5KL8


Conserved Protein Domain Family
zf-nanos
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pfam05741: zf-nanos 
Nanos RNA binding domain
This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.
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Statistics
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PSSM-Id: 461728
Aligned: 69 rows
Threshold Bit Score: 62.5941
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5KL8_B        32 CVFCENNN--------------EPEAVINSHSVRDnFN-------RVLCPKLRTYVCPICGASGDSAHTIKYCPK 85 
EGT41018     119 CSFCFGTAtqragemgerlperDDWGTWSTHSCKE-RG-------IVTCPFLWQVTCPICGATGAAAHTRAEHVR 185
EGT48749     113 CSFCYGTAaqmareqgqpvpdkDDYGPWSSHSCKM-NG-------HVSCPFLWQVVCPLCGATGPVAHTRAEHLR 179
9_pfamImport   1 CSFCYGTYvtfarlsgnpilskDDSGPWSDHQCKT-NG-------IVSCPVLRRNKCTVCGATGDYAHTSKYHHE 67 
6_pfamImport   1 CSFCYGLAakkaeeagepiadrDDDGPWSNHQLKS-DG-------AVSCPVLRAVVCNICGATGETAHTTVYHST 67 
EGT48747     112 CSFCYKVAaqwaaeqevqvpskDDYGYWSSHSLMGrYG-------VVVCPVLRRVVCGHCGATGDHAHTTRFHEQ 179
PDM83437     773 CVYCKGTLk-------------LSEEEYSSHTLHDpSRprcgperRVTCPRLRETGCQYCGLKGDLAHDQFFCER 834
1_pfamImport   1 CYHCAYYN--------------KPTEEISSHNIRKpNG-------DLWCEDLQKQKCQHCEATGEKGHHHLICPK 54 
EFO91655     287 CFRCAYYD--------------MSKEEIASHNIRKeNG-------DLWCEHMKKIACVHCDAIGEKGHHPLVCPK 340
EGT40897      90 CSFCWKRAarwaredgvpvpskNARGSWSTHSLKG-PGpn----rVVTCPVLRQVVCGHCGATGDHAHTTHHHET 159
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