALSSLNLSSSLLTEVRTAVMAT 264 
XP_005469603  188 KDLASKLMELVSVAPVEVQRDIITSLPEILEDSQHNDTARELNSLLQEKTQLTVPILDALSSLNLASSLLTEVRGAVMAT 267 
XP_015202792  193 KDLANKLMQLVAVAPVEIQRDIISSLPEILEDAQHNDIARELNSLLQKNTQLTLPILDALSSLNLSPTLLAEVRQAVMTT 272  spotted gar
3S4W_B        236 LSSVRLEDFPVIVKFLLHSVTDTTSLEVIAELRENLNVQQFILPSRIQASQSKLKSK-GLASS---SGNQENSDKDCIVL 311  house mouse
XP_013001742  272 LVSIKLDDFPVIIKFILHSITATNAFEVISELRRKLDLQHFIFPSLLQASQFTLKRK-GGASS---SGSQNSSHPDYVTL 347 
7AY1_B        274 LSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSK-GRASS---SGNQESSGQSCIIL 349  human
XP_023353940  269 LSAVTLENLPVIIKFILHAVTVTDALEVISELRKKLDLEYCILPPQLQTSQSKLKNK-GLM-S---SGNQENSHQDCVSL 343 
XP_008103225  271 VAAVQVEDLPVVVKFILRSIKETNAVEVISDLRKKLDLDSFVSLPQIQASQSKLRNQ-PQASL---PASQVNVNQDCIKL 346 
XP_005166084  269 LSAVQLEDLPVVVKFVLHSISASDANEVVCDLRKKLELEQCVLPAVLQASQSRMKNKtVSRSS---SVPSCSSGQDSVAL 345 
XP_011472951  265 MAAVQLEDLPVVVKFILHSVSSSDAYEVVCSLRKNLELEQCVLPAALQASQTLLKTK-RAAVSapaAAAAASSSQDSISL 343 
XP_005469603  268 LAAVQLEDLPVVVKFILHSVSASDAYEVVCNLRKKLELEQCVLPPVLQASQSRMNSKaAAGSA---SAAAAGSSQDSISL 344 
XP_015202792  273 LSAVELEDLPVVVKFILHNLSGAEAYEVICDLRKKLELESCVLPPVLQASQNRLKSKgPAGSS---HHPAASCSQDCVSL 349  spotted gar
3S4W_B        312 VFDVIKSAIRYEKTISEAWFKAIERIESAAEHKSLDVVMLLIIYSTSTQT-KKGVEKLLRNKIQSDCIQEQLLDSAFSTH 390  house mouse
XP_013001742  348 IFDVIKSAVRYEKAISEAWVKAIETTVLGSDHSTFDVVMLFIIYSTSPQT-KKYIEKVLRSKIRSGCFHQQLLESTFCVH 426 
7AY1_B        350 LFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQT-KKYIDRVLRNKIRSGCIQEQLLQSTFSVH 428  human
XP_023353940  344 LFDVIKSAVRYERAISEAWIKAIENIDSVSDHKVLDLLMLLIIYSVNTQS-KKYIERVLRNKVQSGCIPEQLLQNTFCTY 422 
XP_008103225  347 LFEVIKSAIKFQKTILEGWIKAIENVYSASDHKVLDLIVLFLIYATNSKI-KKQIERMLRNKIRSGCLREQLLRSAFRYH 425 
XP_005166084  346 ILDVIKSAIRFQKTISEAWLKAIENIDESEDHKVVDLLVLFILHSTNANHsRRGAERVLKVKVRKGLIQESLLQKTFKGH 425 
XP_011472951  344 VLDGIKSAVRFQKTIAEAWLKAIESVEEEEEHKVIDLLMLFILHSTNANQsRRGAERMLKLKVRTGLIQEPLLQRTFRDY 423 
XP_005469603  345 ILDCIKSAVRFQKTISEAWLKAIESVDEVEGHKVMDLLVLLILHSTNANQsRRGAERVLKVKVRNGLIQEALLQRTFRDY 424 
XP_015202792  350 VLDVIKSAVRFQKPISEAWLkAIENIDATEDHKVIDIMALLILHSATANQgRREVERLLRVKVRAGQVRESLLQTAFRGH 429  spotted gar
3S4W_B        391 YLVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGALVTHVCSGTEAEVDTALDVLLELIVLNA 470  house mouse
XP_013001742  427 FMVLEDVCPSILLVAQNLFHSQEQSITSFASLLYKYSFRSFDTYCQQEVVGALVTHVCSGNEAEVDAALYVLLELSVLDP 506 
7AY1_B        429 YLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNP 508  human
XP_023353940  423 MSVLRDVFPSILSLAQSLLHSTEQSVISFGSLLYKYAFVSFDTYYQQEVIGALVTHVCSGNDAEVDIALEVLSELVVLNL 502 
XP_008103225  426 PLVMRDLFPAILSLAEVFVHSADSCIVSFGSYMYKQAFTAFDVYCQQEIVGALVTHACGGNSEEVDVALDMLTDLVSLHT 505 
XP_005166084  426 AQVMRGYFPSILALAQGLLRSPDCCVVPFGGHMYKQAFTAFDSYCQQEVVGSLVTHACSGVSGEVDVALELLCELVSQKP 505 
XP_011472951  424 VQVLRGYFSSILALAQSLLRSPDPGLVAFGGHMYRCSFTAFDSYCQQEVVGSLVTHVCSGAGGEVDMALELLCGLVTEKP 503 
XP_005469603  425 AQVMRGYFPSTLALAQSLVRSPDPCMVPFGGHMYRHAFTAFDSYCHQEVVGSLVTHVCSGVGGEVDVALELLCGLVNEKP 504 
XP_015202792  430 ALVMCGYFPSILALAQTLLRSPDSSVLTFGSHMYKHAFMAFDSYCQQEVVGSLVAHVCSGYAHEVDVSLELLGELVTQRP 509  spotted gar
3S4W_B        471 SAMRLNAAFVKGILDYLENMSPQQIRKIFCILSTLAFSqQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGI 550  house mouse
XP_013001742  507 SAMRLNAAFVKGLLDYLDNMSPQQIRKLFHILSTLAFSeQHEASSHIKDDMHLVIRKQLSSSIVKYKLIGIIGAVTMAGI 586 
7AY1_B        509 SAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFSkQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGI 588  human
XP_023353940  503 SAVRLYAVFVKGILDYLDNLTPSQIRKLFHILSTLAFSkGHEDSSHIQDDMYLVIRKQLSSTVFKYKLIGIIGAITMVGS 582 
XP_008103225  506 SSVVPYGVFLKSILDYMDNLSPQQIRKLFHILSVLAFS-QGHRSSHIQDDIHMVIRKQLSSTIPKYRRIGIIGALTMVGS 584 
XP_005166084  506 AEMSQFTVFVKGILDYMDNLTSQQIRRLFHLLSRLAFG-QEQHGGHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVMMVGS 584 
XP_011472951  504 SEMALYAVFVKGILDYMDNLTSQQIRKLFQLLSRLAFGqQQQQGSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVMIIGS 583 
XP_005469603  505 SEMAMYAVFVKGILDYMDNLTPQQIRRLFHLLSRLAFG--QKQGSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVMIVGS 582 
XP_015202792  510 SDMSLYAVFIKGILDYMDNLTPQQIRRLFFILSQLAFG-SHPQGSHIQDDIHIVIRKQLSSTVSKYKRIGIIGAVMVVGG 588  spotted gar
3S4W_B        551 MAEDrsvpsnsSQRSANVSSEQRTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIFNDFQDAF 630  house mouse
XP_013001742  587 MAAD-------SQERVDPSNEQCTQVMSLLQLVQSCSEQSPQASALYYDEFANLIQEGNIAPKTLEWVGQTICSDFQDAF 659 
7AY1_B        589 MAADrsespslTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAF 668  human
XP_023353940  583 MAADsda-sgsTSDGTELSSERCKQMTSLLQLVHSCSEQSPQASALYYDEFASLIAKGKLPPKTLEWIEQTICNDFQDAF 661 
XP_008103225  585 MAAKrskengqILEQAQLSKEQCRQITSLLELVYSSCGQIPQALALYYDELANLIQKGNMDLQILDWIGSSVVKDFEEDF 664 
XP_005166084  585 MGAcrn--khdGSQGGTLPKETNRQVMALLELVRSCSESSPEAAALCYDELANLLQTCKLDPLVQAWIGKSVLEDFQDDF 662 
XP_011472951  584 MGArse---gtDSQNGSLSQETLRQVTALMELVKSSSESSPEAAALYYDELANLIWSSTLDPQVQEMMGSRVLDDFQEDF 660 
XP_005469603  583 MGAfrs--kakESQSGSLSQETLRQVTALLELVKSSSESSPEAAALYYDELANLILSSALDPQVQDMIGKSVLQDFEDDF 660 
XP_015202792  589 MASHrtnsassNGQEPSLSKEICRQVTALLELVRSCSEGSPEAAALYYDELANLVQTGHLDKVVQEWIGKSVLEDFQDDF 668  spotted gar
3S4W_B        631 VVDFCAAPE-GDFPFPVKALYGLE-EYSTQDGIVINLLPLFY-QECAKDASRATSQESSQRSMSSLCLASHFRLLRLCVA 707  house mouse
XP_013001742  660 VVDLCDVSE-GALPFPGKALYGLE-EYNTCDGIAINLLPLLYsEEFAKDGGHMTAQESGQKLVSTLCLAPYFRLLRFCVA 737 
7AY1_B        669 VVDSCVVPE-GDFPFPVKALYGLE-EYDTQDGIAINLLPLLFsQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVE 746  human
XP_023353940  662 VVDLSALPKvSDYPFPVKALYGLD-EDESQDGIAINLLPLLLhQNLKSDMGAMTFQDQDQKLVSPVCLSPYFRLLRLCVE 740 
XP_008103225  665 VTDLVPIED-SAFLFPVKALYCLE-DEESEATIAINLLPLVSqSYLNKHENEVTAKSKEKRIVSPVCLSPFFRLLRLCIS 742 
XP_005166084  663 VVDLGPDIS-GAFMFPTSVLYNLD-EEESEGGIAVNLLPLMAlDQQHKTDTSQPAGVKRERRVSPLCLSPFFRLLRLCEE 740 
XP_011472951  661 VVDLGPDIT-GSFLLPPRVMYNLD-DDESQGGIAINLLPLLAkDTQSKGD-ELTHDKKPLKRVSPLCLSPFFRLLRLCEE 737 
XP_005469603  661 VVDLGPEIS-GSFPFPARAMYKLY-EDEDQGGIAINLMPLLAkDIQNKGE-QQNQVNKAHKRVSSLCLSPFFRLLRLCVE 737 
XP_015202792  669 VVDLGPEIQ-GDFPFPVKVMYSLDeEEESQGGIAVNLLPLLVkDLSQKGAQWSQPGEENKKQVSPLRLASFFRLLRLCEE 747  spotted gar
3S4W_B        708 RQHDGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVEL 787  house mouse
XP_013001742  738 KQHNGNLEEIDGLLDCPLFLTDLEPGERLESMPAKERSFLCSLTFLTLNWFREVVNAFCQQPSPEMKGKVLMRLKVIVEL 817 
7AY1_B        747 RQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVEL 826  human
XP_023353940  741 KQH-GDLEEIDGLLDCPLYLTDLDLGEKLASLSVQERSFRCSLLFLVINWFREIVNAFCQQKSAEMKGKVLIRLRHITEL 819 
XP_008103225  743 ELNSGNLEDIDALLVCPLYLTNLEVGGKLDSLSKEEREFLCTLLFHALNWFHEVVNAFCRQNDAEIKGRVLARLQNITEL 822 
XP_005166084  741 VQHEGDLEEIDALLGCPLILTDMEVVEKVDSLSKSEREFLCSLLFHTINWFREVVNAFCRQNDPEMKMKVVTRIQNITYL 820 
XP_011472951  738 KRHQGDLEEIDALLGCPLILADMDVVEKVESLSKAERDFLCALLFHAINWFREVVNAFCKQTETEMKMKVMTRLQNITYL 817 
XP_005469603  738 KRHQGDLEEIDGLLGCPLILTNMDVVEKVESLSKAEREFLCTLLFHTINWFREVVNAFCTQKDTDMKMRVLTRLQNITYL 817 
XP_015202792  748 EQHDGDLEEIDALIGCPLILTDLDVVDKIESLSKSEKEFLCTLLFYTINWFREVVNGFCRQKDPEVKLKVVMRLQNITYL 827  spotted gar
3S4W_B        788 QGILEKYLAVIPDYVPPFASVDL----------------------------------------DTL--------DMMPR- 818  house mouse
XP_013001742  818 QDILEKHLAVTPDYVPPFAHFDLetldviphsssasaksrsk---gkirgrkqkaddgkaspaDKLskednsecEPVASg 894 
7AY1_B        827 QIILEKYLAVTPDYVPPLGNFDVetlditphtvtaisakirk---kgkierkqktdgsktsssDTLseeknsecDPTPSh 903  human
XP_023353940  820 QTLLENYLAVTPDYIPLLANFDLetldggphtsaavsvknkkkgekaqggkkrkadggksfslERHskedssecEHSQSd 899 
XP_008103225  823 QSLLEKVLAASPGYTPPLANFDSetvegmpinntvgttkk------knkgkkalksdsktsstDNSqmeedtesNLPESe 896 
XP_005166084  821 QSLLQTCLAATPGYIPPQANFDGesadvmipsssvvqqkkgk---kessgrkrkasasknssgDKSqlegaadaEESQPd 897 
XP_011472951  818 QTLLEKALAETPGFVPPVSNFDGessdrlalssavpalkpk-----kdgagkkrkaaarrsseGSSqpaeaaeaDETQQe 892 
XP_005469603  818 QTLLERALAGTPGYVPPIANFDGdgtdgivpnstvpvikik-----kdgtgkkrkapgknsseSSSqaeeateaDETQQe 892 
XP_015202792  828 QSILERCLAATPSYVPPPANFDCetaeggpaptstiplkkar---kelggkkrkaqaskavpgDSSqqeeggeaEESQQe 904  spotted gar
3S4W_B        819 --------------KT-FVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLE 883  house mouse
XP_013001742  895 rsqldk-eftgkeaRA-SVSLQNYRAFFRELDIEVFSILRCGLVTKVILDTEMHTEATEVLQLGPPELLFLLEDLSQKLE 972 
7AY1_B        904 rgqlnk-eftgkeeKT-SLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLE 981  human
XP_023353940  900 ksqpek-eftekeeEKaSVSLQNYTTFFRELDLEVFSVLHCGLLTKSLLDTEMHTEAIEVVQLGPPELLLLLNDLSQKLE 978 
XP_008103225  897 asqlek-dspgkesRTsLIPLQSYSAYFRELDLEVFNILHCGLLTKSILDTEMHTKTREIVQIGPAELLFLLEDLCRKLE 975 
XP_005166084  898 ppekesekekekdgKS-GVSLSSYWPFFRELDVEALSVLQCGLLSRTLLDTELHSKLREEVQLGPAELLFLLEDMWRKLD 976 
XP_011472951  893 hpeke----kdkdvWP-GVSLSVFRPFFRELDLEVLSVLQSGLLSRSLLDSELHTKVREEVLLGPAELVFLLEDLLHKLE 967 
XP_005469603  893 qpeke----kekeiRP-GVSLASYRPFFRELDMEVLSVLQCGLLSRSLLDSELHTKVREEVLLGPAELVLLLEDMLRKLE 967 
XP_015202792  905 kdhaek-ekekeegKA-GVSLASFRPYFRELDIEVLNVLQCGVLSRSLLDSELHTRVREEVRLGPSELVFLLEDLSRKLE 982  spotted gar
3S4W_B        884 NMLTAPFAKRICCFKNKGRQNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAEHLSA--DDKARATAQEQ 961  house mouse
XP_013001742  973 NMLLPSCTKRMSFLKSKGSRNIGFSHLHQSSASEVVNCVVQLVTPMCNHLENIHNYFQCLVPENHGVptVGGPGGNAQEY 1052
7AY1_B        982 SMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGV--VDGPGVKVQEY 1059 human
XP_023353940  979 NMFVPTATKRISFLKSKGSRNIGFSHLHQRSAQEVAHYLMLLLTPLCNHLENMHNYFQCLATENHGV--IDGPVVKIQEH 1056
XP_008103225  976 HVLIPAPAKRAPFLKGKGKRNAGFSHLCQRTSQEVIERVVEFLKPLCNHMENMHNFFQALMAENHGV--VDGPGVNIQEH 1053
XP_005166084  977 FSLTSAPAKKAPFLKGKMDKAVGFAHLQQKNAKEIATCCSDLLPTLCTHLENCHNHFQTLLTENQGV--VDAPNVDVKEN 1054
XP_011472951  968 FRLTAAPTKRAPFLKTRADRSVGFSHLQQRSTKDIASYCVQLLPALCTHLENCHNHFQALLSKNDGC--VDAAAADLQEH 1045
XP_005469603  968 FSLTAAPAKRAPFLKGRTDKSVGFSHLQQRSSKDIASYCVQLMPALCSHLENCHNHFQIMLSENNGV--VDGPATDVEEH 1045
XP_015202792  983 FSLAASPAKRAPFLKGKADKTVGFSHLQQKSPAEIAACCVQLLPTLCTHLENSHNYFQGLLTENQGV--VDALGVDVKEY 1060 spotted gar
3S4W_B        962 HTMACCYQKLLQVLHALFAWKGFTHQSKHRLLHSALEVLSNRLKQMEQDQPLEELVSQSFSYLQNFHHSVPSFQCGLYLL 1041 house mouse
XP_013001742 1053 QIMSSCYLRLLQIFHWLFAWSGFSNIENHSYLYSALEVLTGRVKQLQPDEALEELLSQSFNYLQNFHNSIPSFQCGLCLI 1132
7AY1_B       1060 HIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLI 1139 human
XP_023353940 1057 QIMSSCYQRLLQIFLSLFAWSGFSQPENRNLMLMALKVLANRLKQGDHEMPLGELFSQSFHYLQNFHHSVPTFQCAVYLI 1136
XP_008103225 1054 QFMSSCYQHLLQIFRLLFAWSGFSQHENHSLLKSGLHVLTDRLKPGEKEFSLEDLLSHSFQYLLNFQHSVPNIYCALSLT 1133
XP_005166084 1055 QLMCSAYQLLLQVLHTMFSWSGFSIPEHRGLLKSALGILAGRLKEDQADLTLDQLSRHAFEYLQNFRSTVPSLNTALCLT 1134
XP_011472951 1046 RLMSASYQLLLQVLNTVFSWSGFSQPGHRNLLKKALGVLAERLKEGDADLTLEQFVKHSFEYLLNFRSTMPSLNTALCLS 1125
XP_005469603 1046 QLMSSAYQLLLQVLNTTFSWSGFSQPGQKSLLKKALGVFAGRLKEGGAELTLEQLVKHSFEYLLNFRSTVPNLSIALCLS 1125
XP_015202792 1061 QLMASCYQLLIQVLHTTFSWNGFLQQEKRKLLKMALGVLAGRLKEKEVELSLEEQVRHSFEYLLNFRSSMPTCCTALSLI 1140 spotted gar
3S4W_B       1042 RLLMALLEKSA-VPNQKKEKLASLAKQLLCRAW--PHGEKEKNPTFNDHLHDVLYIYLEHTDNVLKAIEEITGVGVPELV 1118 house mouse
XP_013001742 1133 RILMALFKRSV-DPAPKKEKIAFLARQFLCRVW--PHGEKEKTSVFKDQLQDLLCIYLEHTDSVLKAIEEIAGVGVPELI 1209
7AY1_B       1140 RLLMVILEKST-ASAQNKEKIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELI 1216 human
XP_023353940 1137 RLLIVISEKS--AASQNKEKLASLARQFLCQVWiqPNGEREKGSSFNDQLHTLLCIYMEQADSVLKLIEEIAGTGVPELI 1214
XP_008103225 1134 QLLLVIAEKS--VINLKHKEIGSITKYFLCQSWmqPNGTRQKGTQFNDALHTLFCIYMEHTDNVLKAIEDISSIGIPELI 1211
XP_005166084 1135 QLLIVLSQYGGsNHRTYREQITSLTKHFLCQEWvtASGEKERGNKYNETLQTLLSIYLEHTDDVLKAVEEIAGEGVPELL 1214
XP_011472951 1126 QLLSTVAERGG-NAAAHRDQTASLARHFLSQVWvtASGERERGNKFNEALHALLTIYLEQVDDILKVVEEIAGEGISELL 1204
XP_005469603 1126 QLLSTVSEKGA-NPAAYREQTASLARRFLNQDWvtASGEKERGTKFNEALHTLLSIYLDHVDDILKAVEEIAAEGIPELL 1204
XP_015202792 1141 QLLILIAECAGpSNSAYREHLASLARRFLCQEWvlPSGERERGNKHNDTLQTLLSIYLDHSADVLKAIEEIAEEGVSELV 1220 spotted gar
3S4W_B       1119 SAPKDAASSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTA-ADSQQVHEEKLLYWNMAVRDFSILLNLMKVFDSYPVL 1197 house mouse
XP_013001742 1210 HSPKDACSPTFPTLTRQTFVIFFRVMMAKLEKTVKSLQAGSA-VQPPKVHEEKLLYWNMAVRDFSILINLIKVFDSHPVL 1288
7AY1_B       1217 NSPKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTA-ADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVL 1295 human
XP_023353940 1215 GSSKDAASSSFPTLTRQTFVVFFRVMMTELEKSVRNLQAGTA-ADLPKVHEEKLLYWSMAVRDFNILINLVKVFDSRPVL 1293
XP_008103225 1212 NSSKDGYSSTYPTLTRQTFPIFFRVMMTQLESSIKSISPGTAsSDTREVQLEKLLQWNMAVRDFHILVNLVKVFDSRPVL 1291
XP_005166084 1215 NAAKDANSRSWPTLNRQTFLVYYKCMMSELEKAVRKIPPSKQ-MDNQEMQSEKLLTWNLAVRDFHILINLVKMFDSRPVL 1293
XP_011472951 1205 NVSKDESSASWPTLNRQTFLVFYKVLLAELEKAVRKIPAGKS-SDDSEAQSEKLLTWNLAVRDFHILVNLVKVFDSRSVL 1283
XP_005469603 1205 NASKDESSASWPTLSRQTFLVFYKVLMAELEKAVRKIPPSKM-SDNTEAQSEKLLTWNLAVRDFHILVNLVKVFDSRPVL 1283
XP_015202792 1221 SSAKDGCSKTFPTLNRQTFLVFYRGMMMELEKSVRRIQPGKQ-TDSSETQTEKLRIWNLAVRDFHILVNLVKVFDSRSVI 1299 spotted gar
3S4W_B       1198 HVCLKYGRRFVEAFLKQCMPLLDFSFRKHREDVLSLLQTLQLNTRLLHHLCGHSKIRQDTRLTKHVPLLKKSLELLVCRV 1277 house mouse
XP_013001742 1289 HACLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKTLEQLVCRV 1368
7AY1_B       1296 HVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRV 1375 human
XP_023353940 1294 NVCLKYGRLFVETFLKQCMPLLDFSFRKHREDVLSLLKTFQLSTRQLHHMCGHSKIHQDTSLTNHVPLLKKTLELFVYRV 1373
XP_008103225 1292 SVCLKYGRLFVETFLKHGMPLLDYSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTSHVPFLKKSLELFVYRV 1371
XP_005166084 1294 TVCLKYGRLFLESFLKLGMPLLDYSFKKHKEDVQGLLKTFQLSTRQLHHMCGHSKIRQDTGLTNHVPALKKSLEQFVYRV 1373
XP_011472951 1284 NVCLKYGRLFLESFLKLGMPLLDYSFKRHKEDVQSLLKTFQLSTRQLHHMCGHSKIRQDTSLTNHVPALKKSLELFLYRV 1363
XP_005469603 1284 NVCLKYGRLFLESFLKLGMPLLDYSFKRHKEDVQSLLKTFQLSTRQLHHMCGHSKMHQDTSLTNHVPALKKSLELFVYRV 1363
XP_015202792 1300 GVCLKYGRLFVEAFLKLGMPLLDFSFKKHKEDVQTLLKTFQLSTRQLHHVCGYSKIRQDTGLTNHVPVLKKTLEQFVYRV 1379 spotted gar
3S4W_B       1278 KAMLVLNNCREAFWLGTLKNRDLQGEEIISQDpsSSESNAEDSEDG 1323 house mouse
XP_013001742 1369 KAMLVLNNCREAFWLGNLKNRDLQGEEIVSQD--SQGSTAEESEDS 1412
7AY1_B       1376 KAMLTLNNCREAFWLGNLKNRDLQGEEIKSQN--SQESTADESEDD 1419 human
XP_023353940 1374 KAMLILNNCQEAFWLGNLKNRDLQGEEILSQQ--SQESSTDENQEE 1417
XP_008103225 1372 KAMLALNHCQEAFWVGVLKNRDLQGDEILSQA--SEASLTEDEEVS 1415
XP_005166084 1374 KAMLTLNHCQEAFWLGNLKNRDLKGEEILSQR--SQAADEEEEESS 1417
XP_011472951 1364 KAMLALNNCQEAFWMGNLKNRNLKGEEILSQR--SQDSDEDEDEEE 1407
XP_005469603 1364 KAMLTLNNCQEAFWLGNLKNRNLKGEEILSQR--SQEDDDDEEEee 1407
XP_015202792 1380 KATLVLNSCQEAFWLGNLKNRDLQGEEILSQR--SQASDEEDEQQV 1423 spotted gar
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