1SFC,1L4A,2KOG,3HD7,1KIL


Conserved Protein Domain Family
R-SNARE_VAMP2

?
cd15870: R-SNARE_VAMP2 
Click on image for an interactive view with Cn3D
SNARE motif of VAMP2
The VAMP-2 (vesicle-associated membrane protein 2, also called synaptobrevin-2) protein belongs to the R-SNARE subgroup of SNAREs and interacts with Syntaxin-1 (Qa) and SNAP-25(Qb/Qc), as well as syntaxin 12 (Qa) and SNAP23 (Qb/Qc). The complexes play a role in transport of secretory granule from trans-Golgi network to the plasma membrane, and in the transport from early endosomes to and from the plasma membrane, respectively. SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins contain coiled-coil helices (called SNARE motifs) which mediate the interactions between SNARE proteins, and a transmembrane domain. The SNARE complex mediates membrane fusion, important for trafficking of newly synthesized proteins, recycling of pre-existing proteins and organelle formation. SNARE proteins are classified into four groups, Qa-, Qb-, Qc- and R-SNAREs, depending on whether the residue in the hydrophilic center layer of the four-helical bundle is a glutamine (Q) or arginine (R). Qa-, as well as Qb- and Qc-SNAREs, are localized to target organelle membranes, while R-SNARE is localized to vesicle membranes. They form unique complexes consisting of one member of each subgroup, that mediate fusion between a specific type of vesicles and their target organelle. Their SNARE motifs form twisted and parallel heterotetrameric helix bundles.
Statistics
?
PSSM-Id: 277223
Aligned: 27 rows
Threshold Bit Score: 91.6781
Created: 16-Jul-2013
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
heterotetramerzero layer
Conserved site includes 48 residues -Click on image for an interactive view with Cn3D
Feature 1:heterotetramer interface [polypeptide binding site]
Evidence:
  • Structure:1SFC, Rattus norvegicus neuronal synaptic fusion complex, contacts 4A
  • Citation:PMID 9759724

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         ### ## ###### ### #  ## ### ###### ###### ###### ###### ###  #
1SFC_A        30 RRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKN 92  Norway rat
O01388        29 KRLQQAQAQVDEVVDMMRVNVDKVLEKDQKLAELDGRADALQAGASQFEASAGKLKRKFWWKN 91  medicinal leech
Q27236        17 KRLQQTQAQVNEVVDIMRVNVDKVLERDKNLSELDGRADALQAGASQFEASAGKLKRKFWWKN 79  Schistosoma mansoni
O02495        22 KRLQQTQAQVDEVVGIMKVNVEKVLERDQKLSQLDDRADALQEGASQFEKSAATLKRKYWWKN 84  Caenorhabditis elegans
XP_001634446   4 KRLQQTQAQVDEVVDIMKVNVDKVLERDAKLSELDNRADALQAGASQFETSASRLKRKMWWQN 66  starlet sea anemone
AAF45301      32 KRMQMAQAQVNEVIDVMRNNVNKVMERDVQLNSLDHRAEVLQNGASQFQQSSRTLRQKYWWQN 94  nematode
XP_001812338  11 EKLKETQAQVDEVVNIMRVNLEKVMEREDNLKRMNTIAEDLIAGSQQFEQQAGKLKKKYWWKN 73  red flour beetle
Q86FE1        53 DRIRQHQAKVQEVVGIMKDNVNLVLERETRLAEIDTRADELQVQSKQFQSAASRVRRKYFWQN 115 Schistosoma japonicum
ACO10223      12 SSFQSTKRQVDEVVNIMRDNINKVIERDQKLESLDTRAANLQENSNAFATTSIRLRRKYWWQN 74  Caligus rogercresseyi
ADD38083      13 PHFENVQNQVDEVVTIMRENVNKVIQRDEKLGDLDDRAANLEANSNSFAASSVRLRRKYWWEN 75  salmon louse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap