Conserved Protein Domain Family
KRTAP
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pfam11759: KRTAP 
Keratin-associated matrix
The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.
Links
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Statistics
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PSSM-Id: 314599
Aligned: 16 rows
Threshold Bit Score: 29.7977
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q925I0   1 MS--YYSGYSGGLGYGY----Gs--SFG-GLG----CGCNsirrlgcgsgyggFgygsgyggfggfgygsgyggygygsg 67  house mouse
Q3V4B6   1 MC--YYGGYYGGLGYGY----------G-GLGcgygC------------------------------------------- 24  house mouse
Q3LI61   1 MC--YYSNYYGGLRYGY----------G-VLGggygCGCgyg-------------------------------------- 29  human
Q3LI59   1 MCcnYYRNCCGGCGYGS----Gw--SSGcGYGcgygCGYGsg---------crYgsg----------------------- 42  human
Q3LHN2   1 MC----------YGYGC--------GCGsFCRlgygCGYE---------------------------------------- 22  human
Q3LI63   1 MI--YYSNYYGGYGYG-------------GLGcgygCGYR---------------------------------------- 25  human
Q3MIV0   1 MS--FDNNYHGGQGYAK----------G-GLGcsygCGLS---------------------------------------- 27  human
Q3LI66   1 MCgsYYGNYYGDHGYGCcgyeGlgyGYG-SLRcgysSC---------------Cgy------------------------ 40  human
Q925H3   1 MCg-YYGNYYGGRGYGCcgcgGlgyGYG-GLGcgygSYYGcgyr------glgCgyg----------------------- 49  house mouse
Q925H4   2 CCn-YYGNSCGGCGYGS----Ry--GYGcGYGsgygCGYG-------------Sgygc---------------------- 39  house mouse

Q925I0  68 yggfGGFGY----GSGYG-GF--GYGSgyggfggfGYGSGYGGY 104 house mouse
Q3V4B6  25 ---------------DYG-SY--GYGC--------CRPLCCRRY 42  house mouse
Q3LI61  30 -hgyGGLGCg--yGRGYG-GY--GYGC--------CRPSCYGRY 59  human
Q3LI59  43 --ygTGCGY----GCGYGsGC--GYGCgysssccgYRPLCYRRC 78  human
Q3LHN2  23 -------GCr--yGCGHR-GC--GDGC--------CCPSCYRRY 46  human
Q3LI63  26 -----GYGCg--yG-GYG-GY--GNGY--------YCPSCYGRY 50  human
Q3MIV0  28 -------------------GY--GYAC--------YCPWCYERS 42  human
Q3LI66  41 ---gHGYGSrffcGCGYGcGS--GY------------------Y 61  human
Q925H3  50 --ygCGYGSrslyGCGYGcGS--GYGS------------GFGYY 77  house mouse
Q925H4  40 -gygSGYGCg--yGSGYGcGYgsGYGC--------GYGSGYGCG 72  house mouse
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