1NQZ,5T3P


Conserved Protein Domain Family
NUDIX_CoAse_Nudt7

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cd03426: NUDIX_CoAse_Nudt7 
coenzyme A pyrophosphatase and similar proteins
Coenzyme A pyrophosphatase (CoAse; EC 3.6.1.1), also called nucleoside diphosphate-linked moiety X)) motif 7, is a member of the NUDIX hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved NUDIX fold and requires a single divalent cation for catalysis. In addition to a signature NUDIX motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.
Statistics
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PSSM-Id: 467532
Aligned: 365 rows
Threshold Bit Score: 86.7787
Created: 12-Sep-2005
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:1NQZ: Deinococcus radiodurans CoAse binds Mg2+
  • Comment:The Mg2+ ion is coodinated by 5 water molecules and a Glu residue.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                           #  ##                     
1NQZ_A     34 RRAAVLVALTreadpRVLLTVRSSElp-tHKGQIAFPGGSLDAg-eTPTQAALREAQEEVALDPaavTLLGELDDVFTPv 111 Deinococcus radiod...
AAY79946    4 CKAAVVALISkv--gKILIIKRKEKpgdpWSGHMALPGGRREDh-eECESTAIRECYEEVRIKPrnlIRVGIYSPNNAPd 80  Sulfolobus acidoca...
AEE95111    3 CDAAVVLLLNce--nKFLLIKRSTNpndpWSGDMALPGGHREGn-eDCETTAKRECKEETGIEP---EIIAFLGYYSPHn 76  Acidianus hospital...
BAB65572    4 CKAAVVALISan--gKILLIKRKENkndpWSGHIALPGGRREGn-eECSFTAIRECLEEVGIRP---CNLIELGIYYPNn 77  Sulfolobus tokodai...
AEF41144   21 MRAATALVLCaepepLFVVIRRATRhgdpWSGHAALPGGRCDKsdvDAAATARRETHEEIGLIVg--EPVGQLDDIGGRf 98  Mycobacterium sp. ...
EHP70576    3 CNAAVVLLKRsd--gKLLIIRRAEVsgdpWSGHMALPGGHREVg-eDCRHTAIRETQEEVGILP---SNLTFLGIYWPNn 76  Metallosphaera yel...
CCC82636   13 NTAAVALLLQg---gRFLLIKRAERegdpWSGHVGFPGGHWKPg-eSLLDTVTREVLEEVGIDLrtaHLMGVMEPDSPMn 88  Thermoproteus tena...
AAL62603   13 DWAAVGVLLRe---gSVLLIKRVERegdpWSGQVAFPGGRWKPg-eDLMDTVVREVEEEVGVRPt--ALVGVLPPQSPSn 86  Pyrobaculum aeroph...
AAT43385    3 CQASVSIIINg---kSILLIKRQINlndpWSGHMALPGGHRLNh-eTCEQAAVRETYEEVGLKI---KIIDFLGIYVPGn 75  Picrophilus torrid...
CAC11497    4 GEAAVGLIIDk---sDILLIKRKTRsddpWSGDVAFPGGFLKEn-eSPAQCVIREIKEEVSLYFterDILAEMPLHYPVs 79  Thermoplasma acido...
Feature 1                                                                                     
1NQZ_A    112 --gFHVTPVLGRIApealdtlrvtpEVAQIITPTLAELRAvplvrerrtlpdg-----tevplyrypwrgLDIWGMTARV 184 Deinococcus radiod...
AAY79946   81 ---MKVSAYISCVEeelep-ivqeeELEKAIWIRISDLKPgdkaf---------------------yyenYRIWGMTYRI 135 Sulfolobus acidoca...
AEE95111   77 a-nITVAAFLGRTCfskik--rdkkEVAKYFWVSFSELKKgeecf---------------------yykkYRIWGMTYRI 132 Acidianus hospital...
BAB65572   78 mptMLVKAYVSCIDkevtl-qiqkeEVDTAFWADINKLEKgkgde--------------------yyfngYRIWGMTYRI 136 Sulfolobus tokodai...
AEF41144   99 h-kGVVTPVVFQISraqpl-hpdprEVAAAHWVPLSLLEDpkrrtrhphrkigpwpawdyqtgdvppldsLIIWGLTHRI 176 Mycobacterium sp. ...
EHP70576   77 rkdLKVAAFLGETDsdiv---rpngEVASYFWVDPQELEQrddcy---------------------mykgFRIWGMTYRI 132 Metallosphaera yel...
CCC82636   89 ardLKVYPFVFELGsvgdi--rlgeEVAGYMWVTKSDLVEtewrgrp-----------------afnvmgWIVWGLTYRF 149 Thermoproteus tena...
AAL62603   87 apwLKVVPFVFSQWvgevr--pnprEVREARWISKGEMSEgewmgrr-----------------ayvagdWVIWGLTYRI 147 Pyrobaculum aeroph...
AAT43385   76 rtdLNVAAFIARPLtlni---kidnEVSECFWASYNDLKElgnty---------------------iiknHVVFGMTYRI 131 Picrophilus torrid...
CAC11497   80 r-qLPVHPFIIKGYsleda--rpgdEVEEVRVANISDLIKdfdpnrg----------------niyryqdWVIWGLTYRI 140 Thermoplasma acido...
Feature 1         
1NQZ_A    185 LHDL 188 Deinococcus radiodurans
AAY79946  136 LNDI 139 Sulfolobus acidocaldarius DSM 639
AEE95111  133 IRDY 136 Acidianus hospitalis W1
BAB65572  137 LRDI 140 Sulfolobus tokodaii str. 7
AEF41144  177 LSNF 180 Mycobacterium sp. DQS39A1
EHP70576  133 LKDY 136 Metallosphaera yellowstonensis MK1
CCC82636  150 IKRA 153 Thermoproteus tenax Kra 1
AAL62603  148 LKRL 151 Pyrobaculum aerophilum str. IM2
AAT43385  132 LKDF 135 Picrophilus torridus DSM 9790
CAC11497  141 LTTY 144 Thermoplasma acidophilum

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