1D1J,1K0K,2BTF,1CQA,1F2K,1CJF


Conserved Protein Domain Family
PROF

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cd00148: PROF 
Click on image for an interactive view with Cn3D
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the cytoskeleton - it may also promote actin polymerization. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway.
Statistics
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PSSM-Id: 238085
Aligned: 26 rows
Threshold Bit Score: 85.0696
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:actin interaction site [polypeptide binding site]
Evidence:
  • Structure:2BTF_P
  • Citation:PMID 8413665
  • Comment:binds monomeric actin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1D1J_D      2 GWQSYVD-NLMCdg-------cCQEAAIVGYcdaKYVWAATaggv-----------fqsITPIEIDMIVg----kDREGF 58  human
2BTF_P      2 GWNAYID-NLMAdg-------tCQDAAIVGYkdsPSVWAAVpgkt-----------fvnITPAEVGILVg----kDRSSF 58  Bos taurus
3024446     2 SWQSYVDdSLVGsg-------fMHSAAIVGLa-dGSYWAYGgt--------------yvPQPEEVTHILkc--leNFSLV 57  Trypanosoma brucei...
7505250     2 SWSDIINnNLIGsg-------nVSKAAILGFd--GAVWAKSdn--------------fnISVEEAVAAGka--ftSLDAL 56  Caenorhabditis ele...
AAK54060    2 AWEAYITsNLMCpvds--egntLDSAAILGLd-gSSVWASSaaf-------------qaLNDEEARKFVa-----AFDDV 60  Chlamydomonas rein...
AAD51420    3 GWDQYIQ-YLLAdk-------kCESAYILGKd-hANIWACStgiaalpty-qinvegknFNVNEAELLVealknnGVPTD 72  Tetrahymena thermo...
400849      2 SWDSYVD-NLIAqskdasgtthCDKACIIGKd--GSAWTTMptsdt--------snnlkLTPEEMANIAkcfkskDFAAF 70  Strongylocentrotus...
7509459     3 GWNAYID-TMTAaa------psIKRCAIVGAa-dGSVWARTeadn-----------vfkASEEELKTFVal--fnDVTQV 61  Caenorhabditis ele...
130981      3 GWDQYVQ-YLTAnq-------qVEYGLILGKt-dGTIWASNvglttlynnyqidvegqkANVNETANLLaamnnnGVPTD 73  Tetrahymena pyrifo...
1346807     2 SWQSYVDsFLVGag-------kGMGGAIIGLq--GGVWAASan--------------ctPSAQESVAIGtac-asNIAGL 57  Entamoeba histolytica
Feature 1     #             ## #           #          #                                      #
1D1J_D     59 FTNGLTLGAKKCSVIRDSlyvdgdcTMDIRTksqggeptyNVAVGRAGRALVIVMGKEG-------------------VH 119 human
2BTF_P     59 FVNGLTLGGQKCSVIRDSllqdgefTMDLRTkstggaptfNITVTMTAKTLVLLMGKEG-------------------VH 119 Bos taurus
3024446    58 QSSGVTICGVKFFGLQSGseg-qmkYIFFKKga------aGGCIYTSKQTAIIAVYGNPgdasalqqdlqkteatyvaVN 130 Trypanosoma brucei...
7505250    57 LGTGLRLEGQKFLVLNADn-----dRIIGKQgg------sGFFIYKTIQAVIISIYEKG-------------------LQ 106 Caenorhabditis ele...
AAK54060   61 SIASVMLAGAKYLKTSADg-----tIFRGRKdk------sGFVARKGAQCIIIGFYTDPp------------------VS 111 Chlamydomonas rein...
AAD51420   73 PNVGLRIKNEKYYTVRFDad---agTWYLKKdq------gGACIAVTKQALVIGTFKNDikmt-----------ngqpQN 132 Tetrahymena thermo...
400849     71 MSSGIYVNGTKYQFLREEds----kLVLGKKkg-----egSLTLQSSKTAIVIGHCPEG-------------------GQ 122 Strongylocentrotus...
7509459    62 PAKGADIEGVHYVVPRTEe-----sLIFGKKen------tGFFAVKTKSAVLIAVYEGPn------------------EV 112 Caenorhabditis ele...
130981     74 PLCGIRIMNQKYYTVKYDad---sqVWYLKKdh------gGACIAITNQALVIGTFDITkkqq-----------ngvaQN 133 Tetrahymena pyrifo...
1346807    58 QQTGVVIGGKKYMITRVDad---egTAMGKKga------eGISIYKTKQAVIIGYFSDAs------------------VS 110 Entamoeba histolytica
Feature 1     ##   #   #          
1D1J_D    120 GGTLNKKAYELALYLRRSDV 139 human
2BTF_P    120 GGMINKKCYEMASHLRRSQY 139 Bos taurus
3024446   131 PADCNTTVKRIAEYLISLDY 150 Trypanosoma brucei brucei
7505250   107 PEMCSKTTGALADYFRSIKY 126 Caenorhabditis elegans
AAK54060  112 AQTCNKVVEALADYLADQGY 131 Chlamydomonas reinhardtii
AAD51420  133 PGAVNAACEKLVESLKSANY 152 Tetrahymena thermophila
400849    123 QGNLNKAVGVIAEYLESLSM 142 Strongylocentrotus purpuratus
7509459   113 AAQVRKAVESMQTYLNNAGY 132 Caenorhabditis elegans
130981    134 PGQVNKVVESLAATLKQAGY 153 Tetrahymena pyriformis
1346807   111 AGQNSDATYKCAKYLMDAGY 130 Entamoeba histolytica

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