Conserved Protein Domain Family
LMBR1

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pfam04791: LMBR1 
LMBR1-like membrane protein
Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.
Statistics
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PSSM-Id: 461429
Aligned: 76 rows
Threshold Bit Score: 132.395
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P34535        68 QQIICMWLFMLLYLFAYWLISRLKRKTEREAlyagee--dyfvyrVSVWISSTATATSIGSLTLLPFSVIGVEll--qLY 143  Caenorhabditis...
Q86AH0        93 EGIVSSIFFLILMIFSHFIIRRYIRKKDDEKki-----------yIPRLLCTVCLSISISAMLLIPITIISNEim--tTF 159  Dictyostelium ...
EXX64430      26 QNIIAFLLFVSLYSISYSLLQRFRRKNRITDieeeeddpygidslIIIILCAGGLAMALAGFLLWPFTMIATAllhneIF 105 
EFN58402       5 LIIITVVVAILVLLVSLYLVVHFQHPEDKNqa------------wLPKLVVLLGFSVAFWTILLFPLDVANQQ-----AC 67  
XP_009392724   8 LLIVAVVVSALVLLVSVYLLVNYQHPDDHNqa------------yFPKLVVVLGISIAAISILMLPADVANRQ-----AC 70  
BAJ85289       8 LVIVAAVVSVLVLLVSVYLLVNYQHPDDANqa------------yFPKLVVVLGITVAVLSILMLPADVANRQ-----AC 70  
Q9SR93         8 LVIVAIVVCVIVFISSIYLLVNYQHPDDANqa------------yFPKFVVVFGLSIAMISILMLPADVANRH-----AC 70   thale cress
XP_002967454   8 LLIIVIVVTVLVFLFNTYLLVNYQHPDDHNqa------------yFPKAVVVFGLSVAQLSILMLPADVANRH-----AC 70  
EFJ25483       7 LLVIVVLLTLLVFAINIYILIRYQHPDDSNqa------------yLPKIIVVIGLSIAQLSILMLPADVANRH-----SC 69  
EEC43650       6 LIVATVVAIVILLIIASYLLVHYQHPDDHNda------------yVPKLIVLLGFVLAGATVLMLPLDVANN------EG 67  
P34535       144 DGNYYLQWLSYSL-IGALWNYVFVLSNVSLFVLLPFSYFFIESQGFSTSKIGnd-----mtQRIYEAMAISFLFAFVLLC 217  Caenorhabditis...
Q86AH0       160 PSSYYTQWLDREL-IFSFWNKIFWGANISLFIILPFTYFLYESEGIRGRSLL---------NRIKEALLILLLVAVIFVG 229  Dictyostelium ...
EXX64430     106 SGNYYLTWLDVEL-LVTLWNYAFIGCNISLFALLPFAFFYSETDQLRTFF-----------AKARETLIIMGLVGMLMYG 173 
EFN58402      68 ELDIPLSSCS-TMpMKELWYAMYIANMAITFIAVPFCIFYYEADSDWSv-----------fRRS-LSGALWAAGTVFVMA 134 
XP_009392724  71 RHAIYNGACSLTLpMKQLWLAVYIADAILVFFVIPFAMFYYEGDQDKGi-----------gKRL-KSALLWVVTSAIVCG 138 
BAJ85289      71 KRAVYSGACSLTLpMKTLWLVVYIIDAVLVFLVIPFAMFYYEGDQDKSv-----------gKRL-KSALIWVVASAVVCG 138 
Q9SR93        71 RHAIYNGACNLTLpMKDLWLAIYIVDAILVFFVIPFAMFFYEGDQDKTl-----------gKRI-KSALIWVVTTAVVCA 138  thale cress
XP_002967454  71 QRALYNGACDLTLpMKDLWYAVYIIDAVLVFLVIPFTMFYYEGDQEKSv-----------aRRA-VGALMWVIVIAIVVG 138 
EFJ25483      70 EKNLYVGACKLTLpMKQLWWAVYIIDTVLVYLVIPFAIFFYEGDQEKTv-----------tQRI-KNALLWVVILLTVFC 137 
EEC43650      68 YAGYDTGLCG-GLnMELMWDIVFWMIPIWVFVLIPFATFYYEADDGMLmagtayapnpvrqSRI-GQAICYQLFVFVIIG 145 
P34535       218 LAEVVLTIl--------------------------------------------------------------dYPVSFLsI 235  Caenorhabditis...
Q86AH0       230 FVFVVFKLfygqq------------------------------------------------------kqpstLMENISiI 255  Dictyostelium ...
EXX64430     174 FIYTLKMLf------------------------------------------------------------------GISnV 187 
EFN58402     135 ILIGIPYAfagnaqytvqgarsgllpisylsnaedsftnciglfsyydqdsgqpklnstlvslgyncdtlinQLSEVWtI 214 
XP_009392724 139 LLLGILYGlvgkvdftvrhlsssaesfpssw------------------tgfsrsqpcisssrlcdayiapaTSEKTWtM 200 
BAJ85289     139 LVLGILYAligkvdftvrhlsssvqtfpgpnqf---------------gaftsgqpciapltrqcsantapaNSQTTWtM 203 
Q9SR93       139 LVLGILYGvigkvdfsvrhlasatstfptsw------------------qfsntqpcigntarqcsaftanpTSEKTWtM 200  thale cress
XP_002967454 139 LVLGILYGligkvdftvrhlssttigfttdysq---------------ltsrspclvptnspnacsaynagyGAEATWsM 203 
EFJ25483     138 LLLGILYAvigyadftvrrlssttlaftndfssl-------------nakapclfpagfslssncaaytsgsLVKTTWsV 204 
EEC43650     146 VIFAVTYIslsdskipvqeyvgpalgkvnqgftysaqr----natddllpfdsdglqpwgdsdttylsnvvdNGEQTLvL 221 
P34535       236 TsVNLPLIYSCVSFIGAVLLLISTPYGFAKM----FSLARdflvteetadieeenseqsedvtepknsssdetihqvdrs 311  Caenorhabditis...
Q86AH0       256 StDYLPFSYSLISTFGTVVVMYSIPSGFNFLiskcISLr----------------------------------------- 294  Dictyostelium ...
EXX64430     188 DeLEMLNLFTCIG--GALICLKATPRGYIEI----FSCISklpl------------------------------------ 225 
EFN58402     215 RvSIIVYAMAIVATLGWVLFMVFGGIGLVALp---IDWIRefiarpkat------------------------------- 260 
XP_009392724 201 RtSFPEYVVALATIVGSVLFTIFGGVGIACLp---LGLIFsfirrpkav------------------------------- 246 
BAJ85289     204 RaTFPEYVVALATIVGSVLFTIFGGVGIACLp---LSLIFsfvrrpkav------------------------------- 249 
Q9SR93       201 RtTFPEYVVALATIVGSVLFTIFGGVGIACLp---LGLITafirrpkav------------------------------- 246  thale cress
XP_002967454 204 RtTFPQYLIALTTIVGSVLFTIFGGVGIACLp---LSLIFaffkrptav------------------------------- 249 
EFJ25483     205 RaPFPTYVIALNTIIGSILFTMFGGVGMATLp---LSLIFafknrpkcv------------------------------- 250 
EEC43650     222 QvSLSTFYAGLMAWLGWFLFAIFGGIGLAALp---LDLYLmfknrprhmdaaef-------------------------- 272 
P34535       312 dtphledvvnditenvdadgefRKDSDSGIESGSTEEMRLNTDDEEMGindsddksafgddgdlgnstptknkkkrrkhd 391  Caenorhabditis...
Q86AH0       295 ---------------------iVRPIEDEIKAAKMEIESITFTLDKAEaagfvnleikksklkkrllncsinsgnnnnnn 353  Dictyostelium ...
EXX64430     226 ------------------rpnyRRSLKEKLKRNKMDITVWQQRLENLE-------------------------------- 255 
EFN58402     261 -------------itrsqyidrARDLA---RRA----------------------------------------------- 277 
XP_009392724 247 -------------itrsqyikgATDLG---KKA----------------------------------------------- 263 
BAJ85289     250 -------------itrsqyikeATELG---KKA----------------------------------------------- 266 
Q9SR93       247 -------------itrsqyikeATELG---KKA----------------------------------------------- 263  thale cress
XP_002967454 250 -------------itrsqyikeATILG---KRA----------------------------------------------- 266 
EFJ25483     251 -------------itraqyvkeATDLA---KRS----------------------------------------------- 267 
EEC43650     273 ---------aeaqlslrervneMVDIGELIKIE----------------------------------------------- 296 
P34535       392 yaattpivrkwdkdvpkkpknpnfdyRNLKEYVKEARRQRSSLSESDdywfgspprssfsanyyssrfsrwkhNSETGLN 471  Caenorhabditis...
Q86AH0       354 nnnnnnnnnnnnnnnngnncndnkveKKKDNKNKNEMKSDKKTNHSN--------------------------VNSDIIS 407  Dictyostelium ...
EXX64430     256 --------------------------RGLRsiysvnn------------------------------------------- 266 
EFN58402     278 --------------------------KDILal------------------------------------------------ 283 
XP_009392724 264 --------------------------RELKkt------------------------------------------------ 269 
BAJ85289     267 --------------------------KELKka------------------------------------------------ 272 
Q9SR93       264 --------------------------RELKka------------------------------------------------ 269  thale cress
XP_002967454 267 --------------------------RELKet------------------------------------------------ 272 
EFJ25483     268 --------------------------NELKaa------------------------------------------------ 273 
EEC43650     297 --------------------------REQKaqaglt-------------------------------------------- 306 
P34535       472 psssllvdpfasgd-fheassseasstpLSPA------------------------------------------------ 502  Caenorhabditis...
Q86AH0       408 sssspsspltpssplsqasnanesnstvNTPNiiatttnsniviindeynnnnnnnninfengnnsnnennnnidndnle 487  Dictyostelium ...
EXX64430     267 ----------------------tsrsaiLVPStesqysysseklya---------------------------------- 290 
EFN58402         --------------------------------------------------------------------------------     
XP_009392724     --------------------------------------------------------------------------------     
BAJ85289         --------------------------------------------------------------------------------     
Q9SR93           --------------------------------------------------------------------------------      thale cress
XP_002967454     --------------------------------------------------------------------------------     
EFJ25483         --------------------------------------------------------------------------------     
EEC43650         --------------------------------------------------------------------------------     
P34535       503 -------------------RRTKSEEAIWKPVLHTVKSSKLYKRAIEKQgrl----------------------vklFMS 541  Caenorhabditis...
Q86AH0       488 tnienkkkinnylikkkkvNVNSNFKITPEEIQKLEDTRDELYLYIDKIsrp----------------------syfSST 545  Dictyostelium ...
EXX64430     291 ------sgianniitnrsgHLSNSRNEIIAKINKLEEEEKRLQKDLSHS------------------------------- 333 
EFN58402     284 -----------------adALKREE--------RERGRSWRWRRNIKALnnqlivleedetqlelvypqsedpdykwVLT 338 
XP_009392724 270 -----------------ieTLHQEE--------RSGSKGRKWRKNLKEAekelflleddmkaleemypqgeqaetvwALT 324 
BAJ85289     273 -----------------aeALHQEE--------RSGNKGRKWRKNVKAVekellllendmnaleemypqgekaeatwAFT 327 
Q9SR93       270 -----------------adGLHQEE--------RSGAKGRKWRKNVKAVekellqleedvnlleemypqgeqaetawAFT 324  thale cress
XP_002967454 273 -----------------tlALQREE--------RSSGKGRKWRKEMKKVqqellyleedvqrleeaypqgekadttwALT 327 
EFJ25483     274 -----------------tlGLQREE--------RGGKKGRKFRKNVKKVqqelvfleddvealneafpqgekadtswALT 328 
EEC43650     307 -------------safatfSLNSDT--------RKAARDEN--QAVLGFkqavylleqdve-----dfqnatvnykkYNV 358 
P34535       542 LRFPVAAAAL----LVLTTCSLIMVATNTL----KLLFgyrsLP-----VYAQYIeVHTRHSFGLFGACIETLLIIYVMI 608  Caenorhabditis...
Q86AH0       546 LVRILSSILLtiinFTITGWVIFKVFITLIkrifELFElesiKAyfdswMSSAIDlSKGSSKLGPFESLLETTIIIYLMI 625  Dictyostelium ...
EXX64430     334 ---PLYRNMLflvlFIVSHFIWLLILGHILyalmKSLLvddgKEl---kNLEALIgKQTVSLFG-FGTLNEITLIFCFTS 406 
EFN58402     339 VMGFWLKFFGgllgLAMSICWVLQIILYILi-----------DPpvtplLNDMFIkA--NDAFPLFGTLLFGLFAFYLQL 405 
XP_009392724 325 VLGYLAKFVLgvvgLIVSVAWVAHIVIYLLi-----------NPplspfLNEVFIkL--DSVWGLLGTAAFAIFCFYLLL 391 
BAJ85289     328 VLAYIGKLIFgivgLIVSIAWVAHIIIYLLv-----------DPplssfLNEIFIkL--DSVWGLLGTAAFAFFCFYLLI 394 
Q9SR93       325 VLGYLAKFILgivgLIVSIAWVAHIIIYLLv-----------DPplspfLNEVFIkL--DDVWGLLGTAAFAFFCFYLLL 391  thale cress
XP_002967454 328 VLGYLSKLLLglvgLVVSGAWVAHIIVYMLi-----------KPpfssfLNQVFIkL--DDVWGLLGTVAFAFFCLYLIL 394 
EFJ25483     329 VLFYLAKLVFgivgLALSIIWLLHIIVFMLv-----------NPpafpfLNQVFIqL--DSAWGLLGTTAFAIFCYYLVM 395 
EEC43650     359 LIPYIA-LLLslcaFIVSIFWFIHVIVYVFp-----------SPplapfLNNYFEwF--DKWFPLFGVLSVALFVSYLLL 424 
P34535       609 TSFVGLYSL---PVLRSLRPv-RKDTPMPTIIINSSIVLVVASa--------------lPVAVNTVGMTTFDLLGSHSSL 670  Caenorhabditis...
Q86AH0       626 SAFVGFLNE---PYFANIKPr-IHSTSLRKMIINTGIILLMSSs--------------fPVVVRILEISRFDLMGYYSHT 687  Dictyostelium ...
EXX64430     407 ATIIGVYSI---SPFKRIRPr-LGKMTVQQIIANVTVLLVISSs--------------wPVLVRVLGLTRLSSAGPYENF 468 
EFN58402     406 CVTKGNFKFglnLLIFRVHPmrRGATIMSSFLFNVALILLATTasiqfctaafalyadgTAINDIFGNQ----------L 475 
XP_009392724 392 AVIAGEMMLglkLVFFTIHPmkWGGTLMNSFLFNVGLILLCSIsviqfcasafayysqaTAAQEIFGHT----------L 461 
BAJ85289     395 AVIAGEMMLglkLVFITIHPmkWGGTLMNSFLFNVGLILLCSIsviqfcatafayyaqaTAAQEIFGHT----------L 464 
Q9SR93       392 AVIAGAMMLglkLVFITIHPmkWGATLMNSFLFNVGLILLCSIsviqfcatafgyyaqaTAAQEIFGHT----------L 461  thale cress
XP_002967454 395 AVISGEMHLglnFGLIAIHPmkYGGTLMNSFLFNVGLILLCSVsviqfcskafalyaraTTAQEIFGLT----------L 464 
EFJ25483     396 SVISGEMHLgmrLLFLSIHPmkYQGTLMNSFLFNVAIILLCSTsviqfctkafslyaeaTAAQEIFGHS----------L 465 
EEC43650     425 AALKGCFKFgirFLFFHIHPmkVGKTYMSSFMFNIALVLLCALpavqfsqaafadyaafAEIRQIFGVQ----------I 494 
P34535       671 QWLGsF--RVVVAYNTLFVVLSVAFLFNQL 698  Caenorhabditis elegans
Q86AH0       688 NYLRgD--FFKIIYSISFLFMVIRSYMLSF 715  Dictyostelium discoideum
EXX64430     469 STMTnIgqYLAMAFRVSALITTVFSTLEYY 498 
EFN58402     476 SSIKgL--KYIYNENIFIYCLLGFMALTLV 503 
XP_009392724 462 QSLRgI--KYLYKYNVFQYGFVGFAVLTLF 489 
BAJ85289     465 QSLRgI--KYLYKYNVFQYGFVALAILTLF 492 
Q9SR93       462 QSLRgI--KYLYKYNVFQIGFVILAGLTFL 489  thale cress
XP_002967454 465 ESLRgI--KYLFRYNVFQIAFCVLSVVTLV 492 
EFJ25483     466 ESLRgL--KYLFIFNVFQIAFIVFAFLSFL 493 
EEC43650     495 QFLQfF--SFFWTNNVFIYCFLAFTVLTSI 522 
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